2.4.1.17: glucuronosyltransferase
This is an abbreviated version!
For detailed information about glucuronosyltransferase, go to the full flat file.
Word Map on EC 2.4.1.17
-
2.4.1.17
-
glucuronidation
-
hyperbilirubinemia
-
hepatocytes
-
irinotecan
-
gilbert
-
s-transferase
-
cyp3a4
-
phenobarbital
-
unconjugated
-
drug-metabolizing
-
disposition
-
pharmacogenetic
-
udp-glucuronic
-
interindividual
-
drug-drug
-
concentration-time
-
extrahepatic
-
acetaminophen
-
sulfotransferase
-
mycophenolic
-
neutropenia
-
pregnane
-
3-methylcholanthrene
-
benzoapyrene
-
o-deethylase
-
jaundice
-
androsterone
-
cyp2c9
-
drug development
-
endobiotics
-
slco1b1
-
vitro-in
-
lamotrigine
-
clint
-
sult1a1
-
herb-drug
-
propofol
-
atazanavir
-
diagnostics
-
cdna-expressed
-
cyp1b1
-
analysis
-
androstane
-
pharmacogenomics
-
raltegravir
-
7-ethoxyresorufin
-
aminopyrine
-
pharmacology
-
medicine
-
ethylmorphine
-
zidovudine
-
ethoxycoumarin
-
sults
-
beta-naphthoflavone
-
oatp1b1
- 2.4.1.17
-
glucuronidation
- hyperbilirubinemia
- hepatocytes
- irinotecan
- gilbert
- s-transferase
- cyp3a4
- phenobarbital
-
unconjugated
-
drug-metabolizing
-
disposition
-
pharmacogenetic
-
udp-glucuronic
-
interindividual
-
drug-drug
-
concentration-time
-
extrahepatic
- acetaminophen
-
sulfotransferase
-
mycophenolic
- neutropenia
-
pregnane
- 3-methylcholanthrene
-
benzoapyrene
-
o-deethylase
- jaundice
- androsterone
- cyp2c9
- drug development
-
endobiotics
-
slco1b1
-
vitro-in
- lamotrigine
-
clint
- sult1a1
-
herb-drug
- propofol
- atazanavir
- diagnostics
-
cdna-expressed
- cyp1b1
- analysis
-
androstane
-
pharmacogenomics
- raltegravir
- 7-ethoxyresorufin
- aminopyrine
- pharmacology
- medicine
- ethylmorphine
- zidovudine
-
ethoxycoumarin
-
sults
- beta-naphthoflavone
-
oatp1b1
Reaction
Synonyms
1-naphthol glucuronyltransferase, 1-naphthol-UDP-glucuronosyltransferase, 17-OH steroid UDPGT, 17beta-hydroxysteroid UDP-glucuronosyltransferase, 1A10, 3,4-catechol estrogen specific UDPGTh-2, 3-OH androgenic UDPGT, 3alpha-hydroxysteroid UDP-glucuronosyltransferase, 4-hydroxybiphenyl UDP-glucuronosyltransferase, 4-methylumbelliferone UDP-glucuronosyltransferase, 4-nitrophenol UDP-glucuronosyltransferase, 4-nitrophenol UDP-glucuronyltransferase, 4-nitrophenol UDPGT, bile acid uridine 5'-diphosphoglucuronyltransferase, bilirubin glucuronyltransferase, bilirubin monoglucuronide glucuronyltransferase, bilirubin UDP-glucuronosyltransferase, bilirubin UDPglucuronosyltransferase, bilirubin UDPGT, bilirubin uridine diphosphoglucuronyltransferase, bilirubin-specific UDPGT isozyme 1, bilirubin-specific UDPGT isozyme 2, ciramadol UDP-glucuronyltransferase, DP-glucuronosyltransferase 1A3, EC 2.4.1.107, EC 2.4.1.108, EC 2.4.1.42, EC 2.4.1.59, EC 2.4.1.61, EC 2.4.1.76, EC 2.4.1.77, EC 2.4.1.84, estriol UDP-glucuronosyltransferase, estrone UDP-glucuronosyltransferase, GlcAT-P, GlcAT-S, glucuronosyltransferase, uridine diphospho-, glucuronosyltransferase, uridine diphosphoglucuronate-1,2-diacylglycerol, glucuronosyltransferase, uridine diphosphoglucuronate-4-hydroxybiphenyl, glucuronosyltransferase, uridine diphosphoglucuronate-bilirubin, glucuronosyltransferase, uridine diphosphoglucuronate-estradiol, glucuronosyltransferase, uridine diphosphoglucuronate-estriol, glucuronosyltransferase, uridine diphosphoglucuronate-estriol 16alpha-, glucuronyltransferase, glucuronyltransferase, uridine diphospho-GT, HUG-BR1, HUG-BR2, inositol phosphorylceramide glucuronosyltransferase1, IPUT1, monUGT1A6, More, morphine glucuronyltransferase, p-hydroxybiphenyl UDP glucuronyltransferase, p-nitrophenol UDP-glucuronosyltransferase, p-nitrophenol UDP-glucuronyltransferase, p-nitrophenylglucuronosyltransferase, p-phenylphenol glucuronyltransferase, phenol-metabolizing UDP-glucuronosyltransferase, phenyl-UDP-glucuronosyltransferase, PNP-UDPGT, UDP glucuronate-estradiol-glucuronosyltransferase, UDP glucuronate-estriol glucuronosyltransferase, UDP glucuronic acid transferase, UDP glucuronosyltransferase, UDP glucuronosyltransferase 1A4, UDP glucuronosyltransferase 2B10, UDP glucuronyltransferase, UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase, UDP-glucuronate-bilirubin glucuronyltransferase, UDP-glucuronosyl-transferase 1A1, UDP-glucuronosyltransferase, UDP-glucuronosyltransferase 1A, UDP-glucuronosyltransferase 1A1, UDP-glucuronosyltransferase 1A10, UDP-glucuronosyltransferase 1A3, UDP-glucuronosyltransferase 1A4, UDP-glucuronosyltransferase 1A5, UDP-glucuronosyltransferase 1A6, UDP-glucuronosyltransferase 1A7, UDP-glucuronosyltransferase 1A8, UDP-glucuronosyltransferase 1A9, UDP-glucuronosyltransferase 2, UDP-glucuronosyltransferase 2A3, UDP-glucuronosyltransferase 2B10, UDP-glucuronosyltransferase 2B15, UDP-glucuronosyltransferase 2B17, UDP-glucuronosyltransferase 2B7, UDP-glucuronosyltransferase-1A10, UDP-glucuronosyltransferases 2B15, UDP-glucuronosyltransferases 2B7, UDP-glucuronyltransferase, UDPGA transferase, UDPGA-glucuronyltransferase, UDPglucuronate beta-D-glucuronosyltransferase, UDPglucuronosyltransferase, UDPGT, UFT1A9, UGT, UGT 1A1, UGT 1A10, UGT 1A3, UGT 1A4, UGT 1A6, UGT 1A7, UGT 1A8, UGT 1A9, UGT 2B15, UGT 2B17, UGT 2B4, UGT 2B7, UGT-1A, UGT-1D, UGT-1F, UGT-1J, UGT1-01, UGT1-03, UGT1-04, UGT1-06, UGT1-10, UGT1-9, UGT1.1, UGT1.10, UGT1.3, UGT1.4, UGT1.6, UGT1.9, UGT1A, UGT1A1, UGT1A10, UGT1A10A, UGT1A10B, UGT1A11, UGT1A2, UGT1A2A, UGT1A3, UGT1A4, UGT1A5, UGT1A5A, UGT1A5B, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1D, UGT1E, UGT1F, UGT1J, UGT2A1, UGT2A2, UGT2A3, UGT2B1, UGT2B10, UGT2B11, UGT2B12, UGT2B15, UGT2B17, UGT2B18, UGT2B19, UGT2B2, UGT2B20, UGT2B23, UGT2B28, UGT2B3, UGT2B30, UGT2B31, UGT2B33, Ugt2b34, Ugt2b36, Ugt2b37, UGT2B39, UGT2B4, UGT2B40, UGT2B41, UGT2B42, UGT2B43, UGT2B44, UGT2B45, UGT2B46, UGT2B7, UGT2B8, UGT2B9, UGT330A3, UGT339A2, UGT341A6, UGT342B3, UGT343C3, UGT344D5, UGT344D8, UGT348A3, UGT349A3, UGT350A3, UGT3A1, UGT3A2, uridine 5'-diphospho-glucuronosyltransferase, uridine 5'-diphosphoglucuronyltransferase, uridine diphosphate glucuronosyltransferase, uridine diphosphate glucuronyltransferase, uridine diphosphate-glucuronosyltransferase, uridine diphosphate-glucuronosyltransferase 2 B15, uridine diphosphate-glucuronosyltransferase 2B10, uridine diphosphate-glucuronosyltransferase 2B11, uridine diphosphate-glucuronosyltransferase 2B15, uridine diphosphate-glucuronosyltransferase 2B17, uridine diphosphate-glucuronosyltransferase 2B4, uridine diphosphate-glucuronosyltransferase 2B7, uridine diphosphoglucuronate-bilirubin glucuronosyltransferase, uridine diphosphoglucuronosyltransferase, uridine diphosphoglucuronyltransferase
ECTree
2.4.1.17 glucuronosyltransferaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.4.1.17 - glucuronosyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(+-)-11-hydroxy-DELTA9-tetrahydrocannabinol + UDP-glucuronate
? + UDP
-
substrate for isoforms UGT1A9 and UGT1A10
-
-
?
(-)-11-nor-9-carboxy-DELTA9-tetrahydrocannabinol + UDP-glucuronate
? + UDP
-
substrate for isoforms UGT1A1 and UGT1A3, no substrate for UGT1A9 and UGT1A10
-
-
?
(-)-borneol + UDP-glucuronate
UDP + (-)-borneol-O-alpha-D-glucuronide
-
-
-
?
(R)-6-hydroxywarfarin + UDP-alpha-D-glucuronate
(R)-6-hydroxywarfarin 6-O-beta-D-glucuronide + UDP
-
-
-
-
?
(R)-7-hydroxywarfarin + UDP-alpha-D-glucuronate
(R)-7-hydroxywarfarin 7-O-beta-D-glucuronide + UDP
-
-
-
-
?
(R)-8-hydroxywarfarin + UDP-alpha-D-glucuronate
(R)-8-hydroxywarfarin 8-O-beta-D-glucuronide + UDP
-
-
-
-
?
(S)-6-hydroxywarfarin + UDP-alpha-D-glucuronate
(S)-6-hydroxywarfarin 6-O-beta-D-glucuronide + UDP
-
-
-
-
?
(S)-7-hydroxywarfarin + UDP-alpha-D-glucuronate
(S)-7-hydroxywarfarin 7-O-beta-D-glucuronide + UDP
-
-
-
-
?
(S)-8-hydroxywarfarin + UDP-alpha-D-glucuronate
(S)-8-hydroxywarfarin 8-O-beta-D-glucuronide + UDP
-
-
-
-
?
(S)-naproxen + UDP-alpha-D-glucuronate
beta-D-glucuronosyl (S)-naproxen + UDP
-
-
-
-
?
(S)-naproxen + UDP-alpha-D-glucuronate
UDP + beta-D-glucuronosyl (S)-naproxen
-
-
-
-
?
(S)-oxazepam + UDP-glucuronate
UDP + (S)-oxazepam beta-D-glucuronoside
-
-
-
?
1-hydroxy-benzo(a)pyrene + UDP-glucuronate
1-hydroxy-benzo(a)pyrene 1-O-glucuronate + UDP
-
-
-
-
?
1-hydroxy-benzo[a]pyrene + UDP-D-glucose
benzo[a]pyrenil-1-O-D-glucoside + UDP
UGT3A2-overexpressing microsomes
-
-
?
1-hydroxy-pyrene + UDP-D-xylose
pyrene 1-O-D-xyloside + UDP
-
-
-
?
1-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-1-yl-beta-D-glucuronide
-
-
-
?
1-hydroxypyrene + UDP-D-glucose
pyrene 1-O-D-glucoside + UDP
-
-
-
?
1-hydroxypyrene + UDP-glucuronate
1-hydroxypyrene 1-O-glucuronate + UDP
-
-
-
-
?
1-hydroxypyrene + UDP-glucuronate
pyrene 1-O-glucuronide + UDP
-
-
-
?
1-hydroxypyrene + UDP-N-acetylglucosamine
pyrenil-1-O-(N-acetylglucosaminide) + UDP
activity of only UGT3A1-overexpressing microsomes, not wild-type cell microsomes
-
-
?
1-hydroxy[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-1-yl-alpha-D-glucuronide
-
-
-
?
1-naphthol + UDP-alpha-D-glucuronate
1-naphthyl O-glucuronide + UDP
-
-
-
-
?
1-naphthol + UDP-D-glucose
naphthyl-1-O-D-glucoside + UDP
UGT3A2-overexpressing microsomes
-
-
?
1-naphthol + UDP-glucuronate
1-naphthyl-O-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
?
-
-
-
?
10-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-10-yl-beta-D-glucuronide
-
-
-
?
11-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-11-yl-beta-D-glucuronide
-
-
-
?
11alpha-hydroxyprogesterone + UDP-glucuronate
UDP + 11alpha-hydroxyprogesterone-11-O-D-glucuronate
-
-
-
?
12-hydroxyeicosatetraenoic acid + UDP-glucuronate
?
-
-
-
?
13-hydroxyoctadecadienoic acid + UDP-glucuronate
?
-
-
-
?
16alpha-hydroxyprogesterone + UDP-glucuronate
UDP + 16alpha-hydroxyprgesterone-16-O-D-glucuronate
17alpha-ethynylestradiol + UDP-glucuronate
UDP + 17alpha-ethynylestradiol 3-O-beta-D-glucuronide
-
-
-
?
17beta-estradiol + UDP-alpha-D-glucuronate
UDP + estradiol-3beta-D-glucuronoside
-
-
-
?
17beta-hydroxy-5alpha-androstan-3-one + UDPglucuronate
UDP + 17beta-hydroxy-5alpha-androstan-3-one 17O-glucuronide
-
-
-
?
2 UDP-D-glucuronate + 2 dexmedetomidine
2 UDP + dexmedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
2 UDP-D-glucuronate + 2 levomedetomidine
2 UDP + levomedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
2',4,4'-trihydroxychalcone + UDP-glucuronate
UDP + 2',4,4'-trihydroxychalcone 4'-O-glucoside + 2',4,4'-trihydroxychalcone 2'-O-glucoside
-
i.e. isoliquiritigenin
-
-
?
2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDPglucuronate
?
glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid is mainly catalyzed by UGT1A1, UGT1A9, and UGT2B7 in the liver, and by UGT1A1, UGT1A3, and UGT2B7 in the intestine in humans
-
-
?
2-aminobiphenyl + UDP-glucuronate
?
-
-
-
?
2-hydroxy-2',3',4',5'-tetrachlorobiphenyl + UDPglucuronate
UDP + 2',3',4',5'-tetrachlorobiphenyl 2-O-glucuronate
-
-
-
?
2-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-2-yl-beta-D-glucuronide
-
-
-
?
2-hydroxyestradiol + UDP-glucuronate
UDP + 2-hydroxyestradiol O-glucuronide
-
-
-
-
?
2-methoxy-4-(2-propenyl)phenol + UDPglucuronate
UDP + 2-methoxy-4-(2-propenyl)phenylglucuronide
21-hydroxyprogesterone + UDP-glucuronate
UDP + 21-hydroxyprogesterone-21-O-D-glucuronate
-
-
-
?
3 quercetin + 3 UDP-glucuronate
3 UDP + quercetin 7-glucuronide + quercetin 3-glucuronide + quercetin 3'-glucuronide
isoform UGT1A9 mainly converts quercetin into three monoglucuronides, including 7-glucuronide, 3-glucuronide, and 3'-glucuronide
-
-
?
3'-azido-3'-deoxythymidine + UDP-alpha-D-glucuronate
3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP
3'-azido-3'-deoxythymidine + UDPglucuronate
3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP
3-azido-4-chlorobenzoic acid + UDP-glucuronate
?
-
-
-
?
3-azidobenzoic acid + UDP-glucuronate
?
-
-
-
?
3-hydroxy-benzo(a)pyrene + UDP-glucuronate
3-hydroxy-benzo(a)pyrene 3-O-glucuronate + UDP
-
-
-
-
?
3-hydroxy-benzo[a]pyrene + UDP-D-glucose
benzo[a]pyrenil-3-O-D-glucoside + UDP
UGT3A2-overexpressing microsomes
-
-
?
3-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-3-yl-beta-D-glucuronide
-
-
-
?
4-aminobiphenyl + UDPglucuronate
UDP + ?
-
catalyzed by isozyme 1 but not by isozyme 2
-
-
?
4-azido-2-hydroxybenzoic acid + UDPglucuronate
?
-
-
-
?
4-azidobenzoic acid + UDP-glucuronate
?
-
-
-
?
4-hydroxy-2',3,3',4',5'-pentachlorobiphenyl + UDPglucuronate
UDP + 2,3,3',4',5'-pentachlorobiphenyl 4-O-glucuronate
-
-
-
?
4-hydroxy-2',3,3',4',5,5'-heptachlorobiphenyl + UDPglucuronate
UDP + 2',3,3',4',5,5'-hexachlorobiphenyl 4-O-glucuronate
-
-
-
?
4-hydroxy-2',3,4',5,6'-pentachlorobiphenyl + UDPglucuronate
UDP + 2',3,4',5,6'-pentachlorobiphenyl 4-O-glucuronate
-
-
-
?
4-hydroxy-2',3,4',6'-tetrachlorobiphenyl + UDP-glucuronate
UDP + 2',4',6'-trichlorobiphenyl 4-O-glucuronate
-
-
-
?
4-hydroxy-2',4',6'-trichlorobiphenyl + UDP-glucuronate
UDP + 2',4',6'-trichlorobiphenyl 4-O-glucuronate
-
-
-
?
4-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-4-yl-beta-D-glucuronide
-
-
-
?
4-hydroxyestrone + UDP-glucuronate
UDP + 4-hydroxyestrone-4-O-beta-D-glucuronide
-
-
-
-
?
4-methylumbeliferone + UDP-alpha-D-glucuronate
4-methylumbelliferyl-7-O-alpha-D-glucuronide
-
-
-
-
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-beta-D-glucuronide
-
-
-
-
?
4-n-octylgallate + UDPglucuronate
UDP + 4-n-octylgallate 3-O-glucuronide
-
highly specific for UGT1A71
-
?
4-nitrophenol + UDP-glucuronate
UDP + 4-nitrophenyl beta-D-glucuronide
the reaction occurs with isoform UGT2B30
-
-
?
5-diethylaminoethylamino-8-hydroxyimidazoacridinone + UDP-alpha-D-glucuronate
5-{[2-(diethylamino)ethyl]amino}-6-oxo-6H-imidazo[4,5,1-de]acridin-8-yl beta-D-glucuronide + UDP
-
i.e. antitumor agent C-1311, NSC-645809
-
-
?
5-dimethylaminopropylamino-8-hydroxytriazoloacridinone + UDP-alpha-D-glucuronate
5-dimethylaminopropylamino-8-hydroxytriazoloacridinone-8-D-glucuronide + UDP
-
i.e. antitumor agent C-1305
-
-
?
5-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-5-yl-beta-D-glucuronide
-
-
-
?
5-hydroxybenzo[a]pyrene + UDPglucuronate
UDP + 5-hydroxybenzo[a]pyrene O-glucuronide
-
glucuronidated by UGT1A3
-
?
5-hydroxyrofecoxib + UDP-glucuronate
UDP + 5-hydroxyrofecoxib beta-D-glucuronide
-
-
-
?
5-methylchrysene-1,2-diol + UDP-D-glucose
1-hydroxy-5-methylchrysene-2-O-D-glucoside + UDP
UGT3A2-overexpressing microsomes
-
-
?
5-methylchrysene-1,2-diol + UDP-D-glucose
2-hydroxy-5-methylchrysene-1-O-D-glucoside + UDP
UGT3A2-overexpressing microsomes
-
-
?
5-methylchrysene-1,2-diol + UDP-D-xylose
1-hydroxy-5-methylchrysene-2-O-D-xyloside + UDP
UGT3A2-overexpressing microsomes
-
-
?
5-methylchrysene-1,2-diol + UDP-D-xylose
2-hydroxy-5-methylchrysene-1-O-D-xyloside + UDP
UGT3A2-overexpressing microsomes
-
-
?
5alpha-androstane-3alpha,17beta-diol + UDP-glucuronate
?
-
-
-
?
5alpha-androstane-3alpha,17beta-diol + UDP-glucuronate
UDP + 5alpha-androstane-3alpha,17beta-diol O-glucuronide
5beta-androstane-3alpha,17beta-diol + UDP-glucuronate
UDP + 5beta-androstane-3alpha,17beta-diol O-glucuronide
-
-
-
?
6-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-6-yl-beta-D-glucuronide
-
-
-
?
6alpha-hydroxyprogesterone + UDP-glucuronate
UDP + 6alpha-hydroxyprogesteron-6-O-alpha-D-glucuronate
-
-
-
?
7,7,7-triphenylheptanoic acid + UDPglucuronate
UDP + 7,7,7-triphenylheptanoic acid glucuronide
7-ethyl-10-hydroxy-camptothecin + UDP-glucuronate
UDP + 7-ethyl-10-hydroxy-camptothecin beta-D-glucuronide
i.e SN-38, substrate for isoform UGT1A1
-
-
?
7-ethyl-10-hydroxy-camptothecin carboxylate + UDP-glucuronate
UDP + 7-ethyl-camptothecin carboxylate-10-yl-beta-D-glucuronate
7-ethyl-10-hydroxy-camptothecin lactone + UDP-glucuronate
UDP + 7-ethyl-camptothecin lactone-10-yl-beta-D-glucuronate
7-ethyl-10-hydroxycamptothecin + UDP-alpha-D-glucuronate
7-ethyl-10-hydroxycamptothecin 10-O-glucuronate + UDP
7-hydroxy-4-(trifluoromethyl)-coumarin + UDPglucuronate
UDP + 7-hydroxy-4-(trifluoromethyl)-coumarin O-glucuronide
-
-
-
?
7-hydroxy-4-trifluoromethylcoumarin + UDP-alpha-D-glucuronate
7-hydroxy-4-trifluoromethylcoumarin 7-O-glucuronate + UDP
7-hydroxy-4-trifluoromethylcoumarin + UDP-glucuronate
UDP + 7-hydroxy-4-trifluoromethylcoumarin beta-D-glucuronide
7-hydroxy-benzo(a)pyrene + UDP-glucuronate
7-hydroxy-benzo(a)pyrene 7-O-glucuronate + UDP
-
-
-
-
?
7-hydroxy-benzo[a]pyrene + UDP-D-glucose
benzo[a]pyrenil-7-O-D-glucoside + UDP
UGT3A2-overexpressing microsomes
-
-
?
7-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-7-yl-beta-D-glucuronide
-
-
-
?
7-hydroxycoumarin + UDP-glucuronate
UDP + coumarin-7-yl-alpha-D-glucuronide
-
-
-
?
8-hydroxy-benzo(a)pyrene + UDP-glucuronate
8-hydroxy-benzo(a)pyrene 8-O-glucuronate + UDP
-
-
-
-
?
8-hydroxy-benzo[a]pyrene + UDP-glucuronate
benzo[a]pyrenil-8-O-glucuronide + UDP
activity of only UGT3A1-overexpressing microsomes, not wild-type cell microsomes
-
-
?
8-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-8-yl-beta-D-glucuronide
-
-
-
?
8-hydroxyquinoline + UDPglucuronate
UDP + 8-hydroxyquinoline 8-O-glucuronide
-
-
-
?
9-hydroxy-benzo[a]pyrene + UDP-D-glucose
benzo[a]pyrenil-9-O-D-glucoside + UDP
UGT3A2-overexpressing microsomes
-
-
?
9-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-9-yl-beta-D-glucuronide
-
-
-
?
anastrozole + UDP-glucuronate
UDP + ?
-
-
-
?
androstane-3alpha,17beta diol + UDPglucuronate
UDP + androstane-3alpha,17beta diol O-glucuronide
-
-
-
?
androsterone + UDP-glucuronate
?
-
-
-
?
benzo[a]pyrene 3,6-diphenol + UDP-glucuronate
?
converted readily to mono- and diglucuronides
-
-
?
benzo[a]pyrene 3,6-quinone + UDPglucuronate
benzo[a]pyrene 3,6-quinol glucuronide + UDP
-
-
no information to which positions 3-, 6-, or both the glucuronate is attached
?
benzo[a]pyrene-3,6-quinol + UDPglucuronate
benzo[a]pyrene 3,6-quinol mono- and diglucuronide + UDP
-
-
-
?
benzo[a]pyrene-7,8-diol + UDP-D-glucose
7-hydroxy-benzo[a]pyrene-8-O-D-glucoside + UDP
UGT3A2-overexpressing microsomes
-
-
?
benzo[a]pyrene-7,8-diol + UDP-D-glucose
8-hydroxy-benzo[a]pyrene-7-O-D-glucoside + UDP
UGT3A2-overexpressing microsomes
-
-
?
benzo[a]pyrene-7,8-diol + UDP-D-xylose
7-hydroxy-benzo[a]pyrene-8-O-D-xyloside + UDP
UGT3A2-overexpressing microsomes
-
-
?
benzo[a]pyrene-7,8-diol + UDP-D-xylose
8-hydroxy-benzo[a]pyrene-7-O-D-xyloside + UDP
UGT3A2-overexpressing microsomes
-
-
?
benzo[a]pyrene-9,10-diol + UDP-D-glucose
10-hydroxy-benzo[a]pyrene-9-O-D-glucoside + UDP
UGT3A2-overexpressing microsomes
-
-
?
benzo[a]pyrene-9,10-diol + UDP-D-glucose
9-hydroxy-benzo[a]pyrene-10-O-D-glucoside + UDP
UGT3A2-overexpressing microsomes
-
-
?
benzo[a]pyrene-9,10-diol + UDP-D-xylose
10-hydroxy-benzo[a]pyrene-9-O-D-xyloside + UDP
UGT3A2-overexpressing microsomes
-
-
?
benzo[a]pyrene-9,10-diol + UDP-D-xylose
9-hydroxy-benzo[a]pyrene-10-O-D-xyloside + UDP
UGT3A2-overexpressing microsomes
-
-
?
benzo[a]pyrene-9,10-diol + UDP-glucuronate
10-hydroxy-benzo[a]pyrene-9-O-glucuronide + UDP
activity of only UGT3A1-overexpressing microsomes, not wild-type cell microsomes
-
-
?
benzo[a]pyrene-9,10-diol + UDP-glucuronate
9-hydroxy-benzo[a]pyrene-10-O-glucuronide + UDP
activity of only UGT3A1-overexpressing microsomes, not wild-type cell microsomes
-
-
?
benzo[a]pyrene-9,10-diol + UDP-N-acetylglucosamine
10-hydroxybenzo[a]pyrene 9-O-(N-acetylglucosaminide) + UDP
activity of only UGT3A1-overexpressing microsomes, not wild-type cell microsomes
-
-
?
benzo[a]pyrene-9,10-diol + UDP-N-acetylglucosamine
9-hydroxybenzo[a]pyrene 10-O-(N-acetylglucosaminide) + UDP
activity of only UGT3A1-overexpressing microsomes, not wild-type cell microsomes
-
-
?
beta-estradiol + UDP-alpha-D-glucuronate
beta-estradiol-3-glucuronide + UDP
-
-
-
-
?
beta-estradiol + UDP-glucuronate
UDP + beta-estradiol 3-O-beta-D-glucuronoside
-
-
-
?
beta-estradiol + UDP-glucuronate
UDP + beta-estradiol 3-O-glucuronide
-
-
-
?
bilirubin + UDP-glucuronate
?
