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0.000008
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microsomes, substrate codeine
0.000009
microsomes, substrate ketoprofen
0.000011
microsomes, substrate naproxen
0.000013
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microsomes, substrate naproxen
0.000028
microsomes, substrate morphine 3-glucuronide
0.000032
microsomes, substrate 4-nitrophenol
0.0000329
25-O-glucuronidation of 1alpha,25-dihydroxyvitamin D3 by liver microsomes
0.0000337
25-O-glucuronidation of 1alpha,25-dihydroxyvitamin D3 by UGT1A4 supersomes
0.000037
microsomes, substrate androstanediol
0.000045
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substrate curcumin in liver microsomes
0.000058
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microsomes, substrates hydromorphone and morphine 3-glucuronide
0.000075
microsomes, substrate 4-methylumbelliferone
0.00008
microsomes, substrate 1-naphthol
0.000082
microsomes, substrate eugenol
0.000102
-
microsomes, substrate valproic acid
0.000105
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microsomes, substrate ibuprofen
0.00011
recombinant isozyme UGT2B17, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C
0.000128
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substrate propofol in liver microsomes
0.000215
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microsomes, substrate 4-methylumbelliferone
0.00022
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microsomes, substrate androstanediol
0.00023
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microsomes, substrate 1-naphthol
0.00027
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microsomes, substrate gemfibrozil
0.00028
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microsomes, substrate diclofenac
0.0004
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microsomes, substrate 4-nitrophenol
0.0005
recombinant isozyme UGT2B4, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C
0.0007
recombinant isozyme UGT1A8, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C
0.00077 - 0.033
liver UGT1A6 of different individuals, microsomes
0.00103
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microsomes, substrate eugenol
0.00124
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microsomes, substrate hyodeoxycholic acid
0.0014
recombinant isozyme UGT1A4, substrate trifluoperazine, pH 7.5, 37°C
0.0015
recombinant isozyme UGT1A1, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C
0.0016
liver microsomes, substrate morphine 3-glucuronide
0.0022
recombinant isozyme UGT1A3, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C
0.0052
liver microsomes, substrate N-acetylserotonin
0.0065
recombinant isozyme UGT1A9, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C
0.0072
liver microsomes, substrate 6-hydroxymelatonin
0.008 - 4
liver microsomes, substrate 5-hydroxytryptophol
0.0126
recombinant isozyme UGT1A7, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C
0.0158
recombinant UGT1A6 from lymphoblasts or insect cells, microsomes
0.0191
jejunum microsomes, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C
0.028
-
4-nitrophenol as substrate, using Wistar strain liver microsomes
0.0622
liver microsomes, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C
0.075
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7,7,7-triphenylheptanoic acid as substrate
0.092
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4-hydroxybiphenyl as substrate, enzyme induced by 3-methylcholanthrene
0.142
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bilirubin as substrate, non-treated Wistar strain
0.168
-
chenodeoxycholic acid, Sprague-Dawley rat treated with phenobarbital
0.45
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purified recombinant GlcAT-S with substrate asialo-orosomucoid
0.67
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morphine as substrate, Wistar strain treated with phenobarbital
0.983
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testosterone, Sprague-Dawley rat treated with phenobarbital
1.11
-
purified recombinant GlcAT-P with substrate asialo-orosomucoid
1.7
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5-hydroxytryptamine, enzyme induced by 3-methylcholanthrene
1.8
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eugenol as substrate, enzyme induced by 3-methylcholanthrene
4
-
1-naphthol as substrate, Wistar strain treated with 3-methylcholanthrene
5
-
4-nitrophenol as substrate, Wistar strain treated with 3-methylcholanthrene
5.35
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1-naphthol as substrate, Wistar strain treated with phenobarbital
6.06
-
1-naphthol as substrate, Wistar strain treated with 3-methylcholanthrene
0.00006
microsomes, substrate lorazepam
0.00006
-
microsomes, substrate ketoprofen
0.00007
microsomes, substrate ethylphenol
0.00007
microsomes, substrate gemfibrozil
0.0002
-
microsomes, substrate ethylphenol
0.0002
recombinant isozyme UGT1A10, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C
0.0037
recombinant isozyme UGT2B15, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C
0.0037
recombinant isozyme UGT2B7, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C
0.0044
liver microsomes, substrate serotonin
0.0044
recombinant isozyme UGT1A6, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C
additional information
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additional information
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hepatic UGTactivity with selective substrates of human in the microminipig compared to those in humans and other experimental animals, overview. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and the other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview
additional information
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a range from 0.5 to 3.8 for 4-nitrophenol as substrate
additional information
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additional information
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additional information
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additional information
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additional information
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additional information
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additional information
activities of wild-type and glycosylation mutant of UGT2B15 and UGT2B20 on 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone
additional information
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activities of wild-type and glycosylation mutant of UGT2B15 and UGT2B20 on 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone
additional information
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specific activity of several endogenous substrates by microsomal membranes for HK293 cells expressing UGT2B7
additional information
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kidney microsomes show a lower activity than liver microsomes for glucuronidation of 3'-azido-3'-deoxythymidine
additional information
2 allelic variants UGT2B7H268 and UGT2B7Y268, the first being 11fold more effective in glucuronidation of aldosterone
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2 allelic variants UGT2B7H268 and UGT2B7Y268, the first being 11fold more effective in glucuronidation of aldosterone
additional information
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activities with morphine, codeine, and 3'-azido-3'-deoxythymidine of different isozymes
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activity at different conditions with different activators and different substrates, microsomes or recombinant isozymes, overview
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activity of diverse recombinant isozymes with the different substrates
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activity of diverse recombinant isozymes with the different substrates
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activity of isozyme UGT1A6 in microsomes of different tissues
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activity of isozyme UGT1A6 in microsomes of different tissues
additional information
