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Enzyme Nomenclature
Information on EC 1.1.1.44 - phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)
Word Map on EC 1.1.1.44
- 1.1.1.44
- glucose-6-phosphate
- pentose
- acp
- gpi
-
lipogenesis
-
lipogenic
-
malic
-
allozymes
- phosphoglucomutase
-
monomorphic
-
4.1.3.8
-
duffy
-
zymodemes
- medicine
- tropica
-
pelteobagrus
-
srebp-1
- fulvidraco
- synthesis
- pharmacology
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
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EC NUMBER 
COMMENTARY 
1.1.1.44
-
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RECOMMENDED NAME
GeneOntology No.
phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+
reductive carboxylation of ribulose-5-phosphate by 6PGDH is investigated using kinetic isotope effects. In the absence of 6-phosphogluconate, a slow step, which precedes the chemical process, is rate-limiting for the reaction, whereas in the presence of 6-phosphogluconate, the rate-limiting step follows the isotope-sensitive step. Full activity of 6PGDH is achieved when one subunit carries out the catalysis and the other subunit carries an unreacted 6-phosphogluconate (allosteric activator)
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
reduction
-
-
-
-
redox reaction
-
-
-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
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SYSTEMATIC NAME
IUBMB Comments
6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating)
The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce NADPH and pentose for biosynthetic reactions. Highly specific for NADP+. cf. EC 1.1.1.343, phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating).
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CAS REGISTRY NUMBER
COMMENTARY
9073-95-4
-
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
fragment. Its is proposed that plastid-lacking excavata acquire cyanobacterial gnd genes via eukaryote-to-eukaryote lateral gene transfer or primary endosymbiotic gene transfer early in eukaryotic evolution, and then lose either their pre-existing or cyanobacterial gene
SwissProt
fragment. Its is proposed that plastid-lacking excavata acquire cyanobacterial gnd genes via eukaryote-to-eukaryote lateral gene transfer or primary endosymbiotic gene transfer early in eukaryotic evolution, and then lose either their pre-existing or cyanobacterial gene
SwissProt
fragment. Its is proposed that plastid-lacking excavata acquire cyanobacterial gnd genes via eukaryote-to-eukaryote lateral gene transfer or primary endosymbiotic gene transfer early in eukaryotic evolution, and then lose either their pre-existing or cyanobacterial gene
SwissProt
fragment. Its is proposed that plastid-lacking excavata acquire cyanobacterial gnd genes via eukaryote-to-eukaryote lateral gene transfer or primary endosymbiotic gene transfer early in eukaryotic evolution, and then lose either their pre-existing or cyanobacterial gene
SWissProt
fragment. Its is proposed that plastid-lacking excavata acquire cyanobacterial gnd genes via eukaryote-to-eukaryote lateral gene transfer or primary endosymbiotic gene transfer early in eukaryotic evolution, and then lose either their pre-existing or cyanobacterial gene
SwissProt
fragment. Its is proposed that plastid-lacking excavata acquire cyanobacterial gnd genes via eukaryote-to-eukaryote lateral gene transfer or primary endosymbiotic gene transfer early in eukaryotic evolution, and then lose either their pre-existing or cyanobacterial gene
SwissProt
-
286824, 286829, 286831, 286833, 286834, 286835, 286836, 286838, 286842, 286849, 286850, 286851, 286852, 286853, 286854, 286860, 286869, 286871, 286873, 286874, 286875, 286881, 286882, 286883, 286884, 286890, 286892, 286893, 286894, 286895, 286901, 286902, 286903, 712444
-
-
human
286834, 286836, 286837, 286838, 286839, 286841, 286849, 286850, 286881, 286890, 286892, 286895, 286897, 286903
-
-
sheep
286827, 286829, 286830, 286831, 286833, 286837, 286838, 286840, 286844, 286849, 286850, 286852, 286855, 286871, 286875, 286881, 286883, 286892, 286898, 286899, 286902, 286903, 286987
-
-
rat
286826, 286829, 286833, 286836, 286838, 286840, 286846, 286849, 286850, 286859, 286868, 286877, 286882, 286892
-
-
-
-
-
mesophilic cyanobacterium, formerly called Coccochloris peniocystis; thermophilic cyanobacterium, formerly called Synechococcus lividus
-
-
mesophilic cyanobacterium, formerly called Coccochloris peniocystis
-
-
thermophilic cyanobacterium, formerly called Synechococcus lividus
-
-
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
metabolism
metabolism
-
phosphogluconate pathway, bacterial 6-phosphogluconate dehydrogenase is a constitutive enzyme, bacterial enzyme is active in young, non-inoculated mesquite seedlings growing under hydroponic conditions, external gluconate has no effect on the activity of 6-phosphogluconate dehydrogenase
metabolism
-
phosphogluconate pathway, bacterial 6-phosphogluconate dehydrogenase is a constitutive enzyme, bacterial enzyme is active in young, non-inoculated mesquite seedlings growing under hydroponic conditions, external gluconate has no effect on the activity of 6-phosphogluconate dehydrogenase
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-deoxy-6-phospho-D-gluconate + NADP+
3-oxo-2-deoxy-6-phosphogluconate + NADPH
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + NADPH + CO2 + H+
-
-
-
-
ir
beta-3-acetylpyridine adenine dinucleotide 2'-phosphate + 6-phosphogluconate
?