-
-
-
?
bilirubin + UDP-glucuronate
bilirubin glucuronoside + UDP
UGT1A1 exhibits the highest tranilast glucuronosyltransferase activity (13.5 pmol/min/mg protein)
-
-
?
bilirubin + UDP-glucuronate
UDP + bilirubin-glucuronoside
-
-
-
?
cannabinol + UDP-glucuronate
? + UDP
-
substrate for hepatic isoform UGT1A9 and extrahepatic UGT1A7, UGT1A8, and UGT1A10
-
-
?
carvacrol + UDP-glucuronate
caervcrol O-glucuronate + UDP
-
isoform UGT1A9 is the major isozyme responsible for glucuronidation in liver microsomes, and isoform UGT1A7 plays a major role for glucuronidation in intestinal microsomes
-
-
?
chenodeoxycholic acid + UDP-glucuronate
UDP + chenodeoxycholic acid 24-acyl-beta-D-glucuronide
-
-
-
?
chenodeoxycholic acid + UDP-glucuronate
UDP + chenodeoxycholic acid 24-beta-D-glucuronoside
-
-
-
?
chenodeoxycholic acid + UDPgalacturonate
UDP + chenodeoxycholic acid O-galacturonide
-
-
-
?
codeine + UDPglucuronate
codeine-6-glucuronide + UDP
-
glucuronidated by HGT2B7H and HGT2B7Y
-
?
deoxycholic acid + UDPglucuronate
UDP + deoxycholic acid O-glucuronide
-
-
-
?
dibenzo[a,1]pyrene-11,12-diol + UDP-D-glucose
11-hydroxy-benzo[a]pyrene-12-O-D-glucoside + UDP
UGT3A2-overexpressing microsomes
-
-
?
dibenzo[a,1]pyrene-11,12-diol + UDP-D-glucose
12-hydroxy-benzo[a]pyrene-11-O-D-glucoside + UDP
UGT3A2-overexpressing microsomes
-
-
?
dibenzo[a,1]pyrene-11,12-diol + UDP-D-xylose
11-hydroxy-benzo[a]pyrene-12-O-D-xyloside + UDP
UGT3A2-overexpressing microsomes
-
-
?
dibenzo[a,1]pyrene-11,12-diol + UDP-D-xylose
12-hydroxy-benzo[a]pyrene-11-O-D-glucoside + UDP
UGT3A2-overexpressing microsomes
-
-
?
digitoxigenin + UDPglucuronate
UDP + digitoxigenin O-glucuronide
-
-
-
?
dihydromorphine + UDPglucuronate
UDP + dihydromorphine O-glucuronide
-
-
-
?
dihydromorphone + UDPglucuronate
UDP + dihydromorphone O-glucuronide
-
-
-
?
dihydrotestosterone + UDP-alpha-D-glucuronate
dihydrotestosterone D-glucuronate + UDP
-
-
-
-
?
dihydrotestosterone + UDPglucuronate
UDP + dihydrotestosterone O-glucuronide
-
-
-
?
edaravone + UDP-alpha-D-glucuronate
edaravone beta-D-glucuronate + UDP
-
i.e. 3-methyl-1-phenyl-2-pyrazolin-5-one. Edaravone glucuronidation in liver microsomes and kidney microsomes exhibits biphasic kinetics. UDP glucuronosyltransferases UGT1A1, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A10, UGT2B7, and UGT2B17 produce a significant amount of glucuronide metabolite. Among them, UGT1A9 exhibits the highest activity, followed by UGT2B17 and UGT1A7
-
-
?
epitestosterone + UDP-glucuronate
UDP + epitestosterone O-glucuronide
-
glucuronidated by HGT2B7H and HGT2B7Y
-
?
estradiol + UDP-alpha-D-glucuronate
estradiol 3-O-glucuronate + UDP
sigmoidal kinetics with n of 1.7
-
-
?
estradiol + UDP-alpha-D-glucuronate
UDP + estradiol 3-O-glucuronide
-
substrate of isoform UGT1A1
-
-
?
estradiol + UDP-glucuronate
estradiol 3-O-glucuronate + UDP
sigmoidal kinetics with n of 1.7
-
-
?
estradiol + UDP-glucuronate
UDP + estradiol 17-O-glucuronide
the reaction occurs with isoforms UGT2B9 and UGT2B30
-
-
?
estradiol-17alpha + UDPglucuronate
UDP + 17-alpha-estradiol O-glucuronide
-
-
-
?
ethinylestradiol + UDPglucuronate
UDP + ethinylestradiol-3-glucuronide
-
-
-
?
eugenol + UDP-glucuronate
UDP + eugenol-O-alpha-D-glucuronide
-
-
-
?
flavopiridol + UDP-glucuronate
UDP + flavopiridol beta-D-glucuronoside
-
-
-
?
flurbiprofen + UDP-glucuronate
?
metabilized by mutant enzyme S432G-UGT1A7, but not by wild-type enzyme UGT1A7
-
-
?
glycolithocholic acid + UDPglucuronate
UDP + glycolithocholic acid O-glucuronide
-
lowest activity among five bile acids studied
-
?
glycyrrhetinic acid + UDP-glucuronate
UDP + glycyrrhetinic acid-3-O-glucuronide
-
-
-
-
?
imipramine + UDP-glucuronate
UDP + ?
-
-
-
?
imipramine + UDP-glucuronate
UDP + imipramine D-glucuronide
the reaction occurs with isoform UGT2B20
-
-
?
morphine + UDP-glucuronate
?
-
-
-
?
morphine + UDP-glucuronate
UDP + morphine 3-beta-D-glucuronoside
-
-
-
?
morphine + UDP-glucuronate
UDP + morphine 3-glucuronide + morphine 6-glucuronide
-
-
-
?
morphine + UDP-glucuronate
UDP + morphine 3-O-glucuronide
the reaction occurs with isoforms UGT2B9 and UGT2B30
-
-
?
mycophenolic acid + UDP-alpha-D-glucuronate
mycophenolic acid D-glucuronide
-
-
-
-
?
mycophenolic acid + UDP-glucuronate
UDP + mycophenolic acid beta-D-glucuronoside
-
-
-
?
N-hydroxy-2-acetylaminofluorene + UDPglucuronate
UDP + N-hydroxy-2-acetylaminofluorene O-glucuronide
-
glucuronidated by UGT1A3 in preference to the ring-hydroxylated derivatives
-
?
nalorphine + UDPglucuronate
UDP + nalorphine O-glucuronate
-
-
-
?
naltrexone + UDPglucuronate
UDP + naltrexone O-glucuronide
-
-
-
?
octylgallate + UDPglucuronate
?
-
-
-
?
opiates + UDPglucuronate
opiates 6-O-glucuronides + UDP
-
substrate for UGT2B7
-
?
oxymorphone + UDPglucuronate
UDP + oxymorphone O-glucuronide
-
-
-
?
p-ethoxyphenylurea + UDP-glucuronate
?
-
-
-
?
planar phenols + UDPglucuronate
UDP + phenylglucuronides
-
expressed before birth
-
-
?
propofol + UDP-glucuronate
UDP + propofol beta-D-glucuronoside
-
-
-
?
propofol + UDP-glucuronate
UDP + propofol O-glucuronide
-
-
-
?
propofol + UDP-glucuronate
UDP + propofyl beta-D-glucuronide
-
-
-
?
quercetin + UDP-glucuronate
UDP + quercetin 7-glucuronide + quercetin 4'-glucuronide + quercetin 3'-glucuronide
isoform UGT1A1 mainly converts quercetin into three monoglucuronides, including 7-glucuronide, 4'-glucuronide, and 3'-glucuronide
-
-
?
scopoletin + UDP-glucuronate
?
-
-
-
?
senecionine + UDP-alpha-D-glucuronate
senecionine N-glucuronide + UDP
-
senecionine is a representative of the hepatotoxic pyrrolizidine alkaloids. Glucuronidation is mediated by isofrom UGT1A4 and follows typical Michaelis-Menten kinetics
-
-
?
serotonin + UDP-glucuronate
UDP + serotonin O-glucuronide
-
-
-
?
SN-38 + UDP-glucuronate
UDP + 7-ethyl-10-hydroxycamptothecin 10-O-beta-D-glucuronoside
-
-
-
?
testosterone + UDP-glucuronate
UDP + testosterone 17-O-glucuronide
-
isoform UGT2B17 is the most active enzyme in testosterone glucuronidation. Isoform UGT2A1, an extrahepatic enzyme that is expressed mainly in the nasal epithelium, catalyzes the glucuronidation of both steroids at considerable rates and similar kinetics
-
-
?
thyroxine + UDP-glucuronate
UDP + thyroxine beta-D-glucuronoside
-
-
-
?
trans-androsterone + UDP-alpha-D-glucuronate
trans-androsterone D-glucuronate + UDP
-
-
-
-
?
trifluoperazine + UDP-glucuronate
UDP + ?
-
substrate for isoform UGT1A4 and isoform UGT1A1 mutant H39P
-
-
?
trifluoperazine + UDP-glucuronate
UDP + trifluoperazine beta-D-glucuronoside
-
-
-
?
trifluoperazine + UDP-glucuronate
UDP + trifluoperazine N-glucuronide
-
-
-
?
trifluoperazine dihydrochloride + UDP-glucuronate
UDP + ?
substrate for isoform UGT1A4
-
-
?
UDP-alpha-D-glucuronate + 3-hydroxyflavone
UDP + 3-[(beta-D-glucopyranurnosyl)oxy]-flavone
isozyme UGT1A1
-
-
?
UDP-alpha-D-glucuronate + biphenyl-4,4'-diol
UDP + 4'-hydroxybiphenyl-4-yl beta-D-glucopyranosiduronate
-
-
-
-
?
UDP-alpha-D-glucuronate + diclofenac
UDP + diclofenac O-beta-D-glucuronide
-
-
-
?
UDP-alpha-D-glucuronate + dopamine
UDP + dopamine 3-O-beta-D-glucopyranosiduronic acid
-
substrate for isoform UGT1A10, no substrate for all other UGT enzymes tested
-
-
?
UDP-alpha-D-glucuronate + dopamine
UDP + dopamine 4-O-beta-D-glucopyranosiduronic acid
-
-
substrate for isoform UGT1A10, no substrate for all other UGT enzymes tested
-
?
UDP-alpha-D-glucuronate + estradiol
UDP + estradiol beta-D-glucuronoside
-
-
-
?
UDP-alpha-D-glucuronate + morphine
UDP + morphine beta-D-glucuronoside
-
-
-
?
UDP-alpha-D-glucuronate + sorafenib
UDP + ?
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-alpha-glucuronate + diclofenac
UDP + beta-D-glucuronosyl-diclofenac
-
-
-
-
?
UDP-D-glucuronate + 11alpha-hydroxyprogesterone
UDP + 11alpha-hydroxyprogesterone 11-O-beta-D-glucuronoside
an UGT2B7 substrate
-
-
?
UDP-D-glucuronate + 17beta-estradiol
UDP + 17beta-estradiol 3-O-beta-D-glucuronoside
-
-
-
?
UDP-D-glucuronate + 17beta-estradiol
UDP + 17beta-estradiol-3-O-beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + 1alpha,25-dihydroxyvitamin D3
UDP + 1alpha,25-dihydroxyvitamin D3 25-O-beta-D-glucuronoside
among 12 different UGT isozymes tested, only UGT1A4, and also UGT2B4 and UGT2B7 support the reaction, the main product by UGT1A4 supersomes and human liver microsomes is the 25-O-glucuronide, product identification and determination by mass spectral and NMR analyses, overview
-
-
?
UDP-D-glucuronate + 2-hydroxyestradiol
UDP + 2-hydroxyestradiol beta-D-glucuronoside
isozyme UGT1A1
-
-
?
UDP-D-glucuronate + 2-hydroxyestrone
UDP + 2-hydroxyestrone beta-D-glucuronoside
isozyme UGT1A1
-
-
?
UDP-D-glucuronate + 3'-azido-3'-deoxythymidine
UDP + 3'-azido-3'-deoxythymidine 5'-O-beta-D-glucuronoside
model substrate for determination of glucuronidation with respect to specificity, linearity, detection limit, recovery, stability, precision and accuracy, method development and validation for assay and chromatographic determination of reaction products, overview
-
-
?
UDP-D-glucuronate + 3-hydroxydesloratadine
UDP + 3-hydroxydesloratadine beta-O-D-glucuronoside
specific substrate of isozyme UGT1A8
-
-
?
UDP-D-glucuronate + 4'-hydroxy-warfarin
UDP + 4'-hydroxy-warfarin beta-D-glucuronoside
substrate of isozyme UGT1A10
-
-
?
UDP-D-glucuronate + 4-(trifluoromethyl)-umbelliferone
UDP + 4-(trifluoromethyl)-umbelliferone beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + 4-hydroxy-N-desmethyl-tamoxifen
UDP + 4-hydroxy-N-desmethyl-tamoxifen beta-D-glucuronoside
UDP-D-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferone beta-D-glucuronoside
UDP-D-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferonyl beta-D-glucuronoside
-
-
-
?
UDP-D-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl beta-O-glucuronoside
-
-
-
?
UDP-D-glucuronate + 4-nitrophenol
UDP + 4-nitrophenyl beta-O-D-glucuronoside
-
-
-
?
UDP-D-glucuronate + apigenin
UDP + apigenin 7-O-beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + beta-D-estradiol
UDP + beta-estradiol 3-O-beta-D-glucuronoside
isozyme UGT1A1
-
-
?
UDP-D-glucuronate + beta-estradiol
UDP + beta-estradiol 3-O-beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + bilirubin
UDP + bilirubin beta-D-glucuronoside
isozyme UGT1A1
-
-
?
UDP-D-glucuronate + bisdemethoxy-curcumin
UDP + bisdemethoxy-curcumin phenolic beta-D-monoglucuronide
-
-
-
-
?
UDP-D-glucuronate + candesartan
UDP + candesartan beta-D-glucuronoside
-
isozyme UGT1A3 exhibites a strong regioselectivity towards the N2 position of the tetrazole ring, also isozyme UGT2B7 glucuronidates candesartan at the tetrazole-N2 position, whereas isozymes UGT1A7, UGT1A8, UGT1A9, and UGT1A10 mainly yield candesartan O-glucuronide
-
-
?
UDP-D-glucuronate + chenodeoxycholic acid
UDP + hyodeoxycholic acid 6-O-glucuronoside
isozyme UGT2A3
-
-
?
UDP-D-glucuronate + curcumin
UDP + curcumin beta-D-glucuronoside
-
low activity, can reverse the inhibitory effect of curcumin on UGTs
-
-
?
UDP-D-glucuronate + dehydrotestosterone
UDP + dehydrotestosterone 17-O-beta-D-glucuronoside
UDP-D-glucuronate + demethoxy-curcumin
UDP + demethoxy-curcumin phenolic beta-D-monoglucuronide
-
-
-
-
?
UDP-D-glucuronate + deoxycholic acid
UDP + hyodeoxycholic acid 6-O-glucuronoside
isozyme UGT2A3
-
-
?
UDP-D-glucuronate + dihydrotestosterone
UDP + dihydrotestosterone 17-O-beta-D-glucuronoside
UDP-D-glucuronate + eriodictyol
UDP + eriodictyol 7-O-beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + flurbiprofen
UDP + flurbiprofen beta-D-glucuronoside
-
isozyme UGT2B7
-
-
?
UDP-D-glucuronate + hesperetin
UDP + hesperetin 7-O-beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + homoeriodictyol
UDP + homoeriodictyol 7-O-beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + hyodeoxycholic acid
UDP + hyodeoxycholic acid 24-carboxy-glucuronoside
recombinant enzyme, expressed in insect cells via baculovirus system, selective glucuronidation
product formation depends on the isozyme, overview
-
?
UDP-D-glucuronate + hyodeoxycholic acid
UDP + hyodeoxycholic acid 3-O-glucuronoside
recombinant enzyme, expressed in insect cells via baculovirus system, selective glucuronidation
product formation depends on the isozyme, overview
-
?
UDP-D-glucuronate + imipramine
UDP + imipramine N-beta-D-glucuronoside
reaction of isozyme UGT1A4
-
-
?
UDP-D-glucuronate + isolongifolol
UDP + isolongifolol beta-D-glucuronoside
-
the compound is substrate and competitive inhibitor
-
-
?
UDP-D-glucuronate + kaempferol
UDP + kaempferol 7-O-beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + longifolol
UDP + longifolol beta-D-glucuronoside
-
the compound is substrate and competitive inhibitor
-
-
?
UDP-D-glucuronate + losartan
UDP + losartan beta-D-glucuronoside
-
no O-glucuronide is generated by any isozyme, while isozymes UGT1A1, UGT1A3, 1A10, UGT2B7, and UGT2B17 glucuronidate losartan at the tetrazole-N2, isozyme UGT1A10 also yields the respective N1-glucuronide, isozyme UGT1A3 exhibites a strong regioselectivity towards the N2 position of the tetrazole ring
-
-
?
UDP-D-glucuronate + menadiol
UDP + mendadiol 1-O-beta-D-glucuronoside
-
-
isoform UGT1A6, formation of 1-menadiol glucuronide and 4-menadiol glucuronide in ratio of about 4:1
-
?
UDP-D-glucuronate + menadiol
UDP + mendadiol 4-O-beta-D-glucuronoside
-
-
isoform UGT1A10, preferential formation of 4-menadiol glucuronoside, isoform UGT1A6, formation of 1-menadiol glucuronide and 4-menadiol glucuronide in ratio of about 4:1
-
?
UDP-D-glucuronate + morphine
UDP + morphine 3-beta-D-glucuronoside
activity of isozyme UGT1A8
-
-
?
UDP-D-glucuronate + morphine
UDP + morphine 6-O-beta-D-glucuronoside
-
-
-
?
UDP-D-glucuronate + mycophenolic acid
UDP + mycophenolic acid beta-D-glucuronoside
K314 and K404m are determined binding sites required for UDP-glcA binding to isozyme UGT1A10, overview
-
-
?
UDP-D-glucuronate + myricetin
UDP + myricetin 7-O-beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + naringenin
UDP + naringenin 7-O-beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + phenolphthalein
UDP + phenolphthalein beta-D-glucuronoside
an UGT2B15 substrate
-
-
?
UDP-D-glucuronate + phenolphthalein
UDP + phenolphthalein beta-D-monoglucuronoside
-
-
-
-
?
UDP-D-glucuronate + quercetin
UDP + quercetin 7-O-beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + serotonin
UDP + serotonin beta-D-glucuronoside
isozyme UGT1A6
-
-
?
UDP-D-glucuronate + serotonin
UDP + serotonin O-beta-D-glucuronoside
reaction of isozyme UGT1A6
-
-
?
UDP-D-glucuronate + testosterone
UDP + testosterone 17-O-beta-D-glucuronoside
an UGT2B15 substrate
-
-
?
UDP-D-glucuronate + trans-4-hydroxytamoxifen
UDP + 4-hydroxytamoxifen beta-D-glucuronoside
UDP-D-glucuronate + trifluoperazine
UDP + trifluoperazine beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + umbelliferone
UDP + umbelliferyl beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + ursodeoxycholic acid
UDP + hyodeoxycholic acid 6-O-glucuronoside
isozyme UGT2A3
-
-
?
UDP-D-glucuronate + zolarsartan
UDP + zolarsartan beta-D-glucuronoside
-
isozyme UGT1A3 exhibites a strong regioselectivity towards the N2 position of the tetrazole ring, the tetrazole-N1 of this aglycone is accessible to other enzymes, including isozyme UGT1A5, zolarsartan O-glucuronide is mainly produced by isozyme UGT1A10 and isozyme UGT2B7
-
-
?
UDP-glucuronate + (E)-2,4-dimethoxy-6-(4-methoxystyryl)benzaldehyde oxime
UDP + 1-O-[(E)-2,4-dimethoxy-6-(4-methoxystyryl)benzaldehyde oxime]-beta-D-glucuronate
UDP-glucuronate + (E)-3-(3-hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)acrylic acid
UDP + ?
-
i.e. NI-12a, low activity, NI-12a is glucuronidated at both the -COOH and -OH functions. NI-12a is primarily metabolized by the hepatic and renal enzyme UGT1A9
-
-
?
UDP-glucuronate + (S)-oxazepam
UDP + (S)-oxazepam beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + 1,25-dihydroxyergocalciferol
UDP + 1,25-dihydroxyergocalciferol beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + 1-hydroxypyrene
UDP + 1-hydroxypyrene beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + 10-gingerol
UDP + 10-gingerol 4'-O-beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + 10-gingerol
UDP + 10-gingerol 5-O-beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + 12-hydroxyeicosatetraenoic acid
UDP + 12-hydroxyeicosatetraenoyl beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + 12-hydroxyeicosatetraenoic acid
UDP + 12-hydroxyeicosatetraenoyl-beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + 15-hydroxyeicosatetraenoic acid
UDP + 15-hydroxyeicosatetraenoyl beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + 15-hydroxyeicosatetraenoic acid
UDP + 15-hydroxyeicosatetraenoyl-beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + 17beta-estradiol
UDP + 17beta-estradiol 3-O-glucuronide
-
-
-
?
UDP-glucuronate + 17beta-estriol
UDP + estriol 17-beta-D-glucuronide
-
-
-
?
UDP-glucuronate + 2',4'-dihydroxychalcone
UDP + 2'-hydroxychalcone 4'-O-beta-D-glucuronoside
-
glucuronidation at the OH-4' position by UGT1A1 and UGT1A10 isoforms, both UGT1A6 and 1A9 produced two chalcone monoglucuronides, the 4'-Oglucuronide and the 2'-O-glucuronide
-
-
?
UDP-glucuronate + 2',4'-dihydroxychalcone
UDP + 4'-hydroxychalcone 2'-O-beta-D-glucuronoside
-
glucuronidation at the OH-2' position with low activity by UGT1A7, UGT1A6, and UGT1A10 isoforms, and with high activity by isozyme UGT1A9. Both UGT1A6 and 1A9 produced two chalcone monoglucuronides, the 4'-Oglucuronide and the 2'-O-glucuronide
-
-
?
UDP-glucuronate + 2'-hydroxychalcone
UDP + chalcone 2'-O-beta-D-glucuronoside
-
glucuronidation at the OH-2' position by UGT1A9 isoform
-
-
?
UDP-glucuronate + 2-hydroxyestrone
UDP + 2-hydroxyestrone beta-D-glucuronide
-
-
-
-
?
UDP-glucuronate + 2-methoxyestrone
UDP + 2-methoxyestrone beta-D-glucuronide
-
-
-
-
?
UDP-glucuronate + 20-hydroxyeicosatetraenoic acid
UDP + 20-hydroxyeicosatetraenoyl beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + 25-hydroxyergocalciferol
UDP + 25-hydroxyergocalciferol beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + 3'-azido-3'-deoxythymidine
UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronide
-
isozymes UGT2B4, UGT2B7, and UGT2B17
-
-
?
UDP-glucuronate + 3'-azido-3'-deoxythymidine
UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronoside
UDP-glucuronate + 3,17-estradiol
UDP + 17-estradiol 3-O-glucuronide
-
isozyme UGT1A1
-
-
?
UDP-glucuronate + 3,17-estradiol
UDP + 3-estradiol 17-O-glucuronide
-
isozyme UGT1A1
-
-
?
UDP-glucuronate + 3,2'-dihydroxychalcone
UDP + 3-hydroxychalcone 2'-O-beta-D-glucuronoside
UDP-glucuronate + 3-epideacetycinobufagin
UDP + 3-epideacetycinobufagin 3-beta-D-glucuronoside
UDP-glucuronate + 3alpha,5beta-tetrahydroaldosterone
UDP + 3alpha,5beta-tetrahydroaldosterone beta-D-glucuronide
high activity
-
-
?
UDP-glucuronate + 4,2'-dihydroxychalcone
UDP + 4-hydroxychalcone 2'-O-beta-D-glucuronoside
-
glucuronidation at the OH-2' position by UGT1A8, UGT1A1, and UGT1A3 isoforms. The A-ring OH-4 group promotes glucuronidation at the 2' position for the reaction of the exclusive substrate 4,2'-dihydroxychalcone of UGT1A1 and 1A3
-
-
?
UDP-glucuronate + 4-hydroxy-estrone
UDP + ?
glucuronidation of 4-hydroxylated estrone is significantly reduced in breast carcinomas compared to healthy
-
-
?
UDP-glucuronate + 4-hydroxyestradiol
UDP + 4-hydroxyestradiol beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + 4-hydroxyretinoic acid
UDP + 4-hydroxyretinoic acid beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
mainly conjugated by UGT2B7
-
-
?
UDP-glucuronate + 4-methoxyestrone
UDP + 4-methoxyestrone beta-D-glucuronide
-
-
-
-
?
UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl-beta-D-glucuronide
-
all isozymes, nonselective substrate
-
-
?
UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl-beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + 4-nitrophenol
UDP + 4-nitrophenol beta-D-glucuronide
-
-
-
?
UDP-glucuronate + 5-hydroxytryptophol
UDP + 5-hydroxy-tryptophol beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + 5-hydroxytryptophol
UDP + 5-hydroxytryptophol beta-D-glucuronide
isozymes UGT1A6 and UGT1A9, the latter shows over 20fold lower activity
-
-
?
UDP-glucuronate + 5-hydroxytryptophol
UDP + 5-hydroxytryptophol beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
mucosal serotonin and its metabolite 5-hydroxytryptophol are solely conjugated by UGT1A6
-
-
?
UDP-glucuronate + 5alpha-dihydroaldosterone
UDP + 5alpha-dihydroaldosterone beta-D-glucuronide
-
-
-
?
UDP-glucuronate + 5alpha-tetrahydrocortisone
UDP + 5alpha-tetrahydrocortisone beta-D-glucuronide
-
-
-
?
UDP-glucuronate + 5beta-tetrahydrocortisone
UDP + 5beta-tetrahydrocortisone beta-D-glucuronide
-
-
-
?
UDP-glucuronate + 6-gingerol
UDP + 6-gingerol 4'-O-beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + 6-gingerol
UDP + 6-gingerol 5-O-beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + 6-hydroxymelatonin
UDP + 6-hydroxymelatonin beta-D-glucuronide
-
-
-
?
UDP-glucuronate + 7-ethyl-10-hydroxy-camptothecin
UDP + 7-ethyl-10-hydroxy-camptothecin beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
i.e. SN-38, an active metabolite of irinotecan
-
-
?
UDP-glucuronate + 7-ethyl-10-hydroxycampothecin
UDP + 7-ethyl-10-hydroxycampothecin 1-O-beta-D-glucuronide
i.e. SN-38, isozymes UGT1A1, UGT1A7, and UGT1A9
-
-
?
UDP-glucuronate + 7-ethyl-10-hydroxycamptothecin
UDP + 7-ethyl-10-hydroxycamptothecin 10-O-beta-D-glucuronoside
i.e. SN-38, an active metabolite of irinotecan
-
-
?
UDP-glucuronate + 7-hydroxy-4-trifluoromethylcoumarin
UDP + 4-trifluoromethylcoumarin 7-O-beta-D-glucuronide
-
-
-
?
UDP-glucuronate + 7-hydroxy-4-trifluoromethylcoumarin
UDP + 7-hydroxy-4-trifluoromethylcoumarin beta-D-glucuronide
-
-
-
?
UDP-glucuronate + 7-hydroxyflavanone
UDP + flavanone 7-O-beta-D-glucuronoside
-
-
-
-
?
UDP-glucuronate + 8-gingerol
UDP + 8-gingerol 4'-O-beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + 8-gingerol
UDP + 8-gingerol 5-O-beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + 8-hydroxyquinoline
UDP + 8-hydroxyquinoline beta-D-glucuronide
-
-
-
?
UDP-glucuronate + aldosterone
UDP + aldosterone beta-D-glucuronide
-
-
-
?
UDP-glucuronate + all-trans-retinoic acid
UDP + all-trans-retinoic acid beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
mainly conjugated by UGT2B7
-
-
?
UDP-glucuronate + Aloe-emodin
UDP + Aloe-emodin beta-D-glucuronide
isozyme UGT1A7
-
-
?
UDP-glucuronate + amitriptyline
UDP + amitriptyline beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + amitryptiline
UDP + amitryptiline beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + androstane-3,17-diol
UDP + androstane-3,17-diol 17-O-beta-D-glucuronide
-
isozyme UGT2B15
-
-
?
UDP-glucuronate + androstanediol
UDP + androstanediol beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + anthraflavic acid
UDP + anthraflavic acid 2-glucuronide
-
isozyme UGT1A1
-
-
?
UDP-glucuronate + asialo-orosomucoid
UDP + asialo-orosomucoid beta-D-glucuronide
-
acceptor is a glycoprotein, preferred substrate
-
-
?
UDP-glucuronate + beta-estradiol
UDP + estradiol 3-beta-D-glucuronide
-
-
-
?
UDP-glucuronate + cardamonin
UDP + cardamonin beta-D-glucuronoside
-
UGT1A9 is the only isoform to glucuronidate cardamonin at the OH-2' position, lower activity with isozyme UGT1A7
-
-
?
