Reference on EC 2.4.1.17 - glucuronosyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bock, K.W.; Burchell, B.; Dutton, G.J.; Hnninen, O.; Mulder, G.J.; Owens, I.S.; Siest, G.; Tephly, T.R.
UDP-glucuronosyltransferase activities. Guidelines for consistent interim terminology and assay conditions
Biochem. Pharmacol.
32
953-955
1983
Rattus norvegicus, Rattus norvegicus Wistar
Burchell, B.
Identification and purification of multiple forms of UDP-glucuronosyltransferase
Rev. Biochem. Toxicol.
3
1-32
1981
Homo sapiens, Rattus norvegicus
-
Green, M.D.; Falany, C.N.; Kirkpatrick, R.B.; Tephly, T.R.
Strain differences in purified rat hepatic 3alpha-hydroxysteroid UDP-glucuronosyltransferase
Biochem. J.
230
403-409
1985
Rattus norvegicus, Rattus norvegicus Wistar
Bock, K.W.; Josting, D.; Lilienblum, W.; Pfeil, H.
Purification of rat-liver microsomal UDP-glucuronyltransferase. Separation of two enzyme forms inducible by 3-methylcholanthrene or phenobarbital
Eur. J. Biochem.
98
19-26
1979
Rattus norvegicus, Rattus norvegicus Wistar
Jansen, P.L.M.
The enzyme-catalyzed formation of bilirubin diglucurionide by a solubilized preparation from cat liver microsomes
Biochim. Biophys. Acta
338
170-182
1974
Felis catus
-
Crawford, J.M.; Ransil, B.J.; Narciso, J.P.; Gollan, J.L.
Hepatic microsomal bilirubin UDP-glucuronosyltransferase. The kinetics of bilirubin mono- and diglucuronide synthesis
J. Biol. Chem.
267
16943-16950
1992
Rattus norvegicus
Said, M.; Noort, D.; Magdalou, J.; Ziegler, J.C.; van der Marel, G.A.; van Boom, J.H.; Mulder, G.J.; Siest, G.
Selective and potent inhibition of different hepatic UDP-glucuronosyltransferase activities by omega,omega,omega-triphenylalcohols and UDP derivatives
Biochem. Biophys. Res. Commun.
187
140-145
1992
Rattus norvegicus, Rattus norvegicus Wistar
Clarke, D.J.; George, S.G.; Burchell, B.
Multiplicity of UDP-glucuronosyltransferases in fish. Purification and characterization of a phenol UDP-glucuronosyltransferase from the liver of a marine teleost, Pleuronectes platessa
Biochem. J.
284
417-423
1992
Pleuronectes platessa
Clarke, D.J.; Keen, J.N.; Burchell, B.
Isolation and characterisation of a new hepatic bilirubin UDP-glucuronosyltransferase. Absence from Gunn rat liver
FEBS Lett.
299
183-186
1992
Rattus norvegicus, Rattus norvegicus Gunn, Rattus norvegicus Wistar
Yokota, H.; Fukuda, T.; Yuasa, A.
Differential effects of phospholipids on two similar forms of UDP-glucuronyltransferase purified from rat liver and kidney microsomes
J. Biochem.
110
50-53
1991
Rattus norvegicus
Rotenberg, M.; Zakim, D.
Effects of cholesterol on the function and thermotropic properties of pure UDP-glucuronosyltransferase
J. Biol. Chem.
266
4159-4161
1991
Sus scrofa
Noort, D.; Coughtrie, M.W.H.; Burchell, B.; van der Marel, G.A.; van Boom, J.H.; van der Gen, A.; Mulder, G.J.
Inhibition of UDP-glucuronosyltransferase activity by possible transition-state analogues in rat-liver microsomes
Eur. J. Biochem.
188
309-312
1990
Rattus norvegicus, Rattus norvegicus Wistar
Haumont, M.; Magdalou, J.; Lafaurie, C.; Ziegler, J.M.; Siest, G.; Colin, J.N.
Phenobarbital inducible UDP-glucuronosyltransferase is responsible for glucuronidation of 3-azido-3-deoxythymidine: characterization of the enzyme in human and rat liver microsomes
Arch. Biochem. Biophys.
281
264-270
1990
Homo sapiens, Macaca mulatta, Rattus norvegicus, Rattus norvegicus Gunn, Rattus norvegicus Wistar
Dannenberg, A.; Wong, T.; Zakim, D.
Effect of brief treatment at alkaline pH on the properties of UDP-glucuronosyltransferase
Arch. Biochem. Biophys.
277
312-317
1990
Sus scrofa
Coffman, B.L.; Tephly, T.R.; Irshaid, Y.M.; Green, M.D.; Smith, C.; Jackson, M.R.; Wooster, R.; Burchell, B.
Characterization and primary sequence of a human hepatic microsomal estriol UDPglucuronosyltransferase
Arch. Biochem. Biophys.
281
170-175
1990
Homo sapiens
Vanstapel, F.; Hammaker, L.; Pua, K.; Blanckaert, N.
Properties of membrane-bound bilirubin UDP-glucuronyltransferase in rough and smooth endoplasmic reticulum and in the nuclear envelope from rat liver
Biochem. J.
259
659-663
1989
Rattus norvegicus, Rattus norvegicus R/A Pfd
Fournel-Gigleux, S.; Shepherd, S.R.P.; Carre, M.C.; Burchell, B.; Siest, G.; Caubere, P.
Novel inhibitors and substrates of bilirubin: UDP-glucuronosyltransferase. Arylalkylcarboxylic acids
Eur. J. Biochem.
