Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bisphenol A | i.e. BPA, inhibits glucuronidation of serotonin and 4-methylumbelliferone | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-D-glucuronate + serotonin | Homo sapiens | isozyme UGT1A6 | UDP + serotonin beta-D-glucuronoside | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P19224 | isozyme UGT1A6 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-D-glucuronate + 4-methylumbelliferone | isozyme UGT1A6 | Homo sapiens | UDP + 4-methylumbelliferyl beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + serotonin | isozyme UGT1A6 | Homo sapiens | UDP + serotonin beta-D-glucuronoside | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UDP-glucuronosyltransferase 1A6 | - |
Homo sapiens |
UGT1A6 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
asay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetics of bisphenol A with isozymes UGT1A6 | Homo sapiens | |
0.0723 | - |
bisphenol A | pH 7.4, 37°C, noncompetitive versus 4-methylumbelliferone, liver microsomes | Homo sapiens | |
0.08 | - |
bisphenol A | pH 7.4, 37°C, mixed type inhibition versus 4-methylumbelliferone, recombinant isozyme UGT1A6 expressed in yeast microsomes | Homo sapiens | |
0.0849 | - |
bisphenol A | pH 7.4, 37°C, competitive versus serotonin, liver microsomes | Homo sapiens | |
0.085 | - |
bisphenol A | pH 7.4, 37°C, competitive versus serotonin, recombinant isozyme UGT1A6 expressed in yeast microsomes | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0425 | - |
pH 7.4, 37°C, versus 4-methylumbelliferone, recombinant isozyme UGT1A6 expressed in yeast microsomes | Homo sapiens | bisphenol A | |
0.0655 | - |
pH 7.4, 37°C, versus serotonin, recombinant isozyme UGT1A6 expressed in yeast microsomes | Homo sapiens | bisphenol A | |
0.156 | - |
pH 7.4, 37°C, versus serotonin, liver microsomes | Homo sapiens | bisphenol A | |
0.163 | - |
pH 7.4, 37°C, versus 4-methylumbelliferone, liver microsomes | Homo sapiens | bisphenol A |