UDP-glucuronate + carvedilol
UDP + carvedilol beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + chenodeoxycholic acid
UDP + chenodeoxycholic acid 24-beta-D-glucuronoside
UDP-glucuronate + citronellol
UDP + citronellol beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + codeine
UDP + beta-D-glucuronosyl-codeine
-
low activity
-
-
?
UDP-glucuronate + codeine
UDP + codeine beta-D-glucuronide
-
isozymes UGT2B4 and UGT2B7
-
-
?
UDP-glucuronate + cotinine
UDP + cotinine N-beta-D-glucuronoside
cotinine is a highly selective substrate of human liver microsomal UGT2B10
-
-
?
UDP-glucuronate + cyproheptadine
UDP + cyproheptadine beta-D-glucuronide
-
-
-
?
UDP-glucuronate + deferiprone
UDP + deferiprone beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + deoxycholic acid
UDP + deoxycholic acid 24-beta-D-glucuronoside
Q6UWM9, Q9Y4X1
-
-
-
?
UDP-glucuronate + dihydrotestosterone
UDP + dihydrotestosterone beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + dopamine
UDP + dopamine beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + epirubicin
UDP + epirubicin beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + estrone
UDP + estrone beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + ethinylestradiol
UDP + ethinylestradiol glucuronide
-
isozyme UGT1A1
-
-
?
UDP-glucuronate + etoposide
UDP + etoposide beta-D-glucuronide
isozyme UGT1A1 is specific for etoposide
-
-
?
UDP-glucuronate + etoposide
UDP + etoposide beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + flavopiridol
UDP + flavopiridol beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + genistein
UDP + genistein beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + gingerol
UDP + gingerol 4'-O-beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + hydromorphone
UDP + beta-D-glucuronosyl-hydromorphone
-
-
-
-
?
UDP-glucuronate + hyodeoxycholic acid
UDP + beta-D-glucuronosyl-hyodeoxycholic acid
-
high activity
-
-
?
UDP-glucuronate + hyodeoxycholic acid
UDP + hyodeoxycholic acid 24G-beta-D-glucuronoside
Q6UWM9, Q9Y4X1
-
-
-
?
UDP-glucuronate + hyodeoxycholic acid
UDP + hyodeoxycholoyl beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + ketoconazole
UDP + ketoconazole beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + ketotifen
UDP + ketotifen beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + ketotifen
UDP + ketotifenbeta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + lamotrigine
UDP + lamotrigine beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + leukotriene B4
UDP + leukotriene B4 beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + lithocholic acid
UDP + lithocholic acid 3-beta-D-glucuronoside + lithocholic acid 24-beta-D-glucuronoside
Q6UWM9, Q9Y4X1
-
-
-
?
UDP-glucuronate + lorazepam
UDP + beta-D-glucuronosyl-lorazepam
-
-
-
?
UDP-glucuronate + lorazepam
UDP + lorazepam beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + midazolam
UDP + midazolam beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + mycophenolic acid
UDP + mycophenolic acid beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + mycophenolic acid
UDP + mycophenoloyl beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + N-acetylserotonin
UDP + N-acetylserotonin beta-D-glucuronide
-
-
-
?
UDP-glucuronate + naproxen
UDP + naproxen beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + p-nitrophenol
UDP + 4-nitrophenyl-alpha-D-glucuronide
-
-
-
?
UDP-glucuronate + paracetamol
UDP + paracetamol beta-D-glucuronide
-
-
-
?
UDP-glucuronate + paracetamol
UDP + paracetamol beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + paragloboside
UDP + paragloboside beta-D-glucuronide
-
acceptor is a glycolipid, activity requires phosphatidylinositol
-
-
?
UDP-glucuronate + phenylbutazone
?
among 16 UDP-glucuronosyltransferase isoforms investigated, only UGT1A9 catalyzes PB C-glucuronidation
-
-
?
UDP-glucuronate + pizotifen
UDP + pizotifen beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + pregnan-3,17-diol
UDP + pregnan-3,17-diol beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + quercetin
UDP + quercetin beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + quinizarin
UDP + quinizarin beta-D-glucuronide
isozyme UGT1A7
-
-
?
UDP-glucuronate + serotonin
UDP + serotonin beta-glucuronoside
isozyme UGT2B7
-
-
?
UDP-glucuronate + tacrolimus
UDP + tacrolimus beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + tamoxifen
UDP + tamoxifen N-beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + Telmisartan
UDP + Telmisartan beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + thymol
UDP + thymol beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + tolcapone
UDP + tolcapone beta-D-glucuronide
-
-
-
?
UDP-glucuronate + trans-androsterone
UDP + trans-androsterone beta-D-glucuronide
-
-
-
?
UDP-glucuronate + trans-resveratrol
UDP + trans-resveratrol beta-D-glucuronoside
-
-
-
-
?
UDP-glucuronate + trifluoperazine
UDP + trifluoperazine beta-D-glucuronide
isozyme UGT1A4
-
-
?
UDP-glucuronate + trifluoroperazine
UDP + trifluoroperazine beta-D-glucuronide
-
-
-
?
UDP-glucuronate + trifluperazine
UDP + trifluperazine
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + valproic acid
UDP + beta-D-glucuronosyl-valproic acid
-
-
-
-
?
UDP-glucuronate + vorinostat
UDP + vorinostat beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + zidovudine
UDP + zidovudine O-beta-D-glucuronoside
-
-
-
?
UDP-glucuronic acid + 7-hydroxy-4-(trifluoromethyl)-coumarin
UDP + 7-hydroxy-4-(trifluoromethyl)-coumarin O-glucuronide
-
UGT1A6, UGT1A9, and UGT2B7
-
-
?
UDP-glucuronic acid + beta-estradiol
UDP + beta-estradiol 3-O-beta-D-glucuronide
-
UGT1A3
-
-
?
UDP-glucuronic acid + bilirubin
bilirubin glucuronoside + UDP
-
-
-
?
UDP-glucuronic acid + trifluoperazine
UDP + trifluoperazine N-glucuronide
-
-
-
?
UDPglucuronate + naproxen
?
UGT2B7 is responsible for human hepatic naproxen acyl glucuronidation, which is the primary elimination pathway for this drug
-
-
?
vanillin + UDP-glucuronate
UDP + vanillin O-glucuronide
-
other 7 phenolic compounds show substrate activity on hUGT2A1
-
?
voriconazole + UDP-alpha-D-glucuronate
voriconazole D-glucuronate + UDP
-
-
-
-
?
vorinostat + UDP-glucuronate
UDP + vorinostat beta-D-glucuronoside
-
-
-
?
zidovudine + UDP-glucuronate
UDP + zidovudine beta-D-glucuronide
substrate for isoform UGT2B7
-
-
?
zidovudine + UDP-glucuronate
UDP + zidovudine O-glucuronide
-
-
-
?
zidovudine + UDP-glucuronate
UDP + zidovudine-5'-glucuronide
-
-
-
?
1-hydroxybenzo(a)pyrene + UDP-glucuronate
?
-
-
-
?
1-hydroxybenzo(a)pyrene + UDP-glucuronate
?
UGT1A10 exhibited considerably more glucuronidation activity than any other glucuronosyltransferase UGT1A family member
-
-
?
1-hydroxypyrene + UDP-glucuronate
UDP + 1-hydroxypyrene-1-O-glucuronide
-
-
-
-
?
1-hydroxypyrene + UDP-glucuronate
UDP + 1-hydroxypyrene-1-O-glucuronide
-
-
-
-
?
1-hydroxypyrene + UDP-glucuronate
UDP + 1-hydroxypyrene-1-O-glucuronide
-
-
-
-
?
1-hydroxypyrene + UDP-glucuronate
UDP + 1-hydroxypyrene-1-O-glucuronide
-
-
-
-
?
1-hydroxypyrene + UDP-glucuronate
UDP + 1-hydroxypyrene-1-O-glucuronide
-
-
-
-
?
1-hydroxypyrene + UDP-glucuronate
UDP + 1-hydroxypyrene-1-O-glucuronide
-
-
-
-
?
1-hydroxypyrene + UDP-glucuronate
UDP + 1-hydroxypyrene-1-O-glucuronide
-
-
-
-
?
1-hydroxypyrene + UDP-glucuronate
UDP + 1-hydroxypyrene-1-O-glucuronide
-
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
naphth-1-yl-beta-D-glucuronide + UDP
-
-
-
?
1-naphthol + UDP-glucuronate
UDP + naphth-1-yl-beta-D-glucuronide
-
-
-
?
1-naphthol + UDP-glucuronate
UDP + naphth-1-yl-beta-D-glucuronide
-
-
-
?
1-naphthol + UDP-glucuronate
UDP + naphth-1-yl-beta-D-glucuronide
-
-
-
?
12-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-12-yl-beta-D-glucuronide
-
glucuronidated by UGT1A3, inactive towards benz[a]pyrene trans 4,5 and 7,8 dihydrodiols
-
?
12-hydroxybenzo[a]pyrene + UDP-glucuronate
UDP + benzo[a]pyren-12-yl-beta-D-glucuronide
-
-
-
?
16alpha-hydroxyprogesterone + UDP-glucuronate
?
-
-
-
?
16alpha-hydroxyprogesterone + UDP-glucuronate
?
UGT2B15 and UGT2B17 are the major enzyme forms involved in the high-affinity component of 16alpha-hydroxyprogesterone glucuronidation
-
-
?
16alpha-hydroxyprogesterone + UDP-glucuronate
UDP + 16alpha-hydroxyprgesterone-16-O-D-glucuronate
-
-
-
?
16alpha-hydroxyprogesterone + UDP-glucuronate
UDP + 16alpha-hydroxyprgesterone-16-O-D-glucuronate
UGT2B15 and UGT2B17 are the major enzyme forms involved in the high-affinity component of 16alpha-hydroxyprogesterone glucuronidation
-
-
?
17beta-estradiol + UDP-glucuronate
?
metabilized by mutant enzyme S432G-UGT1A7, but not by wild-type enzyme UGT1A7
-
-
?
2 UDP-D-glucuronate + 2 dexmedetomidine
2 UDP + dexmedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
low activity
-
-
?
2 UDP-D-glucuronate + 2 dexmedetomidine
2 UDP + dexmedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
the major metabolic pathway of dexmedetomidine, i.e. (4S)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, in humans is N-glucuronidation at the imidazolate nitrogens to N3- and N1-glucuronides
-
-
?
2 UDP-D-glucuronate + 2 dexmedetomidine
2 UDP + dexmedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
i.e. (+)-4-(S)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, NMR product structure analysis, product ratios of isozyme UGT1A4, overview
-
-
?
2 UDP-D-glucuronate + 2 dexmedetomidine
2 UDP + dexmedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
i.e. (+)-4-(S)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, NMR product structure analysis, product ratios of isozyme UGT2B10, overview
-
-
?
2 UDP-D-glucuronate + 2 dexmedetomidine
2 UDP + dexmedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
veryl low activity
-
-
?
2 UDP-D-glucuronate + 2 levomedetomidine
2 UDP + levomedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
the major metabolic pathway of levomedetomidine, i.e. (4R)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, in humans is N-glucuronidation at the imidazolate nitrogens to N3-glucuronide
-
-
?
2 UDP-D-glucuronate + 2 levomedetomidine
2 UDP + levomedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
i.e. (4R)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, NMR product structure analysis, product ratios of isozyme UGT1A4, isozyme UGT1A4 shows low activity producing N1- and N3-glucuronides, overview
-
-
?
2 UDP-D-glucuronate + 2 levomedetomidine
2 UDP + levomedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
i.e. (4R)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, NMR product structure analysis, product ratios of isozyme UGT2B10, isozyme UGT2B10 exclusively produces N3-glucuronides, overview
-
-
?
2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDP-glucuronate
?
-
-
-
?
2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDP-glucuronate
?
glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid is mainly catalyzed by UGT1A1, UGT1A9, and UGT2B7 in the liver, and by UGT1A1, UGT1A3, and UGT2B7 in the intestine
-
-
?
2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDP-glucuronate
?
glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid is mainly catalyzed by UGT1A1, UGT1A9, and UGT2B7 in the liver, and by UGT1A1, UGT1A3, and UGT2B7 in the intestine i humans
-
-
?
2-aminophenol + UDPglucuronate
UDP + (2-aminophenyl)-O-glucuronide
-
-
-
?
2-aminophenol + UDPglucuronate
UDP + (2-aminophenyl)-O-glucuronide
-
-
-
?
2-aminophenol + UDPglucuronate
UDP + (2-aminophenyl)-O-glucuronide
-
-
-
?
2-aminophenol + UDPglucuronate
UDP + (2-aminophenyl)-O-glucuronide
-
-
-
?
2-aminophenol + UDPglucuronate
UDP + (2-aminophenyl)-O-glucuronide
-
-
-
?
2-aminophenol + UDPglucuronate
UDP + (2-aminophenyl)-O-glucuronide
-
-
-
?
2-aminophenol + UDPglucuronate
UDP + (2-aminophenyl)-O-glucuronide
-
-
-
?
2-aminophenol + UDPglucuronate
UDP + (2-aminophenyl)-O-glucuronide
-
-
-
?
2-aminophenol + UDPglucuronate
UDP + (2-aminophenyl)-O-glucuronide
-
-
-
?
2-hydroxyestradiol + UDPglucuronate
UDP + 2-hydroxyestradiol O-glucuronide
-
-
-
?
2-hydroxyestradiol + UDPglucuronate
UDP + 2-hydroxyestradiol O-glucuronide
-
-
?
2-hydroxyestrone + UDPglucuronate
2-hydroxyestrone 2-O-glucuronide + UDP
-
-
-
?
2-hydroxyestrone + UDPglucuronate
2-hydroxyestrone 2-O-glucuronide + UDP
-
-
-
?
2-hydroxyestrone + UDPglucuronate
2-hydroxyestrone 2-O-glucuronide + UDP
-
-
?
2-hydroxyestrone + UDPglucuronate
2-hydroxyestrone 2-O-glucuronide + UDP
-
glucuronidated by UGT1A3 and HGT1A9
-
?
2-hydroxyestrone + UDPglucuronate
2-hydroxyestrone 2-O-glucuronide + UDP
-
-
-
?
2-methoxy-4-(2-propenyl)phenol + UDPglucuronate
UDP + 2-methoxy-4-(2-propenyl)phenylglucuronide
-
-
-
?
2-methoxy-4-(2-propenyl)phenol + UDPglucuronate
UDP + 2-methoxy-4-(2-propenyl)phenylglucuronide
-
i.e. eugenol
-
?
3'-azido-3'-deoxythymidine + UDP-alpha-D-glucuronate
3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP
-
substrate of isoform UGT2B7
-
-
?
3'-azido-3'-deoxythymidine + UDP-alpha-D-glucuronate
3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP
-
-
-
-
?
3'-azido-3'-deoxythymidine + UDPglucuronate
3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP
-
-
-
?
3'-azido-3'-deoxythymidine + UDPglucuronate
3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP
-
-
-
?
3'-azido-3'-deoxythymidine + UDPglucuronate
3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP
-
-
-
?
3'-azido-3'-deoxythymidine + UDPglucuronate
3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP
-
-
-
?
3-hydroxybenzo(a)pyrene + UDP-glucuronate
?
-
-
-
?
3-hydroxybenzo(a)pyrene + UDP-glucuronate
?
UGT1A10 exhibited considerably more glucuronidation activity than any other glucuronosyltransferase UGT1A family member
-
-
?
3-hydroxybenzo[a]pyrene + UDPglucuronate
UDP + 3-hydroxybenzo[a]pyrene-O-glucuronide
-
-
-
?
3-hydroxybenzo[a]pyrene + UDPglucuronate
UDP + 3-hydroxybenzo[a]pyrene-O-glucuronide
-
-
-
?
3-hydroxybenzo[a]pyrene + UDPglucuronate
UDP + 3-hydroxybenzo[a]pyrene-O-glucuronide
-
-
-
?
3-hydroxybenzo[a]pyrene + UDPglucuronate
UDP + 3-hydroxybenzo[a]pyrene-O-glucuronide
-
-
-
?
3-hydroxydesloratadine + UDP-glucuronate
UDP + 3-hydroxydesloratadinyl-O-glucuronide
specific substrate of isoform UGT1A8
-
-
?
3-hydroxydesloratadine + UDP-glucuronate
UDP + 3-hydroxydesloratadinyl-O-glucuronide
specific substrate of isoform UGT1A8, substrate of isoform UGT1A9 mutant N152A
-
-
?
4-hydroxybiphenyl + UDP-glucuronate
UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide
-
-
-
?
4-hydroxybiphenyl + UDP-glucuronate
UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide
-
UGT2B7H and UGT2B7Y inactive
-
-
?
4-hydroxybiphenyl + UDP-glucuronate
UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide
-
-
-
?
4-hydroxybiphenyl + UDP-glucuronate
UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide
-
-
-
?
4-hydroxybiphenyl + UDP-glucuronate
UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide
-
-
-
?
4-hydroxybiphenyl + UDP-glucuronate
UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide
-
-
-
?
4-hydroxybiphenyl + UDP-glucuronate
UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide
-
-
-
?
4-hydroxybiphenyl + UDP-glucuronate
UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide
-
no activity
-
-
?
4-hydroxybiphenyl + UDP-glucuronate
UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide
-
very low activity
-
?
4-hydroxybiphenyl + UDP-glucuronate
UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide
-
very low activity
-
?
4-hydroxybiphenyl + UDP-glucuronate
UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide
-
-
-
?
4-hydroxybiphenyl + UDP-glucuronate
UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide
-
no activity
-
-
?
4-hydroxybiphenyl + UDPglucuronate
UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide
-
conjugated by UGT1A71 but not by UGT1A61
-
?
4-hydroxybiphenyl + UDPglucuronate
UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide
-
-
-
?
4-hydroxyestradiol + UDPglucuronate
UDP + 4-hydroxyestradiol O-glucuronide
-
-
-
?
4-hydroxyestradiol + UDPglucuronate
UDP + 4-hydroxyestradiol O-glucuronide
-
-
?
4-hydroxyestrone + UDP-glucuronate
UDP + 4-hydroxyestrone 4-O-glucuronide
-
-
-
?
4-hydroxyestrone + UDP-glucuronate
UDP + 4-hydroxyestrone 4-O-glucuronide
-
-
-
-
?
4-hydroxyestrone + UDP-glucuronate
UDP + 4-hydroxyestrone 4-O-glucuronide
-
-
?
4-hydroxyestrone + UDP-glucuronate
UDP + 4-hydroxyestrone 4-O-glucuronide
-
conjugated by UGT1A71 but not by UGT1A61
-
?
4-methylumbeliferone + UDP-glucuronate
4-methylumbelliferyl-7-O-beta-D-glucuronide
-
-
-
-
?
4-methylumbeliferone + UDP-glucuronate
4-methylumbelliferyl-7-O-beta-D-glucuronide
-
-
-
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl beta-D-glucuronide
-
-
-
-
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl beta-D-glucuronide
-
-
-
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl beta-D-glucuronide
-
-
-
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl beta-D-glucuronide
-
-
-
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl beta-D-glucuronide
the reaction occurs with isoform UGT2B20
-
-
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl beta-D-glucuronide
-
-
-
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
-
-
-
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
-
-
-
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
-
-
-
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
-
-
-
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
-
-
-
-
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
-
-
-
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
-
-
-
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
-
-
-
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
-
-
-
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
-
-
-
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
Phe90 and Phe93 are directly involved in the catalytic activity of UGT1A10 towards 4-methylumbelliferone
-
-
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
very low rate of glucuronidation
-
-
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
-
-
-
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
-
-
-
-
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
-
-
-
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
-
-
-
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
-
-
-
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
-
-
-
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
-
-
-
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
-
-
-
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
-
-
-
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
-
-
-
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
-
-
-
?
4-methylumbelliferone + UDP-glucuronate
UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
Phe90 and Phe93 are directly involved in the catalytic activity of UGT1A10 towards 4-nitrophenol
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
3-methylcholanthrene-inducible 4-nitrophenol UDP-glucuronyltransferase and 17-OH steroid UDP-glucuronyltransferase isoenzymes
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrophenol + UDP-glucuronate
4-nitrophenyl beta-D-glucuronide + UDP
-
-
-
?
4-nitrothiophenol + UDP-glucuronate
4-nitrothiophenyl thio-beta-D-glucuronide + UDP
-
-
-
?
4-nitrothiophenol + UDP-glucuronate
4-nitrothiophenyl thio-beta-D-glucuronide + UDP
-
-
-
?
4-nitrothiophenol + UDP-glucuronate
4-nitrothiophenyl thio-beta-D-glucuronide + UDP
-
-
-
?
4-nitrothiophenol + UDP-glucuronate
4-nitrothiophenyl thio-beta-D-glucuronide + UDP
-
-
-
?
4-nitrothiophenol + UDP-glucuronate
4-nitrothiophenyl thio-beta-D-glucuronide + UDP
-
-
-
?
5alpha-androstane-3alpha,17beta-diol + UDP-glucuronate
UDP + 5alpha-androstane-3alpha,17beta-diol O-glucuronide
-
-
-
?
5alpha-androstane-3alpha,17beta-diol + UDP-glucuronate
UDP + 5alpha-androstane-3alpha,17beta-diol O-glucuronide
-
-
?
5alpha-androstane-3alpha,17beta-diol + UDP-glucuronate
UDP + 5alpha-androstane-3alpha,17beta-diol O-glucuronide
-
-
-
?
7,7,7-triphenylheptanoic acid + UDPglucuronate
UDP + 7,7,7-triphenylheptanoic acid glucuronide
-
-
-
?
7,7,7-triphenylheptanoic acid + UDPglucuronate
UDP + 7,7,7-triphenylheptanoic acid glucuronide
-
-
-
?
7,7,7-triphenylheptanoic acid + UDPglucuronate
UDP + 7,7,7-triphenylheptanoic acid glucuronide
-
-
-
?
7,7,7-triphenylheptanoic acid + UDPglucuronate
UDP + 7,7,7-triphenylheptanoic acid glucuronide
-
-
-
?
7-ethyl-10-hydroxy-camptothecin carboxylate + UDP-glucuronate
UDP + 7-ethyl-camptothecin carboxylate-10-yl-beta-D-glucuronate
-
-
-
?
7-ethyl-10-hydroxy-camptothecin carboxylate + UDP-glucuronate
UDP + 7-ethyl-camptothecin carboxylate-10-yl-beta-D-glucuronate
-
-
-
?
7-ethyl-10-hydroxy-camptothecin lactone + UDP-glucuronate
UDP + 7-ethyl-camptothecin lactone-10-yl-beta-D-glucuronate
-
-
-
?
7-ethyl-10-hydroxy-camptothecin lactone + UDP-glucuronate
UDP + 7-ethyl-camptothecin lactone-10-yl-beta-D-glucuronate
-
-
-
?
7-ethyl-10-hydroxycamptothecin + UDP-alpha-D-glucuronate
7-ethyl-10-hydroxycamptothecin 10-O-glucuronate + UDP
-
-
-
?
7-ethyl-10-hydroxycamptothecin + UDP-alpha-D-glucuronate
7-ethyl-10-hydroxycamptothecin 10-O-glucuronate + UDP
-
-
-
?
7-hydroxy benzo(a)pyrene + UDP-glucuronate
?
-
-
-
?
7-hydroxy benzo(a)pyrene + UDP-glucuronate
?
UGT1A10 exhibited considerably more glucuronidation activity than any other glucuronosyltransferase UGT1A family member
-
-
?
7-hydroxy-4-trifluoromethylcoumarin + UDP-alpha-D-glucuronate
7-hydroxy-4-trifluoromethylcoumarin 7-O-glucuronate + UDP
-
-
-
?
7-hydroxy-4-trifluoromethylcoumarin + UDP-alpha-D-glucuronate
7-hydroxy-4-trifluoromethylcoumarin 7-O-glucuronate + UDP
-
-
-
?
7-hydroxy-4-trifluoromethylcoumarin + UDP-glucuronate
UDP + 7-hydroxy-4-trifluoromethylcoumarin beta-D-glucuronide
-
-
-
?
7-hydroxy-4-trifluoromethylcoumarin + UDP-glucuronate
UDP + 7-hydroxy-4-trifluoromethylcoumarin beta-D-glucuronide
-
-
-
?
9-hydroxybenzo(a)pyrene + UDP-glucuronate
?
-
-
-
?
9-hydroxybenzo(a)pyrene + UDP-glucuronate
?
UGT1A10 exhibited considerably more glucuronidation activity than any other glucuronosyltransferase UGT1A family member
-
-
?
acetaminophen + UDP-glucuronate
?
with human UGT1A6, only monoglucuronides are formed, which, however, can be converted to diglucuronides by UGT1A9
-
-
?
acetaminophen + UDP-glucuronate
?
-
-
-
?
acetaminophen + UDP-glucuronate
UDP + ?
-
-
-
?
androsterone + UDPglucuronate
UDP + androsterone O-glucuronide
-
-
?
androsterone + UDPglucuronate
UDP + androsterone O-glucuronide
-
glucuronidated by HGT2B7H and HGT2B7Y
-
?
androsterone + UDPglucuronate
UDP + androsterone O-glucuronide
-
-
-
?
androsterone + UDPglucuronate
UDP + androsterone O-glucuronide
-
-
-
?
androsterone + UDPglucuronate
UDP + androsterone O-glucuronide
-
-
-
?
androsterone + UDPglucuronate
UDP + androsterone O-glucuronide
-
-
-
?
androsterone + UDPglucuronate
UDP + androsterone O-glucuronide
-
-
-
?
androsterone + UDPglucuronate
UDP + androsterone O-glucuronide
-
-
-
?
androsterone + UDPglucuronate
UDP + androsterone O-glucuronide
-
-
-
?
anthraflavic acid + UDPglucuronate
UDP + ?
-
3 and 7-hydroxyflavone also tested
-
-
?
bakuchiol + UDP-glucuronate
UDP + bakuchiol beta-D-glucuronide
bakuchiol is 1-(4-hydroxyphenyl)-3,7-dimethyl-3-vinyl-1,6-octadiene. Isoform UGT1A1 is a main contributor to glucuronidation of bakuchiol
-
-
?
bakuchiol + UDP-glucuronate
UDP + bakuchiol beta-D-glucuronide
bakuchiol is 1-(4-hydroxyphenyl)-3,7-dimethyl-3-vinyl-1,6-octadiene. Isoform UGT1A3 is a main contributor to glucuronidation of bakuchiol
-
-
?
bakuchiol + UDP-glucuronate
UDP + bakuchiol beta-D-glucuronide
bakuchiol is 1-(4-hydroxyphenyl)-3,7-dimethyl-3-vinyl-1,6-octadiene. Isoform UGT2B15 is a main contributor to glucuronidation of bakuchiol
-
-
?
beta-estradiol + UDP-glucuronate
UDP + beta-estradiol-3-glucuronide
-
-
-
-
?
beta-estradiol + UDP-glucuronate
UDP + beta-estradiol-3-glucuronide
-
-
-
-
?
beta-estradiol + UDP-glucuronate
UDP + beta-estradiol-3-glucuronide
-
-
-
?
beta-estradiol + UDP-glucuronate
UDP + beta-estradiol-3-glucuronide
substrate for isoform UGT1A1
-
-
?
beta-estradiol + UDP-glucuronate
UDP + beta-estradiol-3-glucuronide
-
-
-
-
?
beta-estradiol + UDP-glucuronate
UDP + beta-estradiol-3-glucuronide
-
-
-
-
?
beta-estradiol + UDP-glucuronate
UDP + beta-estradiol-3-glucuronide
-
-
-
-
?
beta-estradiol + UDP-glucuronate
UDP + beta-estradiol-3-glucuronide
-
-
-
-
?
beta-estradiol + UDP-glucuronate
UDP + beta-estradiol-3-glucuronide
-
-
-
-
?
beta-estradiol + UDPglucuronate
beta-estradiol-3-glucuronide + UDP
-
inactive
-
-
?
beta-estradiol + UDPglucuronate
beta-estradiol-3-glucuronide + UDP
-
-
-
?
beta-estradiol + UDPglucuronate
beta-estradiol-3-glucuronide + UDP
-
-
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
cat liver enzyme active
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
UGT1A61: no activity
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
no activity
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
no activity
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
very low activity
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
Gunn strain liver enzyme inactive
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
Gunn strain liver enzyme inactive
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
Gunn strain liver enzyme inactive
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
Gunn strain liver enzyme inactive
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
no activity can be detected until highly purified fractions are reconstituted with lecithin liposomes
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
bilirubin-UDPGT and 3-methylcholantrene-UDPGT share an identical point deletion at a region which is conserved in these two isoforms
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
not inducible by phenobarbital, methylcholanthrene, 2,3,7,8-tetrachlorodibenzo-p-dioxin
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
expressed after birth
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
Gunn strain liver enzyme inactive
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
Gunn strain liver enzyme inactive
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
bilirubin-UDPGT and 3-methylcholantrene-UDPGT share an identical point deletion at a region which is conserved in these two isoforms
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
Gunn strain liver enzyme inactive
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
Gunn strain liver enzyme inactive
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
very low activity
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
no activity
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
no activity can be detected until highly purified fractions are reconstituted with lecithin liposomes
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
Gunn strain liver enzyme inactive
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
no activity
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
-
-
?
bilirubin + UDPglucuronate
bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
no activity
-
-
?
bilirubin + UDPglucuronate
UDP + bilirubin O-glucuronide
-
physiological elimination of bilirubin
-
-
?
bilirubin monoglucuronide + UDPglucuronate
bilirubin diglucuronide + UDP
-
-
-
?
bilirubin monoglucuronide + UDPglucuronate
bilirubin diglucuronide + UDP
-
-
-
?
bilirubin monoglucuronide + UDPglucuronate
bilirubin diglucuronide + UDP
-
-
-
?
bilirubin monoglucuronide + UDPglucuronate
bilirubin diglucuronide + UDP
-
-
-
?
bilirubin monoglucuronide + UDPglucuronate
bilirubin diglucuronide + UDP
-
-
-
?
borneol + UDPglucuronate
UDP + borneol O-glucuronide
-
other 4 monoterpenoid tested on hUGT2A1
-
?
borneol + UDPglucuronate
UDP + borneol O-glucuronide
-
other 7 monoterpenoid alcohols show substrate activity with UGT2B9
-
?
buprenorphine + UDPglucuronate
UDP + buprenorphine O-glucuronide
-
-
-
?
buprenorphine + UDPglucuronate
UDP + buprenorphine O-glucuronide
-
-
-
?
