Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.46 extracted from

  • Atsumi, T.; Nishio, T.; Niwa, H.; Takeuchi, J.; Bando, H.; Shimizu, C.; Yoshioka, N.; Bucala, R.; Koike, T.
    Expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase/PFKFB3 isoforms in adipocytes and their potential role in glycolytic regulation (2005), Diabetes, 54, 3349-3357.
    View publication on PubMed
Search for more literature for 3.1.3.46

Cloned(Commentary)

Cloned (Comment) Organism
isozyme PFKFB3 from 3T3-L1 adipocytes, expression and splicing analysis, overview, expression as His-tagged enzyme in Escherichia coli, expression of His-tagged enzyme in COS-7 cells Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information PFKFB3 overexpression increases the glycolysis level in recombinant COS-7 cells Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information expression of isozyme PFKFB3 is reduced by treatment of 3T3-L1 cells with insulin Homo sapiens
additional information expression of isozyme PFKFB3 is reduced by prolonged treatment of 3T3-L1 cells with insulin Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
beta-D-fructose 2,6-bisphosphate + H2O Mus musculus the bifunctional enzyme is responsible for regulation of intracellular beta-D-fructose 2,6-bisphosphate level, isozyme PFKFB3 mediates beta-D-fructose 2,6-bisphosphate production in proliferating cells, isozyme roles in glycolysis regulation in adipocytes, overview D-fructose 6-phosphate + phosphate
-
 ?
beta-D-fructose 2,6-bisphosphate + H2O Homo sapiens the bifunctional enzyme is responsible for regulation of intracellular beta-D-fructose 2,6-bisphosphate level, isozyme PFKFB3 mediates beta-D-fructose 2,6-bisphosphate production in proliferating cells, isozyme roles in glycolysis regulation in adipocytes, overview D-fructose 6-phosphate + phosphate
-
 ?
additional information Mus musculus PFKFB3 overexpression increases the glycolysis level ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isozymes PFKFB1-4
-
Mus musculus
-
 male C57BL7& mice, isozyme PFKFB3
-

Source Tissue

Source Tissue Comment Organism Textmining
3T3-L1 cell adipocyte cell line Mus musculus
-
adipocyte inducible expression of isozyme PFKFB3 Mus musculus
-
adipocyte inducible expression of isozyme PFKFB3, visceral fat cell Homo sapiens
-
epididymis
-
 Mus musculus
-
fat pad epididymal, reduced expression of isozyme PFKFB3 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-D-fructose 2,6-bisphosphate + H2O
-
 Mus musculus D-fructose 6-phosphate + phosphate
-
 ?
beta-D-fructose 2,6-bisphosphate + H2O
-
 Homo sapiens D-fructose 6-phosphate + phosphate
-
 ?
beta-D-fructose 2,6-bisphosphate + H2O the bifunctional enzyme is responsible for regulation of intracellular beta-D-fructose 2,6-bisphosphate level, isozyme PFKFB3 mediates beta-D-fructose 2,6-bisphosphate production in proliferating cells, isozyme roles in glycolysis regulation in adipocytes, overview Mus musculus D-fructose 6-phosphate + phosphate
-
 ?
beta-D-fructose 2,6-bisphosphate + H2O the bifunctional enzyme is responsible for regulation of intracellular beta-D-fructose 2,6-bisphosphate level, isozyme PFKFB3 mediates beta-D-fructose 2,6-bisphosphate production in proliferating cells, isozyme roles in glycolysis regulation in adipocytes, overview Homo sapiens D-fructose 6-phosphate + phosphate
-
 ?
additional information PFKFB3 overexpression increases the glycolysis level Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
-
 Mus musculus
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
-
 Homo sapiens
More bifunctional enzyme, cf. EC 2.7.1.105 Mus musculus
PFKFB
-
 Mus musculus
PFKFB
-
 Homo sapiens