-
-
-
-
?
beta-nicotinamide 1-N6-ethenoadenine dinucleotide 2'-phosphate + 6-phosphogluconate
?
-
-
-
-
?
beta-nicotinamide adenine dinucleotide 3'-phosphate + 6-phosphogluconate
?
-
-
-
-
?
beta-nicotinamide hypoxanthine dinucleotide 2'-phosphate + 6-phosphogluconate
?
-
-
-
-
?
2-deoxy-3-oxo 6-phosphogluconate + ?
?
-
no decarboxylation by the liver enzyme
-
-
-
2-deoxy-6-phosphogluconate + NADP+
2-deoxy-3-oxo 6-phosphogluconate + NADPH
-
-
-
-
r
2-deoxy-6-phosphogluconate + NADP+
2-deoxy-3-oxo 6-phosphogluconate + NADPH
-
-
-
-
-
2-deoxy-6-phosphogluconate + NADP+
2-deoxy-3-oxo 6-phosphogluconate + NADPH
-
-
-
r
2-deoxy-6-phosphogluconate + NADP+
2-deoxy-3-oxo 6-phosphogluconate + NADPH
-
-
-
r
2-deoxy-6-phosphogluconate + NADP+
3-oxo-2-deoxy-6-phosphogluconate + NADPH
-
-
-
-
r
2-deoxy-6-phosphogluconate + NADP+
3-oxo-2-deoxy-6-phosphogluconate + NADPH
-
oxidation, 1.5% activity of that of 6-phosphogluconate
-
-
r
3-keto-6-phosphono-D-gluconate + ?
D-ribulose 5-phosphate + CO2
via 1,2-enediol intermediate
-
-
-
3-keto-6-phosphono-D-gluconate + ?
D-ribulose 5-phosphate + CO2
-
via 1,2-enediol intermediate
-
-
-
3-keto-6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2
-
via 1,2-enediol intermediate
-
-
?
3-keto-6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2
-
via 1,2-enediol intermediate
-
-
?
3-keto-6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2
-
via 1,2-enediol intermediate
-
-
?
3-keto-6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2
via 1,2-enediol intermediate
-
-
?
3-keto-6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2
-
via 1,2-enediol intermediate
-
-
?