C-1748 + UDP-glucuronate
UDP + C-1748 O-glucuronide
C-1748 is 9-(2'-hydroxyethylamino)-4-methyl-1-nitroacridine. The reaction is selectively catalyzed by isoform UGT2B17
-
-
?
C-1748 + UDP-glucuronate
UDP + C-1748 O-glucuronide
C-1748 is 9-(2'-hydroxyethylamino)-4-methyl-1-nitroacridine. The reaction is selectively catalyzed by isoform UGT2B7
-
-
?
chenodeoxycholic acid + UDP-glucuronate
UDP + ?
-
low activity in patients with liver cirrhosis and granulomatous hepatitis
-
-
?
chenodeoxycholic acid + UDP-glucuronate
UDP + ?
substrate for isoform UGT1A3
-
-
?
diclofenac + UDPalpha-D-glucuronate
UDP + ?
-
UGT2B7 active at high rate, recombinant UGT1A9 active at moderate rate, UGT1A6 and UGT2B15 active at low rates
-
-
?
diclofenac + UDPalpha-D-glucuronate
UDP + ?
-
recombinant UGT2B1 displays moderate rate
-
-
?
epirubicin + UDP-glucuronate
UDP + epirubicin beta-D-glucuronoside
-
-
-
?
epirubicin + UDP-glucuronate
UDP + epirubicin beta-D-glucuronoside
substrate for isoform UGT2B7
-
-
?
epitestosterone + UDP-glucuronate
UDP + epitestosterone 17-O-glucuronide
-
-
-
?
epitestosterone + UDP-glucuronate
UDP + epitestosterone 17-O-glucuronide
-
epitestosterone glucuronidation is catalyzed mainly by UGT2B7. No substrate for isoform UGT2B17, but it binds epitestosterone with affinity similar to that of testosterone. Isoform UGT2A1 catalyzes the glucuronidation of both steroids at considerable rates and similar kinetics
-
-
?
estradiol + UDP-glucuronate
?
-
-
-
?
estradiol-17beta + UDPglucuronate
estradiol-17beta-3-monoglucuronide + UDP
-
UGT1A61 no activity
-
-
?
estradiol-17beta + UDPglucuronate
estradiol-17beta-3-monoglucuronide + UDP
-
-
-
-
?
estradiol-17beta + UDPglucuronate
estradiol-17beta-3-monoglucuronide + UDP
-
-
-
-
?
estradiol-17beta + UDPglucuronate
estradiol-17beta-3-monoglucuronide + UDP
-
-
-
?
estriol + UDP-glucuronate
?
metabilized by mutant enzyme S432G-UGT1A7, but not by wild-type enzyme UGT1A7
-
-
?
estriol + UDPglucuronate
UDP + estriol-16 alpha-glucuronide
-
UGT1A3 inactive
-
-
?
estriol + UDPglucuronate
UDP + estriol-16 alpha-glucuronide
-
catalyzed by isozyme 1 but not by isozyme 2
-
?
estrogen + UDP-glucuronate
?
UDP-glucuronosyltransferase 1A10 has been identified as the major isoform involved in the biotransformation of a wide range of phenolic substrates, including native estrogens and their oxidized metabolites
-
-
?
estrogen + UDP-glucuronate
?
phenylalanine(90) and phenylalanine(93) are crucial amino acids within the estrogen binding site of the human UDP-glucuronosyltransferase 1A10
-
-
?
estrone + UDPglucuronate
UDP + estrone 3-O-glucuronide
-
glucuronidated by UGT1A3 and HGT1A9
-
?
estrone + UDPglucuronate
UDP + estrone 3-O-glucuronide
-
estrone-specific activity inactive towards 4-nitrophenol
-
?
estrone + UDPglucuronate
UDP + estrone 3-O-glucuronide
-
estrone-specific activity inactive towards 4-nitrophenol
-
?
estrone + UDPglucuronate
UDP + estrone 3-O-glucuronide
-
UGT1A61 inactive
-
-
?
estrone + UDPglucuronate
UDP + estrone 3-O-glucuronide
-
-
-
?
estrone + UDPglucuronate
UDP + estrone 3-O-glucuronide
-
affinity increases during storage period at -20ºC for more than 4 months
-
r
etiocholanone + UDPglucuronate
UDP + etiocholanone O-glucuronide
-
-
-
?
etiocholanone + UDPglucuronate
UDP + etiocholanone O-glucuronide
-
3-OH androgenic UDP-glucuronyltransferase isoenzyme
-
?
etoposide + UDP-glucuronate
UDP + etoposide glucuronide
-
-
-
?
etoposide + UDP-glucuronate
UDP + etoposide glucuronide
UGT1A1 is principally responsible for the formation of etoposide glucuronides, mainly in the form of phenolic glucuronide
-
-
?
etoposide + UDP-glucuronate
UDP + etoposide glucuronide
activity with UGT1A3 is much lower than activity with UGT1A1
-
-
?
etoposide + UDP-glucuronate
UDP + etoposide glucuronide
activity with UGT1A8 is much lower than activity with UGT1A1
-
-
?
hyodeoxycholic acid + UDP-glucuronate
?
-
-
-
?
hyodeoxycholic acid + UDPglucuronate
UDP + hyodeoxycholic acid O-glucuronide
-
-
-
?
hyodeoxycholic acid + UDPglucuronate
UDP + hyodeoxycholic acid O-glucuronide
-
UGT2B9 glucuronidates hyodeoxycholate
-
-
?
ibuprofen + UDPglucuronate
UDP + ?
-
R and S isomers tested separately
-
-
?
imipramine + UDPglucuronate
UDP + ?
-
conjugated by UGT1A7 but not by UGT1A4
-
-
?
lithocholic acid + UDPglucuronate
UDP + ?
-
highest activity among five bile acids studied
-
-
?
morphine + UDP-glucuronate
UDP + morphine 3,6-diglucuronide
-
substrate for UGT2B7
-
?
morphine + UDP-glucuronate
UDP + morphine 3,6-diglucuronide
-
glucuronidated by HGT2B7H and HGT2B7Y at 3 and 6 hydroxy positions
-
?
morphine + UDP-glucuronate
UDP + morphine 3,6-diglucuronide
-
3 and 6-glucuronide formation with UGT2B9, other 9 morphian opioids can act as substrates
-
?
morphine + UDP-glucuronate
UDP + morphine 3,6-diglucuronide
-
substrate for UGT2B1
-
?
morphine + UDP-glucuronate
UDP + morphine 3,6-diglucuronide
-
-
-
?
morphine + UDP-glucuronate
UDP + morphine 3,6-diglucuronide
-
-
-
?
morphine + UDP-glucuronate
UDP + morphine 3,6-diglucuronide
-
-
-
?
morphine + UDP-glucuronate
UDP + morphine 3,6-diglucuronide
-
-
-
?
morphine + UDP-glucuronate
UDP + morphine beta-D-glucuronide
-
-
-
?
morphine + UDP-glucuronate
UDP + morphine beta-D-glucuronide
Ugt2b36 is the predominant isoform involved in morphine glucuronidation
-
-
?
N-hydroxy-2-naphthylamine + UDPglucuronate
UDP + N-hydroxy-2-naphthylamine-O-glucuronide
-
-
-
?
N-hydroxy-2-naphthylamine + UDPglucuronate
UDP + N-hydroxy-2-naphthylamine-O-glucuronide
-
-
-
?
N-hydroxy-2-naphthylamine + UDPglucuronate
UDP + N-hydroxy-2-naphthylamine-O-glucuronide
-
-
-
?
N-hydroxy-2-naphthylamine + UDPglucuronate
UDP + N-hydroxy-2-naphthylamine-O-glucuronide
-
-
-
?
phenolphthalein + UDPglucuronate
UDP + phenolphthalein O-glucuronide
-
-
-
?
phenolphthalein + UDPglucuronate
UDP + phenolphthalein O-glucuronide
-
-
-
?
phenolphthalein + UDPglucuronate
UDP + phenolphthalein O-glucuronide
-
-
-
?
phenolphthalein + UDPglucuronate
UDP + phenolphthalein O-glucuronide
-
-
-
-
?
phenolphthalein + UDPglucuronate
UDP + phenolphthalein O-glucuronide
-
-
-
?
propofol + UDP-alpha-D-glucuronate
UDP + propofol D-glucuronide
-
substrate of isoform UGT1A9
-
-
?
scopoletin + UDP-glucuronate
UDP + scopoletin O-glucuronide
very low rate of glucuronidation
-
-
?
scopoletin + UDPglucuronate
UDP + scopoletin O-glucuronide
-
other 3 coumarines show substrate activity on hUGT2A1
-
?
scopoletin + UDPglucuronate
UDP + scopoletin O-glucuronide
-
-
-
?
serotonin + UDP-glucuronate
UDP + 3-(2-aminoethyl)-1H-indol-5-yl beta-D-glucuronide
-
-
-
-
?
serotonin + UDP-glucuronate
UDP + 3-(2-aminoethyl)-1H-indol-5-yl beta-D-glucuronide
coexpression of UGT1A6 with UGT2B7 influences wild-type UGT1A6, increasing the normalized activity of UGT1A6
-
-
?
serotonin + UDP-glucuronate
UDP + 3-(2-aminoethyl)-1H-indol-5-yl beta-D-glucuronide
highly selective substrate of UGT1A6 in human liver microsomes, with human UGT1A6, only monoglucuronides are formed, which, however, can be converted to diglucuronides by UGT1A9
-
-
?
serotonin + UDP-glucuronate
UDP + 3-(2-aminoethyl)-1H-indol-5-yl beta-D-glucuronide
-
-
-
?
serotonin + UDP-glucuronate
UDP + 3-(2-aminoethyl)-1H-indol-5-yl beta-D-glucuronide
-
-
-
?
serotonin + UDP-glucuronate
UDP + serotonin beta-D-glucuronide
-
-
-
?
serotonin + UDP-glucuronate
UDP + serotonin beta-D-glucuronide
substrate for isoform UGT1A6
-
-
?
serotonin + UDPglucuronate
tryptamine 5-O-beta-D-glucuronide + UDP
-
i.e. 5-hydroxytryptamine, liver enzyme inactive
-
-
?
serotonin + UDPglucuronate
tryptamine 5-O-beta-D-glucuronide + UDP
-
-
-
?
serotonin + UDPglucuronate
tryptamine 5-O-beta-D-glucuronide + UDP
-
Gunn strain liver enzyme active
-
?
serotonin + UDPglucuronate
tryptamine 5-O-beta-D-glucuronide + UDP
-
Gunn strain liver enzyme active
-
?
serotonin + UDPglucuronate
tryptamine 5-O-beta-D-glucuronide + UDP
-
Gunn strain liver enzyme active
-
?
testosterone + UDP-glucuronate
UDP + testosterone beta-D-glucuronoside
-
-
-
?
testosterone + UDP-glucuronate
UDP + testosterone beta-D-glucuronoside
-
-
-
?
testosterone + UDP-glucuronate
UDP + testosterone beta-D-glucuronoside
UGT2B15 and UGT2B17 are the major enzyme forms involved in human liver microsomal testosterone 17beta-glucuronidation
-
-
?
testosterone + UDP-glucuronate
UDP + testosterone beta-D-glucuronoside
-
-
-
?
testosterone + UDPglucuronate
UDP + testosterone O-glucuronide
-
-
-
?
testosterone + UDPglucuronate
UDP + testosterone O-glucuronide
-
no activity
-
-
?
testosterone + UDPglucuronate
UDP + testosterone O-glucuronide
-
-
-
?
testosterone + UDPglucuronate
UDP + testosterone O-glucuronide
-
other 17 hydroxylated androgens tested
-
?
testosterone + UDPglucuronate
UDP + testosterone O-glucuronide
-
no activity
-
-
?
testosterone + UDPglucuronate
UDP + testosterone O-glucuronide
-
-
-
?
testosterone + UDPglucuronate
UDP + testosterone O-glucuronide
-
-
-
?
testosterone + UDPglucuronate
UDP + testosterone O-glucuronide
-
-
-
?
testosterone + UDPglucuronate
UDP + testosterone O-glucuronide
-
-
-
?
testosterone + UDPglucuronate
UDP + testosterone O-glucuronide
-
-
-
?
testosterone + UDPglucuronate
UDP + testosterone O-glucuronide
-
-
-
?
testosterone + UDPglucuronate
UDP + testosterone O-glucuronide
-
-
-
?
testosterone + UDPglucuronate
UDP + testosterone O-glucuronide
-
-
-
?
testosterone + UDPglucuronate
UDP + testosterone O-glucuronide
-
-
-
?
testosterone + UDPglucuronate
UDP + testosterone O-glucuronide
-
-
-
?
testosterone + UDPglucuronate
UDP + testosterone O-glucuronide
-
-
-
?
testosterone + UDPglucuronate
UDP + testosterone O-glucuronide
-
-
-
?
testosterone + UDPglucuronate
UDP + testosterone O-glucuronide
-
no activity
-
-
?
testosterone + UDPglucuronate
UDP + testosterone O-glucuronide
-
UDPglucuronate can be substituted by UDPgalacturonate yielding 83-88% of the activity
-
?
testosterone + UDPglucuronate
UDP + testosterone O-glucuronide
-
isozyme 17-OH steroid UDPGT
-
?
testosterone + UDPglucuronate
UDP + testosterone O-glucuronide
-
low transferase activity during purification, not detectable in the final enzyme preparation in the absence of phospholipid, detectable after reconstitution with phosphatidylcholine liposomes
-
?
testosterone + UDPglucuronate
UDP + testosterone O-glucuronide
-
-
-
?
testosterone + UDPglucuronate
UDP + testosterone O-glucuronide
-
-
-
?
testosterone + UDPglucuronate
UDP + testosterone O-glucuronide
-
no activity
-
-
?
testosterone + UDPglucuronate
UDP + testosterone O-glucuronide
-
-
-
?
testosterone + UDPglucuronate
UDP + testosterone O-glucuronide
-
-
-
?
testosterone + UDPglucuronate
UDP + testosterone O-glucuronide
-
-
-
?
testosterone + UDPglucuronate
UDP + testosterone O-glucuronide
-
-
-
?
testosterone + UDPglucuronate
UDP + testosterone O-glucuronide
-
low transferase activity during purification, not detectable in the final enzyme preparation in the absence of phospholipid, detectable after reconstitution with phosphatidylcholine liposomes
-
?
testosterone + UDPglucuronate
UDP + testosterone O-glucuronide
-
no activity
-
-
?
thiophenol + UDPglucuronate
thiophenyl thio-beta-D-glucuronide + UDP
-
-
-
?
thiophenol + UDPglucuronate
thiophenyl thio-beta-D-glucuronide + UDP
-
-
-
?
thiophenol + UDPglucuronate
thiophenyl thio-beta-D-glucuronide + UDP
-
-
-
?
troglitazone + UDPglucuronate
UDP + troglitazone 6-O-glucuronide
-
Gunn and Wistar strains
-
?
troglitazone + UDPglucuronate
UDP + troglitazone 6-O-glucuronide
-
Gunn and Wistar strains
-
?
troglitazone + UDPglucuronate
UDP + troglitazone 6-O-glucuronide
-
Gunn and Wistar strains
-
?
UDP-alpha-D-glucuronate + (R)-propranolol
UDP + (R)-propranolol beta-D-glucuronoside
-
-
-
?
UDP-alpha-D-glucuronate + (R)-propranolol
UDP + (R)-propranolol beta-D-glucuronoside
-
-
-
?
UDP-alpha-D-glucuronate + (R)-propranolol
UDP + (R)-propranolol beta-D-glucuronoside
high activity
-
-
?
UDP-alpha-D-glucuronate + (S)-naproxen
UDP + beta-D-glucuronosyl (S)-naproxen
-
low activity
-
?
UDP-alpha-D-glucuronate + (S)-naproxen
UDP + beta-D-glucuronosyl (S)-naproxen
-
-
-
-
?
UDP-alpha-D-glucuronate + (S)-propranolol
UDP + (S)-propranolol beta-D-glucuronoside
-
-
-
?
UDP-alpha-D-glucuronate + (S)-propranolol
UDP + (S)-propranolol beta-D-glucuronoside
very low activity
-
-
?
UDP-alpha-D-glucuronate + (S)-propranolol
UDP + (S)-propranolol beta-D-glucuronoside
-
-
-
?
UDP-alpha-D-glucuronate + (S)-propranolol
UDP + (S)-propranolol beta-D-glucuronoside
high activity
-
-
?
UDP-alpha-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
-
-
-
?
UDP-alpha-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
-
-
-
-
?
UDP-alpha-D-glucuronate + chloramphenicol
UDP + chloramphenicol beta-D-glucuronide
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-alpha-D-glucuronate + chloramphenicol
UDP + chloramphenicol beta-D-glucuronide
-
-
-
?
UDP-alpha-D-glucuronate + chloramphenicol
UDP + chloramphenicol beta-D-glucuronide
-
-
-
?
UDP-alpha-D-glucuronate + chloramphenicol
UDP + chloramphenicol beta-D-glucuronide
-
no activity
-
-
?
UDP-alpha-D-glucuronate + chloramphenicol
UDP + chloramphenicol beta-D-glucuronide
-
very low activity
-
?
UDP-D-glucuronate + 1-naphthol
UDP + 1-naphthyl beta-D-glucuronoside
-
-
-
?
UDP-D-glucuronate + 1-naphthol
UDP + 1-naphthyl beta-D-glucuronoside
isozyme UGT1A1
-
-
?
UDP-D-glucuronate + 1-naphthol
UDP + 1-naphthyl beta-D-glucuronoside
reaction of isozyme UGT1A6
-
-
?
UDP-D-glucuronate + 2-naphthol
UDP + 2-naphthyl beta-D-glucuronoside
-
-
-
?
UDP-D-glucuronate + 2-naphthol
UDP + 2-naphthyl beta-D-glucuronoside
isozyme UGT1A7
-
-
?
UDP-D-glucuronate + 4-hydroxy-N-desmethyl-tamoxifen
UDP + 4-hydroxy-N-desmethyl-tamoxifen beta-D-glucuronoside
the enzyme is involved in metabolism and elimination of tamoxifen, TAM, and its major active metabolites 4-hydroxytamoxifen and 4-hydroxy-N-desmethyl-tamoxifen, i.e. endoxifen, by glucuronidation, overview
-
-
?
UDP-D-glucuronate + 4-hydroxy-N-desmethyl-tamoxifen
UDP + 4-hydroxy-N-desmethyl-tamoxifen beta-D-glucuronoside
i.e. endoxifen, substrate synthesis, overview, O-glucuronidation by liver microsomes
product identification by HPLC and mass spectrometry analysis
-
?
UDP-D-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferone beta-D-glucuronoside
isozyme UGT1A1
-
-
?
UDP-D-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferone beta-D-glucuronoside
isozyme UGT1A6
-
-
?
UDP-D-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferone beta-D-glucuronoside
non-selective substrate
-
-
?
UDP-D-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl beta-D-glucuronoside
-
-
-
?
UDP-D-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl beta-D-glucuronoside
-
-
-
?
UDP-D-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl beta-D-glucuronoside
isozyme UGT1A6
-
-
?
UDP-D-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl beta-D-glucuronoside
recombinant isozyme UGT1A1
-
-
?
UDP-D-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + 4-nitrophenol
UDP + 4-nitrophenyl beta-D-glucuronoside
-
-
-
?
UDP-D-glucuronate + 4-nitrophenol
UDP + 4-nitrophenyl beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + 4-nitrophenol
UDP + 4-nitrophenyl beta-D-glucuronoside
isozyme UGT1A1
-
-
?
UDP-D-glucuronate + 4-nitrophenol
UDP + 4-nitrophenyl O-beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + 4-nitrophenol
UDP + 4-nitrophenyl O-beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + 6-hydroxy-warfarin
UDP + 6-hydroxy-warfarin beta-D-glucuronoside
substrate of isozyme UGT1A1
-
-
?
UDP-D-glucuronate + 6-hydroxy-warfarin
UDP + 6-hydroxy-warfarin beta-D-glucuronoside
substrate of isozyme UGT1A10
-
-
?
UDP-D-glucuronate + 7-hydroxy-warfarin
UDP + 7-hydroxy-warfarin beta-D-glucuronoside
substrate of isozyme UGT1A1
-
-
?
UDP-D-glucuronate + 7-hydroxy-warfarin
UDP + 7-hydroxy-warfarin beta-D-glucuronoside
substrate of isozyme UGT1A10
-
-
?
UDP-D-glucuronate + 8-hydroxy-warfarin
UDP + 8-hydroxy-warfarin beta-D-glucuronoside
substrate of isozyme UGT1A1
-
-
?
UDP-D-glucuronate + 8-hydroxy-warfarin
UDP + 8-hydroxy-warfarin beta-D-glucuronoside
substrate of isozyme UGT1A10
-
-
?
UDP-D-glucuronate + 8-hydroxy-warfarin
UDP + 8-hydroxy-warfarin beta-D-glucuronoside
substrate of isozyme UGT1A9
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
-
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
-
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
-
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
-
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
-
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
-
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
-
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
-
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
-
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
-
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
-
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
-
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
conjugation by UDP-glucuronosyltransferase is the major pathway of androgen metabolism and elimination in the human
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
-
glucuronidation is a major phase II conjugation reaction of numerous xenobiotic as well as endobiotic compounds
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
-
potential role of UGTs in regulating aldosterone
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
-
protein kinases are involved in UGT regulation, UGTs inactivate aromatic-like metabolites and a vast number of dietary and environmental chemicals, which reduces the risk of toxicities, mutagenesis, and carcinogenesis, primarily in liver, kidney, and gastrointestinal tract, overview
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
the enzyme is involved in detoxification reactions
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
the enzyme plays a key role in the metabolism of endogenous and exogenous compounds
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
UDP-glucuronosyltransferases are membrane-bound proteins localized to the endoplasmic reticulum and catalyze the formation of beta-D-glucopyranosiduronic acids using UDP-D-glucuronic acid and acceptor substrates such as drugs, steroids, bile acids, xenobiotics, and dietary nutrients
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
-
UDP-glucuronosyltransferases play important roles in the metabolism, detoxification,and clearance of many different xenobiotics, including drugs and endogenous compounds
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
UGT isozyme substrate specificity, overview
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
differences in substrate binding between isozymes of different oligomeric state, overview
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
the recombinant isozyme 2A3, expressed in insect cells via baculovirus system, selectively glucuronidates bile acids, particularly hyodeoxycholic acid at the 6-hydroxy position, wide substrate specificity, detailed overview
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
-
UGTs contain a Rossman fold motif predicted to bind the UDP-containing sugar donor substrate
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
-
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
-
differences in substrate binding between isozymes of different oligomeric state, overview
-
-
?
UDP-D-glucuronate + androstane-3alpha,17beta-diol
UDP + ?
isozyme UGT2B15
-
-
?
UDP-D-glucuronate + androstane-3alpha,17beta-diol
UDP + ?
isozyme UGT2B17
-
-
?
UDP-D-glucuronate + androstane-3alpha,17beta-diol
UDP + ?
isozyme UGT2B7
-
-
?
UDP-D-glucuronate + androstane-3alpha,17beta-diol
UDP + ?
in epithelial cells of the human prostate
-
-
?
UDP-D-glucuronate + androstane-3alpha,17beta-diol
UDP + ?
isozyme UGT2B15 in the liver
-
-
?
UDP-D-glucuronate + androstane-3alpha,17beta-diol
UDP + ?
isozyme UGT2B17 in the liver
-
-
?
UDP-D-glucuronate + androstane-3alpha,17beta-diol
UDP + ?
isozyme UGT2B7in the liver
-
-
?
UDP-D-glucuronate + androsterone
UDP + androsterone 3-O-beta-D-glucuronoside
-
-
-
?
UDP-D-glucuronate + androsterone
UDP + androsterone 3-O-beta-D-glucuronoside
isozyme UGT2B15
-
-
?
UDP-D-glucuronate + androsterone
UDP + androsterone 3-O-beta-D-glucuronoside
isozyme UGT2B17
-
-
?
UDP-D-glucuronate + androsterone
UDP + androsterone 3-O-beta-D-glucuronoside
isozyme UGT2B7
-
-
?
UDP-D-glucuronate + androsterone
UDP + androsterone 3-O-beta-D-glucuronoside
in epithelial cells of the human prostate
-
-
?
UDP-D-glucuronate + androsterone
UDP + androsterone 3-O-beta-D-glucuronoside
isozyme UGT2B15 in the liver
-
-
?
UDP-D-glucuronate + androsterone
UDP + androsterone 3-O-beta-D-glucuronoside
isozyme UGT2B17 in the liver
-
-
?
UDP-D-glucuronate + androsterone
UDP + androsterone 3-O-beta-D-glucuronoside
isozyme UGT2B7in the liver
-
-
?
UDP-D-glucuronate + cis-4-hydroxytamoxifen
UDP + 4-hydroxytamoxifen beta-D-glucuronoside
the enzyme is involved in metabolism and elimination of tamoxifen, TAM, and its major active metabolites 4-hydroxytamoxifen and 4-hydroxy-N-desmethyl-tamoxifen, i.e. endoxifen, by glucuronidation, overview
-
-
?
UDP-D-glucuronate + cis-4-hydroxytamoxifen
UDP + 4-hydroxytamoxifen beta-D-glucuronoside
N- and O-glucuronidation by liver microsomes
product identification by HPLC and mass spectrometry analysis
-
?
UDP-D-glucuronate + cotinine
UDP + ?
isozyme UGT2B10, cotinine is exclusively glucuronized in liver, no activity in intestinal microsomes
-
-
?
UDP-D-glucuronate + curcumin
UDP + curcumin phenolic beta-D-monoglucuronide
-
-
-
-
?
UDP-D-glucuronate + curcumin
UDP + curcumin phenolic beta-D-monoglucuronide
-
glucuronidation is an important pathway in the metabolism of curcumin
-
-
?
UDP-D-glucuronate + dehydrotestosterone
UDP + dehydrotestosterone 17-O-beta-D-glucuronoside
isozyme UGT2B15
-
-
?
UDP-D-glucuronate + dehydrotestosterone
UDP + dehydrotestosterone 17-O-beta-D-glucuronoside
isozyme UGT2B17
-
-
?
UDP-D-glucuronate + dehydrotestosterone
UDP + dehydrotestosterone 17-O-beta-D-glucuronoside
isozyme UGT2B7
-
-
?
UDP-D-glucuronate + dehydrotestosterone
UDP + dehydrotestosterone 17-O-beta-D-glucuronoside
isozyme UGT2B15in the liver
-
-
?
