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2.4.1.17: glucuronosyltransferase

This is an abbreviated version!
For detailed information about glucuronosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.17

Reaction

UDP-alpha-D-glucuronate
+
acceptor
=
UDP
 +
acceptor beta-D-glucuronoside

Synonyms

1-naphthol glucuronyltransferase, 1-naphthol-UDP-glucuronosyltransferase, 17-OH steroid UDPGT, 17beta-hydroxysteroid UDP-glucuronosyltransferase, 1A10, 3,4-catechol estrogen specific UDPGTh-2, 3-OH androgenic UDPGT, 3alpha-hydroxysteroid UDP-glucuronosyltransferase, 4-hydroxybiphenyl UDP-glucuronosyltransferase, 4-methylumbelliferone UDP-glucuronosyltransferase, 4-nitrophenol UDP-glucuronosyltransferase, 4-nitrophenol UDP-glucuronyltransferase, 4-nitrophenol UDPGT, bile acid uridine 5'-diphosphoglucuronyltransferase, bilirubin glucuronyltransferase, bilirubin monoglucuronide glucuronyltransferase, bilirubin UDP-glucuronosyltransferase, bilirubin UDPglucuronosyltransferase, bilirubin UDPGT, bilirubin uridine diphosphoglucuronyltransferase, bilirubin-specific UDPGT isozyme 1, bilirubin-specific UDPGT isozyme 2, ciramadol UDP-glucuronyltransferase, DP-glucuronosyltransferase 1A3, EC 2.4.1.107, EC 2.4.1.108, EC 2.4.1.42, EC 2.4.1.59, EC 2.4.1.61, EC 2.4.1.76, EC 2.4.1.77, EC 2.4.1.84, estriol UDP-glucuronosyltransferase, estrone UDP-glucuronosyltransferase, GlcAT-P, GlcAT-S, glucuronosyltransferase, uridine diphospho-, glucuronosyltransferase, uridine diphosphoglucuronate-1,2-diacylglycerol, glucuronosyltransferase, uridine diphosphoglucuronate-4-hydroxybiphenyl, glucuronosyltransferase, uridine diphosphoglucuronate-bilirubin, glucuronosyltransferase, uridine diphosphoglucuronate-estradiol, glucuronosyltransferase, uridine diphosphoglucuronate-estriol, glucuronosyltransferase, uridine diphosphoglucuronate-estriol 16alpha-, glucuronyltransferase, glucuronyltransferase, uridine diphospho-GT, HUG-BR1, HUG-BR2, inositol phosphorylceramide glucuronosyltransferase1, IPUT1, monUGT1A6, More, morphine glucuronyltransferase, p-hydroxybiphenyl UDP glucuronyltransferase, p-nitrophenol UDP-glucuronosyltransferase, p-nitrophenol UDP-glucuronyltransferase, p-nitrophenylglucuronosyltransferase, p-phenylphenol glucuronyltransferase, phenol-metabolizing UDP-glucuronosyltransferase, phenyl-UDP-glucuronosyltransferase, PNP-UDPGT, UDP glucuronate-estradiol-glucuronosyltransferase, UDP glucuronate-estriol glucuronosyltransferase, UDP glucuronic acid transferase, UDP glucuronosyltransferase, UDP glucuronosyltransferase 1A4, UDP glucuronosyltransferase 2B10, UDP glucuronyltransferase, UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase, UDP-glucuronate-bilirubin glucuronyltransferase, UDP-glucuronosyl-transferase 1A1, UDP-glucuronosyltransferase, UDP-glucuronosyltransferase 1A, UDP-glucuronosyltransferase 1A1, UDP-glucuronosyltransferase 1A10, UDP-glucuronosyltransferase 1A3, UDP-glucuronosyltransferase 1A4, UDP-glucuronosyltransferase 1A5, UDP-glucuronosyltransferase 1A6, UDP-glucuronosyltransferase 1A7, UDP-glucuronosyltransferase 1A8, UDP-glucuronosyltransferase 1A9, UDP-glucuronosyltransferase 2, UDP-glucuronosyltransferase 2A3, UDP-glucuronosyltransferase 2B10, UDP-glucuronosyltransferase 2B15, UDP-glucuronosyltransferase 2B17, UDP-glucuronosyltransferase 2B7, UDP-glucuronosyltransferase-1A10, UDP-glucuronosyltransferases 2B15, UDP-glucuronosyltransferases 2B7, UDP-glucuronyltransferase, UDPGA transferase, UDPGA-glucuronyltransferase, UDPglucuronate beta-D-glucuronosyltransferase, UDPglucuronosyltransferase, UDPGT, UFT1A9, UGT, UGT 1A1, UGT 1A10, UGT 1A3, UGT 1A4, UGT 1A6, UGT 1A7, UGT 1A8, UGT 1A9, UGT 2B15, UGT 2B17, UGT 2B4, UGT 2B7, UGT-1A, UGT-1D, UGT-1F, UGT-1J, UGT1-01, UGT1-03, UGT1-04, UGT1-06, UGT1-10, UGT1-9, UGT1.1, UGT1.10, UGT1.3, UGT1.4, UGT1.6, UGT1.9, UGT1A, UGT1A1, UGT1A10, UGT1A10A, UGT1A10B, UGT1A11, UGT1A2, UGT1A2A, UGT1A3, UGT1A4, UGT1A5, UGT1A5A, UGT1A5B, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1D, UGT1E, UGT1F, UGT1J, UGT2A1, UGT2A2, UGT2A3, UGT2B1, UGT2B10, UGT2B11, UGT2B12, UGT2B15, UGT2B17, UGT2B18, UGT2B19, UGT2B2, UGT2B20, UGT2B23, UGT2B28, UGT2B3, UGT2B30, UGT2B31, UGT2B33, Ugt2b34, Ugt2b36, Ugt2b37, UGT2B39, UGT2B4, UGT2B40, UGT2B41, UGT2B42, UGT2B43, UGT2B44, UGT2B45, UGT2B46, UGT2B7, UGT2B8, UGT2B9, UGT330A3, UGT339A2, UGT341A6, UGT342B3, UGT343C3, UGT344D5, UGT344D8, UGT348A3, UGT349A3, UGT350A3, UGT3A1, UGT3A2, uridine 5'-diphospho-glucuronosyltransferase, uridine 5'-diphosphoglucuronyltransferase, uridine diphosphate glucuronosyltransferase, uridine diphosphate glucuronyltransferase, uridine diphosphate-glucuronosyltransferase, uridine diphosphate-glucuronosyltransferase 2 B15, uridine diphosphate-glucuronosyltransferase 2B10, uridine diphosphate-glucuronosyltransferase 2B11, uridine diphosphate-glucuronosyltransferase 2B15, uridine diphosphate-glucuronosyltransferase 2B17, uridine diphosphate-glucuronosyltransferase 2B4, uridine diphosphate-glucuronosyltransferase 2B7, uridine diphosphoglucuronate-bilirubin glucuronosyltransferase, uridine diphosphoglucuronosyltransferase, uridine diphosphoglucuronyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.17 glucuronosyltransferase