183
653-659
1989
Rattus norvegicus, Rattus norvegicus Gunn, Rattus norvegicus Wistar
Yokota, H.; Ohgiya, N.; Ishihara, G.; Ohta, K.; Yuasa, A.
Purification and properties of UDP-glucuronyltransferase from kidney microsomes of beta-naphthoflavone-treated rat
J. Biochem.
106
248-252
1989
Rattus norvegicus, Rattus norvegicus Wistar
Hutabarat, R.M.; Yost, G.S.
Purification and characterization of an ethanol-induced UDP-glucuronosyltransferase
Arch. Biochem. Biophys.
273
16-25
1989
Oryctolagus cuniculus
Dannenberg, A.; Rotenberg, M.; Zakim, D.
Regulation of UDP-glucuronosyltransferase by lipid-protein interactions. Comparison of the thermotropic properties of pure reconstituted enzyme with microsomal enzyme
J. Biol. Chem.
264
238-242
1989
Sus scrofa
Yokota, H.; Yuasa, A.; Sato, R.
Purification and properties of a form of UDP-glucuronyltransferase from liver microsomes of 3-methylcholanthrene-treated rats
J. Biochem.
104
531-536
1988
Rattus norvegicus, Rattus norvegicus Wistar
Vanstapel, F.; Blanckaert, N.
Topology and regulation of bilirubin UDP-glucuronyltransferase in sealed native microsomes from rat liver
Arch. Biochem. Biophys.
263
216-225
1988
Rattus norvegicus, Rattus norvegicus R/A Pfd
Odell, G.; Mogilevsky, W.S.; Siegel, F.L.
Isolation of an activator of bilirubin glucuronyltransferase from normal and jaundiced Gunn rats
Biochem. Biophys. Res. Commun.
154
1212-1221
1988
Rattus norvegicus, Rattus norvegicus Gunn, Rattus norvegicus Wistar
Falany, C.N.; Green, M.D.; Swain, E.; Tephly, T.R.
Substrate specificity and characterization of rat liver p-nitrophenol, 3alpha-hydroxysteroid and 17beta-hydroxysteroid UDP-glucuronosyltransferases
Biochem. J.
238
65-73
1986
Rattus norvegicus
Roy Chowdhury, J.; Roy Chowdhury, N.; Falany, C.N.; Tephly, T.R.; Arias, I.M.
Isolation and characterization of multiple forms of rat liver UDP-glucuronate glucuronosyltransferase
Biochem. J.
233
827-837
1986
Rattus norvegicus, Rattus norvegicus Wistar
Fournel, S.; Gergoire, B.; Magdalou, J.; Carre, M.C.; Lafaurie, C.; Siest, G.; Caubere, P.
Inhibition of bilirubin UDPglucuronosyltransferase activity by triphenylacetic acid and related compounds
Biochim. Biophys. Acta
883
190-196
1986
Homo sapiens, Rattus norvegicus, Rattus norvegicus Wistar
Peters, W.H.M.; Jansen, P.L.M.; Nauta, H.
The molecular weights of UDP-glucuronyltransferase determined with radiation-inactivation analysis. A molecular model of bilirubin UDP-glucuronyltransferase
J. Biol. Chem.
259
11701-11706
1984
Rattus norvegicus, Rattus norvegicus Wistar
Mackenzie, P.I.; Hjelmeland, L.M.; Owens, I.S.
Purification and immunochemical characterization of a low-pI form of UDP glucuronosyltransferase from mouse liver
Arch. Biochem. Biophys.
231
487-497
1984
Mus musculus
Burchell, B.; Blanckaert, N.
Bilirubin mono- and di-glucuronide formation by purified rat liver microsomal bilirubin UDP-glucuronyltransferase
Biochem. J.
223
461-465
1984
Rattus norvegicus, Rattus norvegicus Wistar
Koster, A.S.; Noordhoek, J.
Kinetic properties of the rat intestinal microsomal 1-naphthol:UDP-glucuronosyl transferase. Inhibition by UDP and UDP-N-acetylglucosamine
Biochim. Biophys. Acta
761
76-85
1983
Rattus norvegicus, Rattus norvegicus Wistar
Falany, C.N.; Tephly, T.R.
Separation, purification and characterization of three isoenzymes of UDP-glucuronyltransferase from rat liver microsomes
Arch. Biochem. Biophys.
227
248-258
1983
Rattus norvegicus
Hochman, Y.; Zakim, D.
A comparison of the kinetic properties of two different forms of microsomal UDPglucuronyltransferase
J. Biol. Chem.
258
4143-4146
1983
Sus scrofa
Matern, H.; Matern, S.; Gerok, W.
Isolation and characterization of rat liver microsomal UDP-glucuronosyltransferase activity toward chenodeoxycholic acid and testosterone as a single form of enzyme
J. Biol. Chem.
257
7422-7429
1982
Rattus norvegicus
Tukey, R.H.; Tephly, T.R.
Purification of properties of rabbit liver estrone and p-nitrophenol UDP-glucuronyltransferases
Arch. Biochem. Biophys.
209
565-578
1981
Oryctolagus cuniculus
Singh, O.M.; Graham, A.B.; Wood, G.C.
The phospholipid-dependence of UDP glucuronosyltransferase. Purification, delipidation and reconstitution of microsomal enzyme from guinea-pig liver
Eur. J. Biochem.
116
311-316
1981
Cavia porcellus
Burchell, B.; Weatherill, P.
4-Nitrophenol UDPglucuronyltransferase (rat liver)
Methods Enzymol.
