Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

2.4.1.17: glucuronosyltransferase

This is an abbreviated version!
For detailed information about glucuronosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.17

Reaction

UDP-alpha-D-glucuronate
+
acceptor
=
UDP
 +
acceptor beta-D-glucuronoside

Synonyms

1-naphthol glucuronyltransferase, 1-naphthol-UDP-glucuronosyltransferase, 17-OH steroid UDPGT, 17beta-hydroxysteroid UDP-glucuronosyltransferase, 1A10, 3,4-catechol estrogen specific UDPGTh-2, 3-OH androgenic UDPGT, 3alpha-hydroxysteroid UDP-glucuronosyltransferase, 4-hydroxybiphenyl UDP-glucuronosyltransferase, 4-methylumbelliferone UDP-glucuronosyltransferase, 4-nitrophenol UDP-glucuronosyltransferase, 4-nitrophenol UDP-glucuronyltransferase, 4-nitrophenol UDPGT, bile acid uridine 5'-diphosphoglucuronyltransferase, bilirubin glucuronyltransferase, bilirubin monoglucuronide glucuronyltransferase, bilirubin UDP-glucuronosyltransferase, bilirubin UDPglucuronosyltransferase, bilirubin UDPGT, bilirubin uridine diphosphoglucuronyltransferase, bilirubin-specific UDPGT isozyme 1, bilirubin-specific UDPGT isozyme 2, ciramadol UDP-glucuronyltransferase, DP-glucuronosyltransferase 1A3, EC 2.4.1.107, EC 2.4.1.108, EC 2.4.1.42, EC 2.4.1.59, EC 2.4.1.61, EC 2.4.1.76, EC 2.4.1.77, EC 2.4.1.84, estriol UDP-glucuronosyltransferase, estrone UDP-glucuronosyltransferase, GlcAT-P, GlcAT-S, glucuronosyltransferase, uridine diphospho-, glucuronosyltransferase, uridine diphosphoglucuronate-1,2-diacylglycerol, glucuronosyltransferase, uridine diphosphoglucuronate-4-hydroxybiphenyl, glucuronosyltransferase, uridine diphosphoglucuronate-bilirubin, glucuronosyltransferase, uridine diphosphoglucuronate-estradiol, glucuronosyltransferase, uridine diphosphoglucuronate-estriol, glucuronosyltransferase, uridine diphosphoglucuronate-estriol 16alpha-, glucuronyltransferase, glucuronyltransferase, uridine diphospho-GT, HUG-BR1, HUG-BR2, inositol phosphorylceramide glucuronosyltransferase1, IPUT1, monUGT1A6, More, morphine glucuronyltransferase, p-hydroxybiphenyl UDP glucuronyltransferase, p-nitrophenol UDP-glucuronosyltransferase, p-nitrophenol UDP-glucuronyltransferase, p-nitrophenylglucuronosyltransferase, p-phenylphenol glucuronyltransferase, phenol-metabolizing UDP-glucuronosyltransferase, phenyl-UDP-glucuronosyltransferase, PNP-UDPGT, UDP glucuronate-estradiol-glucuronosyltransferase, UDP glucuronate-estriol glucuronosyltransferase, UDP glucuronic acid transferase, UDP glucuronosyltransferase, UDP glucuronosyltransferase 1A4, UDP glucuronosyltransferase 2B10, UDP glucuronyltransferase, UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase, UDP-glucuronate-bilirubin glucuronyltransferase, UDP-glucuronosyl-transferase 1A1, UDP-glucuronosyltransferase, UDP-glucuronosyltransferase 1A, UDP-glucuronosyltransferase 1A1, UDP-glucuronosyltransferase 