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Literature summary for 2.4.1.17 extracted from

  • Hanioka, N.; Takeda, Y.; Tanaka-Kagawa, T.; Hayashi, K.; Jinno, H.; Narimatsu, S.
    Interaction of bisphenol A with human UDP-glucuronosyltransferase 1A6 enzyme (2008), Environ. Toxicol., 23, 407-412.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
bisphenol A i.e. BPA, inhibits glucuronidation of serotonin and 4-methylumbelliferone Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-D-glucuronate + serotonin Homo sapiens isozyme UGT1A6 UDP + serotonin beta-D-glucuronoside
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P19224 isozyme UGT1A6
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-D-glucuronate + 4-methylumbelliferone isozyme UGT1A6 Homo sapiens UDP + 4-methylumbelliferyl beta-D-glucuronoside
-
?
UDP-D-glucuronate + serotonin isozyme UGT1A6 Homo sapiens UDP + serotonin beta-D-glucuronoside
-
?

Synonyms

Synonyms Comment Organism
UDP-glucuronosyltransferase 1A6
-
Homo sapiens
UGT1A6
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
asay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information inhibition kinetics of bisphenol A with isozymes UGT1A6 Homo sapiens
0.0723
-
bisphenol A pH 7.4, 37°C, noncompetitive versus 4-methylumbelliferone, liver microsomes Homo sapiens
0.08
-
bisphenol A pH 7.4, 37°C, mixed type inhibition versus 4-methylumbelliferone, recombinant isozyme UGT1A6 expressed in yeast microsomes Homo sapiens
0.0849
-
bisphenol A pH 7.4, 37°C, competitive versus serotonin, liver microsomes Homo sapiens
0.085
-
bisphenol A pH 7.4, 37°C, competitive versus serotonin, recombinant isozyme UGT1A6 expressed in yeast microsomes Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0425
-
pH 7.4, 37°C, versus 4-methylumbelliferone, recombinant isozyme UGT1A6 expressed in yeast microsomes Homo sapiens bisphenol A
0.0655
-
pH 7.4, 37°C, versus serotonin, recombinant isozyme UGT1A6 expressed in yeast microsomes Homo sapiens bisphenol A
0.156
-
pH 7.4, 37°C, versus serotonin, liver microsomes Homo sapiens bisphenol A
0.163
-
pH 7.4, 37°C, versus 4-methylumbelliferone, liver microsomes Homo sapiens bisphenol A