77
169-177
1981
Rattus norvegicus, Rattus norvegicus Wistar
Tukey, R.H.; Tephly, T.R.
Estrone and 4-nitrophenol UDPglucuronyltransferases (rabbit liver)
Methods Enzymol.
77
177-188
1981
Oryctolagus cuniculus
Burchell, B.
Bilirubin UDPglucuronyltransferase
Methods Enzymol.
77
188-192
1981
Rattus norvegicus
Bock, K.W.; Lilienblum, W.; Pfeil, H.
Conversion of benzo[a]pyrene-3,6-quinone to quinol glucuronides with rat liver microsomes or purified NADPH-cytochrome c reductase and UDP-glucuronosyltransferase
FEBS Lett.
121
269-272
1980
Rattus norvegicus
Weatherill, P.J.; Burchell, B.
The separation and purification of rat liver UDP-glucuronyltransferase activities towards testosterone and oestrone
Biochem. J.
189
377-380
1980
Rattus norvegicus, Rattus norvegicus Wistar
Burchell, B.
Isolation and purification of bilirubin UDP-glucuronyl-transferase from rat liver
FEBS Lett.
111
131-135
1980
Rattus norvegicus, Rattus norvegicus Wistar
Leakey, J.E.A.
An improved assay technique for uridine diphosphate glucuronosyltransferase activity towards 5-hydroxytryptamine and some properties of the enzyme
Biochem. J.
175
1119-1124
1978
Felis catus, Mus musculus, Rattus norvegicus, Rattus norvegicus Gunn, Rattus norvegicus Wistar
Burchell, B.
Substrate specificity and properties of uridine diphosphate glucuronyltransferase purified to apparent homogeneity from phenobarbital-treated rat liver
Biochem. J.
173
749-757
1978
Rattus norvegicus, Rattus norvegicus Wistar
Gorski, J.P.; Kasper, C.B.
Purification and properties of microsomal UDP-glucuronosyltransferase from rat liver
J. Biol. Chem.
252
1336-1343
1977
Rattus norvegicus
Burchell, B.
Purification of UDP-glucuronyltransferase from untreated rat liver
FEBS Lett.
78
101-104
1977
Rattus norvegicus, Rattus norvegicus Wistar
Burchell, B.
Studies on the purification of rat liver uridine diphosphate glucuronyltransferase
Biochem. J.
161
543-549
1977
Rattus norvegicus, Rattus norvegicus Wistar
Zakim, D.; Vessey, D.A.
The properties of uridine diphosphate glucuronyltransferase(s) which catalyse the synthesis of steroid glucuronides in microsomal fractions from guinea-pig liver
Biochem. J.
157
667-673
1976
Cavia porcellus
Rao, M.L.; Rao, G.S.; Breuer, H.
Investigations on the kinetic properties of estrone glucuronyltransferase from pig kidney
Biochim. Biophys. Acta
452
89-100
1976
Sus scrofa
Zakim, D.; Vessey, D.A.
Membrane dependence of uridine diphosphate glucuronosyltransferase: effect of the membrane on kinetic properties
Biochem. Soc. Trans.
2
1165-1167
1974
Homo sapiens
-
Graham, A.B.; Pechey, D.T.; Wood, G.C.; Woodcock, B.G.
The role of the microsomal membrane in control of uridine diphosphate glucuronosyltransferase in vitro and in vivo
Biochem. Soc. Trans.
2
1167-1172
1974
Cavia porcellus, Rattus norvegicus
-
Mulder, G.J.
Heterogeneity of hepatic microsomal uridine diphosphate glucuronosyltransferase: a critical evaluation
Biochem. Soc. Trans.
2
1172-1176
1974
Rattus norvegicus
-
Illing, H.P.A.; Dutton, G.J.
Some properties of the uridine diphosphate glucuronyltransferase activity synthesizing thio-beta-D-glucuronides
Biochem. J.
131
139-147
1973
Gallus gallus, Mus musculus, Rattus norvegicus, Rattus norvegicus Gunn, Rattus norvegicus Wistar
Vessey, D.A.; Goldenberg, J.; Zakim, D.
Kinetic properties of microsomal UDP-glucuronyltransferase. Evidence for cooperative kinetics and activation by UDP-N-acetylglucosamine
Biochim. Biophys. Acta
309
58-66
1973
Cavia porcellus
Zakim, D.; Goldenberg, J.; Vessey, D.A.
Effects of metals on the properties of hepatic microsomal uridine diphosphate glucuronyltransferase
Biochemistry
12
4068-4074
1973
Cavia porcellus, Rattus norvegicus
Gregory, D.H.; Strickland, R.D.
Solubilization and characterization of hepatic bilirubin UDP-glucuronyltransferase
Biochim. Biophys. Acta
327
36-45
1973
Rattus norvegicus
Winsnes, A.
Kinetic properties of different forms of hepatic UDPglucuronyltransferase
Biochim. Biophys. Acta
284
394-405
1972
Cavia porcellus, Mus musculus, Rattus norvegicus, Rattus norvegicus Wistar
Winsnes, A.
Inhibition of hepatic UDPglucuronyltransferase by nucleotides
Biochim. Biophys. Acta
289
88-96
1972
Mus musculus
Heirwegh, K.P.M.; van de Vijver, M.; Fevery, J.
Assay and properties of dititonin-activated bilirubin uridine diphosphate glucuronyltransferase from rat liver
Biochem. J.
129
605-618
1972
Rattus norvegicus, Rattus norvegicus Wistar
Schumacher, R.; Rao, G.S.; Rao, L.M.; Breuer, H.