1A10, UDP-glucuronosyltransferase 1A3, UDP-glucuronosyltransferase 1A4, UDP-glucuronosyltransferase 1A5, UDP-glucuronosyltransferase 1A6, UDP-glucuronosyltransferase 1A7, UDP-glucuronosyltransferase 1A8, UDP-glucuronosyltransferase 1A9, UDP-glucuronosyltransferase 2, UDP-glucuronosyltransferase 2A3, UDP-glucuronosyltransferase 2B10, UDP-glucuronosyltransferase 2B15, UDP-glucuronosyltransferase 2B17, UDP-glucuronosyltransferase 2B7, UDP-glucuronosyltransferase-1A10, UDP-glucuronosyltransferases 2B15, UDP-glucuronosyltransferases 2B7, UDP-glucuronyltransferase, UDPGA transferase, UDPGA-glucuronyltransferase, UDPglucuronate beta-D-glucuronosyltransferase, UDPglucuronosyltransferase, UDPGT, UFT1A9, UGT, UGT 1A1, UGT 1A10, UGT 1A3, UGT 1A4, UGT 1A6, UGT 1A7, UGT 1A8, UGT 1A9, UGT 2B15, UGT 2B17, UGT 2B4, UGT 2B7, UGT-1A, UGT-1D, UGT-1F, UGT-1J, UGT1-01, UGT1-03, UGT1-04, UGT1-06, UGT1-10, UGT1-9, UGT1.1, UGT1.10, UGT1.3, UGT1.4, UGT1.6, UGT1.9, UGT1A, UGT1A1, UGT1A10, UGT1A10A, UGT1A10B, UGT1A11, UGT1A2, UGT1A2A, UGT1A3, UGT1A4, UGT1A5, UGT1A5A, UGT1A5B, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1D, UGT1E, UGT1F, UGT1J, UGT2A1, UGT2A2, UGT2A3, UGT2B1, UGT2B10, UGT2B11, UGT2B12, UGT2B15, UGT2B17, UGT2B18, UGT2B19, UGT2B2, UGT2B20, UGT2B23, UGT2B28, UGT2B3, UGT2B30, UGT2B31, UGT2B33, Ugt2b34, Ugt2b36, Ugt2b37, UGT2B39, UGT2B4, UGT2B40, UGT2B41, UGT2B42, UGT2B43, UGT2B44, UGT2B45, UGT2B46, UGT2B7, UGT2B8, UGT2B9, UGT330A3, UGT339A2, UGT341A6, UGT342B3, UGT343C3, UGT344D5, UGT344D8, UGT348A3, UGT349A3, UGT350A3, UGT3A1, UGT3A2, uridine 5'-diphospho-glucuronosyltransferase, uridine 5'-diphosphoglucuronyltransferase, uridine diphosphate glucuronosyltransferase, uridine diphosphate glucuronyltransferase, uridine diphosphate-glucuronosyltransferase, uridine diphosphate-glucuronosyltransferase 2 B15, uridine diphosphate-glucuronosyltransferase 2B10, uridine diphosphate-glucuronosyltransferase 2B11, uridine diphosphate-glucuronosyltransferase 2B15, uridine diphosphate-glucuronosyltransferase 2B17, uridine diphosphate-glucuronosyltransferase 2B4, uridine diphosphate-glucuronosyltransferase 2B7, uridine diphosphoglucuronate-bilirubin glucuronosyltransferase, uridine diphosphoglucuronosyltransferase, uridine diphosphoglucuronyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.17 glucuronosyltransferase

IC50 Value

IC50 Value on EC 2.4.1.17 - glucuronosyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.214
(-)-nicotine
Homo sapiens
pH 7.4, 37°C
0.0004
(1R)-1-cyclopropyl-2-methylpropan-1-ol
Homo sapiens
IC50: 0.0004 mM
0.0004 - 0.0009
(1R)-1-cyclopropylbut-3-en-1-ol
0.0004
(1R)-1-cyclopropylbut-3-ene-1,3-diol
Homo sapiens
IC50: 0.0004 mM
0.0005
(1R)-1-cyclopropylethanol
Homo sapiens
IC50: 0.0005 mM
0.0003
(1R)-1-cyclopropylprop-2-en-1-ol
Homo sapiens
IC50: 0.0003 mM
0.0002
(1R)-1-cyclopropylpropan-1-ol
Homo sapiens
IC50: 0.0002 mM
0.0002