3-oxo-2-deoxy-6-phosphogluconate + NADP+
1-deoxyribulose 5-phosphate + CO2 + NADPH
-
reaction requires presence of NADPH, but the reduced coenzyme does not play a redox role
-
-
-
3-oxo-2-deoxy-6-phosphogluconate + NADP+
1-deoxyribulose 5-phosphate + CO2 + NADPH
-
decarboxylation
-
-
r
3-oxo-2-deoxy-6-phosphogluconate + NADPH
2-deoxy-6-phosphogluconate + NADP+
-
-
-
-
r
3-oxo-2-deoxy-6-phosphogluconate + NADPH
2-deoxy-6-phosphogluconate + NADP+
-
reduction
-
-
r
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH
-
-
-
-
-
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH
-
the enzyme prefers NADP+ to NAD+ as an electron acceptor
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
Corynebacterium glutamicum ssp. flavum
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
286824, 286829, 286831, 286833, 286834, 286835, 286836, 286838, 286842, 286846, 286849, 286850, 286851, 286852, 286853, 286854, 286856, 286860, 286869, 286871, 286873, 286874, 286875, 286881, 286882, 286883, 286884, 286890, 286892, 286893, 286894, 286895, 286901, 286902, 286903
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
6-phosphogluconate modulates 6PGDH activity. In the forward reaction, it suppresses inhibition by NADP and decreases inhibition by NADPH by increasing the Kd of the reduced coenzyme 6fold it increases the rate of decarboxylation of the 3-keto intermediate , whereas in the reverse reaction, it decreases the Km and removes the slow step
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
286834, 286836, 286837, 286838, 286839, 286841, 286846, 286849, 286850, 286881, 286890, 286892, 286895, 286897, 286903
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
ir
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
mammary gland enzyme involved in NADPH production which is essential for lipogenesis
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
286827, 286829, 286830, 286831, 286833, 286837, 286838, 286840, 286844, 286849, 286850, 286852, 286855, 286862, 286871, 286872, 286875, 286881, 286883, 286884, 286890, 286892, 286894, 286898, 286899, 286901, 286902, 286903, 286904, 286987, 667652, 667707, 670006
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
oxidative enzyme of pentose phosphate pathway
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
286826, 286827, 286829, 286833, 286836, 286838, 286840, 286846, 286849, 286850, 286859, 286863, 286868, 286877, 286882, 286886, 286892, 286895
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
endosperm contains both cytosolic and plastic glycolytic and pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
pivotal enzyme links the gluconate route and the oxidative phase of the pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
the enzyme prefers NADP+ to NAD+ as an electron acceptor
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
?
6-phosphono-D-gluconate + NADP+
3-keto-6-phosphono-D-gluconate + NADPH
-
-
-
-
?
6-phosphono-D-gluconate + NADP+
3-keto-6-phosphono-D-gluconate + NADPH
-
-
-
-
6-phosphono-D-gluconate + NADP+
3-keto-6-phosphono-D-gluconate + NADPH
-
-
-
-
?
6-phosphono-D-gluconate + NADP+
3-keto-6-phosphono-D-gluconate + NADPH
-
-
-
-
-
6-phosphono-D-gluconate + NADP+
3-keto-6-phosphono-D-gluconate + NADPH
-
-
-
?
6-phosphono-D-gluconate + NADP+
3-keto-6-phosphono-D-gluconate + NADPH
-
-
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
part of oxidative pentosephosphate pathway, predominant enzyme in glucose and cluconate catabolism, pathway regulation, overview
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
the glucose-6-phosphate dehydrogenase/6-phosphogluconate dehydrogenase ratio in plants infected with potato virus Y is lower than in healthy plants, with glucose 6-phosphate dehydrogenase being the regulating enzyme of the oxidative pentosephosphate pathway
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
one of the key enzymes in the pentose phosphate pathway, may be important for cell division and salt response
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
the enzyme expression and activity is independently regulated in different tissues
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
third step in pentose phosphate metabolic pathway
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + NADPH
-
overall reaction
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + NADPH
overall reaction
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + NADPH
-
overall reaction
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + NADPH
-
overall reaction
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + NADPH
overall reaction
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + NADPH
-
overall reaction
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + NADPH
-
overall reaction
-
-
?
D-ribulose 5-phosphate + CO2 + NADPH
6-phospho-D-gluconate + NADP+
-
reverse reaction only to a very limited extent
-
-
r
ribulose 5-phosphate + H2O + NADPH
?
-
tritium exchange reaction between tritiated ribulose 5-phosphate and water, reaction requires presence of NADPH, but the reduced coenzyme does not play a redox role
-
-
?
additional information
?
-
-
glucose-6-phosphate is no substrate
-
-
-
additional information
?
