Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

2.4.1.17: glucuronosyltransferase

This is an abbreviated version!
For detailed information about glucuronosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.17

Reaction

UDP-alpha-D-glucuronate
+
acceptor
=
UDP
 +
acceptor beta-D-glucuronoside

Synonyms

1-naphthol glucuronyltransferase, 1-naphthol-UDP-glucuronosyltransferase, 17-OH steroid UDPGT, 17beta-hydroxysteroid UDP-glucuronosyltransferase, 1A10, 3,4-catechol estrogen specific UDPGTh-2, 3-OH androgenic UDPGT, 3alpha-hydroxysteroid UDP-glucuronosyltransferase, 4-hydroxybiphenyl UDP-glucuronosyltransferase, 4-methylumbelliferone UDP-glucuronosyltransferase, 4-nitrophenol UDP-glucuronosyltransferase, 4-nitrophenol UDP-glucuronyltransferase, 4-nitrophenol UDPGT, bile acid uridine 5'-diphosphoglucuronyltransferase, bilirubin glucuronyltransferase, bilirubin monoglucuronide glucuronyltransferase, bilirubin UDP-glucuronosyltransferase, bilirubin UDPglucuronosyltransferase, bilirubin UDPGT, bilirubin uridine diphosphoglucuronyltransferase, bilirubin-specific UDPGT isozyme 1, bilirubin-specific UDPGT isozyme 2, ciramadol UDP-glucuronyltransferase, DP-glucuronosyltransferase 1A3, EC 2.4.1.107, EC 2.4.1.108, EC 2.4.1.42, EC 2.4.1.59, EC 2.4.1.61, EC 2.4.1.76, EC 2.4.1.77, EC 2.4.1.84, estriol UDP-glucuronosyltransferase, estrone UDP-glucuronosyltransferase, GlcAT-P, GlcAT-S, glucuronosyltransferase, uridine diphospho-, glucuronosyltransferase, uridine diphosphoglucuronate-1,2-diacylglycerol, glucuronosyltransferase, uridine diphosphoglucuronate-4-hydroxybiphenyl, glucuronosyltransferase, uridine diphosphoglucuronate-bilirubin, glucuronosyltransferase, uridine diphosphoglucuronate-estradiol, glucuronosyltransferase, uridine diphosphoglucuronate-estriol, glucuronosyltransferase, uridine diphosphoglucuronate-estriol 16alpha-, glucuronyltransferase, glucuronyltransferase, uridine diphospho-GT, HUG-BR1, HUG-BR2, inositol phosphorylceramide glucuronosyltransferase1, IPUT1, monUGT1A6, More, morphine glucuronyltransferase, p-hydroxybiphenyl UDP glucuronyltransferase, p-nitrophenol UDP-glucuronosyltransferase, p-nitrophenol UDP-glucuronyltransferase, p-nitrophenylglucuronosyltransferase, p-phenylphenol glucuronyltransferase, phenol-metabolizing UDP-glucuronosyltransferase, phenyl-UDP-glucuronosyltransferase, PNP-UDPGT, UDP glucuronate-estradiol-glucuronosyltransferase, UDP glucuronate-estriol glucuronosyltransferase, UDP glucuronic acid transferase, UDP glucuronosyltransferase, UDP glucuronosyltransferase 1A4, UDP glucuronosyltransferase 2B10, UDP glucuronyltransferase, UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase, UDP-glucuronate-bilirubin glucuronyltransferase, UDP-glucuronosyl-transferase 1A1, UDP-glucuronosyltransferase, UDP-glucuronosyltransferase 1A, UDP-glucuronosyltransferase 1A1, UDP-glucuronosyltransferase 1A10, UDP-glucuronosyltransferase 1A3, UDP-glucuronosyltransferase 1A4, UDP-glucuronosyltransferase 1A5, UDP-glucuronosyltransferase 1A6, UDP-glucuronosyltransferase 1A7, UDP-glucuronosyltransferase 1A8, UDP-glucuronosyltransferase 1A9, UDP-glucuronosyltransferase 2, UDP-glucuronosyltransferase 2A3, UDP-glucuronosyltransferase 2B10, UDP-glucuronosyltransferase 2B15, UDP-glucuronosyltransferase 2B17, UDP-glucuronosyltransferase 2B7, UDP-glucuronosyltransferase-1A10, UDP-glucuronosyltransferases 2B15, UDP-glucuronosyltransferases 2B7, UDP-glucuronyltransferase, UDPGA transferase, UDPGA-glucuronyltransferase, UDPglucuronate beta-D-glucuronosyltransferase, UDPglucuronosyltransferase, UDPGT, UFT1A9, UGT, UGT 1A1, UGT 1A10, UGT 1A3, UGT 1A4, UGT 1A6, UGT 1A7, UGT 1A8, UGT 1A9, UGT 2B15, UGT 2B17, UGT 2B4, UGT 2B7, UGT-1A, UGT-1D, UGT-1F, UGT-1J, UGT1-01, UGT1-03, UGT1-04, UGT1-06, UGT1-10, UGT1-9, UGT1.1, UGT1.10, UGT1.3, UGT1.4, UGT1.6, UGT1.9, UGT1A, UGT1A1, UGT1A10, UGT1A10A, UGT1A10B, UGT1A11, UGT1A2, UGT1A2A, UGT1A3, UGT1A4, UGT1A5, UGT1A5A, UGT1A5B, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1D, UGT1E, UGT1F, UGT1J, UGT2A1, UGT2A2, UGT2A3, UGT2B1, UGT2B10, UGT2B11, UGT2B12, UGT2B15, UGT2B17, UGT2B18, UGT2B19, UGT2B2, UGT2B20, UGT2B23, UGT2B28, UGT2B3, UGT2B30, UGT2B31, UGT2B33, Ugt2b34, Ugt2b36, Ugt2b37, UGT2B39, UGT2B4, UGT2B40, UGT2B41, UGT2B42, UGT2B43, UGT2B44, UGT2B45, UGT2B46, UGT2B7, UGT2B8, UGT2B9, UGT330A3, UGT339A2, UGT341A6, UGT342B3, UGT343C3, UGT344D5, UGT344D8, UGT348A3, UGT349A3, UGT350A3, UGT3A1, UGT3A2, uridine 5'-diphospho-glucuronosyltransferase, uridine 5'-diphosphoglucuronyltransferase, uridine diphosphate glucuronosyltransferase, uridine diphosphate glucuronyltransferase, uridine diphosphate-glucuronosyltransferase, uridine diphosphate-glucuronosyltransferase 2 B15, uridine diphosphate-glucuronosyltransferase 2B10, uridine diphosphate-glucuronosyltransferase 2B11, uridine diphosphate-glucuronosyltransferase 2B15, uridine diphosphate-glucuronosyltransferase 2B17, uridine diphosphate-glucuronosyltransferase 2B4, uridine diphosphate-glucuronosyltransferase 2B7, uridine diphosphoglucuronate-bilirubin glucuronosyltransferase, uridine diphosphoglucuronosyltransferase, uridine diphosphoglucuronyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.17 glucuronosyltransferase