Steroidglucuronyltransferases. 3. Oestradiol-17 3-glucuronyltransferase of the mitochondria of pig intestine
Hoppe-Seyler's Z. Physiol. Chem.
353
1784-1788
1972
Sus scrofa
Rao, G.S.; Schumacher, R.; Rao, M.L.; Breuer, H.
Steroidglucuronyltransferases. IV. Localization of the oestradiol-17beta-glucuronyltransferase in the outer membrane of the mitochondria of pig intestine
Hoppe-Seyler's Z. Physiol. Chem.
353
1789-1797
1972
Sus scrofa
Gtze, W.; Grube, E.; Rao, G.S.; Rao, M.L.; Breuer, H.
Steroid glucuronyltransferases. II. Solubilization, purification aand kinetic properties of oestradiol-17 3-glucuronyltransferase from the microsomal fraction of pig intestine
Hoppe-Seyler's Z. Physiol. Chem.
352
1223-1230
1971
Sus scrofa
Styczynski, P.; Green, M.; Puig, J.; Coffman, B.; Tephly, T.
Purification and properties of a rat liver phenobarbital-inducible 4-hydroxybiphenyl UDP-glucuronosyltransferase
Mol. Pharmacol.
40
80-84
1991
Rattus norvegicus
Clarke, D.J.; Burchell, B.; George, S.
Characterization and molecular analysis of hepatic microsomal UDP-glucuronosyltransferases in the marine fish, Pleuronestes platessa
Mar. Environ. Res.
24
105-109
1988
Pleuronectes platessa
-
Bock, K.W.; Schirmer, G.; Green, M.D.; Tephly, T.R.
Properties of a 3-methylcholanthrene-inducible phenol UDP-glucuronosyltransferase from rat liver
Biochem. Pharmacol.
37
1439-1443
1988
Rattus norvegicus
Pesonen, M.; Andersson, T.
Subcellular localization and properties of cytochrome P-450 and UDP glucuronosyltransferase in the rainbow trout kidney
Biochem. Pharmacol.
36
823-829
1987
Oncorhynchus mykiss
Coughtrie, M.W.H.; Burchell, B.; Bend, J.R.
Purification and properties of rat kidney UDP-glucuronosyltransferase
Biochem. Pharmacol.
36
245-251
1987
Rattus norvegicus
Irshaid, Y.M.; Tephly, T.R.
Isolation and purification of two human liver UDP-glucuronosyltransferases
Mol. Pharmacol.
31
27-34
1987
Homo sapiens
Puig, J.F.; Tephly, T.R.
Isolation and purification of rat liver morphine UDP-glucuronosyltransferase
Mol. Pharmacol.
30
558-565
1986
Homo sapiens, Rattus norvegicus, Rattus norvegicus Wistar
Matern, S.; Matern, H.; Farthmann, E.H.; Gerok, W.
Hepatic and extrahepatic glucuronidation of bile acids in man. Characterization of bile acid uridine 5-diphosphate-glucuronosyltransferase in hepatic, renal, and intestinal microsomes
J. Clin. Invest.
74
402-410
1984
Homo sapiens
Aitio, A.; Parkki, M.G.
Activation and inhibition of rat hepatic UDP-glucuronyltransferase by mercuric acetate
Xenobiotica
11
97-102
1981
Rattus norvegicus
Tukey, R.; Tephly, T.
Phospholipid dependency of purified estrone and p-nitrophenol UDP-glucuronyltransferases
Life Sci.
27
2471-2476
1980
Oryctolagus cuniculus
Moulder, G.J.
Glucuronidation and its role in regulation of biological activity of drugs
Annu. Rev. Pharmacol. Toxicol.
32
25-49
1992
Homo sapiens
Burchell, B.; Coughtrie, M.W.H.
UDP-glucuronosyltransferases
Pharmacol. Ther.
43
261-289
1989
Homo sapiens, Mus musculus, Rattus norvegicus
Tephly, T.R.
Isolation and purification of UDP-glucuronosyltransferases
Chem. Res. Toxicol.
3
509-516
1990
Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus
Dutton, G.J.
Glucuronidation of Drugs and other Compounds
Glucuronidation of Drugs and other Compounds (CRC Press, Boca Raton, Florida)
1980
Mammalia
-
Ritter, J.K.; Crawford, J.M.; Owens, I.S.
Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells
J. Biol. Chem.
266
1043-1047
1991
Homo sapiens, Mus musculus
Roy-Chowhury, J.; Huang, T.; Kesari, K.; Lederstein, M.; Arias, I.M.; Roy-Chowhury, N.
Molecular basis for the lack of bilirubin-specific and 3-methylcholanthrene-inducible UDP-glucuronosyltransferase activities in Gunn rats. The two isoforms are encoded by distinct mRNA species that share an identical single base deletion
J. Biol. Chem.
266
18294-18298
1991
Rattus norvegicus, Rattus norvegicus Gunn
Matern, H.; Matern, S.; Schelzig, C.; Gerok, W.
Bile acid UDP-glucoronyltransferase from human liver. Properties and studies on aglycone substrate specificity
FEBS Lett.
118
251-254
1980
Homo sapiens
Hauser, S.C.; Ziurys, J.C.; Gollan, J.L.
Subcellular distribution and regulation of hepatic bilirubin UDP-glucuronyltransferase
J. Biol. Chem.
259
4527-4533
1984
Rattus norvegicus
Tukey, R.H.; Billings, R.E.; Tephly, T.R.
Separation of oestrone UDP-glucuronyltransferase and p-nitrophenol UDP-glucuronyltransferase activities
Biochem. J.