-
-
neither gluconic acid nor glucose-6-phosphate can replace 6-phosphogluconate as substrate
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
Corynebacterium glutamicum ssp. flavum
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
286824, 286829, 286831, 286833, 286834, 286835, 286836, 286838, 286842, 286846, 286849, 286850, 286851, 286852, 286853, 286854, 286856, 286860, 286869, 286871, 286873, 286874, 286875, 286881, 286882, 286883, 286884, 286890, 286892, 286893, 286894, 286895, 286901, 286902, 286903
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
ir
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
mammary gland enzyme involved in NADPH production which is essential for lipogenesis
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
286827, 286833, 286837, 286838, 286840, 286844, 286849, 286850, 286855, 286871, 286881, 286884, 286890, 286892, 286894, 286898, 286899, 286902, 286903, 286987
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
oxidative enzyme of pentose phosphate pathway
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
286826, 286827, 286833, 286836, 286838, 286840, 286846, 286849, 286850, 286868, 286877, 286886, 286892
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
endosperm contains both cytosolic and plastic glycolytic and pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
pivotal enzyme links the gluconate route and the oxidative phase of the pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
enzyme specific for the oxidative pentose phosphate pathway
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
P31072
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
Q6NHC5
-
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
P80859
part of oxidative pentosephosphate pathway, predominant enzyme in glucose and cluconate catabolism, pathway regulation, overview
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
the glucose-6-phosphate dehydrogenase/6-phosphogluconate dehydrogenase ratio in plants infected with potato virus Y is lower than in healthy plants, with glucose 6-phosphate dehydrogenase being the regulating enzyme of the oxidative pentosephosphate pathway
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
Q9LI00
one of the key enzymes in the pentose phosphate pathway, may be important for cell division and salt response
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
-
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
the enzyme expression and activity is independently regulated in different tissues
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
-
third step in pentose phosphate metabolic pathway
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
NADP+
-
specific for NADP+, no activity observed when NAD+ is substituted for NADP+
NADP+
-
strictly specific for NADP+, no activity observed with NAD+
NADP+
-
absolutely specific with respect to NADP+, no reaction can be detected in the presence of NAD+
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
Mg2+
Mn2+
Mg2+
-
MgCl2 stimulation for the oxidative decarboxylation of 6-phosphogluconate
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
(-)-catechin gallate
-
NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase
(-)-epigallocatechin
-
NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase
(-)-epigallocatechin gallate
-
NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase
(-)-gallocatechin gallate
-
NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase
(2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid
(4S)-trans-4-ethylammonio-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
-
i.e. dorzolamide, competitive
(5-(dimethylamine)naphthalin-1-sulfonylchloride)
-
dansyl chloride, DNSCl, rapid inactivation at pH 7.5, 95% inhibition at pH 6.2
3-methyl-4-oxo-4,7-dihydro-5H-thiopyrano[3,4-b]furan-2-carboxylic acid
-
-
5-(3,7,12-trioxo-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
weak inhibition
5-(3alpha,7alpha,12alpha-triacetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
competitive
5-(3alpha,7alpha,12alpha-trihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
competitive
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
sodium (4E)-4-(hydroxyimino)-3-oxo-1,2,3,4-tetrahydronaphthalene-1-sulfonate
-
-
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
-
compound shows in vitro antiparasitic activity
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
-
compound shows in vitro antiparasitic activity
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
-
compound shows in vitro antiparasitic activity
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
-
compound shows in vitro antiparasitic activity
(2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
(2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
(2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
(2R,3R)-2,3,4,N-tetrahydroxybutyramide
-
compound shows in vitro antiparasitic activity
(2R,3R)-2,3,4,N-tetrahydroxybutyramide
-
compound shows in vitro antiparasitic activity
(2R,3R)-2,3,4,N-tetrahydroxybutyramide
-
compound shows in vitro antiparasitic activity
(2R,3R)-2,3,4,N-tetrahydroxybutyramide
-
compound shows in vitro antiparasitic activity