(1R)-1-cyclopropylpropane-1,3-diol
Homo sapiens
IC50: 0.0002 mM
0.0002
(1R)-2-chloro-1-cyclopropylethanol
Homo sapiens
IC50: 0.0002 mM
0.0002
(1S)-1-cyclopropyl-2,2-dimethylpropan-1-ol
Homo sapiens
IC50: 0.0002 mM
0.0004
(1S)-1-cyclopropyl-2-methylpropan-1-ol
Homo sapiens
IC50: 0.0004 mM
0.0002
(1S)-1-cyclopropylbut-3-en-1-ol
Homo sapiens
IC50: 0.0002 mM
0.0007
(1S)-1-cyclopropylethanol
Homo sapiens
IC50: 0.0007 mM
0.0006
(1S)-1-cyclopropylprop-2-en-1-ol
Homo sapiens
IC50: 0.0006 mM
0.0005
(1S)-1-cyclopropylpropan-1-ol
Homo sapiens
IC50: 0.0005 mM
0.0003
(1S)-1-cyclopropylpropane-1,3-diol
Homo sapiens
IC50: 0.0003 mM
0.012
(2-cyclopropylethyl)phosphonic acid
Homo sapiens
IC50: 0.012 mM
0.003
(2E)-3-cyclopropylacrylic acid
Homo sapiens
IC50: 0.003 mM
0.0008
(2E)-3-cyclopropylprop-2-en-1-ol
Homo sapiens
IC50: 0.0008 mM
0.003
(2Z)-3-cyclopropylacrylic acid
Homo sapiens
IC50: 0.003 mM
0.0007
(2Z)-3-cyclopropylprop-2-en-1-ol
Homo sapiens
IC50: 0.0007 mM
0.032
(3-cyclopropylpropyl)phosphonic acid
Homo sapiens
IC50: 0.032 mM
0.001
(3S)-3-cyclopropyl-3-hydroxypropanoic acid
Homo sapiens
IC50: 0.001 mM
0.412 - 0.429
(5alpha)-17-allyl-3,14-dihydroxy-4,5-epoxymorphinan-6-one
0.333
(R)-7-hydroxywarfarin
Homo sapiens
-
isoform UGT1A10, substrate (S)-7-hydroxywarfarin, pH 7.6, 37°C
0.401
(R)-8-hydroxywarfarin
Homo sapiens
-
isoform UGT1A10, substrate (S)-6-hydroxywarfarin, pH 7.6, 37°C
0.0002
(R)-chloro(cyclopropyl)methanol
Homo sapiens
IC50: 0.0002 mM
0.00007
(R)-cyclopropyl(phenyl)methanol
Homo sapiens
IC50: 0.00007 mM
0.344
(S)-8-hydroxywarfarin
Homo sapiens
-
isoform UGT1A10, substrate (R)-8-hydroxywarfarin, pH 7.6, 37°C
0.0009
(S)-cyclopropyl(phenyl)methanol
Homo sapiens
IC50: 0.0009 mM
0.0008
1-cyclopropyl-2,2-dimethylpropan-1-ol
Homo sapiens
IC50: 0.0008 mM
0.0352
1-naphthol
Homo sapiens
isoform UGT1A6, at pH 7.6 and 37°C
0.042 - 0.21
17alpha-ethinylestradiol
0.0086
17alpha-ethynylestradiol
Homo sapiens
pH 7.5, 37°C, inhibition of glucuronidation of 4-methylumbelliferone by isozyme UGT1A1
0.0016 - 0.01502
2'-OH-PCB106
0.00064 - 0.00858
2,4,6-tribromophenol
0.00013 - 0.00022
2,4-Dibromophenol
0.00014 - 0.00507
2,5-dibromophenol
0.0019
2-bromophenol
Homo sapiens
isoform UGT1A6, at pH 7.4 and 37°C
0.005
2-cyclopropyl-N,N-dimethylethanamine
Homo sapiens
IC50: 0.005 mM
0.0005
2-cyclopropylethanol
Homo sapiens
IC50: 0.0005 mM
0.023 - 0.149
2-phenyl-4H-benzo[h]chromen-4-one
0.0324 - 0.1
20(R)-ginsenoside Rg2
0.0114 - 0.1
20(R)-ginsenoside Rg3
0.1
20(R)-ginsenoside Rh1
0.1
20(R)-ginsenoside Rh2
0.0268 - 0.1
20(R)-protopanaxadiol
0.0135 - 0.1
20(R)-protopanaxatriol
0.1
20(S)-ginsenoside Rg2
0.0117 - 0.1
20(S)-ginsenoside Rg3
0.077 - 0.1
20(S)-ginsenoside Rh1
0.00585 - 0.1
20(S)-ginsenoside Rh2
0.0256 - 0.1
20(S)-protopanaxadiol
0.012 - 0.1
20(S)-protopanaxatriol
0.00018 - 0.01
3,5-dibromophenol
0.0009
3-cyclopropylpropan-1-ol
Homo sapiens
IC50: 0.0009 mM
0.002