UDP-D-glucuronate + dehydrotestosterone
UDP + dehydrotestosterone 17-O-beta-D-glucuronoside
isozyme UGT2B17in the liver
-
-
?
UDP-D-glucuronate + dehydrotestosterone
UDP + dehydrotestosterone 17-O-beta-D-glucuronoside
isozyme UGT2B7in the liver
-
-
?
UDP-D-glucuronate + dihydrotestosterone
UDP + dihydrotestosterone 17-O-beta-D-glucuronoside
-
-
-
?
UDP-D-glucuronate + dihydrotestosterone
UDP + dihydrotestosterone 17-O-beta-D-glucuronoside
in epithelial cells of the human prostate
-
-
?
UDP-D-glucuronate + estradiol
UDP + estradiol 3-O-beta-D-glucuronoside
-
isozymes UGT1A1 and UGT1A9
-
-
?
UDP-D-glucuronate + estradiol
UDP + estradiol 3-O-beta-D-glucuronoside
reaction of isozyme UGT1A1
-
-
?
UDP-D-glucuronate + estradiol
UDP + estradiol 3-O-beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + estradiol
UDP + estradiol 3-O-beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + estradiol
UDP + estradiol-3-beta-D-glucuronoside
liver microsomes
-
-
?
UDP-D-glucuronate + estradiol
UDP + estradiol-3-beta-D-glucuronoside
recombinant isozyme UGT1A1
-
-
?
UDP-D-glucuronate + estradiol
UDP + estradiol-3-beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + eugenol
UDP + eugenol beta-D-glucuronoside
isozyme UGT1A1
-
-
?
UDP-D-glucuronate + frusemide
UDP + frusemide beta-D-glucuronoside
-
substrate of isozymes UGT 1A1, UGT1A3, UGT1A6, UGT1A7, UGT1A9, UGT1A10 and UGT2B7, with a predominant role of UGT1A9 in liver and kidney
-
-
?
UDP-D-glucuronate + gemfibrozil
UDP + gemfibrozil beta-D-glucuronoside
-
gemfibrozil is a fibrate hypolipidemic agent, isozyme UGT2B7 in the liver
-
-
?
UDP-D-glucuronate + gemfibrozil
UDP + gemfibrozil beta-D-glucuronoside
-
activity with isozymes UGT1A1, UGT1A3, UGT1A9, UGT2B4, UGT2B7, UGT2B17, and especially with isozyme UGT2B7 showing the highest activity
-
-
?
UDP-D-glucuronate + hyodeoxycholic acid
UDP + hyodeoxycholic acid 6-O-glucuronoside
isozyme UGT2A3
-
-
?
UDP-D-glucuronate + hyodeoxycholic acid
UDP + hyodeoxycholic acid 6-O-glucuronoside
recombinant enzyme, expressed in insect cells via baculovirus system, selective glucuronidation
product formation depends on the isozyme, overview
-
?
UDP-D-glucuronate + labetalol
UDP + ?
-
-
-
?
UDP-D-glucuronate + labetalol
UDP + ?
the reaction is catalyzed mainly by isozymes UGT1A1 and UGT2B7, overview
-
-
?
UDP-D-glucuronate + labetalol
UDP + ?
the reaction is catalyzed mainly by isozymes UGT1A1 and UGT2B7, potential role for progesterone in regulating labetalol elimination by modulating the expression of UGT1A1, leading to enhanced drug metabolism during pregnancy, overview
-
-
?
UDP-D-glucuronate + morphine
UDP + morphine 3-O-beta-D-glucuronoside
isozyme UGT1A1
-
-
?
UDP-D-glucuronate + morphine
UDP + morphine 3-O-beta-D-glucuronoside
-
isozyme UGT2B7
-
-
?
UDP-D-glucuronate + morphine
UDP + morphine 3-O-beta-D-glucuronoside
-
-
-
?
UDP-D-glucuronate + morphine
UDP + morphine 3-O-beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + morphine
UDP + morphine 6-beta-D-glucuronoside
the metabolic conversion of morphine to morphine-6-glucuronide plays a significant role in mediation of the clinical effect of morphine because of the superior analgesic effect of morphine-6-glucuronide
-
-
?
UDP-D-glucuronate + morphine
UDP + morphine 6-beta-D-glucuronoside
isozyme UGT1A1, as the morphine concentration approaches 0.1 mM, morphine-6-glucuronidation activity gradually decreases, and the kinetics closely resemble substrate inhibition Michaelis-Menten kinetic behavior
-
-
?
UDP-D-glucuronate + morphine
UDP + morphine 6-beta-D-glucuronoside
isozyme UGT1A8, as the morphine concentration approaches 0.1 mM, morphine-6-glucuronidation activity gradually decreases, and the kinetics closely resemble substrate inhibition Michaelis-Menten kinetic behavior
-
-
?
UDP-D-glucuronate + nicotine
UDP + ?
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-D-glucuronate + nicotine
UDP + ?
isozyme UGT2B10, nicotine is mainly glucuronized in liver, very low activity in intestinal microsomes
-
-
?
UDP-D-glucuronate + octylgallate
UDP + octylgallate beta-D-glucuronoside
isozyme UGT1A1
-
-
?
UDP-D-glucuronate + octylgallate
UDP + octylgallate beta-D-glucuronoside
isozyme UGT1A1
-
-
?
UDP-D-glucuronate + octylgallate
UDP + octylgallate beta-D-glucuronoside
isozyme UGT1A3
-
-
?
UDP-D-glucuronate + propofol
UDP + propofol beta-D-glucuronoside
-
-
-
-
?
UDP-D-glucuronate + propofol
UDP + propofol beta-D-glucuronoside
-
isozymes UGT1A1 and UGT1A9
-
-
?
UDP-D-glucuronate + protocatechuic aldehyde
UDP + ?
i.e. 3,4-dihydroxybenzaldehyde, the reaction is catalyzed by recombinant isozyme UGT1A6, especially, and also by isozyme UGT1A9, as well as by liver and intestine microsomes, overview
-
-
?
UDP-D-glucuronate + scopoletin
UDP + scopoletin beta-D-glucuronoside
-
-
-
?
UDP-D-glucuronate + scopoletin
UDP + scopoletin beta-D-glucuronoside
isozyme UGT1A1
-
-
?
UDP-D-glucuronate + scopoletin
UDP + scopoletin beta-D-glucuronoside
-
substrate binding structure, UGT1A6 residues His371 and Glu379 are directly involved in UDPGA binding but are not the general acid or general base, homology mocelling, overview
-
-
?
UDP-D-glucuronate + tamoxifen + H+
UDP + tamoxifen beta-D-glucuronoside
the enzyme is involved in metabolism and elimination of tamoxifen, TAM, and its major active metabolites 4-hydroxytamoxifen and 4-hydroxy-N-desmethyl-tamoxifen, i.e. endoxifen, by glucuronidation, overview
-
-
?
UDP-D-glucuronate + tamoxifen + H+
UDP + tamoxifen beta-D-glucuronoside
N- and O-glucuronidation by liver microsomes
product identification by HPLC and mass spectrometry analysis
-
?
UDP-D-glucuronate + thyroxine
UDP + thyroxine beta-D-glucuronoside
-
glucuronidation of the thyroid hormone thyroxine, T4, in the human liver, the T4 glucuronidation activities of recombinant human UGT isoforms and microsomes
-
-
?
UDP-D-glucuronate + trans-4-hydroxytamoxifen
UDP + 4-hydroxytamoxifen beta-D-glucuronoside
the enzyme is involved in metabolism and elimination of tamoxifen, TAM, and its major active metabolites 4-hydroxytamoxifen and 4-hydroxy-N-desmethyl-tamoxifen, i.e. endoxifen, by glucuronidation, overview
-
-
?
UDP-D-glucuronate + trans-4-hydroxytamoxifen
UDP + 4-hydroxytamoxifen beta-D-glucuronoside
N- and O-glucuronidation by liver microsomes
product identification by HPLC and mass spectrometry analysis
-
?
UDP-D-glucuronate + trans-4-hydroxytamoxifen
UDP + 4-hydroxytamoxifen beta-D-glucuronoside
N- and O-glucuronidation by liver microsomes, no activity by isozyme UGT2B15
product identification by HPLC and mass spectrometry analysis
-
?
UDP-D-glucuronate + zidovudine
UDP + zidovudine beta-D-glucuronoside
-
-
-
?
UDP-D-glucuronate + zidovudine
UDP + zidovudine beta-D-glucuronoside
an UGT2B7 substrate
-
-
?
UDP-glucuronate + (E)-2,4-dimethoxy-6-(4-methoxystyryl)benzaldehyde oxime
UDP + 1-O-[(E)-2,4-dimethoxy-6-(4-methoxystyryl)benzaldehyde oxime]-beta-D-glucuronate
-
i.e. NI-ST-05, low activity, NI-ST-05 forms a distinct N-O-glucuronide. NI-ST-05 is primarily metabolized by an extrahepatic enzyme, UGT1A10
-
-
?
UDP-glucuronate + (E)-2,4-dimethoxy-6-(4-methoxystyryl)benzaldehyde oxime
UDP + 1-O-[(E)-2,4-dimethoxy-6-(4-methoxystyryl)benzaldehyde oxime]-beta-D-glucuronate
-
i.e. NI-ST-05, low activity, NI-ST-05 forms a distinct N-O-glucuronide. NI-ST-05 is primarily metabolized by an extrahepatic enzyme, UGT1A10, in cooperative binding
-
-
?
UDP-glucuronate + 1-naphthol
UDP + 1-naphthol beta-D-glucuronide
isozyme UGT1A1
-
-
?
UDP-glucuronate + 1-naphthol
UDP + 1-naphthol beta-D-glucuronide
isozyme UGT1A10
-
-
?
UDP-glucuronate + 1-naphthol
UDP + 1-naphthol beta-D-glucuronide
isozyme UGT1A3
-
-
?
UDP-glucuronate + 1-naphthol
UDP + 1-naphthol beta-D-glucuronide
isozyme UGT1A6
-
-
?
UDP-glucuronate + 1-naphthol
UDP + 1-naphthol beta-D-glucuronide
isozyme UGT1A7
-
-
?
UDP-glucuronate + 1-naphthol
UDP + 1-naphthol beta-D-glucuronide
isozyme UGT1A8
-
-
?
UDP-glucuronate + 1-naphthol
UDP + 1-naphthol beta-D-glucuronide
isozyme UGT1A9
-
-
?
UDP-glucuronate + 1-naphthol
UDP + 1-naphthol beta-D-glucuronide
isozyme UGT2B7
-
-
?
UDP-glucuronate + 1-naphthol
UDP + beta-D-glucuronosyl-(1-naphthol)
-
-
-
?
UDP-glucuronate + 1-naphthol
UDP + beta-D-glucuronosyl-(1-naphthol)
-
-
-
?
UDP-glucuronate + 17-alpha-estradiol
UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + 17-alpha-estradiol
UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside
low activity
-
-
?
UDP-glucuronate + 17-alpha-estradiol
UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside
good substrate
-
-
?
UDP-glucuronate + 17-alpha-estradiol
UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside
higher activity
-
-
?
UDP-glucuronate + 17-alpha-estradiol
UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside
very low activity
-
-
?
UDP-glucuronate + 17-alpha-estradiol
UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside
low activity
-
-
?
UDP-glucuronate + 17-alpha-estradiol
UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside
lower activity
-
-
?
UDP-glucuronate + 17-alpha-estradiol
UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside
very high activity with UGT1A10
-
-
?
UDP-glucuronate + 17-beta-estradiol
UDP + 17-beta-estradiol 3-beta-D-glucuronoside
-
-
-
-
?
UDP-glucuronate + 17-beta-estradiol
UDP + 17-beta-estradiol 3-beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + 17-beta-estradiol
UDP + 17-beta-estradiol 3-beta-D-glucuronoside
-
-
-
-
?
UDP-glucuronate + 17-beta-estradiol
UDP + 17-beta-estradiol 3-beta-D-glucuronoside
-
-
-
-
?
UDP-glucuronate + 17-beta-estradiol
UDP + 17-beta-estradiol 3-beta-D-glucuronoside
-
-
-
-
?
UDP-glucuronate + 17-beta-estradiol
UDP + 17-beta-estradiol 3-beta-D-glucuronoside
-
high levels of estradiol-3-glucuronidation in microsomes of 1-day-old microminipigs
-
-
?
UDP-glucuronate + 17-beta-estradiol
UDP + 17-beta-estradiol 3-O-beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + 17-beta-estradiol
UDP + 17-beta-estradiol 3-O-beta-D-glucuronoside
low activity
-
-
?
UDP-glucuronate + 17-beta-estradiol
UDP + 17-beta-estradiol 3-O-beta-D-glucuronoside
low activity
-
-
?
UDP-glucuronate + 17-beta-estradiol
UDP + 17-beta-estradiol 3-O-beta-D-glucuronoside
lower activity
-
-
?
UDP-glucuronate + 17-beta-estradiol
UDP + 17-beta-estradiol 3-O-beta-D-glucuronoside
very high activity
-
-
?
UDP-glucuronate + 2',4,4',6'-tetrahydroxychalcone
?
isozyme UGT1A1
-
-
?
UDP-glucuronate + 2',4,4',6'-tetrahydroxychalcone
?
isozyme UGT1A7
-
-
?
UDP-glucuronate + 2',4,4',6'-tetrahydroxychalcone
?
isozymes UGT1A1, UGT1A7, and UGT1A10
-
-
?
UDP-glucuronate + 3'-azido-3'-deoxythymidine
UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronoside
-
-
-
-
?
UDP-glucuronate + 3'-azido-3'-deoxythymidine
UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + 3'-azido-3'-deoxythymidine
UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronoside
-
-
-
-
?
UDP-glucuronate + 3'-azido-3'-deoxythymidine
UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronoside
-
-
-
-
?
UDP-glucuronate + 3'-azido-3'-deoxythymidine
UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronoside
-
-
-
-
?
UDP-glucuronate + 3'-azido-3'-deoxythymidine
UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronoside
-
-
-
-
?
UDP-glucuronate + 3,2'-dihydroxychalcone
UDP + 3-hydroxychalcone 2'-O-beta-D-glucuronoside
-
glucuronidation at the OH-2' position by UGT1A8 isoform
-
-
?
UDP-glucuronate + 3,2'-dihydroxychalcone
UDP + 3-hydroxychalcone 2'-O-beta-D-glucuronoside
-
very low activity with isozyme UGT1A6
-
-
?
UDP-glucuronate + 3-epideacetycinobufagin
UDP + 3-epideacetycinobufagin 3-beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + 3-epideacetycinobufagin
UDP + 3-epideacetycinobufagin 3-beta-D-glucuronoside
3-epideacetycinobufagin is a highly isoform-specific probe substrate for 3-glucuronidation mediated by UDP-glucuronosyltransferase 2B7 determined in recombinant UGT supersomes, overview
-
-
?
UDP-glucuronate + 4-ethylphenol
UDP + beta-D-glucuronosyl-(4-ethylphenol)
-
-
-
?
UDP-glucuronate + 4-ethylphenol
UDP + beta-D-glucuronosyl-(4-ethylphenol)
-
-
-
-
?
UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferone beta-D-glucuronide
-
-
-
?
UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferone beta-D-glucuronide
isozyme UGT1A1
-
-
?
UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferone beta-D-glucuronide
isozyme UGT1A10
-
-
?
UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferone beta-D-glucuronide
isozyme UGT1A3
-
-
?
UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferone beta-D-glucuronide
isozyme UGT1A6
-
-
?
UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferone beta-D-glucuronide
isozyme UGT1A7
-
-
?
UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferone beta-D-glucuronide
isozyme UGT1A8
-
-
?
UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferone beta-D-glucuronide
isozyme UGT1A9
-
-
?
UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferone beta-D-glucuronide
isozyme UGT2B15
-
-
?
UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferone beta-D-glucuronide
isozyme UGT2B17
-
-
?
UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferone beta-D-glucuronide
isozyme UGT2B7
-
-
?
UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl beta-D-glucuronoside
low activity
-
-
?
UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl beta-D-glucuronoside
high activity
-
-
?
UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + 4-methylumbelliferone
UDP + 4-methylumbelliferyl beta-D-glucuronoside
high activity
-
-
?
UDP-glucuronate + 4-methylumbelliferone
UDP + beta-D-glucuronosyl-(4-methylumbelliferone)
-
-
-
?
UDP-glucuronate + 4-methylumbelliferone
UDP + beta-D-glucuronosyl-(4-methylumbelliferone)
-
-
-
-
?
UDP-glucuronate + 4-methylumbelliferone
UDP + beta-D-glucuronosyl-(4-methylumbelliferone)
-
-
-
?
UDP-glucuronate + 4-nitrophenol
UDP + 4-nitrophenyl beta-D-glucuronide
recombinant isozyme UGT1A6 from lymphoblasts or insect cells
-
-
?
UDP-glucuronate + 4-nitrophenol
UDP + 4-nitrophenyl beta-D-glucuronide
-
-
-
?
UDP-glucuronate + 4-nitrophenol
UDP + beta-D-glucuronosyl-(4-nitrophenol)
-
-
-
?
UDP-glucuronate + 4-nitrophenol
UDP + beta-D-glucuronosyl-(4-nitrophenol)
-
-
-
-
?
UDP-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
transfer of glucuronic acid (GlcA) from UDP-GlcA to glycosyl inositol phosphorylceramides (GIPCs)
-
-
?
UDP-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
UGT1A10 is an important detoxifier of polycyclic aromatic hydrocarbons
-
-
?
UDP-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
-
transfer of glucuronic acid (GlcA) from UDP-GlcA to glycosyl inositol phosphorylceramides (GIPCs)
-
-
?
UDP-glucuronate + acceptor
UDP + acceptor beta-glucuronoside
-
-
-
?
UDP-glucuronate + acceptor
UDP + acceptor beta-glucuronoside
differences in substrate binding between isozymes of different oligomeric state, overview
-
-
?
UDP-glucuronate + androstane-3,17-diol
UDP + beta-D-glucuronosyl-androstane-3,17-diol
-
-
-
?
UDP-glucuronate + androstane-3,17-diol
UDP + beta-D-glucuronosyl-androstane-3,17-diol
-
-
-
-
?
UDP-glucuronate + anthraflavic acid
UDP + anthraflavic acid 2-O-beta-D-glucuronide
isozyme UGT1A1
-
-
?
UDP-glucuronate + anthraflavic acid
UDP + anthraflavic acid 2-O-beta-D-glucuronide
isozyme UGT1A9
-
-
?
UDP-glucuronate + anthraflavic acid
UDP + anthraflavic acid 2-O-beta-D-glucuronide
isozymes UGT1A1, and UGT1A9
-
-
?
UDP-glucuronate + apigenin
UDP + apigenin beta-D-glucuronide
isozyme UGT1A1
-
-
?
UDP-glucuronate + apigenin
UDP + apigenin beta-D-glucuronide
isozyme UGT1A7
-
-
?
UDP-glucuronate + apigenin
UDP + apigenin beta-D-glucuronide
isozymes UGT1A1, UGT1A7, and UGT1A10
-
-
?
UDP-glucuronate + bilirubin
UDP + bilirubin beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + bilirubin
UDP + bilirubin beta-D-glucuronoside
very low activity
-
-
?
UDP-glucuronate + bilirubin
UDP + bilirubin beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + bilirubin
UDP + bilirubin beta-D-glucuronoside
very high activity
-
-
?
UDP-glucuronate + biochanin A
UDP + biochanin A beta-D-glucuronide
isozyme UGT1A1
-
-
?
UDP-glucuronate + biochanin A
UDP + biochanin A beta-D-glucuronide
isozyme UGT1A7
-
-
?
UDP-glucuronate + biochanin A
UDP + biochanin A beta-D-glucuronide
isozymes UGT1A1, UGT1A7, and UGT1A10
-
-
?
UDP-glucuronate + buprenorphine
UDP + buprenorphine glucuronide
-
isozyme UGT1A1
-
-
?
UDP-glucuronate + buprenorphine
UDP + buprenorphine glucuronide
-
-
-
?
UDP-glucuronate + capsaicin
UDP + capsaicin beta-D-glucuronide
isozyme UGT1A1
-
-
?
UDP-glucuronate + capsaicin
UDP + capsaicin beta-D-glucuronide
isozyme UGT1A7
-
-
?
UDP-glucuronate + capsaicin
UDP + capsaicin beta-D-glucuronide
isozymes UGT1A1, UGT1A7, and UGT1A10
-
-
?
UDP-glucuronate + chenodeoxycholic acid
UDP + chenodeoxycholic acid 24-beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + chenodeoxycholic acid
UDP + chenodeoxycholic acid 24-beta-D-glucuronoside
Q6UWM9, Q9Y4X1
-
-
-
?
UDP-glucuronate + chenodeoxycholic acid
UDP + chenodeoxycholic acid 24-beta-D-glucuronoside
Q6UWM9, Q9Y4X1
best substrate
-
-
?
UDP-glucuronate + cholic acid
UDP + cholic acid 24-beta-D-glucuronoside
Q6UWM9, Q9Y4X1
best substrate
-
-
?
UDP-glucuronate + chrysin
UDP + chrysin beta-D-glucuronide
isozyme UGT1A1
-
-
?
UDP-glucuronate + chrysin
UDP + chrysin beta-D-glucuronide
isozyme UGT1A7
-
-
?
UDP-glucuronate + chrysin
UDP + chrysin beta-D-glucuronide
isozyme UGT1A8
-
-
?
UDP-glucuronate + chrysin
UDP + chrysin beta-D-glucuronide
isozyme UGT1A9
-
-
?
UDP-glucuronate + chrysin
UDP + chrysin beta-D-glucuronide
isozymes UGT1A1, UGT1A7, UGT1A8, UGT1A9, and UGT1A10
-
-
?
UDP-glucuronate + curcumin
UDP + curcumin beta-D-glucuronide
isozyme UGT1A1
-
-
?
UDP-glucuronate + curcumin
UDP + curcumin beta-D-glucuronide
isozyme UGT1A7
-
-
?
UDP-glucuronate + curcumin
UDP + curcumin beta-D-glucuronide
isozyme UGT1A8
-
-
?
UDP-glucuronate + curcumin
UDP + curcumin beta-D-glucuronide
isozymes UGT1A1, UGT1A7, UGT1A8, and UGT1A10
-
-
?
UDP-glucuronate + denopamine
UDP + denopamine beta-D-glucuronide
-
-
formation of 2 product metabolites termed G1 and G2
-
?
UDP-glucuronate + denopamine
UDP + denopamine beta-D-glucuronide
-
formation of 1 product metabolite termed G2
-
?
UDP-glucuronate + denopamine
UDP + denopamine beta-D-glucuronide
-
-
formation of 2 product metabolites termed G1 and G2
-
?
UDP-glucuronate + denopamine
UDP + denopamine beta-D-glucuronide
-
-
formation of 1 product metabolite termed G1
-
?
UDP-glucuronate + denopamine
UDP + denopamine beta-D-glucuronide
-
-
formation of 1 product metabolite termed G1
-
?
UDP-glucuronate + desmethylnaproxen
?
UGT 1A3 forms only the acyl glucuronide
-
-
?
UDP-glucuronate + desmethylnaproxen
?
UGT 1A6 forms only the acyl glucuronide
-
-
?
UDP-glucuronate + desmethylnaproxen
?
UGT1A1 catalyzes both the phenolic and acyl glucuronidation of desmethylnaproxen
-
-
?
UDP-glucuronate + desmethylnaproxen
?
UGT1A7 catalyzes both the phenolic and acyl glucuronidation of desmethylnaproxen UGT 1A6 forms only the acyl glucuronide
-
-
?
UDP-glucuronate + desmethylnaproxen
?
UGT1A9 catalyzes both the phenolic and acyl glucuronidation of desmethylnaproxen UGT 1A6 forms only the acyl glucuronide
-
-
?
UDP-glucuronate + desmethylnaproxen
?
UGT2B7 forms only the acyl glucuronide
-
-
?
UDP-glucuronate + diclofenac
UDP + diclofenac beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + diclofenac
UDP + diclofenac beta-D-glucuronoside
very low activity
-
-
?
UDP-glucuronate + diclofenac
UDP + diclofenac beta-D-glucuronoside
low activity
-
-
?
UDP-glucuronate + diclofenac
UDP + diclofenac beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + diclofenac
UDP + diclofenac beta-D-glucuronoside
very low activity
-
-
?
UDP-glucuronate + diclofenac
UDP + diclofenac beta-D-glucuronoside
low activity
-
-
?
UDP-glucuronate + diclofenac
UDP + diclofenac beta-D-glucuronoside
high activity
-
-
?
UDP-glucuronate + diphenhydramine
UDP + diphenhydramine beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + diphenhydramine
UDP + diphenhydramine beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + entacapone
UDP + entacapone beta-D-glucuronide
-
-
-
?
UDP-glucuronate + entacapone
UDP + entacapone beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + entacapone
UDP + entacapone beta-D-glucuronoside
high activity
-
-
?
UDP-glucuronate + entacapone
UDP + entacapone beta-D-glucuronoside
very low activity
-
-
?
UDP-glucuronate + entacapone
UDP + entacapone beta-D-glucuronoside
low activity
-
-
?
UDP-glucuronate + entacapone
UDP + entacapone beta-D-glucuronoside
high activity
-
-
?
UDP-glucuronate + entacapone
UDP + entacapone beta-D-glucuronoside
very high activity
-
-
?
UDP-glucuronate + epitestosterone
UDP + epitestosterone beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + epitestosterone
UDP + epitestosterone beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + estradiol
UDP + estradiol beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + estradiol
UDP + estradiol beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
the enzyme UGT1A9 is active with estrogens
-
-
?
UDP-glucuronate + ethanol
UDP + ethyl beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + ethanol
UDP + ethyl beta-D-glucuronoside
high activity
-
-
?
UDP-glucuronate + ethanol
UDP + ethyl beta-D-glucuronoside
highest activity with enzymes UGT1A9 and UGT2B7
-
-
?
UDP-glucuronate + ethinylestradiol
UDP + ethinylestradiol beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + ethinylestradiol
UDP + ethinylestradiol beta-D-glucuronoside
very low activity
-
-
?
UDP-glucuronate + ethinylestradiol
UDP + ethinylestradiol beta-D-glucuronoside
low activity
-
-
?
UDP-glucuronate + ethinylestradiol
UDP + ethinylestradiol beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + ethinylestradiol
UDP + ethinylestradiol beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + ethinylestradiol
UDP + ethinylestradiol beta-D-glucuronoside
very low activity
-
-
?
UDP-glucuronate + eugenol
UDP + beta-D-glucuronosyl-eugenol
-
-
-
?
UDP-glucuronate + eugenol
UDP + beta-D-glucuronosyl-eugenol
-
high activity
-
-
?
UDP-glucuronate + eugenol
UDP + eugenol beta-D-glucuronide
isozyme UGT1A7
-
-
?
UDP-glucuronate + eugenol
UDP + eugenol beta-D-glucuronide
isozymes UGT1A7, and UGT1A10
-
-
?
UDP-glucuronate + gemfibrozil
UDP + beta-D-glucuronosyl-gemfibrozil
-
-
-
?
UDP-glucuronate + genistein
UDP + genistein beta-D-glucuronide
isozyme UGT1A1
-
-
?
UDP-glucuronate + genistein
UDP + genistein beta-D-glucuronide
isozyme UGT1A7
-
-
?
UDP-glucuronate + genistein
UDP + genistein beta-D-glucuronide
isozymes UGT1A1, UGT1A7, and UGT1A10
-
-
?
UDP-glucuronate + grepafloxacin
UDP + grepafloxacin beta-D-glucuronide
-
-
-
?
UDP-glucuronate + grepafloxacin
UDP + grepafloxacin beta-D-glucuronide
high activity with isozyme UGT1A9
-
-
?
UDP-glucuronate + grepafloxacin
UDP + grepafloxacin beta-D-glucuronide
low activity with isozyme UGT1A1
-
-
?
UDP-glucuronate + grepafloxacin
UDP + grepafloxacin beta-D-glucuronide
low activity with isozyme UGT1A3
-
-
?
UDP-glucuronate + imipramine
UDP + imipramine beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + imipramine
UDP + imipramine beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + imipramine
UDP + imipramine N-beta-D-glucuronoside
specific substrate of UGT1A4
-
-
?
UDP-glucuronate + indomethacin
UDP + indomethacin beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + indomethacin
UDP + indomethacin beta-D-glucuronoside
low activity
-
-
?