(3aR,6aR)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4-one
-
compound shows in vitro antiparasitic activity
(3aR,6aR)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4-one
-
compound shows in vitro antiparasitic activity
(3aR,6aR)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4-one
-
compound shows in vitro antiparasitic activity
(3aR,6aR)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4-one
-
compound shows in vitro antiparasitic activity
(3R,4R)-3,4-di(tetrahydro-2H-pyranyloxy)tetrahydro-2-furanone
-
compound shows in vitro antiparasitic activity
(3R,4R)-3,4-di(tetrahydro-2H-pyranyloxy)tetrahydro-2-furanone
-
compound shows in vitro antiparasitic activity
(3R,4R)-3,4-di(tetrahydro-2H-pyranyloxy)tetrahydro-2-furanone
-
compound shows in vitro antiparasitic activity
(3R,4R)-3,4-di(tetrahydro-2H-pyranyloxy)tetrahydro-2-furanone
-
compound shows in vitro antiparasitic activity
(4R,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid benzyloxyamide
-
compound shows in vitro antiparasitic activity
(4R,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid benzyloxyamide
-
compound shows in vitro antiparasitic activity
(4R,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid benzyloxyamide
-
compound shows in vitro antiparasitic activity
(4R,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid benzyloxyamide
-
compound shows in vitro antiparasitic activity
2-deoxy-6-phosphono-D-gluconate
-
compound shows in vitro antiparasitic activity
2-deoxy-6-phosphono-D-gluconate
-
compound shows in vitro antiparasitic activity
2-deoxy-6-phosphono-D-gluconate
-
compound shows in vitro antiparasitic activity
2-deoxy-6-phosphono-D-gluconate
-
compound shows in vitro antiparasitic activity
4,N-dihydroxy(2R,3R)-2,3-bis(tetrahydropyran-2-yloxy)butyramide
-
compound shows in vitro antiparasitic activity
4,N-dihydroxy(2R,3R)-2,3-bis(tetrahydropyran-2-yloxy)butyramide
-
compound shows in vitro antiparasitic activity
4,N-dihydroxy(2R,3R)-2,3-bis(tetrahydropyran-2-yloxy)butyramide
-
compound shows in vitro antiparasitic activity
4,N-dihydroxy(2R,3R)-2,3-bis(tetrahydropyran-2-yloxy)butyramide
-
compound shows in vitro antiparasitic activity
4-phospho-D-erythronamide
-
compound shows in vitro antiparasitic activity
4-phospho-D-erythronamide
-
compound shows in vitro antiparasitic activity
4-phospho-D-erythronamide
-
compound shows in vitro antiparasitic activity
4-phospho-D-erythronate
-
compound shows in vitro antiparasitic activity
4-phospho-D-erythronate
-
mimics the transition state of dehydrogenation. The inhibitor forces the catalytic lysine 185 into the protonated state
4-phospho-D-erythronohydroxamic acid
-
compound shows low in vitro antiparasitic activity
4-phospho-D-erythronohydroxamic acid
-
compound shows low in vitro antiparasitic activity
4-phospho-D-erythronohydroxamic acid
-
compound shows low in vitro antiparasitic activity
4-phospho-D-erythronohydroxamic acid
-
conversion of the 6-PGDH inhibitor into prodrugs to increase its activity against the Trypanosoma brucei by enhancing uptake by passive permeation across the plasma membrane. Production of five different phosphate-masking groups (phosphoramidate, bis-S-acyl thioethyl esters, bis-pivaloxymethyl, cycloSaligenyl and phenyl, S-acyl thioethyl mixed phosphate esters). Prodrugs are studied for stability and activity against the intact parasites. Most prodrugs cause inhibition of the growth of the parasites. The activity of the prodrugs against the parasites appears to be related to their stability in aqueous buffer
4-phospho-D-erythronohydroxamic acid
-
compound shows low in vitro antiparasitic activity
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
-
Ellman's reagent
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
-
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
-
compound shows in vitro antiparasitic activity
D-fructose 1,6-diphosphate
-
-
NADPH
-
6-phosphogluconate modulates 6PGDH activity. In the forward reaction, it suppresses inhibition by NADP and decreases inhibition by NADPH by increasing the Kd of the reduced coenzyme 6fold it increases the rate of decarboxylation of the 3-keto intermediate , whereas in the reverse reaction, it decreases the Km and removes the slow step
NADPH
-
competitive inhibition versus NADP+ with 6-phospho-D-gluconate equal to its Km and at a saturating concentration
phosphoric acid dibenzyl ester (2R,3R)-3-benzyloxycarbamoyl-2,3-dihydroxypropyl ester
-
compound shows in vitro antiparasitic activity
phosphoric acid dibenzyl ester (2R,3R)-3-benzyloxycarbamoyl-2,3-dihydroxypropyl ester
-
compound shows in vitro antiparasitic activity
phosphoric acid dibenzyl ester (2R,3R)-3-benzyloxycarbamoyl-2,3-dihydroxypropyl ester
-
compound shows in vitro antiparasitic activity
phosphoric acid dibenzyl ester (2R,3R)-3-benzyloxycarbamoyl-2,3-dihydroxypropyl ester
-
compound shows in vitro antiparasitic activity
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
-
compound shows in vitro antiparasitic activity
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
-
compound shows in vitro antiparasitic activity
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
-