3-cyclopropylpropanoic acid
Homo sapiens
IC50: 0.002 mM
0.00156 - 0.03047
4'-OH-PCB106
0.003
4-cyclopropylbutan-1-ol
Homo sapiens
IC50: 0.003 mM
0.016
4-cyclopropylbutanoic acid
Homo sapiens
IC50: 0.016 mM
0.0259 - 0.0774
ADP
0.16
alisol B
Homo sapiens
-
at pH 7.4 and 37°C
0.163
alisol B acetate
Homo sapiens
-
at pH 7.4 and 37°C
0.00645 - 0.159
amitriptyline
0.031
AMP
Rattus norvegicus
-
pH 7.1, 37°C, inhibition of estradiol 17-glucuronidation activity
0.0271
androsterone
Homo sapiens
pH 7.5, 37°C, recombinant isozyme UGT1A9
0.0558
aripiprazole
Homo sapiens
pH 7.4, 37°C
0.0117 - 0.0352
ATP
0.00829
auriculasin
Homo sapiens
-
isoform UGT1A8, at pH 7.4 and 37°C
0.068 - 0.086
beta-estradiol
Homo sapiens
exhibits strong inhibition on etoposide phenolic glucuronide (IC50: 0.068 mM) and etoposide alcoholic glucuronide EAG2 (IC50: 0.086 mM). The inhibitory effect of beta-estradiol on the formation of etoposide alcoholic glucuronide EAG1 is not so significant
0.1
BIBF 1202
0.054 - 0.14
bilirubin
0.0425 - 0.163
bisphenol A
0.088 - 0.152
bupropion
0.0397 - 0.0845
C-1748
0.431 - 0.456
carbamazepine
0.164
catechin
Homo sapiens
-
at pH 7.4 and 37°C
0.079
chlorpromazine
Homo sapiens
pH 7.4, 37°C
0.0283
chrysin
Homo sapiens
isoform UGT1A1, at pH 7.6 and 37°C
0.218
citalopram
Homo sapiens
pH 7.4, 37°C
0.026 - 0.04
clomipramine
0.0613
clozapine
Homo sapiens
pH 7.4, 37°C
0.0059 - 0.0558
CTP
0.001
cyclopropanecarboxylic acid
Homo sapiens
IC50: 0.001 mM
0.023 - 0.048
cyclosporine A
0.0022 - 0.1
dabrafenib
0.0064
deoxyschizandrin
Homo sapiens
isoform UGT1A3, at pH 7.4 and 37°C
0.0341
desipramine
Homo sapiens
pH 7.4, 37°C
0.00386
desloratadine
Homo sapiens
pH 7.4, 37°C
0.0437
desmethylnortriptyline
Homo sapiens
pH 7.4, 37°C
0.44
desvenlafaxine
Homo sapiens
pH 7.4, 37°C
0.062 - 0.089
dextromethorphan
0.053 - 0.057
diazepam
0.0104 - 0.192
diclofenac
0.0362
didesmethylimipramine
Homo sapiens
pH 7.4, 37°C
0.01
diethyl [(2R)-2-cyclopropyl-2-hydroxyethyl]phosphonate
Homo sapiens
IC50: 0.01 mM
0.005
diethyl [(3R)-3-cyclopropyl-3-hydroxypropyl]phosphonate
Homo sapiens
IC50: 0.005 mM
0.004
diethyl [(3S)-3-cyclopropyl-3-hydroxypropyl]phosphonate
Homo sapiens
IC50: 0.004 mM
0.01
diethyl [(R)-cyclopropyl(hydroxy)methyl]phosphonate
Homo sapiens
IC50: 0.01 mM
0.003
dimethyl [(3R)-3-cyclopropyl-3-hydroxypropyl]phosphonate
Homo sapiens
IC50: 0.003 mM
0.004
dimethyl [(3S)-3-cyclopropyl-3-hydroxypropyl]phosphonate
Homo sapiens
IC50: 0.004 mM
0.00364
doxepin
Homo sapiens
pH 7.4, 37°C
0.0812
duloxetine
Homo sapiens
pH 7.4, 37°C
0.0289 - 0.0754
efavirenz
0.0003
ethyl (3S)-3-cyclopropyl-3-hydroxypropanoate
Homo sapiens
IC50: 0.0003 mM
0.98 - 1.136
fluconazole
0.0724
fluoxetine
Homo sapiens
pH 7.4, 37°C
0.0535
fluphenazine
Homo sapiens
pH 7.4, 37°C
0.224
fluvoxamine
Homo sapiens
pH 7.4, 37°C
0.108 - 0.227
GTP
0.00677
hecogenin
Homo sapiens
isoform UGT1A4, at pH 7.4 and 37°C
0.0614 - 0.102