UDP-glucuronate + indomethacin
UDP + indomethacin beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + indomethacin
UDP + indomethacin beta-D-glucuronoside
very low activity
-
-
?
UDP-glucuronate + indomethacin
UDP + indomethacin beta-D-glucuronoside
low activity
-
-
?
UDP-glucuronate + indomethacin
UDP + indomethacin beta-D-glucuronoside
high activity
-
-
?
UDP-glucuronate + ketoprofen
UDP + beta-D-glucuronosyl-ketoprofen
-
low activity
-
?
UDP-glucuronate + L-thyroxine
UDP + L-thyroxyl beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + L-thyroxine
UDP + L-thyroxyl beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
UGT1A1 and UGT1A3 are the major UGTs glucuronidating T4 at the hydroxyl and carboxyl groups, respectively
-
-
?
UDP-glucuronate + levofloxacin
UDP + levofloxacin beta-D-glucuronide
high activity with isozyme UGT1A1
-
-
?
UDP-glucuronate + levofloxacin
UDP + levofloxacin beta-D-glucuronide
high activity with isozyme UGT1A3
-
-
?
UDP-glucuronate + levofloxacin
UDP + levofloxacin beta-D-glucuronide
high activity with isozyme UGT1A7
-
-
?
UDP-glucuronate + levofloxacin
UDP + levofloxacin beta-D-glucuronide
high activity with isozyme UGT1A9
-
-
?
UDP-glucuronate + levomedetomidine
UDP + levomedetomidine beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + levomedetomidine
UDP + levomedetomidine beta-D-glucuronoside
low activity
-
-
?
UDP-glucuronate + morphine
UDP + morphine 3-beta-D-glucuronoside
-
-
-
-
?
UDP-glucuronate + morphine
UDP + morphine 3-beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + morphine
UDP + morphine 3-beta-D-glucuronoside
morphine-3-glucuronidation is a marker of conjugation by human UGT2B7
-
-
?
UDP-glucuronate + morphine
UDP + morphine 3-beta-D-glucuronoside
-
-
-
-
?
UDP-glucuronate + morphine
UDP + morphine-3-beta-D-glucuronide
regioselectivity of activity is altered by cytochrome P450 enzyme CYP3A4 so that the ratio of morphine activation/detoxification is increased
-
-
?
UDP-glucuronate + morphine
UDP + morphine-3-beta-D-glucuronide
-
isozyme UGT1A1
-
-
?
UDP-glucuronate + morphine
UDP + morphine-3-beta-D-glucuronide
-
isozyme UGT2B7, low activity with isozymes UGT1A3, UGT1A10, UGT2B4 and UGT1A9
-
-
?
UDP-glucuronate + morphine
UDP + morphine-3-beta-D-glucuronide
-
isozymes UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT1A10, and UGT2B7
-
-
?
UDP-glucuronate + morphine
UDP + morphine-3-beta-D-glucuronide
regioselective
-
-
?
UDP-glucuronate + morphine
UDP + morphine-6-beta-D-glucuronide
-
isozyme UGT1A1
-
-
?
UDP-glucuronate + morphine
UDP + morphine-6-beta-D-glucuronide
-
isozyme UGT2B7
-
-
?
UDP-glucuronate + morphine
UDP + morphine-6-beta-D-glucuronide
-
isozymes UGT2B4 and UGT2B7, low activity with isozymes UGT1A1, and UGT1A3
-
-
?
UDP-glucuronate + morphine 3-glucuronide
UDP + morphine 3,6-diglucuronide
-
-
-
?
UDP-glucuronate + morphine 3-glucuronide
UDP + morphine 3,6-diglucuronide
-
-
-
-
?
UDP-glucuronate + moxifloxacin
UDP + moxifloxacin beta-D-glucuronide
high activity with isozyme UGT1A1
-
-
?
UDP-glucuronate + moxifloxacin
UDP + moxifloxacin beta-D-glucuronide
low activity with isozyme UGT1A7
-
-
?
UDP-glucuronate + moxifloxacin
UDP + moxifloxacin beta-D-glucuronide
low activity with isozyme UGT1A9
-
-
?
UDP-glucuronate + moxifloxacin
UDP + moxifloxacin beta-D-glucuronide
very low activity with isozyme UGT1A3
-
-
?
UDP-glucuronate + mycophenolic acid
UDP + mycophenolic acid-acyl-glucuronide
-
mycophenolic acid is the active metabolite of immunosuppressant mycophenolate mofetil
-
-
?
UDP-glucuronate + mycophenolic acid
UDP + mycophenolic acid-acyl-glucuronide
-
isozymes UGT1A9 and UGT2B7
-
-
?
UDP-glucuronate + mycophenolic acid
UDP + mycophenolic acid-phenyl-glucuronide
-
mycophenolic acid is the active metabolite of immunosuppressant mycophenolate mofetil
-
-
?
UDP-glucuronate + mycophenolic acid
UDP + mycophenolic acid-phenyl-glucuronide
-
isozymes UGT1A9 and UGT2B7
-
-
?
UDP-glucuronate + naproxen
?
-
-
-
?
UDP-glucuronate + naproxen
?
UGT2B7 is responsible for human hepatic naproxen acyl glucuronidation, which is the primary elimination pathway for this drug
-
-
?
UDP-glucuronate + naringenin
UDP + naringenin beta-D-glucuronide
isozyme UGT1A1
-
-
?
UDP-glucuronate + naringenin
UDP + naringenin beta-D-glucuronide
isozyme UGT1A7
-
-
?
UDP-glucuronate + naringenin
UDP + naringenin beta-D-glucuronide
isozymes UGT1A1, UGT1A7, and UGT1A10
-
-
?
UDP-glucuronate + olanzapine
UDP + olanzapine beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + olanzapine
UDP + olanzapine beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + phloretin
UDP + phloretin beta-D-glucuronide
isozyme UGT1A7
-
-
?
UDP-glucuronate + phloretin
UDP + phloretin beta-D-glucuronide
isozyme UGT1A8
-
-
?
UDP-glucuronate + phloretin
UDP + phloretin beta-D-glucuronide
isozymes UGT1A7, UGT1A8, and UGT1A10
-
-
?
UDP-glucuronate + propofol
UDP + propofol beta-D-glucuronide
-
-
-
?
UDP-glucuronate + propofol
UDP + propofol beta-D-glucuronide
-
isozyme UGT1A9
-
-
?
UDP-glucuronate + propofol
UDP + propofol beta-D-glucuronoside
-
-
-
-
?
UDP-glucuronate + propofol
UDP + propofol beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + propofol
UDP + propofol beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + propofol
UDP + propofol beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + propofol
UDP + propofol beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + quercetin
UDP + quercetin beta-D-glucuronide
isozyme UGT1A1
-
-
?
UDP-glucuronate + quercetin
UDP + quercetin beta-D-glucuronide
isozyme UGT1A7
-
-
?
UDP-glucuronate + quercetin
UDP + quercetin beta-D-glucuronide
isozymes UGT1A1, UGT1A7, and UGT1A10
-
-
?
UDP-glucuronate + quinazarin
UDP + quinazarin beta-D-glucuronide
isozyme UGT1A1
-
-
?
UDP-glucuronate + quinazarin
UDP + quinazarin beta-D-glucuronide
isozyme UGT1A7
-
-
?
UDP-glucuronate + quinazarin
UDP + quinazarin beta-D-glucuronide
isozymes UGT1A1, UGT1A7, and UGT1A10
-
-
?
UDP-glucuronate + serotonin
UDP + serotonin beta-D-glucuronide
in vitro substrate, isozyme UGT1A6
-
-
?
UDP-glucuronate + serotonin
UDP + serotonin beta-D-glucuronoside
-
-
-
-
?
UDP-glucuronate + serotonin
UDP + serotonin beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + serotonin
UDP + serotonin beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
mucosal serotonin and its metabolite 5-hydroxytryptophol are solely conjugated by UGT1A6
-
-
?
UDP-glucuronate + serotonin
UDP + serotonin beta-D-glucuronoside
-
-
-
-
?
UDP-glucuronate + sitafloxacin
UDP + sitafloxacin beta-D-glucuronide
high activity with isozyme UGT1A1
-
-
?
UDP-glucuronate + sitafloxacin
UDP + sitafloxacin beta-D-glucuronide
high activity with isozyme UGT1A9
-
-
?
UDP-glucuronate + sitafloxacin
UDP + sitafloxacin beta-D-glucuronide
low activity with isozyme UGT1A3
-
-
?
UDP-glucuronate + sitafloxacin
UDP + sitafloxacin beta-D-glucuronide
low activity with isozyme UGT1A7
-
-
?
UDP-glucuronate + tamoxifen
UDP + tamoxifen beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + tamoxifen
UDP + tamoxifen beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + testosterone
UDP + testosterone beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + testosterone
UDP + testosterone beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + testosterone
UDP + testosterone beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + thymol
UDP + thymol beta-D-glucuronide
isozyme UGT1A7
-
-
?
UDP-glucuronate + thymol
UDP + thymol beta-D-glucuronide
isozymes UGT1A7, and UGT1A10
-
-
?
UDP-glucuronate + umbelliferone
UDP + umbelliferone beta-D-glucuronide
-
-
-
?
UDP-glucuronate + umbelliferone
UDP + umbelliferone beta-D-glucuronide
-
-
-
?
UDP-glucuronate + zidovudine
UDP + zidovudine beta-D-glucuronoside
O60656, O75310, O75795, P06133, P16662, P19224, P22309, P22310, P35503, P35504, P36537, P54855, Q6UWM9, Q9BY64, Q9HAW7, Q9HAW8, Q9HAW9, Q9Y4X1
-
-
-
?
UDP-glucuronate + zidovudine
UDP + zidovudine beta-D-glucuronoside
-
-
-
?
UDP-glucuronate + zidovudine
UDP + zidovudine beta-D-glucuronoside
-
-
-
?
UDP-glucuronic acid + bilirubin
UDP + bilirubin-glucuronoside
-
UGT1A1
-
-
?
UDP-glucuronic acid + bilirubin
UDP + bilirubin-glucuronoside
-
-
-
?
ursodeoxycholic acid + UDPglucuronate
UDP + ursodeoxycholic acid O-glucuronide
-
-
-
?
ursodeoxycholic acid + UDPglucuronate
UDP + ursodeoxycholic acid O-glucuronide
-
highest activity among five bile acids studied
-
?
xanthotoxol + UDP-glucuronate
UDP + xanthotoxol 8-O-glucuronide
-
-
-
?
xanthotoxol + UDP-glucuronate
UDP + xanthotoxol 8-O-glucuronide
isoform UGT1A1 is mainly responsible for xanthotoxol glucuronidation in the human liver
-
-
?
xanthotoxol + UDP-glucuronate
UDP + xanthotoxol 8-O-glucuronide
isoform UGT1A10 is mainly responsible for xanthotoxol glucuronidation in the human small intestine
-
-
?
xanthotoxol + UDP-glucuronate
UDP + xanthotoxol 8-O-glucuronide
isoform UGT2B7 is mainly responsible for xanthotoxol glucuronidation in the human liver
-
-
?
additional information
?
-
enzyme UGT2B31 plays a crucial role in drug detoxificiation
-
-
?
additional information
?
-
-
enzyme UGT2B31 plays a crucial role in drug detoxificiation
-
-
?
additional information
?
-
substrate specificity, no substrates are hyodeoxycholic acid, lithocholic acid, diclofenac, furosemide, ibuprofen, valproic acid, codeine, hydromorphone, morphine 6-glucuronide, propofol, ethinylestradiol, and testosterone
-
-
?
additional information
?
-
-
substrate specificity, no substrates are hyodeoxycholic acid, lithocholic acid, diclofenac, furosemide, ibuprofen, valproic acid, codeine, hydromorphone, morphine 6-glucuronide, propofol, ethinylestradiol, and testosterone
-
-
?
additional information
?
-
-
no activity with bilirubin, dexmedetomidine, levomedetomidine, and S-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, dexmedetomidine, levomedetomidine, and S-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
-
no or poor activity with 4-methylumbelliferone, dexmedetomidine, levomedetomidine, and S-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with 4-methylumbelliferone, dexmedetomidine, levomedetomidine, and S-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
-
no or poor activity with bilirubin, ethinylestradiol, 17-alpha-estradiol, 17-beta-estradiol, levomedetomidine, dexmedetomidine, diclofenac, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with bilirubin, ethinylestradiol, 17-alpha-estradiol, 17-beta-estradiol, levomedetomidine, dexmedetomidine, diclofenac, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
-
no or poor activity with bilirubin, levomedetomidine, dexmedetomidine, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with bilirubin, levomedetomidine, dexmedetomidine, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
-
no or poor activity with bilirubin, levomedetomidine, dexmedetomidine, and (R)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with bilirubin, levomedetomidine, dexmedetomidine, and (R)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
-
no or poor activity with bilirubin, levomedetomidine, dexmedetomidine, indomethacin, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with bilirubin, levomedetomidine, dexmedetomidine, indomethacin, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
-
no or poor activity with bilirubin,levomedetomidine, dexmedetomidine, diclofenac, 4-methylumbelliferone, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with bilirubin,levomedetomidine, dexmedetomidine, diclofenac, 4-methylumbelliferone, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
-
no or poor activity with levomedetomidine, 4-methylumbelliferone, dexmedetomidine, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with levomedetomidine, 4-methylumbelliferone, dexmedetomidine, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
-
36 substrates for HGT2B7H and HGT2B7Y. HGT2B7 glucuronidates both hydroxyl and carboxyl functions of bile acids, retinols and hydroxylated fatty acids
-
-
?
additional information
?
-
-
36 substrates for HGT2B7H and HGT2B7Y. HGT2B7 glucuronidates both hydroxyl and carboxyl functions of bile acids, retinols and hydroxylated fatty acids
-
-
?
additional information
?
-
-
36 substrates for HGT2B7H and HGT2B7Y. HGT2B7 glucuronidates both hydroxyl and carboxyl functions of bile acids, retinols and hydroxylated fatty acids
-
-
?
additional information
?
-
-
36 substrates for HGT2B7H and HGT2B7Y. HGT2B7 glucuronidates both hydroxyl and carboxyl functions of bile acids, retinols and hydroxylated fatty acids
-
-
?
additional information
?
-
-
36 substrates for HGT2B7H and HGT2B7Y. HGT2B7 glucuronidates both hydroxyl and carboxyl functions of bile acids, retinols and hydroxylated fatty acids
-
-
?
additional information
?
-
-
36 substrates for HGT2B7H and HGT2B7Y. HGT2B7 glucuronidates both hydroxyl and carboxyl functions of bile acids, retinols and hydroxylated fatty acids
-
-
?
additional information
?
-
-
36 substrates for HGT2B7H and HGT2B7Y. HGT2B7 glucuronidates both hydroxyl and carboxyl functions of bile acids, retinols and hydroxylated fatty acids
-
-
?
additional information
?
-
-
simple planar phenols, anthraquinones and opioid compounds glucuronidated by UGT1.1, aliphatic and monoterpenoid alcohols and amines not glucuronidated
-
-
?
additional information
?
-
-
UGT1A3 inactive towards 4-hydroxyestrone and 16 alpha-hydroxyestrone
-
-
?
additional information
?
-
-
no activity with androsterone, 5alpha-androstane-3alpha,17beta-diol
-
-
?
additional information
?
-
-
affinity of unconjugated bile acids decrease with increasing number of hydroxyl groups in the bile acid skeleton
-
-
?
additional information
?
-
substrate specificity of isozymes, overview
-
-
?
additional information
?
-
substrate specificity of isozymes, overview
-
-
?
additional information
?
-
substrate specificity of isozymes, overview
-
-
?
additional information
?
-
substrate specificity of isozymes, overview
-
-
?
additional information
?
-
substrate specificity of isozymes, overview
-
-
?
additional information
?
-
wide variety of endogenous steroidal hormones, bile acids, retinoids and tyroid hormones glucuronidated by isozymes of UGT1A family
-
-
?
additional information
?
-
-
elimination of lipid-soluble endogenous compounds and xenobiotics
-
-
?
additional information
?
-
-
elimination of lipid-soluble endogenous compounds and xenobiotics
-
-
?
additional information
?
-
-
elimination of lipid-soluble endogenous compounds and xenobiotics
-
-
?
additional information
?
-
steroid hormones, bile acids, all trans retinoic acids and fatty acids glucuronidated by isozymes of UGTB2 family
-
-
?
additional information
?
-
-
certain endogenous estrogens glucuronidated by UGT1.1 at 3-hydroxyl group of the A ring of steroids
-
-
?
additional information
?
-
-
enzyme are involved in biosynthesis of HNK-1 carbohydrate
-
-
?
additional information
?
-
-
enzyme UGT2B7 plays a crucial role in drug detoxificiation
-
-
?
additional information
?
-
-
isozyme UGT2B7 is involved in glucuronidation of a wide array of clinically important drugs and endogenous compounds in humans
-
-
?
additional information
?
-
isozyme UGT2B7 is involved in metabolism of mineralocorticoid and glucocorticoid hormones, two-cell mechanism of aldosterone action and metabolism in the kidney
-
-
?
additional information
?
-
-
isozyme UGT2B7 is involved in metabolism of mineralocorticoid and glucocorticoid hormones, two-cell mechanism of aldosterone action and metabolism in the kidney
-
-
?
additional information
?
-
-
isozyme UGT2B7 is the major isozyme involved in metabolization of morphine in the liver
-
-
?
additional information
?
-
isozymes are involved in detoxification of metabolites, drugs, toxins, and environmental chemicals via conjugation to glucuronic acid, physiological roles and overlapping activities
-
-
?
additional information
?
-
isozymes are involved in detoxification of metabolites, drugs, toxins, and environmental chemicals via conjugation to glucuronic acid, physiological roles and overlapping activities
-
-
?
additional information
?
-
isozymes are involved in detoxification of metabolites, drugs, toxins, and environmental chemicals via conjugation to glucuronic acid, physiological roles and overlapping activities
-
-
?
additional information
?
-
isozymes are involved in detoxification of metabolites, drugs, toxins, and environmental chemicals via conjugation to glucuronic acid, physiological roles and overlapping activities
-
-
?
additional information
?
-
-
isozymes are involved in detoxification of metabolites, drugs, toxins, and environmental chemicals via conjugation to glucuronic acid, physiological roles and overlapping activities
-
-
?
additional information
?
-
-
isozymes facilitate the excretion of estrogens to glucuronides, the most abundant estrogen conjugates
-
-
?
additional information
?
-
the enzyme is involved acyl glucuronidation, an important metabolic pathway for fluoroquinolone antobiotics
-
-
?
additional information
?
-
the enzyme is involved acyl glucuronidation, an important metabolic pathway for fluoroquinolone antobiotics
-
-
?
additional information
?
-
the enzyme is involved acyl glucuronidation, an important metabolic pathway for fluoroquinolone antobiotics
-
-
?
additional information
?
-
the enzyme is involved acyl glucuronidation, an important metabolic pathway for fluoroquinolone antobiotics
-
-
?
additional information
?
-
-
the enzyme is involved acyl glucuronidation, an important metabolic pathway for fluoroquinolone antobiotics
-
-
?
additional information
?
-
in contrast to isozymes UGT1A1 and UGT1A7, the isozyme UGT1A9 does not show polymorphism influencing the glucuronidation activity of SN-38
-
-
?
additional information
?
-
-
in contrast to isozymes UGT1A1 and UGT1A7, the isozyme UGT1A9 does not show polymorphism influencing the glucuronidation activity of SN-38
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?
additional information
?
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-
substrate specificities of different isozymes
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?
additional information
?
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substrate specificities of isozymes, overview
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?
additional information
?
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substrate specificities of isozymes, overview
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?
additional information
?
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substrate specificities of isozymes, overview
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?
additional information
?
-
substrate specificities of isozymes, overview
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?
additional information
?
-
-
substrate specificities of isozymes, overview
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?
additional information
?
-
substrate specificities of wild-type and recombinant soluble mutant isozyme UGT1A9
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?
additional information
?
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substrate specificities of wild-type and recombinant soluble mutant isozyme UGT1A9
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?
additional information
?
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-
substrate specificity, no substrates are lorazepam, lithocholic acid, furosemide, propofol, ethinylestradiol, and testosterone
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?
additional information
?
-
substrate specificty of isozymes of the 1A subfamily
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?
additional information
?
-
substrate specificty of isozymes of the 1A subfamily
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?
additional information
?
-
substrate specificty of isozymes of the 1A subfamily
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?
additional information
?
-
substrate specificty of isozymes of the 1A subfamily
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?
additional information
?
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-
substrate specificty of isozymes of the 1A subfamily
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?
additional information
?
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-
the recombinant GlcAT-P is highly specific for terminal type II structure, Galbeta1-4GlcNAc, while the recombinant GlcAT-S recognizes type I, Galbeta1-3GlcNAc, and type II structures
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?
additional information
?
-
-
the UGT2B7*2 polymorphism is not a determinant of glucuronodation specificity, substrate specificity by isozyme UGT2B7, overview
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?
additional information
?
-
UGT2B7 interacts with CYP3A4, the latter reduces UGT2B7 activity in detergent n-octylglucoside treated recombinant COS-cell microsomes
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?
additional information
?
-
-
UGT2B7 interacts with CYP3A4, the latter reduces UGT2B7 activity in detergent n-octylglucoside treated recombinant COS-cell microsomes
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?
additional information
?
-
-
direct inhibition of UGT1A1-mediated bilirubin glucuronidation may provide a mechanism for the reversible hyperbilirubinemia associated with administration of atazanavir as well as indinavir
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?
additional information
?
-
-
glucuronidation by the UDP glucuronosyltransferase 1A enzymes is a major pathway for elimination of drugs and endogenous substances, such as bilirubin
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?
additional information
?
-
-
general chemical properties, such as chemical size, shape, flexibility, and hydrophobicity, may be of secondary importance to the steric and electronic character immediately local to the nucleophilic atom. Molecular recognition based on the local structure is likely to be important for the ability of UGT to detoxify chemicals that differ greatly in gross molecular structure
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?
additional information
?
-
no glucuronidation of 4-aminobiphenyl, a good substrate for the highly homologous enzymes UGT1A4 and UGT1A3
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?
additional information
?
-
-
no glucuronidation of 4-aminobiphenyl, a good substrate for the highly homologous enzymes UGT1A4 and UGT1A3
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-
?
additional information
?
-
isozyme UGT2B15 is a critical enzyme for the local inactivation of androgens and major determinants of the androgen response in prostate cancer LNCaP cells, overview
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?
additional information
?
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isozyme UGT2B15 is a critical enzyme for the local inactivation of androgens and major determinants of the androgen response in prostate cancer LNCaP cells, overview
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-
?
additional information
?
-
-
isozyme UGT2B15 is a critical enzyme for the local inactivation of androgens and major determinants of the androgen response in prostate cancer LNCaP cells, overview
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?
additional information
?
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isozyme UGT2B17 is a critical enzyme for the local inactivation of androgens and major determinants of the androgen response in prostate cancer LNCaP cells, overview
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-
?
additional information
?
-
isozyme UGT2B17 is a critical enzyme for the local inactivation of androgens and major determinants of the androgen response in prostate cancer LNCaP cells, overview
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?
additional information
?
-
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isozyme UGT2B17 is a critical enzyme for the local inactivation of androgens and major determinants of the androgen response in prostate cancer LNCaP cells, overview
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-
?
additional information
?
-
regulation of isozyme UGT1A1 by progesterone and its impact on labetalol elimination, overview
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-
?
additional information
?
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regulation of isozyme UGT1A1 by progesterone and its impact on labetalol elimination, overview
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-
?
additional information
?
-
regulation of isozyme UGT1A1 by progesterone and its impact on labetalol elimination, overview
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?
additional information
?
-
regulation of isozyme UGT1A1 by progesterone and its impact on labetalol elimination, overview
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-
?
additional information
?
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regulation of isozyme UGT1A1 by progesterone and its impact on labetalol elimination, overview
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-
?
additional information
?
-
regulation of isozyme UGT1A1 by progesterone and its impact on labetalol elimination, overview
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-
?
additional information
?
-
-
regulation of isozyme UGT1A1 by progesterone and its impact on labetalol elimination, overview
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-
?
additional information
?
-
the enzyme is involved in clearance and detoxification of many chemical compounds, overview
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?
additional information
?
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-
The phenolic glucuronidation of the curcuminoids is predominantly catalyzed by hepatic isozyme UGT1A1 and intestinal isozymes UGT1A8 and UGT1A10, whereas isozymes UGT1A9, UGT2B7, and UGT1A8 exhibit high activities for hexahydro-curcuminoids, substrate specificities of recombinant isozymes in insect cell microsomes, overview
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?
additional information
?
-
-
the role of UGT enzymes in the liver is recognized as a highly efficient and constitutive mechanism of detoxification of endogenous and exogenous compounds, particularly for steroid hormones, metabolism of adrenal and testicular steroid hormones, overview
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?
additional information
?
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the role of UGT enzymes in the liver is recognized as a highly efficient and constitutive mechanism of detoxification of endogenous and exogenous compounds, particularly for steroid hormones, metabolism of adrenal and testicular steroid hormones, overview
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?
additional information
?
-
the role of UGT enzymes in the liver is recognized as a highly efficient and constitutive mechanism of detoxification of endogenous and exogenous compounds, particularly for steroid hormones, metabolism of adrenal and testicular steroid hormones, overview
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-
?
additional information
?
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the UGT1A family of proteins forms oligomerized complexes in the membrane, a property that may influence function and substrate selectivity
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?
additional information
?
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the UGT1A family of proteins forms oligomerized complexes in the membrane, a property that may influence function and substrate selectivity
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-
?
additional information
?
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the UGT1A family of proteins forms oligomerized complexes in the membrane, a property that may influence function and substrate selectivity
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-
?
additional information
?
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the UGT1A family of proteins forms oligomerized complexes in the membrane, a property that may influence function and substrate selectivity
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-
?
additional information
?
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the UGT1A family of proteins forms oligomerized complexes in the membrane, a property that may influence function and substrate selectivity
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-
?
additional information
?
-
the UGT1A family of proteins forms oligomerized complexes in the membrane, a property that may influence function and substrate selectivity
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-
?
additional information
?
-
the UGT1A family of proteins forms oligomerized complexes in the membrane, a property that may influence function and substrate selectivity
-
-
?
additional information
?
-
the UGT1A family of proteins forms oligomerized complexes in the membrane, a property that may influence function and substrate selectivity
-
-
?
additional information
?
-
UGTs play an important role in the defense against potentially hazardous xenobiotics, and they participate in the metabolism and homeostasis of many endogenous compounds, including bilirubin and steroid hormones, overview
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-
?
additional information
?
-
UGTs play an important role in the defense against potentially hazardous xenobiotics, and they participate in the metabolism and homeostasis of many endogenous compounds, including bilirubin and steroid hormones, overview
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-
?
additional information
?
-
UGTs play an important role in the defense against potentially hazardous xenobiotics, and they participate in the metabolism and homeostasis of many endogenous compounds, including bilirubin and steroid hormones, overview
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-
?
additional information
?
-
UGTs play an important role in the defense against potentially hazardous xenobiotics, and they participate in the metabolism and homeostasis of many endogenous compounds, including bilirubin and steroid hormones, overview
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-
?
additional information
?
-
-
detailed structure-activity relationships with respect to functionality, stereochemical properties, and steric features, with 3D-quantitative structure-activity relationship using comparative molecular similarity analysis, overview. The glucuronidation of substrate compounds is prevented by the introduction of bulky substituents such as isopropyl, tert-butyl, and phenyl groups, overview
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-
?
additional information
?
-
determination of UDP-glucuronate binding sites in isozymes UGT1A10 and UGT1A7 using inhibitor binding and peptide mapping, overview
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-
?
additional information
?
-
inhibitor beta-phenyllongifolol is not glucuronidated by UGT2B7 or other hepatic UGTs
-
-
?
additional information
?
-
-
inhibitor beta-phenyllongifolol is not glucuronidated by UGT2B7 or other hepatic UGTs
-
-
?
additional information
?
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isozyme UGT1A10 exhibits high overall glucuronidating activities compared to other UGT isozymes
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-
?
additional information
?
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isozyme UGT1A10 exhibits high overall glucuronidating activities compared to other UGT isozymes
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-
?
additional information
?
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isozyme UGT1A10 exhibits high overall glucuronidating activities compared to other UGT isozymes
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-
?
additional information
?
-
isozyme UGT1A10 exhibits high overall glucuronidating activities compared to other UGT isozymes
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-
?
additional information
?