171
659-663
1978
Oryctolagus cuniculus
Grube, E.; Gtze, W.; Rao, G.S.; Rao, M.L.
Steroid glucuronyltransferases. I. Morphological and biochemical investigations on the oestradiol-17 3-glucuronyltransferase in subcellular fractions of the pig intestine
Hoppe-Seyler's Z. Physiol. Chem.
352
1215-1222
1971
Sus scrofa
Jansen, P.L.M.; Mulder, G.J.; Burchell, B.; Bock, K.W.
New developments in glucuronidation research: report of a workshop on "glucuronidation, its role in health and disease"
Hepatology
15
532-544
1992
Homo sapiens, Rattus norvegicus
Wooster, R.; Sutherland, L.; Ebner, T.; Clarke, D.; Da Cruz, E.; Silva, O.; Burchell, B.
Cloning and stable expression of a new member of the human liver phenol/bilirubin: UDP-glucuronosyltransferase cDNA family
Biochem. J.
278
465-469
1991
Homo sapiens
-
Yamashita, A.; Watanabe, M.; Tonegawa, T.; Sugiura, T.; Waku, K.
Acyl-CoA binding and acylation of UDP-glucuronosyltransferase isoforms of rat liver: their effect on enzyme activity
Biochem. J.
312
301-308
1995
Rattus norvegicus
-
King, C.D.; Green, M.D.; Rios, G.R.; Coffman, B.L.; Owens, I.S.; Bishop, W.P.; Tephly, T.R.
The glucuronidation of exogenous and endogenous compounds by stably expressed rat and human UDP-glucuronosyltransferase 1.1
Arch. Biochem. Biophys.
332
92-100
1996
Homo sapiens, Rattus norvegicus
Mojarrabi, B.; Butler, R.; Mackenzie, P.I.
cDNA cloning and characterization of the human UDP glucuronosyltransferase, UGT1A3
Biochem. Biophys. Res. Commun.
225
785-790
1996
Homo sapiens
Bruck, M.; Li, Q.; Lamb, J.G.; Tukey, R.H.
Characterization of rabbit UDP-glucuronosyltransferase UGT1A7: tertiary amine glucuronidation is catalyzed by UGT1A7 and UGT1A4
Arch. Biochem. Biophys.
344
357-364
1997
Oryctolagus cuniculus
Green, M.D.; Belanger, G.; Hum, D.W.; Belanger, A.; Tephly, T.R.
Glucuronidation of opioids, carboxylic acid-containing drugs, and hydroxylated xenobiotics catalyzed by expressed monkey UDP-glucuronosyltransferase 2B9 protein
Drug Metab. Dispos.
25
1389-1394
1997
Macaca fascicularis, Homo sapiens
Meech, R.; Mackenzie, P.I.
Structure and function of uridine diphosphate glucuronosyltransferases
Clin. Exp. Pharmacol. Physiol.
24
907-915
1997
Rattus norvegicus
Cheng, Z.; Rios, G.R.; King, C.D.; Coffman, B.L.; Green, M.D.; Mojarrabi, B.; Mackenzie, P.I.; Tephly, T.R.
Glucuronidation of catechol estrogens by expressed human UDP-glucuronosyltransferases (UGTs) 1A1, 1A3, and 2B7
Toxicol. Sci.
45
52-57
1998
Homo sapiens
Barbier, O.; Belanger, A.; Hum, D.W.
Cloning and characterization of a simian UDP-glucuronosyltransferase enzyme UGT2B20, a novel C19 steroid-conjugating protein
Biochem. J.
337
567-574
1999
Macaca fascicularis, Homo sapiens
Iwano, H.; Yokota, H.; Ohgiya, S.; Yuasa, A.
The significance of amino acid residue Asp446 for enzymic stability of rat UDP-glucuronosyltransferase UGT1A6
Arch. Biochem. Biophys.
363
116-120
1999
Homo sapiens, Rattus norvegicus
Jedlitschky, G.; Cassidy, A.J.; Sales, M.; Pratt, N.; Burchell, B.
Cloning and characterization of a novel human olfactory UDP-glucuronosyltransferase
Biochem. J.
340
837-843
1999
Homo sapiens
-
Little, J.M.; Lester, R.; Kuipers, F.; Vonk, R.; Mackenzie, P.I.; Drake, R.R.; Frame, L.; Radominska-Pandya, A.
Variability of human hepatic UDP-glucuronosyltransferase activity
Acta Biochim. Pol.
46
351-363
1999
Homo sapiens
Radominska-Pandya, A.; Czernik, P.J.; Little, J.M.; Battaglia, E.; Mackenzie, P.I.
Structural and functional studies of UDP-Glucuronosyltransferases
Drug Metab. Rev.
31
817-899
1999
Rattus norvegicus, Homo sapiens (P19224)
Barbier, O.; Girard, C.; Breton, R.; Belanger, A.; Hum, D.W.
N-Glycosylation and Residue 96 Are Involved in the Functional Properties of UDP-Glucuronosyltransferase Enzymes
Biochemistry
39
11540-11552
2000
Platyrrhini, Homo sapiens (O75795), Homo sapiens
Yoshigae, Y.; Konno, K.; Takasaki, W.; Ikeda, T.
Characterization of UDP-glucuronosyltransferases (UGTS) involved in the metabolism of troglitazone in rats and humans
J. Toxicol. Sci.
25
433-441
2000
Homo sapiens, Rattus norvegicus, Rattus norvegicus Gunn, Rattus norvegicus Wistar
King, C.; Tang, W.; Ngui, J.; Tephly, T.; Braun, M.