hyodeoxycholic acid
0.0007 - 0.083
ibrutinib
0.0428 - 0.129
imipramine
0.0964
isoliquiritigenin
Homo sapiens
-
at pH 7.4 and 37°C
0.0001
isolongifolol
Homo sapiens
IC50: 0.0001 mM
0.0104 - 0.0385
kaempferol
0.0041 - 0.06
ketoconazole
0.000536 - 0.0092
lapatinib
0.0698
lithocholic acid
Homo sapiens
isoform UGT1A3, at pH 7.6 and 37°C
0.00218
loratadine
Homo sapiens
pH 7.4, 37°C
0.056 - 0.065
lorazepam
0.036
loxapine
Homo sapiens
pH 7.4, 37°C
0.00224
mianserin
Homo sapiens
pH 7.4, 37°C
0.023 - 0.147
midazolam
0.031
mirtazapine
Homo sapiens
pH 7.4, 37°C
0.00936
monobenzyl phthalate
Homo sapiens
-
isoform UGT1A9, at pH 7.4 and 37°C
0.00329
monocyclohexyl phthalate
Homo sapiens
-
isoform UGT1A9, at pH 7.4 and 37°C
0.00157 - 0.01071
monoethylhexyl phthalate
0.01246
monohexyl phthalate
Homo sapiens
-
isoform UGT1A9, at pH 7.4 and 37°C
0.00758
monooctyl phthalate
Homo sapiens
-
isoform UGT1A9, at pH 7.4 and 37°C
0.341 - 0.389
mycophenolate
0.009 - 0.0321
NAD+
0.008 - 0.0252
NADP+
0.000402 - 0.168
niflumic acid
0.00104
nilotinib
Homo sapiens
isoform UGT1A1, at pH 7.4 and 37°C
0.0005 - 0.18
nintedanib
0.0508
norclomipramine
Homo sapiens
pH 7.4, 37°C
0.0453
nortriptyline
Homo sapiens
pH 7.4, 37°C
0.276 - 0.368
olanzapine
0.044 - 0.272
oleandomycin
0.056 - 0.185
Omeprazole
0.109 - 0.119
oxazepam
0.0049 - 0.074
paclitaxel
0.0635
paroxetine
Homo sapiens
pH 7.4, 37°C
0.000187 - 0.0442
pazopanib
0.0662
perphenazine
Homo sapiens
pH 7.4, 37°C
0.0942
Phenelzine
Homo sapiens
pH 7.4, 37°C
0.0455 - 0.22
Phenylbutazone
0.059 - 0.228
propofol
0.0592
protopanaxadiol
Homo sapiens
-
at pH 7.4 and 37°C
0.0343
protriptyline
Homo sapiens
pH 7.4, 37°C
0.003 - 0.1526
quercetin
0.0439
quetiapine
Homo sapiens
pH 7.4, 37°C
0.166
quinidine
Homo sapiens
-
isoform UGT1A4, substrate midazolam, pH 7.4, 37°C
0.000045 - 0.0655
regorafenib
0.125
rosmarinic acid
Homo sapiens
-
at pH 7.4 and 37°C
0.000279 - 0.0439
sauchinone
0.0672
selegiline
Homo sapiens
pH 7.4, 37°C
0.0927
sertraline
Homo sapiens
pH 7.4, 37°C
0.000066 - 0.0587
sorafenib
0.384 - 0.488
tacrolimus
0.093 - 0.107
tamoxifen
0.043 - 0.165
testosterone
0.0713
thioridazine
Homo sapiens
pH 7.4, 37°C
0.281
Tolbutamide
Homo sapiens
-
isoform UGT1A6, substrate 1-naphthol, pH 7.4, 37°C
0.0011 - 0.1
trametinib
0.0326
trimipramine
Homo sapiens
pH 7.4, 37°C
0.007 - 0.047
UDP
2.54 - 3.59
zidovudine
0.041
[(1E)-3-cyclopropylprop-1-en-1-yl]phosphonic acid
Homo sapiens
IC50: 0.041 mM
0.013
[(2R)-2-cyclopropyl-2-hydroxyethyl]phosphonic acid
Homo sapiens
IC50: 0.013 mM
0.028
[(3R)-3-cyclopropyl-3-hydroxypropyl]phosphonic acid
Homo sapiens
IC50: 0.028 mM
0.018
[(3S)-3-cyclopropyl-3-hydroxypropyl]phosphonic acid
Homo sapiens
IC50: 0.018 mM
0.008
[(E)-2-cyclopropylvinyl]phosphonic acid
Homo sapiens
IC50: 0.008 mM
0.018
[(R)-cyclopropyl(hydroxy)methyl]phosphonic acid
Homo sapiens
IC50: 0.018 mM
additional information
additional information
-