-
isozyme UGT1A10 exhibits high overall glucuronidating activities compared to other UGT isozymes
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-
?
additional information
?
-
isozyme UGT1A10 exhibits high overall glucuronidating activities compared to other UGT isozymes
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-
?
additional information
?
-
isozyme UGT1A10 exhibits high overall glucuronidating activities compared to other UGT isozymes
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-
?
additional information
?
-
-
isozyme UGT1A10 exhibits high overall glucuronidating activities compared to other UGT isozymes
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-
?
additional information
?
-
isozyme UGT1A8 exhibits high overall glucuronidating activities compared to other UGT isozymes
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-
?
additional information
?
-
isozyme UGT1A8 exhibits high overall glucuronidating activities compared to other UGT isozymes
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-
?
additional information
?
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isozyme UGT1A8 exhibits high overall glucuronidating activities compared to other UGT isozymes
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-
?
additional information
?
-
isozyme UGT1A8 exhibits high overall glucuronidating activities compared to other UGT isozymes
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-
?
additional information
?
-
isozyme UGT1A8 exhibits high overall glucuronidating activities compared to other UGT isozymes
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-
?
additional information
?
-
isozyme UGT1A8 exhibits high overall glucuronidating activities compared to other UGT isozymes
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-
?
additional information
?
-
isozyme UGT1A8 exhibits high overall glucuronidating activities compared to other UGT isozymes
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-
?
additional information
?
-
-
isozyme UGT1A8 exhibits high overall glucuronidating activities compared to other UGT isozymes
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-
?
additional information
?
-
isozyme UGT2B7 exhibits high overall glucuronidating activities compared to other UGT isozymes
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-
?
additional information
?
-
isozyme UGT2B7 exhibits high overall glucuronidating activities compared to other UGT isozymes
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-
?
additional information
?
-
isozyme UGT2B7 exhibits high overall glucuronidating activities compared to other UGT isozymes
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-
?
additional information
?
-
isozyme UGT2B7 exhibits high overall glucuronidating activities compared to other UGT isozymes
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?
additional information
?
-
isozyme UGT2B7 exhibits high overall glucuronidating activities compared to other UGT isozymes
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-
?
additional information
?
-
isozyme UGT2B7 exhibits high overall glucuronidating activities compared to other UGT isozymes
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-
?
additional information
?
-
isozyme UGT2B7 exhibits high overall glucuronidating activities compared to other UGT isozymes
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-
?
additional information
?
-
-
isozyme UGT2B7 exhibits high overall glucuronidating activities compared to other UGT isozymes
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-
?
additional information
?
-
isozymes UGT1A10, UGT1A8, and UGT2B7 exhibit the highest overall glucuronidating activities of the UGT isozymes
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-
?
additional information
?
-
isozymes UGT1A10, UGT1A8, and UGT2B7 exhibit the highest overall glucuronidating activities of the UGT isozymes
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-
?
additional information
?
-
isozymes UGT1A10, UGT1A8, and UGT2B7 exhibit the highest overall glucuronidating activities of the UGT isozymes
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-
?
additional information
?
-
isozymes UGT1A10, UGT1A8, and UGT2B7 exhibit the highest overall glucuronidating activities of the UGT isozymes
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-
?
additional information
?
-
isozymes UGT1A10, UGT1A8, and UGT2B7 exhibit the highest overall glucuronidating activities of the UGT isozymes
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-
?
additional information
?
-
isozymes UGT1A10, UGT1A8, and UGT2B7 exhibit the highest overall glucuronidating activities of the UGT isozymes
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-
?
additional information
?
-
isozymes UGT1A10, UGT1A8, and UGT2B7 exhibit the highest overall glucuronidating activities of the UGT isozymes
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-
?
additional information
?
-
-
isozymes UGT1A10, UGT1A8, and UGT2B7 exhibit the highest overall glucuronidating activities of the UGT isozymes
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-
?
additional information
?
-
-
key amino acid residues responsible for the differences in substrate specificity of isozymes UGT1A9 and UGT1A8, overview
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-
?
additional information
?
-
key amino acid residues responsible for the differences in substrate specificity of isozymes UGT1A9 and UGT1A8, overview
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-
?
additional information
?
-
key amino acid residues responsible for the differences in substrate specificity of isozymes UGT1A9 and UGT1A8, overview
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-
?
additional information
?
-
key amino acid residues responsible for the differences in substrate specificity of isozymes UGT1A9 and UGT1A8, overview
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-
?
additional information
?
-
key amino acid residues responsible for the differences in substrate specificity of isozymes UGT1A9 and UGT1A8, overview
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-
?
additional information
?
-
kinetic modeling of the interactions between 4-methylumbelliferone, 1-naphthol, and zidovudine glucuronidation by UGT2B7 provides evidence for multiple substrate binding and effector sites, overview
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-
?
additional information
?
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no activity by isozyme UGT2B15 with trans-4-hydroxytamoxifen
-
-
?
additional information
?
-
no activity by isozyme UGT2B15 with trans-4-hydroxytamoxifen
-
-
?
additional information
?
-
no activity by isozyme UGT2B15 with trans-4-hydroxytamoxifen
-
-
?
additional information
?
-
no activity by isozyme UGT2B15 with trans-4-hydroxytamoxifen
-
-
?
additional information
?
-
no activity by isozyme UGT2B15 with trans-4-hydroxytamoxifen
-
-
?
additional information
?
-
no activity by isozyme UGT2B15 with trans-4-hydroxytamoxifen
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-
?
additional information
?
-
no activity by isozyme UGT2B15 with trans-4-hydroxytamoxifen
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-
?
additional information
?
-
-
no activity by isozyme UGT2B15 with trans-4-hydroxytamoxifen
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-
?
additional information
?
-
no activity of UGT2A3 with 4-nitrophenol, 4-methylumbelliferone, or any other small phenolic substrate
-
-
?
additional information
?
-
-
no activity of UGT2A3 with 4-nitrophenol, 4-methylumbelliferone, or any other small phenolic substrate
-
-
?
additional information
?
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prediction of substrates for several isozymes by two dimensional-QSAR modelling, regioselective glucuronidation of isozymes, overview, substrate recognition, and multiple pharmacophore perception, overview
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-
?
additional information
?
-
-
regioselectivity of recombinant isozymes and liver microsomes, overview
-
-
?
additional information
?
-
regioselectivity of recombinant isozymes and liver microsomes, overview
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-
?
additional information
?
-
-
regiospecific glucuronidation of sartans by different isozymes, overview
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-
?
additional information
?
-
-
specific phospho-groups in UGT1A7 determine substrate selections, suggests regulated phosphorylation allows adaptations regarding differential phosphate utilization by UGTs to function efficiently
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-
?
additional information
?
-
substrate concentration-rate profiles of 25-O-glucuronide formation by UGT1A4, UGT2B4, and UGT2B7, overview
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-
?
additional information
?
-
-
substrate concentration-rate profiles of 25-O-glucuronide formation by UGT1A4, UGT2B4, and UGT2B7, overview
-
-
?
additional information
?
-
substrate specificity of isozyme UGT2B15, overview
-
-
?
additional information
?
-
substrate specificity of isozyme UGT2B15, overview
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-
?
additional information
?
-
-
substrate specificity of isozyme UGT2B15, overview
-
-
?
additional information
?
-
substrate specificity of isozyme UGT2B7, overview
-
-
?
additional information
?
-
substrate specificity of isozyme UGT2B7, overview
-
-
?
additional information
?
-
-
substrate specificity of isozyme UGT2B7, overview
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-
?
additional information
?
-
-
substrate specificity of UGT isozymes with morphine, overview, no or poor activity with isozymes UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A9, UGT1A10, UGT2B15, and UGT2B17
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-
?
additional information
?
-
substrate specificity of UGT isozymes with morphine, overview, no or poor activity with isozymes UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A9, UGT1A10, UGT2B15, and UGT2B17
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-
?
additional information
?
-
-
substrate specificity, UGT1A1 does not show activity with with (R)- and (S)-warfarin, racemic warfarin, or 10-hydroxywarfarin, overview
-
-
?
additional information
?
-
substrate specificity, UGT1A1 does not show activity with with (R)- and (S)-warfarin, racemic warfarin, or 10-hydroxywarfarin, overview
-
-
?
additional information
?
-
substrate specificity, UGT1A1 does not show activity with with (R)- and (S)-warfarin, racemic warfarin, or 10-hydroxywarfarin, overview
-
-
?
additional information
?
-
substrate specificity, UGT1A1 does not show activity with with (R)- and (S)-warfarin, racemic warfarin, or 10-hydroxywarfarin, overview
-
-
?
additional information
?
-
-
substrate specificity, UGT1A10 does not show activity with with (R)- and (S)-warfarin, racemic warfarin, or 10-hydroxywarfarin, overview
-
-
?
additional information
?
-
substrate specificity, UGT1A10 does not show activity with with (R)- and (S)-warfarin, racemic warfarin, or 10-hydroxywarfarin, overview
-
-
?
additional information
?
-
substrate specificity, UGT1A10 does not show activity with with (R)- and (S)-warfarin, racemic warfarin, or 10-hydroxywarfarin, overview
-
-
?
additional information
?
-
substrate specificity, UGT1A10 does not show activity with with (R)- and (S)-warfarin, racemic warfarin, or 10-hydroxywarfarin, overview
-
-
?
additional information
?
-
-
substrate specificity, UGT1A8, UGT1A4, UGT1A6, UGT1A7, and UGT2B7 do not show activity with with (R)- and (S)-warfarin, racemic warfarin, or 10-hydroxywarfarin, overview
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-
?
additional information
?
-
substrate specificity, UGT1A8, UGT1A4, UGT1A6, UGT1A7, and UGT2B7 do not show activity with with (R)- and (S)-warfarin, racemic warfarin, or 10-hydroxywarfarin, overview
-
-
?
additional information
?
-
substrate specificity, UGT1A8, UGT1A4, UGT1A6, UGT1A7, and UGT2B7 do not show activity with with (R)- and (S)-warfarin, racemic warfarin, or 10-hydroxywarfarin, overview
-
-
?
additional information
?
-
substrate specificity, UGT1A8, UGT1A4, UGT1A6, UGT1A7, and UGT2B7 do not show activity with with (R)- and (S)-warfarin, racemic warfarin, or 10-hydroxywarfarin, overview
-
-
?
additional information
?
-
-
substrate specificity, UGT1A9 does not show activity with with (R)- and (S)-warfarin, racemic warfarin, or 10-hydroxywarfarin, overview
-
-
?
additional information
?
-
substrate specificity, UGT1A9 does not show activity with with (R)- and (S)-warfarin, racemic warfarin, or 10-hydroxywarfarin, overview
-
-
?
additional information
?
-
substrate specificity, UGT1A9 does not show activity with with (R)- and (S)-warfarin, racemic warfarin, or 10-hydroxywarfarin, overview
-
-
?
additional information
?
-
substrate specificity, UGT1A9 does not show activity with with (R)- and (S)-warfarin, racemic warfarin, or 10-hydroxywarfarin, overview
-
-
?
additional information
?
-
-
ten flavonoid aglycons are used as substrates, spanning the subclasses of flavones, flavonols, and flavanones. The products are characterized by LC-MS and LC-MSn, with post-column cobalt complexation employed to pinpoint the specific sites of conjugation. The dissociation of complexes of the form [Co(II) (flavonoid glucuronide-H) (4,7-diphenyl-1,10-phenanthroline)2]+ allow identification of the products and differentiation of isomers. The correlation between glycosylation site and elution order is used to provide additional structural confirmation. Flavonoids lacking a 3' hydroxyl group are glucuronidated only at position 7, while those containing this functionality also form 3'-O-glucuronides and sometimes 4'-O-glucuronides, thus supporting the conclusion that the presence or absence of the 3'-OH group is the major determinant of the regioselectivity of glucuronidation. Moreover, the specific distribution of multiple glucuronide products, 7-O, 3'-O, 4'-O, is governed by the subclass of flavonoid, structure-activity relationships, overview
-
-
?
additional information
?
-
-
no substrate of isoform UGT1A8: 4-nitrophenol
-
-
?
additional information
?
-
no substrate of isoform UGT1A8: 4-nitrophenol
-
-
?
additional information
?
-
no substrate of isoform UGT1A8: 4-nitrophenol
-
-
?
additional information
?
-
no substrate of isoform UGT1A8: 4-nitrophenol
-
-
?
additional information
?
-
no substrate of isoform UGT1A8: 4-nitrophenol
-
-
?
additional information
?
-
there are no significant differences in the levels of kinetic parameters for 7-hydroxy-4-trifluoromethylcoumarin, estradiol at 3-hydroxy position and 7-ethyl-10-hydroxycamptothecin glucuronidation between humans and cynomolgus monkeys in enzymes from liver microsomes and recombinant isoforms UGT1A1. 7-Hydroxy-4-trifluoromethylcoumarin and estradiol glucuronidation by human liver microsomes exhibits biphasic and sigmoidal kinetics, respectively. 7-Ethyl-10-hydroxycamptothecin glucuronidation by human liver microsomes exhibits autoactivation kinetics
-
-
?
additional information
?
-
-
there are no significant differences in the levels of kinetic parameters for 7-hydroxy-4-trifluoromethylcoumarin, estradiol at 3-hydroxy position and 7-ethyl-10-hydroxycamptothecin glucuronidation between humans and cynomolgus monkeys in enzymes from liver microsomes and recombinant isoforms UGT1A1. 7-Hydroxy-4-trifluoromethylcoumarin and estradiol glucuronidation by human liver microsomes exhibits biphasic and sigmoidal kinetics, respectively. 7-Ethyl-10-hydroxycamptothecin glucuronidation by human liver microsomes exhibits autoactivation kinetics
-
-
?
additional information
?
-
-
isoform UGT2A1 is not active with substrates that form N-glucuronides, such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, nicotine, or N-hydroxy-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
-
-
?
additional information
?
-
-
the orientation of the substrate correlates with the conjugation capacity in in vitro experiments. As glucuronidation is an intermolecular rearrangement reaction, the conjugation reaction proceeds only when the hydroxyl group of the substrate is oriented towards the coenzyme, which allows the proton transfer to occur
-
-
?
additional information
?
-
-
the pattern of human UDP-glucuronosyltransferases of subfamily 2B that glucuronidate ent-17beta-estradiol, particularly 2B15 and 2B17, resembles the glucuronidation of 17alpha-estradiol rather than 17beta-estradiol. The UDP-glucuronosyltransferases of subfamilies 1A and 2A exhibit higher degree of regioselectivity than enantioselectivity in the conjugation of these estradiols, regardless of whether the activity is primarily toward the non-chiral site, 3-OH, or the 17-OH group
-
-
?
additional information
?
-
-
UGT1A4 is the main enzyme involved in the metabolism of all compounds tested except for fluconazole, which is mainly metabolized by UGT2B7, probably mediating its O-glucuronide metabolism. UGT1A3 is also involved in the metabolism of all imidazoles but not triazoles
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. Formation of 5-O-glucuronide is mainly catalysed by UGT1A9
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. Formation of 5-O-glucuronide is mainly catalysed by UGT1A9
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. Formation of 5-O-glucuronide is mainly catalysed by UGT1A9
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. Formation of 5-O-glucuronide is mainly catalysed by UGT1A9
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. Formation of 5-O-glucuronide is mainly catalysed by UGT1A9
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. Formation of 5-O-glucuronide is mainly catalysed by UGT1A9
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. Formation of 5-O-glucuronide is mainly catalysed by UGT1A9
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. Formation of 5-O-glucuronide is mainly catalysed by UGT1A9
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. Formation of 5-O-glucuronide is mainly catalysed by UGT1A9
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. Formation of 5-O-glucuronide is mainly catalysed by UGT1A9
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. Formation of 5-O-glucuronide is mainly catalysed by UGT1A9
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. Formation of 5-O-glucuronide is mainly catalysed by UGT1A9
-
-
?
additional information
?
-
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. Formation of 5-O-glucuronide is mainly catalysed by UGT1A9
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A1 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A1 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A1 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A1 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A1 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A1 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A1 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A1 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A1 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A1 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A1 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A1 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A1 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A10 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A10 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A10 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A10 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A10 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A10 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A10 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A10 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A10 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A10 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A10 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A10 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A10 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A7 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A7 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A7 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A7 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A7 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A7 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A7 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A7 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A7 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A7 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A7 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A7 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A7 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A8 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A8 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A8 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A8 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A8 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A8 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A8 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A8 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A8 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A8 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A8 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A8 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT1A8 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B15 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B15 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B15 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B15 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B15 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B15 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B15 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B15 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B15 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B15 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B15 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B15 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B15 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B17 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B17 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B17 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B17 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B17 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B17 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B17 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B17 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B17 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B17 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B17 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B17 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B17 generates glucuronides at 4'-OH sites
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B7 is the only isozyme that generates glucuronides at both 4'-OH and 5-OH sites, although a strong position preference is observed with 4'-OH of over 80.2%
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B7 is the only isozyme that generates glucuronides at both 4'-OH and 5-OH sites, although a strong position preference is observed with 4'-OH of over 80.2%
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B7 is the only isozyme that generates glucuronides at both 4'-OH and 5-OH sites, although a strong position preference is observed with 4'-OH of over 80.2%
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B7 is the only isozyme that generates glucuronides at both 4'-OH and 5-OH sites, although a strong position preference is observed with 4'-OH of over 80.2%
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B7 is the only isozyme that generates glucuronides at both 4'-OH and 5-OH sites, although a strong position preference is observed with 4'-OH of over 80.2%
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B7 is the only isozyme that generates glucuronides at both 4'-OH and 5-OH sites, although a strong position preference is observed with 4'-OH of over 80.2%
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B7 is the only isozyme that generates glucuronides at both 4'-OH and 5-OH sites, although a strong position preference is observed with 4'-OH of over 80.2%
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B7 is the only isozyme that generates glucuronides at both 4'-OH and 5-OH sites, although a strong position preference is observed with 4'-OH of over 80.2%
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B7 is the only isozyme that generates glucuronides at both 4'-OH and 5-OH sites, although a strong position preference is observed with 4'-OH of over 80.2%
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B7 is the only isozyme that generates glucuronides at both 4'-OH and 5-OH sites, although a strong position preference is observed with 4'-OH of over 80.2%
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B7 is the only isozyme that generates glucuronides at both 4'-OH and 5-OH sites, although a strong position preference is observed with 4'-OH of over 80.2%
-
-
?
additional information
?
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B7 is the only isozyme that generates glucuronides at both 4'-OH and 5-OH sites, although a strong position preference is observed with 4'-OH of over 80.2%
-
-
?
additional information
?
-
-
main UGT enzymes involved in regioselective glucuronidation of gingerols are isozymes UGT1A9 and UGT2B7. UGT2B7 is the only isozyme that generates glucuronides at both 4'-OH and 5-OH sites, although a strong position preference is observed with 4'-OH of over 80.2%
-
-
?
additional information
?
-
morphine glucuronidation and glucosidation represent complementary metabolic pathways that are both catalyzed by UDP-glucuronosyltransferase 2B7. Glucuronidation is the dominant metabolic pathway because the binding affinity of UDP-glucuronic acid to UGT2B7 is higher than that of UDPglucose
-
-
?
additional information
?
-
-
morphine glucuronidation and glucosidation represent complementary metabolic pathways that are both catalyzed by UDP-glucuronosyltransferase 2B7. Glucuronidation is the dominant metabolic pathway because the binding affinity of UDP-glucuronic acid to UGT2B7 is higher than that of UDPglucose
-
-
?
additional information
?
-
-
no activity with (E)-4-(3,5-dimethoxystyryl)-2,6-dinitrophenol, i.e. DNR-1, glucuronide formation is verified by beta-glucuronidase hydrolysis and LC-MS/MS analysis
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A3
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A3
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A3
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A3
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A3
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A3
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A3
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A3
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A3
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A3
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A3
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A3
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A4
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A4
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A4
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A4
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A4
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A4
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A4
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A4
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A4
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A4
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A4
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A4
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A6
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A6
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A6
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A6
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A6
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A6
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A6
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A6
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A6
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A6
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A6
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT1A6
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT2B4
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT2B4
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT2B4
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT2B4
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT2B4
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT2B4
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT2B4
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT2B4
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT2B4
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT2B4
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT2B4
-
-
?
additional information
?
-
no activity with gingerols by enzyme UGT2B4
-
-
?
additional information
?
-
-
the human UGTs of subfamily 2A, UGT2A1, 2A2, and 2A3, show bile acid-conjugating activity
-
-
?
additional information
?
-
the human UGTs of subfamily 2A, UGT2A1, 2A2, and 2A3, show bile acid-conjugating activity
-
-
?
additional information
?
-
Q9Y4X1
the human UGTs of subfamily 2A, UGT2A1, 2A2, and 2A3, show bile acid-conjugating activity
-
-
?
additional information
?
-
-
trans-Resveratrol has powerful antioxidant, anti-inflammatory, anticarcinogenic, and antiaging properties, but its use as a therapeutic agent is limited by its rapid metabolism into its conjugated forms by UDP-glucuronosyltransferases. The limited bioavailability of tRes can be improved by modifying its structure to create analogues which can be glucuronidated at a lower rate than tRes itself. Three synthetic stilbenoids ((E)-3-(3-hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)acrylic acid, (E)-2,4-dimethoxy-6-(4-methoxystyryl)benzaldehyde oxime, and (E)-4-(3,5-dimethoxystyryl)-2,6-dinitrophenol) are designed based on the structure of tRes and synthesized. UDP-glucuronosyltransferases recognize and glucuronidate trans-resveratrol at each of the 3 hydroxyl groups attached to its aromatic rings
-
-
?
additional information
?
-
3'-azido-3'-deoxythymidine-glucuronidation activity is low in the microminipig compared with humans, morphine-3-glucuronidation activity in the microminipig is higher than that in humans
-
-
?
additional information
?
-
3'-azido-3'-deoxythymidine-glucuronidation activity is low in the microminipig compared with humans, morphine-3-glucuronidation activity in the microminipig is higher than that in humans
-
-
?
additional information
?
-
3'-azido-3'-deoxythymidine-glucuronidation activity is low in the microminipig compared with humans, morphine-3-glucuronidation activity in the microminipig is higher than that in humans
-
-
?
additional information
?
-
3'-azido-3'-deoxythymidine-glucuronidation activity is low in the microminipig compared with humans, morphine-3-glucuronidation activity in the microminipig is higher than that in humans
-
-
?
additional information
?
-
3'-azido-3'-deoxythymidine-glucuronidation activity is low in the microminipig compared with humans, morphine-3-glucuronidation activity in the microminipig is higher than that in humans
-
-
?
additional information
?
-
-
3'-azido-3'-deoxythymidine-glucuronidation activity is low in the microminipig compared with humans, morphine-3-glucuronidation activity in the microminipig is higher than that in humans
-
-
?
additional information
?
-
-
activity with all tested bile acids is high with isozyme UGT2A1
-
-
?
additional information
?
-
activity with all tested bile acids is high with isozyme UGT2A1
-
-
?
additional information
?
-
Q9Y4X1
activity with all tested bile acids is high with isozyme UGT2A1
-
-
?
additional information
?
-
-
activity with all tested bile acids is low with isozyme UGT2A3
-
-
?
additional information
?
-
activity with all tested bile acids is low with isozyme UGT2A3
-
-
?
additional information
?
-
Q9Y4X1
activity with all tested bile acids is low with isozyme UGT2A3
-
-
?
additional information
?
-
-
human UGT1A enzymes display unique regioselectivity for the site of glucuronidation and this selectivity is affected strongly by structural differences among the dihydroxychalcones. Several of the UGT1A isoforms show poor reactivity toward the chalcones including UGT1A4, 1A6, and 1A10. UGT1A9 promotes glucuronidation at the 2'-OH-position, and formation of the 2'-O-glucuronide. Several UGT isoforms promote the formation of the 4'-O-glucuronide, particularly UGT1A8, which produces the monoglucuronide in high yield is enhanced for dihydroxychalcones with hydroxy substituents on the A-ring. Although UGT1A8 reacts with 3,2'-dihydroxychalcone and 4,2'-dihydroxychalcone to form 2'-O-glucuronides, the presence of the B-ring hydroxy group at the 4'-position in both cardamonin and 2',4'-dihydroxychalcone renders the OH-2'-position inactive to glucuronidation with the 1A8 isoform. For UGT1A7, hydroxy substituents on the chalcone A-ring enhance the overall yield of glucuronide product and especially promote formation of the corresponding flavanone glucuronide. UGT1A3 strongly promotes glucuronidation at the OH-7 position of the flavanone A-ring in 7-hydroxyflavanone and alpinetin, but leads to much lower glucuronide product yields for flavanones with B-ring hydroxy groups such as 3'-hydroxyflavanone and 4'-hydroxyflavanone. While UGT1A1 catalyzes the formation of glucuronide products in relatively high yields for all of the flavanones studied, in general, glucuronide product formation is less for the flavanones with a B-ring hydroxy group compared to those with an A-ring hydroxy moiety. Isozyme substrate specificity with analysis of multiple product reactions with dihydroxychalcones, product anaysis, detailed overview
-
-
?
additional information
?
-
most, if not all, UGT2B10 substrates are additionally glucuronidated by UGT1A4 and biphasic kinetics are frequently observed when human liver microsomes are used as the enzyme source. UGT2B10 is the high-affinity enzyme involved in most reactions. Thirteen recombinant human UGTs are screened for cotinine N-glucuronide formation, i.e. UGT 1A1, 1A3, 1A4, 1A6, 1A7, 1A8, 1A9, 1A10, 2B4, 2B7, 2B10, 2B15, and 2B17, cotinine is a highly selective substrate of human liver microsomal UGT2B10
-
-
?
additional information
?
-
-
most, if not all, UGT2B10 substrates are additionally glucuronidated by UGT1A4 and biphasic kinetics are frequently observed when human liver microsomes are used as the enzyme source. UGT2B10 is the high-affinity enzyme involved in most reactions. Thirteen recombinant human UGTs are screened for cotinine N-glucuronide formation, i.e. UGT 1A1, 1A3, 1A4, 1A6, 1A7, 1A8, 1A9, 1A10, 2B4, 2B7, 2B10, 2B15, and 2B17, cotinine is a highly selective substrate of human liver microsomal UGT2B10
-
-
?
additional information
?
-
no activity by isozyme UGT2B15 with 8-gingerol and 10-gingerol
-
-
?
additional information
?
-
no activity by isozyme UGT2B15 with 8-gingerol and 10-gingerol
-
-
?
additional information
?
-
no activity by isozyme UGT2B15 with 8-gingerol and 10-gingerol
-
-
?
additional information
?
-
no activity by isozyme UGT2B15 with 8-gingerol and 10-gingerol
-
-
?
additional information
?
-
no activity by isozyme UGT2B15 with 8-gingerol and 10-gingerol
-
-
?
additional information
?
-
no activity by isozyme UGT2B15 with 8-gingerol and 10-gingerol
-
-
?
additional information
?
-
no activity by isozyme UGT2B15 with 8-gingerol and 10-gingerol
-
-
?
additional information
?
-
no activity by isozyme UGT2B15 with 8-gingerol and 10-gingerol
-
-
?
additional information
?
-
no activity by isozyme UGT2B15 with 8-gingerol and 10-gingerol
-
-
?
additional information
?
-
no activity by isozyme UGT2B15 with 8-gingerol and 10-gingerol
-
-
?
additional information
?
-
no activity by isozyme UGT2B15 with 8-gingerol and 10-gingerol
-
-
?
additional information
?
-
no activity by isozyme UGT2B15 with 8-gingerol and 10-gingerol
-
-
?
additional information
?
-
-
no activity by isozyme UGT2B15 with 8-gingerol and 10-gingerol
-
-
?
additional information
?
-
no activity with 8-gingerol and 10-gingerol
-
-
?
additional information
?
-
no activity with 8-gingerol and 10-gingerol
-
-
?
additional information
?
-
no activity with 8-gingerol and 10-gingerol
-
-
?
additional information
?
-
no activity with 8-gingerol and 10-gingerol
-
-
?
additional information
?
-
no activity with 8-gingerol and 10-gingerol
-
-
?
additional information
?
-
no activity with 8-gingerol and 10-gingerol
-
-
?
additional information
?
-
no activity with 8-gingerol and 10-gingerol
-
-
?
additional information
?
-
no activity with 8-gingerol and 10-gingerol
-
-
?
additional information
?
-
no activity with 8-gingerol and 10-gingerol
-
-
?
additional information
?
-
no activity with 8-gingerol and 10-gingerol
-
-
?
additional information
?
