Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.48 extracted from

  • Song, D.D.; Chen, Y.; Li, Z.Y.; Guan, Y.F.; Zou, D.J.; Miao, C.Y.
    Protein tyrosine phosphatase 1B inhibits adipocyte differentiation and mediates TNFalpha action in obesity (2013), Biochim. Biophys. Acta, 1831, 1368-1376.
    View publication on PubMed
Search for more literature for 3.1.3.48

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
 x * 50000, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[a protein]-tyrosine phosphate + H2O Mus musculus
-
 [a protein]-tyrosine + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
3T3-L1 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[a protein]-tyrosine phosphate + H2O
-
 Mus musculus [a protein]-tyrosine + phosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 50000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
protein tyrosine phosphatase 1B
-
 Mus musculus
PTP1B
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus PTP1B expression decreases progressively with adipocyte maturation down

General Information

General Information Comment Organism
malfunction PTP1B knockdown accelerates adipocyte differentiation Mus musculus
physiological function protein tyrosine phosphatase 1B is a negative regulator of systemic glucose and insulin homeostasis and inhibits adipocyte differentiation and mediates TNFalpha action in obesity Mus musculus