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Literature summary for 2.4.1.17 extracted from

  • Haumont, M.; Magdalou, J.; Lafaurie, C.; Ziegler, J.M.; Siest, G.; Colin, J.N.
    Phenobarbital inducible UDP-glucuronosyltransferase is responsible for glucuronidation of 3-azido-3-deoxythymidine: characterization of the enzyme in human and rat liver microsomes (1990), Arch. Biochem. Biophys., 281, 264-270.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
p-[di-n-Propylsulfamoyl]benzoic acid i.e. probenecid Homo sapiens
p-[di-n-Propylsulfamoyl]benzoic acid i.e. probenecid Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
11.6
-
3'-azido-3'-deoxythymidine
-
Macaca mulatta
13.4
-
3'-azido-3'-deoxythymidine
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-
microsome
-
Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Macaca mulatta
-
rhesus monkey
-
Rattus norvegicus
-
Wistar strain
-
Rattus norvegicus
-
Gunn strain
-
Rattus norvegicus Gunn
-
Gunn strain
-
Rattus norvegicus Wistar
-
Wistar strain
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Homo sapiens
-
kidney
-
Rattus norvegicus
-
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-
liver
-
Macaca mulatta
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Rattus norvegicus
additional information
-
kidney microsomes show a lower activity than liver microsomes for glucuronidation of 3'-azido-3'-deoxythymidine Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-azido-3'-deoxythymidine + UDP-alpha-D-glucuronate
-
Macaca mulatta 3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP
-
?
3'-azido-3'-deoxythymidine + UDPglucuronate
-
Homo sapiens 3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP
-
?
3'-azido-3'-deoxythymidine + UDPglucuronate
-
Rattus norvegicus 3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP
-
?
3'-azido-3'-deoxythymidine + UDPglucuronate
-
Rattus norvegicus Gunn 3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP
-
?
3'-azido-3'-deoxythymidine + UDPglucuronate
-
Rattus norvegicus Wistar 3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP
-
?