Characterization of rat and human UDP-glucuronosyltransferases responsible for the in vitro glucuronidation of diclofenac
Toxicol. Sci.
61
49-53
2001
Homo sapiens, Rattus norvegicus
Radominska-Pandya, A.; Little, J.M.; Czernik, P.J.
Human UDP-glucuronosyltransferase 2B7
Curr. Drug Metab.
2
283-298
2001
Homo sapiens, Rattus norvegicus
Vallee, M.; Albert, C.; Beaudry, G.; Hum, D.W.; Belanger, A.
Isolation and characterization of the monkey UDP-glucuronosyltransferase cDNA clone monUGT1A01 active on bilirubin and estrogens
J. Steroid Biochem. Mol. Biol.
77
239-249
2001
Homo sapiens, Platyrrhini
Videira, P.; Fialho, A.; Geremia, R.A.; Breton, C.; Sa-Correia, I.
Biochemical characterization of the beta-1,4-glucuronosyltransferase GelK in the gellan gum-producing strain Sphingomonas paucimobilis A.T.C.C. 31461
Biochem. J.
358
457-464
2001
Sphingomonas paucimobilis
Dean, B.; Chang, S.; Stevens, J.; Thomas, P.E.; King, C.
Isolation and characterization of a UDP-glucuronosyltransferase (UGT1A01) cloned from female rhesus monkey
Arch. Biochem. Biophys.
402
289-295
2002
Macaca mulatta
Mano, N.; Nishimura, K.; Narui, T.; Ikegawa, S.; Goto, J.
Characterization of rat liver bile acid acyl glucuronosyltransferase
Steroids
67
257-262
2002
Rattus norvegicus
Nakajima, M.; Tanaka, E.; Kobayashi, T.; Ohashi, N.; Kume, T.; Yokoi, T.
Imipramine N-glucuronidation in human liver microsomes: biphasic kinetics and characterization of UDP-glucuronosyltransferase isoforms
Drug Metab. Dispos.
30
636-642
2002
Homo sapiens, Rattus norvegicus
Yamashiki, N.; Yokota, H.; Sakamoto, M.; Yuasa, A.
Presence of phenol UDP-glucuronosyltransferase in bovine alveolar macrophages and bronchial epithelial cells
Toxicology
176
221-227
2002
Bos taurus
Kurkela, M.; Garcia-Horsman, J.A.; Luukkanen, L.; Moersky, S.; Taskinen, J.; Baumann, M.; Kostiainen, R.; Hirvonen, J.; Finel, M.
Expression and Characterization of Recombinant Human UDP-glucuronosyltransferases (UGTs)
J. Biol. Chem.
278
3536-3544
2003
Homo sapiens
Hakala, K.S.; Suchanova, B.; Luukkanen, L.; Ketola, R.A.; Finel, M.; Kostiainen, R.
Rapid simultaneous determination of metabolic clearance of multiple compounds catalyzed in vitro by recombinant human UDP-glucuronosyltransferases
Anal. Biochem.
341
105-112
2005
Homo sapiens, Homo sapiens (O60656), Homo sapiens (P16662), Homo sapiens (P22309), Homo sapiens (P35503), Homo sapiens (P54855)
Soars, M.G.; Fettes, M.; O'Sullivan, A.C.; Riley, R.J.; Ethell, B.T.; Burchell, B.
Cloning and characterisation of the first drug-metabolising canine UDP-glucuronosyltransferase of the 2B subfamily
Biochem. Pharmacol.
65
1251-1259
2003
Homo sapiens, Canis lupus familiaris (Q6K1J1), Canis lupus familiaris
Stone, A.N.; MacKenzie, P.I.; Galetin, A.; Houston, B.J.; Miners, J.O.
Isoform selectivity and kinetics of morphine 3- and 6-glucuronidation by human UDP-glucuronosyltransferases: Evidence for atypical glucuronidation kinetics by UGT2B7
Drug Metab. Dispos.
31
1086-1089
2003
Homo sapiens
Court, M.H.; Krishnaswamy, S.; Hao, Q.; Duan, S.X.; Patten, C.J.; Von Moltke, L.L.; Greenblatt, D.J.
Evaluation of 3'-azido-3'-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: specificity and influence of the UGT2B7*2 polymorphism
Drug Metab. Dispos.
31
1125-1133
2003
Homo sapiens
Krishnaswamy, S.; Duan, S.X.; Von Moltke, L.L.; Greenblatt, D.J.; Court, M.H.
Validation of serotonin (5-hydroxtryptamine) as an in vitro substrate probe for human UDP-glucuronosyltransferase (UGT) 1A6
Drug Metab. Dispos.
31
133-139
2003
Homo sapiens (P19224), Homo sapiens
Jinno, H.; Saeki, M.; Tanaka-Kagawa, T.; Hanioka, N.; Saito, Y.; Ozawa, S.; Ando, M.; Shirao, K.; Minami, H.; Ohtsu, A.; Yoshida, T.; Saijo, N.; Sawada, J.
Functional characterization of wild-type and variant (T202I and M59I) human UDP-glucuronosyltransferase 1A10
Drug Metab. Dispos.
31
528-532
2003
Homo sapiens (Q9HAW8), Homo sapiens
Watanabe, Y.; Nakajima, M.; Ohashi, N.; Kume, T.; Yokoi, T.
Glucuronidation of etoposide in human liver microsomes is specifically catalyzed by UDP-glucuronosyltransferase 1A1
Drug Metab. Dispos.
31
589-595
2003
Homo sapiens (P22309), Homo sapiens
Soars, M.G.; Ring, B.J.; Wrighton, S.A.