substrate specificities of isozymes
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substrate specificities of isozymes
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substrate specificities of isozymes
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substrate specificities of isozymes
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substrate specificities of isozymes
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catalytic efficiency of frusemide glucuronidation of different microsome types from liver and kidney, overview
additional information
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substrate specificity of liver microsome samples, overview
additional information
hepatic UGTactivity with selective substrates of human in the microminipig compared to those in humans and other experimental animals, overview. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and the other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview. 3'-Azido-3'-deoxythymidine glucuronidation is approximately 26fold lower in microminipig microsomes than in human microsomes
additional information
hepatic UGTactivity with selective substrates of human in the microminipig compared to those in humans and other experimental animals, overview. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and the other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview. 3'-Azido-3'-deoxythymidine glucuronidation is approximately 26fold lower in microminipig microsomes than in human microsomes
additional information
hepatic UGTactivity with selective substrates of human in the microminipig compared to those in humans and other experimental animals, overview. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and the other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview. 3'-Azido-3'-deoxythymidine glucuronidation is approximately 26fold lower in microminipig microsomes than in human microsomes
additional information
hepatic UGTactivity with selective substrates of human in the microminipig compared to those in humans and other experimental animals, overview. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and the other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview. 3'-Azido-3'-deoxythymidine glucuronidation is approximately 26fold lower in microminipig microsomes than in human microsomes
additional information
hepatic UGTactivity with selective substrates of human in the microminipig compared to those in humans and other experimental animals, overview. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and the other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview. 3'-Azido-3'-deoxythymidine glucuronidation is approximately 26fold lower in microminipig microsomes than in human microsomes
additional information
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hepatic UGTactivity with selective substrates of human in the microminipig compared to those in humans and other experimental animals, overview. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and the other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview. 3'-Azido-3'-deoxythymidine glucuronidation is approximately 26fold lower in microminipig microsomes than in human microsomes
additional information
Vmax values for all enzymes with ethanol
additional information
Vmax values for all enzymes with ethanol
additional information
Vmax values for all enzymes with ethanol
additional information
Vmax values for all enzymes with ethanol
additional information
Vmax values for all enzymes with ethanol
additional information
Vmax values for all enzymes with ethanol
additional information
Vmax values for all enzymes with ethanol
additional information
Vmax values for all enzymes with ethanol
additional information
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Vmax values for all enzymes with ethanol
additional information
Vmax values of isozymes using different specific substrates with healthy and hepatitis B virus-positive liver microsomes, overview
additional information
Vmax values of isozymes using different specific substrates with healthy and hepatitis B virus-positive liver microsomes, overview
additional information
Vmax values of isozymes using different specific substrates with healthy and hepatitis B virus-positive liver microsomes, overview
additional information
Vmax values of isozymes using different specific substrates with healthy and hepatitis B virus-positive liver microsomes, overview
additional information
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Vmax values of isozymes using different specific substrates with healthy and hepatitis B virus-positive liver microsomes, overview
additional information
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additional information
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hepatic UGTactivity with selective substrates of human in the microminipig compared to those in humans and other experimental animals, overview. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and the other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview
additional information
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hepatic UGTactivity with selective substrates of human in the microminipig compared to those in humans and other experimental animals, overview. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and the other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview
additional information
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additional information
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additional information
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additional information
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additional information
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additional information
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activities of 14 substrates for UGTA1A7 and UGTA1A6
additional information
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activities of wild-type and glycosylation mutant of UGT2B15 and UGT2B20 on 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone
additional information
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additional information
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additional information
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additional information
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additional information
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additional information
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additional information
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additional information
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additional information
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additional information
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additional information
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additional information
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comparison of activities between different rat strains
additional information
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comparison of activities between differentially inducible forms
additional information
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assay conditions
additional information
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assay conditions
additional information
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hepatic UGTactivity with selective substrates of human in the microminipig compared to those in humans and other experimental animals, overview. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and the other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview
additional information
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hepatic UGTactivity with selective substrates of human in the microminipig compared to those in humans and other experimental animals, overview. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and the other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview. 3'-Azido-3'-deoxythymidine glucuronidation is approximately 26fold lower in microminipig microsomes than in human microsomes