-
no activity with 8-gingerol and 10-gingerol
-
-
?
additional information
?
-
no activity with 8-gingerol and 10-gingerol
-
-
?
additional information
?
-
no activity with bilirubin, 17-alpha-estradiol, 17-beta-estradiol, dexmedetomidine, entacapone, levomedetomidine, diclofenac, indomethacin, 4-methylumbelliferone, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, 17-alpha-estradiol, 17-beta-estradiol, dexmedetomidine, entacapone, levomedetomidine, diclofenac, indomethacin, 4-methylumbelliferone, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, 17-alpha-estradiol, 17-beta-estradiol, dexmedetomidine, entacapone, levomedetomidine, diclofenac, indomethacin, 4-methylumbelliferone, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, 17-alpha-estradiol, 17-beta-estradiol, dexmedetomidine, entacapone, levomedetomidine, diclofenac, indomethacin, 4-methylumbelliferone, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, 17-alpha-estradiol, 17-beta-estradiol, dexmedetomidine, entacapone, levomedetomidine, diclofenac, indomethacin, 4-methylumbelliferone, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, 17-alpha-estradiol, 17-beta-estradiol, dexmedetomidine, entacapone, levomedetomidine, diclofenac, indomethacin, 4-methylumbelliferone, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, 17-alpha-estradiol, 17-beta-estradiol, dexmedetomidine, entacapone, levomedetomidine, diclofenac, indomethacin, 4-methylumbelliferone, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, 17-alpha-estradiol, 17-beta-estradiol, dexmedetomidine, entacapone, levomedetomidine, diclofenac, indomethacin, 4-methylumbelliferone, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, 17-alpha-estradiol, 17-beta-estradiol, dexmedetomidine, entacapone, levomedetomidine, diclofenac, indomethacin, 4-methylumbelliferone, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
-
no activity with bilirubin, 17-alpha-estradiol, 17-beta-estradiol, dexmedetomidine, entacapone, levomedetomidine, diclofenac, indomethacin, 4-methylumbelliferone, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, 4-methylumbelliferone, (R)-propranolol, (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, 4-methylumbelliferone, (R)-propranolol, (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, 4-methylumbelliferone, (R)-propranolol, (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, 4-methylumbelliferone, (R)-propranolol, (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, 4-methylumbelliferone, (R)-propranolol, (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, 4-methylumbelliferone, (R)-propranolol, (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, 4-methylumbelliferone, (R)-propranolol, (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, 4-methylumbelliferone, (R)-propranolol, (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, 4-methylumbelliferone, (R)-propranolol, (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
-
no activity with bilirubin, 4-methylumbelliferone, (R)-propranolol, (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, ethinylestradiol, 17-beta-estradiol, dexmedetomidine, and levomedetomidine, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, ethinylestradiol, 17-beta-estradiol, dexmedetomidine, and levomedetomidine, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, ethinylestradiol, 17-beta-estradiol, dexmedetomidine, and levomedetomidine, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, ethinylestradiol, 17-beta-estradiol, dexmedetomidine, and levomedetomidine, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, ethinylestradiol, 17-beta-estradiol, dexmedetomidine, and levomedetomidine, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, ethinylestradiol, 17-beta-estradiol, dexmedetomidine, and levomedetomidine, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, ethinylestradiol, 17-beta-estradiol, dexmedetomidine, and levomedetomidine, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, ethinylestradiol, 17-beta-estradiol, dexmedetomidine, and levomedetomidine, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, ethinylestradiol, 17-beta-estradiol, dexmedetomidine, and levomedetomidine, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
-
no activity with bilirubin, ethinylestradiol, 17-beta-estradiol, dexmedetomidine, and levomedetomidine, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, ethinylestradiol, 17beta- and 17alpha-estradiol, diclofenac, entacapone, 4-methylumbelliferone, indomethacin, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, ethinylestradiol, 17beta- and 17alpha-estradiol, diclofenac, entacapone, 4-methylumbelliferone, indomethacin, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, ethinylestradiol, 17beta- and 17alpha-estradiol, diclofenac, entacapone, 4-methylumbelliferone, indomethacin, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, ethinylestradiol, 17beta- and 17alpha-estradiol, diclofenac, entacapone, 4-methylumbelliferone, indomethacin, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, ethinylestradiol, 17beta- and 17alpha-estradiol, diclofenac, entacapone, 4-methylumbelliferone, indomethacin, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, ethinylestradiol, 17beta- and 17alpha-estradiol, diclofenac, entacapone, 4-methylumbelliferone, indomethacin, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, ethinylestradiol, 17beta- and 17alpha-estradiol, diclofenac, entacapone, 4-methylumbelliferone, indomethacin, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, ethinylestradiol, 17beta- and 17alpha-estradiol, diclofenac, entacapone, 4-methylumbelliferone, indomethacin, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with bilirubin, ethinylestradiol, 17beta- and 17alpha-estradiol, diclofenac, entacapone, 4-methylumbelliferone, indomethacin, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
-
no activity with bilirubin, ethinylestradiol, 17beta- and 17alpha-estradiol, diclofenac, entacapone, 4-methylumbelliferone, indomethacin, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with dexmedetomidine, levomedetomidine, 4-methylumbelliferone, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with dexmedetomidine, levomedetomidine, 4-methylumbelliferone, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with dexmedetomidine, levomedetomidine, 4-methylumbelliferone, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with dexmedetomidine, levomedetomidine, 4-methylumbelliferone, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with dexmedetomidine, levomedetomidine, 4-methylumbelliferone, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with dexmedetomidine, levomedetomidine, 4-methylumbelliferone, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with dexmedetomidine, levomedetomidine, 4-methylumbelliferone, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with dexmedetomidine, levomedetomidine, 4-methylumbelliferone, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no activity with dexmedetomidine, levomedetomidine, 4-methylumbelliferone, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
-
no activity with dexmedetomidine, levomedetomidine, 4-methylumbelliferone, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with bilirubin, 17-alpha-estradiol, 17-beta-estradiol, dexmedetomidine, levomedetomidine, diclofenac, indomethacin, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with bilirubin, 17-alpha-estradiol, 17-beta-estradiol, dexmedetomidine, levomedetomidine, diclofenac, indomethacin, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with bilirubin, 17-alpha-estradiol, 17-beta-estradiol, dexmedetomidine, levomedetomidine, diclofenac, indomethacin, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with bilirubin, 17-alpha-estradiol, 17-beta-estradiol, dexmedetomidine, levomedetomidine, diclofenac, indomethacin, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with bilirubin, 17-alpha-estradiol, 17-beta-estradiol, dexmedetomidine, levomedetomidine, diclofenac, indomethacin, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with bilirubin, 17-alpha-estradiol, 17-beta-estradiol, dexmedetomidine, levomedetomidine, diclofenac, indomethacin, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with bilirubin, 17-alpha-estradiol, 17-beta-estradiol, dexmedetomidine, levomedetomidine, diclofenac, indomethacin, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with bilirubin, 17-alpha-estradiol, 17-beta-estradiol, dexmedetomidine, levomedetomidine, diclofenac, indomethacin, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with bilirubin, 17-alpha-estradiol, 17-beta-estradiol, dexmedetomidine, levomedetomidine, diclofenac, indomethacin, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
-
no or poor activity with bilirubin, 17-alpha-estradiol, 17-beta-estradiol, dexmedetomidine, levomedetomidine, diclofenac, indomethacin, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with bilirubin, dexmedetomidine, diclofenac, levomedetomidine, (R)-propranolol, (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with bilirubin, dexmedetomidine, diclofenac, levomedetomidine, (R)-propranolol, (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with bilirubin, dexmedetomidine, diclofenac, levomedetomidine, (R)-propranolol, (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with bilirubin, dexmedetomidine, diclofenac, levomedetomidine, (R)-propranolol, (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with bilirubin, dexmedetomidine, diclofenac, levomedetomidine, (R)-propranolol, (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with bilirubin, dexmedetomidine, diclofenac, levomedetomidine, (R)-propranolol, (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with bilirubin, dexmedetomidine, diclofenac, levomedetomidine, (R)-propranolol, (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with bilirubin, dexmedetomidine, diclofenac, levomedetomidine, (R)-propranolol, (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with bilirubin, dexmedetomidine, diclofenac, levomedetomidine, (R)-propranolol, (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
-
no or poor activity with bilirubin, dexmedetomidine, diclofenac, levomedetomidine, (R)-propranolol, (S)-propranolol, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with bilirubin, levomedetomidine, and dexmedetomidine, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with bilirubin, levomedetomidine, and dexmedetomidine, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with bilirubin, levomedetomidine, and dexmedetomidine, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with bilirubin, levomedetomidine, and dexmedetomidine, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with bilirubin, levomedetomidine, and dexmedetomidine, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with bilirubin, levomedetomidine, and dexmedetomidine, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with bilirubin, levomedetomidine, and dexmedetomidine, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with bilirubin, levomedetomidine, and dexmedetomidine, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
no or poor activity with bilirubin, levomedetomidine, and dexmedetomidine, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
-
no or poor activity with bilirubin, levomedetomidine, and dexmedetomidine, substrate specificities of isozymes, overview
-
-
?
additional information
?
-
-
the enzyme UGT2B4 is also active with bile acids
-
-
?
additional information
?
-
the enzyme UGT2B4 is also active with bile acids
-
-
?
additional information
?
-
the enzyme UGT2B4 is also active with bile acids
-
-
?
additional information
?
-
the enzyme UGT2B4 is also active with bile acids
-
-
?
additional information
?
-
the enzyme UGT2B4 is also active with bile acids
-
-
?
additional information
?
-
the enzyme UGT2B4 is also active with bile acids
-
-
?
additional information
?
-
the enzyme UGT2B4 is also active with bile acids
-
-
?
additional information
?
-
the enzyme UGT2B4 is also active with bile acids
-
-
?
additional information
?
-
the enzyme UGT2B4 is also active with bile acids
-
-
?
additional information
?
-
the enzyme UGT2B4 is also active with bile acids
-
-
?
additional information
?
-
the enzyme UGT2B4 is also active with bile acids
-
-
?
additional information
?
-
the enzyme UGT2B4 is also active with bile acids
-
-
?
additional information
?
-
the enzyme UGT2B4 is also active with bile acids
-
-
?
additional information
?
-
the enzyme UGT2B4 is also active with bile acids
-
-
?
additional information
?
-
the enzyme UGT2B4 is also active with bile acids
-
-
?
additional information
?
-
the enzyme UGT2B4 is also active with bile acids
-
-
?
additional information
?
-
the enzyme UGT2B4 is also active with bile acids
-
-
?
additional information
?
-
the enzyme UGT2B4 is also active with bile acids
-
-
?
additional information
?
-
Q9Y4X1
the enzyme UGT2B4 is also active with bile acids
-
-
?
additional information
?
-
UDP-glucuronosyltransferase 2B10 catalyzes N-glucuronidation of amine-containing compounds, substrate specificity overview. Enzyme UGT2B10 preferably conjugates tertiary amines, but not conjugate the tertiary cyclic amine in trifluoperazin, substrate specificity, overview. No activity with desipramine, nortriptyline, carbamazepine, and afloqualone, UGT2B10 does not conjugate the tertiary cyclic amine in trifluoperazine. The affinity and clearance of UGT2B10 for amitriptyline, imipramine, and diphenhydramine are significantly higher than the corresponding values of UGT1A4 and UGT1A3, although the Vmax values of UGT1A4 toward these drugs are considerably higher
-
-
?
additional information
?
-
UDP-glucuronosyltransferase 2B10 catalyzes N-glucuronidation of amine-containing compounds, substrate specificity overview. Enzyme UGT2B10 preferably conjugates tertiary amines, but not conjugate the tertiary cyclic amine in trifluoperazin, substrate specificity, overview. No activity with desipramine, nortriptyline, carbamazepine, and afloqualone, UGT2B10 does not conjugate the tertiary cyclic amine in trifluoperazine. The affinity and clearance of UGT2B10 for amitriptyline, imipramine, and diphenhydramine are significantly higher than the corresponding values of UGT1A4 and UGT1A3, although the Vmax values of UGT1A4 toward these drugs are considerably higher
-
-
?
additional information
?
-
UDP-glucuronosyltransferase 2B10 catalyzes N-glucuronidation of amine-containing compounds, substrate specificity overview. Enzyme UGT2B10 preferably conjugates tertiary amines, but not conjugate the tertiary cyclic amine in trifluoperazin, substrate specificity, overview. No activity with desipramine, nortriptyline, carbamazepine, and afloqualone, UGT2B10 does not conjugate the tertiary cyclic amine in trifluoperazine. The affinity and clearance of UGT2B10 for amitriptyline, imipramine, and diphenhydramine are significantly higher than the corresponding values of UGT1A4 and UGT1A3, although the Vmax values of UGT1A4 toward these drugs are considerably higher
-
-
?
additional information
?
-
-
UDP-glucuronosyltransferase 2B10 catalyzes N-glucuronidation of amine-containing compounds, substrate specificity overview. Enzyme UGT2B10 preferably conjugates tertiary amines, but not conjugate the tertiary cyclic amine in trifluoperazin, substrate specificity, overview. No activity with desipramine, nortriptyline, carbamazepine, and afloqualone, UGT2B10 does not conjugate the tertiary cyclic amine in trifluoperazine. The affinity and clearance of UGT2B10 for amitriptyline, imipramine, and diphenhydramine are significantly higher than the corresponding values of UGT1A4 and UGT1A3, although the Vmax values of UGT1A4 toward these drugs are considerably higher
-
-
?
additional information
?
-
UDP-glucuronosyltransferase 2B10 catalyzes N-glucuronidation of amine-containing compounds, substrate specificity overview. Enzyme UGT2B10 preferably conjugates tertiary amines, but not conjugate the tertiary cyclic amine in trifluoperazine. The affinity and clearance of UGT2B10 for amitriptyline, imipramine, and diphenhydramine are significantly higher than the corresponding values of UGT1A4 and UGT1A3, although the Vmax values of UGT1A4 toward these drugs are considerably higher
-
-
?
additional information
?
-
UDP-glucuronosyltransferase 2B10 catalyzes N-glucuronidation of amine-containing compounds, substrate specificity overview. Enzyme UGT2B10 preferably conjugates tertiary amines, but not conjugate the tertiary cyclic amine in trifluoperazine. The affinity and clearance of UGT2B10 for amitriptyline, imipramine, and diphenhydramine are significantly higher than the corresponding values of UGT1A4 and UGT1A3, although the Vmax values of UGT1A4 toward these drugs are considerably higher
-
-
?
additional information
?
-
UDP-glucuronosyltransferase 2B10 catalyzes N-glucuronidation of amine-containing compounds, substrate specificity overview. Enzyme UGT2B10 preferably conjugates tertiary amines, but not conjugate the tertiary cyclic amine in trifluoperazine. The affinity and clearance of UGT2B10 for amitriptyline, imipramine, and diphenhydramine are significantly higher than the corresponding values of UGT1A4 and UGT1A3, although the Vmax values of UGT1A4 toward these drugs are considerably higher
-
-
?
additional information
?
-
-
UDP-glucuronosyltransferase 2B10 catalyzes N-glucuronidation of amine-containing compounds, substrate specificity overview. Enzyme UGT2B10 preferably conjugates tertiary amines, but not conjugate the tertiary cyclic amine in trifluoperazine. The affinity and clearance of UGT2B10 for amitriptyline, imipramine, and diphenhydramine are significantly higher than the corresponding values of UGT1A4 and UGT1A3, although the Vmax values of UGT1A4 toward these drugs are considerably higher
-
-
?
additional information
?
-
UDP-glucuronosyltransferase 2B10 catalyzes N-glucuronidation of amine-containing compounds, substrate specificity overview. Enzyme UGT2B10 preferably conjugates tertiary amines, but not conjugate the tertiary cyclic amine in trifluoperazine. The affinity and clearance of UGT2B10 for amitriptyline, imipramine, and diphenhydramine are significantly higher than the corresponding values of UGT1A4 and UGT1A3, although the Vmax values of UGT1A4 toward these drugs are considerably higher. No activity with diphenhydramine
-
-
?
additional information
?
-
UDP-glucuronosyltransferase 2B10 catalyzes N-glucuronidation of amine-containing compounds, substrate specificity overview. Enzyme UGT2B10 preferably conjugates tertiary amines, but not conjugate the tertiary cyclic amine in trifluoperazine. The affinity and clearance of UGT2B10 for amitriptyline, imipramine, and diphenhydramine are significantly higher than the corresponding values of UGT1A4 and UGT1A3, although the Vmax values of UGT1A4 toward these drugs are considerably higher. No activity with diphenhydramine
-
-
?
additional information
?
-
UDP-glucuronosyltransferase 2B10 catalyzes N-glucuronidation of amine-containing compounds, substrate specificity overview. Enzyme UGT2B10 preferably conjugates tertiary amines, but not conjugate the tertiary cyclic amine in trifluoperazine. The affinity and clearance of UGT2B10 for amitriptyline, imipramine, and diphenhydramine are significantly higher than the corresponding values of UGT1A4 and UGT1A3, although the Vmax values of UGT1A4 toward these drugs are considerably higher. No activity with diphenhydramine
-
-
?
additional information
?
-
-
UDP-glucuronosyltransferase 2B10 catalyzes N-glucuronidation of amine-containing compounds, substrate specificity overview. Enzyme UGT2B10 preferably conjugates tertiary amines, but not conjugate the tertiary cyclic amine in trifluoperazine. The affinity and clearance of UGT2B10 for amitriptyline, imipramine, and diphenhydramine are significantly higher than the corresponding values of UGT1A4 and UGT1A3, although the Vmax values of UGT1A4 toward these drugs are considerably higher. No activity with diphenhydramine
-
-
?
additional information
?
-
isoform UGT1A1 does not show activity with zidovudine
-
-
-
additional information
?
-
isoform UGT1A1 does not show activity with zidovudine
-
-
-
additional information
?
-
isoform UGT1A1 does not show activity with zidovudine
-
-
-
additional information
?
-
-
isoform UGT1A1 does not show activity with zidovudine
-
-
-
additional information
?
-
isoform UGT1A9 does not show activity with zidovudine
-
-
-
additional information
?
-
isoform UGT1A9 does not show activity with zidovudine
-
-
-
additional information
?
-
isoform UGT1A9 does not show activity with zidovudine
-
-
-
additional information
?
-
-
isoform UGT1A9 does not show activity with zidovudine
-
-
-
additional information
?
-
isoform UGT2B7 is not capable of converting quercetin
-
-
-
additional information
?
-
isoform UGT2B7 is not capable of converting quercetin
-
-
-
additional information
?
-
isoform UGT2B7 is not capable of converting quercetin
-
-
-
additional information
?
-
-
isoform UGT2B7 is not capable of converting quercetin
-
-
-
additional information
?
-
isozyme UGT3A1 can also use UDP-N-acetylglucosamine as cosubstrate. UGT3A1-overexpressing microsomes also demonstrates activity against 8-hydroxy-benzo[a]pyrene (8-OH-BaP) and BaP-9,10-diol. Two GlcNAc conjugates are observed for BaP-9,10-diol, likely representing N-acetylglucosaminides at the 9- and 10-diol positions. No detectable glycosylation activity for any other PAH tested is seen with UGT3A1-overexpressing microsomes. No glycosylation is observed for microsomes from the parent HEK293 cell line for 1-OH-pyrene, 8-OH-BaP, or BaP-9,10-diol using UDP-GlcNAc as cosubstrate or when using either UDP-Glc, UDP-Xyl, or UDP-GlcUA as cosubstrate
-
-
-
additional information
?
-
isozyme UGT3A1 can also use UDP-N-acetylglucosamine as cosubstrate. UGT3A1-overexpressing microsomes also demonstrates activity against 8-hydroxy-benzo[a]pyrene (8-OH-BaP) and BaP-9,10-diol. Two GlcNAc conjugates are observed for BaP-9,10-diol, likely representing N-acetylglucosaminides at the 9- and 10-diol positions. No detectable glycosylation activity for any other PAH tested is seen with UGT3A1-overexpressing microsomes. No glycosylation is observed for microsomes from the parent HEK293 cell line for 1-OH-pyrene, 8-OH-BaP, or BaP-9,10-diol using UDP-GlcNAc as cosubstrate or when using either UDP-Glc, UDP-Xyl, or UDP-GlcUA as cosubstrate
-
-
-
additional information
?
-
-
isozyme UGT3A1 can also use UDP-N-acetylglucosamine as cosubstrate. UGT3A1-overexpressing microsomes also demonstrates activity against 8-hydroxy-benzo[a]pyrene (8-OH-BaP) and BaP-9,10-diol. Two GlcNAc conjugates are observed for BaP-9,10-diol, likely representing N-acetylglucosaminides at the 9- and 10-diol positions. No detectable glycosylation activity for any other PAH tested is seen with UGT3A1-overexpressing microsomes. No glycosylation is observed for microsomes from the parent HEK293 cell line for 1-OH-pyrene, 8-OH-BaP, or BaP-9,10-diol using UDP-GlcNAc as cosubstrate or when using either UDP-Glc, UDP-Xyl, or UDP-GlcUA as cosubstrate
-
-
-
additional information
?
-
UGT3A2 exhibits glycosylation activity against all of the simple and complex polycyclic aromatic hydrocarbons (PAHs)tested. Isozyme UGT3A2 can also use UDP-D-glucose and UDP-D-xylose as cosubstrates. After screening for activity against the PAH substrates, kinetic parameters are determined for UGT3A2 using UDP-Glc or UDPXyl as cosubstrates
-
-
-
additional information
?
-
UGT3A2 exhibits glycosylation activity against all of the simple and complex polycyclic aromatic hydrocarbons (PAHs)tested. Isozyme UGT3A2 can also use UDP-D-glucose and UDP-D-xylose as cosubstrates. After screening for activity against the PAH substrates, kinetic parameters are determined for UGT3A2 using UDP-Glc or UDPXyl as cosubstrates
-
-
-
additional information
?
-
-
UGT3A2 exhibits glycosylation activity against all of the simple and complex polycyclic aromatic hydrocarbons (PAHs)tested. Isozyme UGT3A2 can also use UDP-D-glucose and UDP-D-xylose as cosubstrates. After screening for activity against the PAH substrates, kinetic parameters are determined for UGT3A2 using UDP-Glc or UDPXyl as cosubstrates
-
-
-
additional information
?
-
there are no significant differences in the levels of kinetic parameters for 7-hydroxy-4-trifluoromethylcoumarin, estradiol at 3-hydroxy position and 7-ethyl-10-hydroxycamptothecin glucuronidation between humans and cynomolgus monkeys in enzymes from liver microsomes and recombinant isoforms UGT1A1. 7-Hydroxy-4-trifluoromethylcoumarin and estradiol glucuronidation by cynomolgus monkey liver microsomes fits the typical Michaelis-Menten model. 7-Ethyl-10-hydroxycamptothecin glucuronidation by by cynomolgus monkey liver microsomes exhibits autoactivation kinetics
-
-
?
additional information
?
-
-
there are no significant differences in the levels of kinetic parameters for 7-hydroxy-4-trifluoromethylcoumarin, estradiol at 3-hydroxy position and 7-ethyl-10-hydroxycamptothecin glucuronidation between humans and cynomolgus monkeys in enzymes from liver microsomes and recombinant isoforms UGT1A1. 7-Hydroxy-4-trifluoromethylcoumarin and estradiol glucuronidation by cynomolgus monkey liver microsomes fits the typical Michaelis-Menten model. 7-Ethyl-10-hydroxycamptothecin glucuronidation by by cynomolgus monkey liver microsomes exhibits autoactivation kinetics
-
-
?
additional information
?
-
-
isoforms UGT2B9 and UGT2B30 do not show activities in estradiol 3-O-glucuronidation
-
-
-
additional information
?
-
isoforms UGT2B9 and UGT2B30 do not show activities in estradiol 3-O-glucuronidation
-
-
-
additional information
?
-
isoforms UGT2B9 and UGT2B30 do not show activities in estradiol 3-O-glucuronidation
-
-
-
additional information
?
-
-
elimination of lipid-soluble endogenous compounds and xenobiotics
-
-
?
additional information
?
-
-
elimination of lipid-soluble endogenous compounds and xenobiotics
-
-
?
additional information
?
-
-
comparison of murine and rat UGT activity and substrate specificity using duodenum and liver microsomes, overview
-
-
?
additional information
?
-
-
tertiary amines give quaternary ammonium glucuronides when conjugated by UGT1A7 but not by UGT1A4
-
-
?
additional information
?
-
-
elimination of lipid-soluble endogenous compounds and xenobiotics
-
-
?
additional information
?
-
glucuronidation by the UDP glucuronosyltransferase 1A enzymes is a major pathway for elimination of drugs and endogenous substances, such as bilirubin
-
-
?
additional information
?
-
glucuronidation by the UDP glucuronosyltransferase 1A enzymes is a major pathway for elimination of drugs and endogenous substances, such as bilirubin
-
-
?
additional information
?
-
glucuronidation by the UDP glucuronosyltransferase 1A enzymes is a major pathway for elimination of drugs and endogenous substances, such as bilirubin
-
-
?
additional information
?
-
glucuronidation by the UDP glucuronosyltransferase 1A enzymes is a major pathway for elimination of drugs and endogenous substances, such as bilirubin
-
-
?
additional information
?
-
glucuronidation by the UDP glucuronosyltransferase 1A enzymes is a major pathway for elimination of drugs and endogenous substances, such as bilirubin
-
-
?
additional information
?
-
glucuronidation by the UDP glucuronosyltransferase 1A enzymes is a major pathway for elimination of drugs and endogenous substances, such as bilirubin
-
-
?
additional information
?
-
glucuronidation by the UDP glucuronosyltransferase 1A enzymes is a major pathway for elimination of drugs and endogenous substances, such as bilirubin
-
-
?
additional information
?
-
glucuronidation by the UDP glucuronosyltransferase 1A enzymes is a major pathway for elimination of drugs and endogenous substances, such as bilirubin
-
-
?
additional information
?
-
glucuronidation by the UDP glucuronosyltransferase 1A enzymes is a major pathway for elimination of drugs and endogenous substances, such as bilirubin
-
-
?
additional information
?
-
glucuronidation by the UDP glucuronosyltransferase 1A enzymes is a major pathway for elimination of drugs and endogenous substances, such as bilirubin
-
-
?
additional information
?
-
glucuronidation by the UDP glucuronosyltransferase 1A enzymes is a major pathway for elimination of drugs and endogenous substances, such as bilirubin
-
-
?
additional information
?
-
-
glucuronidation by the UDP glucuronosyltransferase 1A enzymes is a major pathway for elimination of drugs and endogenous substances, such as bilirubin
-
-
?
additional information
?
-
-
substrate specificity determinates by amino acid sequences in the variable amino-terminal half of the enzyme molecule
-
-
?
additional information
?
-
-
simple planar phenols, anthraquinones and opioid compounds glucuronidated by UGT1.1, aliphatic and monoterpenoid alcohols and amines not glucuronidated
-
-
?
additional information
?
-
-
specificity not influenced by lysophosphatidylcholine
-
-
?
additional information
?
-
-
no activity with 4-hydroxycoumarin or 7-methoxycoumarin, conjugation of androsterone
-
-
?
additional information
?
-
-
elimination of lipid-soluble endogenous compounds and xenobiotics
-
-
?
additional information
?
-
-
elimination of lipid-soluble endogenous compounds and xenobiotics
-
-
?
additional information
?
-
-
elimination of lipid-soluble endogenous compounds and xenobiotics
-
-
?
additional information
?
-
-
certain endogenous estrogens glucuronidated by UGT1.1 at 3-hydroxyl group of the A ring of steroids
-
-
?
additional information
?
-
-
comparison of murine and rat UGT activity and substrate specificity using duodenum and liver microsomes, overview
-
-
?
additional information
?
-
-
the enzyme is involved in clearance and detoxification of many chemical compounds, overview
-
-
?
additional information
?
-
-
UGTs play an important role in the defense against potentially hazardous xenobiotics, and they participate in the metabolism and homeostasis of many endogenous compounds, including bilirubin and steroid hormones, overview
-
-
?
additional information
?
-
-
tight protein-protein interaction between members of subfamilies UGT1A and UGT2B
-
-
?
additional information
?
-
-
elimination of lipid-soluble endogenous compounds and xenobiotics
-
-
?
additional information
?
-
-
specificity not influenced by lysophosphatidylcholine
-
-
?
additional information
?
-
-
3'-azido-3'-deoxythymidine-glucuronidation activity is low in the microminipig compared with humans, morphine-3-glucuronidation activity in the microminipig is higher than that in humans
-
-
?