The effect of incubation conditions on the enzyme kinetics of UDP-glucuronosyltransferases
Drug Metab. Dispos.
31
762-767
2003
Homo sapiens
Uchaipichat, V.; Mackenzie, P.I.; Guo, X.H.; Gardner-Stephen, D.; Galentin, A.; Houston, B.; Miners, J.O.
Human UDP-glucuronosyltransferases: isoform selectivity and kinetics of a 4-methylumbelliferone and 1-naphthol glucuronidation, effects of organic solvents, and inhibition by diclofenac and probenecid
Drug Metab. Dispos.
32
413-423
2004
Homo sapiens, Homo sapiens (O60656), Homo sapiens (P16662), Homo sapiens (P22309), Homo sapiens (P22310), Homo sapiens (P35503), Homo sapiens (P54855), Homo sapiens (Q9HAW7), Homo sapiens (Q9HAW8), Homo sapiens (Q9HAW9)
Krishnaswamy, S.; Hao, Q.; Von Moltke, L.L.; Greenblatt, D.J.; Court, M.H.
Evaluation of 5-hydroxytryptophol and other endogenous serotonin (5-hydroxytryptamine) analogs as substrates for UDP-glucuronosyltransferase 1A6
Drug Metab. Dispos.
32
862-869
2004
Homo sapiens (P19224), Homo sapiens
Picard, N.; Ratanasavanh, D.; Premaud, A.; Le Meur, Y.; Marquet, P.
Identification of the UDP-glucuronosyltransferase isoforms involved in mycophenolic acid phase II metabolism
Drug Metab. Dispos.
33
139-146
2005
Homo sapiens
Kaji, H.; Kume, T.
Regioselective glucuronidation of denopamine: marked species differences and identification of human UDP-glucuronosyltransferase isoform
Drug Metab. Dispos.
33
403-412
2005
Canis lupus familiaris, Oryctolagus cuniculus, Macaca fascicularis, Homo sapiens, Homo sapiens (O60656), Homo sapiens (O75795), Homo sapiens (P16662), Homo sapiens (P22309), Homo sapiens (P22310), Homo sapiens (P35503), Homo sapiens (P54855), Homo sapiens (Q9HAW7), Homo sapiens (Q9HAW8), Homo sapiens (Q9HAW9), Rattus norvegicus
Mori, A.; Maruo, Y.; Iwai, M.; Sato, H.; Takeuchi, Y.
UDP-glucuronosyltransferase 1A4 polymorphisms in a Japanese population and kinetics of clozapine glucuronidation
Drug Metab. Dispos.
33
672-675
2005
Homo sapiens (P22310), Homo sapiens
Tachibana, M.; Tanaka, M.; Masubuchi, Y.; Horie, T.
Acyl glucuronidation of fluoroquinolone antibiotics by the UDP-glucuronosyltransferase 1A subfamily in human liver microsomes
Drug Metab. Dispos.
33
803-811
2005
Homo sapiens (O60656), Homo sapiens (P22309), Homo sapiens (P35503), Homo sapiens (Q9HAW7), Homo sapiens
Girard, C.; Barbier, O.; Veilleux, G.; El-Alfy, M.; Belanger, A.
Human uridine diphosphate-glucuronosyltransferase UGT2B7 conjugates mineralocorticoid and glucocorticoid metabolites
Endocrinology
144
2659-2668
2003
Homo sapiens (P16662), Homo sapiens
Basu, N.K.; Ciotti, M.; Hwang, M.S.; Kole, L.; Mitra, P.S.; Cho, J.W.; Owens, I.S.
Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake
J. Biol. Chem.
279
1429-1441
2004
Homo sapiens (O60656), Homo sapiens (P22309), Homo sapiens (Q9HAW7), Homo sapiens (Q9HAW9), Homo sapiens
Lepine, J.; Bernard, O.; Plante, M.; Tetu, B.; Pelletier, G.; Labrie, F.; Belanger, A.; Guillemette, C.
Specificity and regioselectivity of the conjugation of estradiol, estrone, and their catecholestrogen and methoxyestrogen metabolites by human uridine diphospho-glucuronosyltransferases expressed in endometrium
J. Clin. Endocrinol. Metab.
89
5222-5232
2004
Homo sapiens
Jinno, H.; Saeki, M.; Saito, Y.; Tanaka-Kagawa, T.; Hanioka, N.; Sai, K.; Kaniwa, N.; Ando, M.; Shirao, K.; Minami, H.; Ohtsu, A.; Yoshida, T.; Saijo, N.; Ozawa, S.; Sawada, J.
Functional characterization of human UDP-glucuronosyltransferase 1A9 variant, D256N, found in Japanese cancer patients
J. Pharmacol. Exp. Ther.
306
688-693
2003
Homo sapiens (O60656), Homo sapiens
Kurkela, M.; Morsky, S.; Hirvonen, J.; Kostiainen, R.; Finel, M.
An active and water-soluble truncation mutant of the human UDP-glucuronosyltransferase 1A9
Mol. Pharmacol.
65
826-831
2004
Homo sapiens (O60656), Homo sapiens
Takeda, S.; Ishii, Y.; Iwanaga, M.; Mackenzie, P.I.; Nagata, K.; Yamazoe, Y.; Oguri, K.; Yamada, H.
Modulation of UDP-glucuronosyltransferase function by cytochrome P450: evidence for the alteration of UGT2B7-catalyzed glucuronidation of morphine by CYP3A4
Mol. Pharmacol.
67
665-672
2005
Homo sapiens (P16662), Homo sapiens
Kakuda, S.; Oka, S.; Kawasaki, T.