Application

Application on EC 2.4.1.17 - glucuronosyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
analysis
-
after infection of Sf9 insect cells with increasing amounts of recombinant baculovirus, encoding either UGT1A9 or UGT2B7, the correlation between glucuronidation rates and degree of infection follows different trends, depending on whether activity is the actual activity measured or is corrected for UDP-glucuronosyltransferase expression level. Above a certain low level of infection, further increases in infection ratios lead to a large decline in normalized activity, presumably due to the presence of full-length but inactive enzyme in the sample. Inaccuracies in comparison of normalized activity between different batches of a recombinant UDP-glucuronosyltransferase can be reduced by lowering the degree of infection of the insect cells, in combination with careful monitoring of UDP-glucuronosyltransferase expression. Poly-His-containing peptides, fused to the UDP-glucuronosyltransferase C-terminus, allow sensitive immunodetection of expressed enzymes with monoclonal antibodies. A minor increase in the Km values has been detected in the His-tagged UDP-glucuronosyltransferases, but no changes in parameters such as the kinetic model and the effects of albumin addition
diagnostics
drug development
-
drug development process aims to produce safe, effective drugs within a reasonable time and at a reasonable cost. Phase II metabolism (glucuronidation) can affect drug action and pharmacokinetics to a considerable extent. Extensive glucuronidation is an obstacle to oral bioavailability because the first-pass glucuronidation or premature clearance by UDP-glucuronosyltransferases of orally administered agents frequently results in poor oral bioavailability and lack of efficacy. Modeling of chemical entities/drugs for UGTs and their kinetic data can be useful in understanding the binding patterns to be used in the design of better molecules, analysis of first-pass glucuronidation by intestinal UGTs, including their topology, expression profile, and pharmacogenomics, and substrate selectivity at the binding pocket, structural requirements, and mechanism of enzyme actions, detailed overview
medicine
pharmacology