compound shows in vitro antiparasitic activity
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
-
compound shows in vitro antiparasitic activity
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
-
-
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
-
compound shows in vitro antiparasitic activity
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
-
compound shows in vitro antiparasitic activity
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
-
compound shows in vitro antiparasitic activity
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
-
compound shows low in vitro antiparasitic activity
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
-
-
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
-
compound shows low in vitro antiparasitic activity
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
-
compound shows low in vitro antiparasitic activity
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
-
compound shows low in vitro antiparasitic activity
[(2R)-2,3-dihydroxypropylsulfanyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
[(2R)-2,3-dihydroxypropylsulfanyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
[(2R)-2,3-dihydroxypropylsulfanyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
[(2R)-2,3-dihydroxypropylsulfanyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propylsulfanyl]acetic acid
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propylsulfanyl]acetic acid
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propylsulfanyl]acetic acid
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propylsulfanyl]acetic acid
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
[(4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylsulfanyl]acetic acid benzyl ester
-
compound shows low in vitro antiparasitic activity
[(4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylsulfanyl]acetic acid benzyl ester
-
compound shows low in vitro antiparasitic activity
[(4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylsulfanyl]acetic acid benzyl ester
-
compound shows low in vitro antiparasitic activity
[(4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylsulfanyl]acetic acid benzyl ester
-
compound shows low in vitro antiparasitic activity
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
additional information
-
the activityand transcript level of 6PGDH decreases to 67% of its initial activity after 7 days of phosphate starvation
-
additional information
-
no inhibition by cefozin, decefin, streptomycin, combisid, and meronem
-
additional information
-
IC50 for antiparasitic activity of inhibitors, overview
-
additional information
-
not inhibited by ungallated catechins like (-)-epigallocatechin, (-)-gallocatechin, (-)-epicatechin, (-)-catechin, and dehydroepiandrosterone
-
additional information
-
infection with potato virus Y increases the enzyme activity but decreases the 6-phosphono-D-gluconate content, maximal decrease of 30-50% at period of the highest virus replication
-
additional information
-
no inhibition by [3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid, [(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester, (2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid, and acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
additional information
-
IC50 for antiparasitic activity of inhibitors, overview
-
additional information
-
ovariectomized rats show a decrease in mRNA level and enzyme activity in the liver, but not in white adipose tissue, which can be restored by 17beta-estradiol administration
-
additional information
-
IC50 values for antiparasitic activity of inhibitors, overview
-
additional information
-
IC50 values for antiparasitic activity of inhibitors, overview
-
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
17beta-estradiol
-
administration causes an increase in liver enzyme, but not in white adipose tissue enzyme, activity and mRNA level in female and male rats
2,3-diphosphoglycerate
-
activates both isoenzymes up to 200% of their original activity
5-(3alpha-acetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
activates
5-(3alpha-hydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
activates
gluconate
6-phosphogluconate dehydrogenase, although constituvely expressed, shows a 3-fold higher specific level in gluconate grown cells than those grown in fructose under similar conditions
additional information
-
external gluconate has no effect on the activity of 6-phosphogluconate dehydrogenase
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.011
6-phospho-D-gluconate
-
in 50 mM HEPES buffer (pH 7.5) containing 5 mM Mg2+, 0.5 mM Mn2+, and 0.5 mg bovine serum albumin, at 80°C
0.04
6-phospho-D-gluconate
-
dimeric enzyme with two 6-phospho-D-gluconate bound, pH not specified in the publication, temperature not specified in the publication
0.07
6-phospho-D-gluconate
-
dimeric enzyme with one 6-phospho-D-gluconate bound, pH not specified in the publication, temperature not specified in the publication
0.093
6-phospho-D-gluconate
in 50 mM Tris-HCl buffer (pH 8.0), 20 mM MgCl2, at 25°C
0.107
6-phospho-D-gluconate
in 50 mM Tris-HCl buffer (pH 8.0), 20 mM MgCl2, at 25°C