KI Value

KI Value on EC 2.4.1.17 - glucuronosyltransferase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.533 - 1.547
17beta-estradiol
0.0004 - 0.0027
2'-OH-PCB106
0.00285 - 0.031
2,4,6-tribromophenol
0.00146 - 0.00372
2,4-Dibromophenol
0.00002 - 0.00156
2,5-dibromophenol
1.56
2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid
-
0.00174
2-bromophenol
isoform UGT1A6, at pH 7.4 and 37°C
0.00048 - 0.00246
3,5-dibromophenol
0.09
3-hydroxyflavone
isozyme UGT1A1
0.0007 - 0.0068
4'-OH-PCB106
0.23 - 3.73
4-Methylumbelliferone
23.4 - 51.2
4-nitrophenol
1.651
5-diethylaminoethylamino-8-hydroxyimidazoacridinone
-
isoform UGT1A9, pH not specified in the publication, temperature not specified in the publication
0.958
5-dimethylaminopropylamino-8-hydroxytriazoloacridinone
-
isoform UGT1A9, pH not specified in the publication, temperature not specified in the publication
0.2 - 0.29
5-hydroxytryptophol
0.82 - 1.1
6-hydroxywarfarin
0.03
7,7,7-triphenylheptyl-UDP
-
apparent Ki for the inhibition of 1-naphthol glucuronidation
0.0996 - 0.161
7-hydroxy-4-trifluoromethylcoumarin
1.1
7-hydroxywarfarin
-
mutant V92A, pH 7.4, 37°C
0.03 - 0.248
amitriptyline
0.009 - 0.149
androsterone
0.0767
arctigenin
isoform UGT2B15, at pH 7.4 and 37°C
0.016
arctiin
isoform UGT2B15, at pH 7.4 and 37°C
0.0019
atazanavir
-
pH 7.5, 37°C, UGT1A1
0.00501
auriculasin
-
isoform UGT1A8, at pH 7.4 and 37°C
0.00000091
beta-phenyllongifolol
-
0.0005 - 0.28
bilirubin
0.0723 - 0.085
bisphenol A
0.081 - 0.0946
C-1748
0.047 - 0.243
carbamazepine
0.006 - 0.02
clomipramine
1.1
codeine
-
competitive with morphine glucuronidation
0.08
cyproheptadine
-
morphine-UDPGT
0.111 - 0.458
desipramine
4
desmethylcyproheptadine
-
-
0.009 - 0.047
diazepam
0.008 - 0.024
diclofenac
0.005 - 0.26
estradiol
0.022 - 0.808
flunitrazepam
0.0164 - 0.0342
gossypol
0.0039
hecogenin
-
pH 7.4, 37°C, substrate senecionine
0.033 - 0.38
imipramine
0.0479
indinavir
-
pH 7.5, 37°C, UGT1A1
0.000023
isolongifolol
-
-
0.0099 - 0.0623
kaempferol
0.000026
longifolol
-
-
0.017 - 0.239
lorazepam
0.00213
monobenzyl phthalate
-
isoform UGT1A9, at pH 7.4 and 37°C
0.00009
monocyclohexyl phthalate
-
isoform UGT1A9, at pH 7.4 and 37°C
0.00117 - 0.01125
monoethylhexyl phthalate
0.00746
monohexyl phthalate
-
isoform UGT1A9, at pH 7.4 and 37°C
0.00016
monooctyl phthalate
-
isoform UGT1A9, at pH 7.4 and 37°C
0.088 - 9
morphine
0.296 - 0.713
mycophenolate
0.518 - 1.298
naloxone
0.196 - 0.266
olanzapine
0.041 - 0.519
oxazepam
0.0359
protopanaxadiol
-
at pH 7.4 and 37°C
0.002 - 0.1132
quercetin
0.000524 - 0.00108
sauchinone
0.046 - 0.347
tacrolimus
0.0046 - 0.081
tamoxifen
0.059 - 2.2
testosterone
0.514
trans-androsterone
-
isoform UGT1A4, pH 7.4, 37°C
0.2639 - 1.8
xanthotoxol
additional information
additional information
-