Purification and characterization of two recombinant human glucuronyltransferases involved in the biosynthesis of HNK-1 carbohydrate in Escherichia coli
Protein Expr. Purif.
35
111-119
2004
Homo sapiens
Nishiyama, T.; Kobori, T.; Arai, K.; Ogura, K.; Ohnuma, T.; Ishii, K.; Hayashi, K.; Hiratsuka, A.
Identification of human UDP-glucuronosyltransferase isoform(s) responsible for the C-glucuronidation of phenylbutazone
Arch. Biochem. Biophys.
454
72-79
2006
Homo sapiens (O60656), Homo sapiens
Uesawa, Y.; Staines, A.G.; Lockley, D.; Mohri, K.; Burchell, B.
Identification of the human liver UDP-glucuronosyltransferase involved in the metabolism of p-ethoxyphenylurea (dulcin)
Arch. Toxicol.
81
163-168
2007
Homo sapiens (O60656), Homo sapiens (P19224), Homo sapiens (P22309), Homo sapiens (P22310), Homo sapiens (P35503), Homo sapiens (Q9HAW7), Homo sapiens
Ghosh, S.S.; Lu, Y.; Lee, S.W.; Wang, X.; Guha, C.; Roy-Chowdhury, J.; Roy-Chowdhury, N.
Role of cysteine residues in the function of human UDP glucuronosyltransferase isoform 1A1 (UGT1A1)
Biochem. J.
392
685-692
2005
Homo sapiens (P22309), Homo sapiens
Gaganis, P.; Miners, J.O.; Knights, K.M.
Glucuronidation of fenamates: kinetic studies using human kidney cortical microsomes and recombinant UDP-glucuronosyltransferase (UGT) 1A9 and 2B7
Biochem. Pharmacol.
73
1683-1691
2007
Homo sapiens (O60656), Homo sapiens (P16662), Homo sapiens
Xiong, Y.; Bernardi, D.; Bratton, S.; Ward, M.D.; Battaglia, E.; Finel, M.; Drake, R.R.; Radominska-Pandya, A.
Phenylalanine 90 and 93 are localized within the phenol binding site of human UDP-glucuronosyltransferase 1A10 as determined by photoaffinity labeling, mass spectrometry, and site-directed mutagenesis
Biochemistry
45
2322-2332
2006
Homo sapiens (O60656), Homo sapiens (P19224), Homo sapiens (P22309), Homo sapiens (Q9HAW7), Homo sapiens (Q9HAW8), Homo sapiens (Q9HAW9), Homo sapiens
Bowalgaha, K.; Elliot, D.J.; Mackenzie, P.I.; Knights, K.M.; Swedmark, S.; Miners, J.O.
S-Naproxen and desmethylnaproxen glucuronidation by human liver microsomes and recombinant human UDP-glucuronosyltransferases (UGT): role of UGT2B7 in the elimination of naproxen
Br. J. Clin. Pharmacol.
60
423-433
2005
Homo sapiens (O60656), Homo sapiens (P16662), Homo sapiens (P19224), Homo sapiens (P22309), Homo sapiens (P35503), Homo sapiens (Q9HAW7), Homo sapiens (Q9HAW9), Homo sapiens
Hanioka, N.; Takeda, Y.; Jinno, H.; Tanaka-Kagawa, T.; Naito, S.; Koeda, A.; Shimizu, T.; Nomura, M.; Narimatsu, S.
Functional characterization of human and cynomolgus monkey UDP-glucuronosyltransferase 1A6 enzymes
Chem. Biol. Interact.
164
136-145
2006
Homo sapiens (P19224), Homo sapiens, Macaca fascicularis
Daidoji, T.; Gozu, K.; Iwano, H.; Inoue, H.; Yokota, H.
UDP-glucuronosyltransferase isoforms catalyzing glucuronidation of hydroxy-polychlorinated biphenyls in rat
Drug Metab. Dispos.
33
1466-1476
2005
Rattus norvegicus, Rattus norvegicus (P08430), Rattus norvegicus (P08542), Rattus norvegicus (P09875), Rattus norvegicus (P36511), Rattus norvegicus (Q64550), Rattus norvegicus (Q64633), Rattus norvegicus (Q64637)
Zhang, D.; Chando, T.J.; Everett, D.W.; Patten, C.J.; Dehal, S.S.; Humphreys, W.G.
In vitro inhibition of UDP glucuronosyltransferases by atazanavir and other HIV protease inhibitors and the relationship of this property to in vivo bilirubin glucuronidation
Drug Metab. Dispos.
33
1729-1739
2005
Homo sapiens
Webb, L.J.; Miles, K.K.; Auyeung, D.J.; Kessler, F.K.; Ritter, J.K.
Analysis of substrate specificities and tissue expression of rat UDP-glucuronosyltransferases UGT1A7 and UGT1A8
Drug Metab. Dispos.
33
77-82
2005
Rattus norvegicus (P70624), Rattus norvegicus (Q64634)
Tallman, M.N.; Ritter, J.K.; Smith, P.C.
Differential rates of glucuronidation for 7-ethyl-10-hydroxy-camptothecin (SN-38) lactone and carboxylate in human and rat microsomes and recombinant UDP-glucuronosyltransferase isoforms
Drug Metab. Dispos.
33
977-983
2005
Homo sapiens (O60656), Homo sapiens (P22309), Homo sapiens (Q9HAW7), Homo sapiens (Q9HAW9), Homo sapiens, Rattus norvegicus (Q64550), Rattus norvegicus (Q64633), Rattus norvegicus (Q64634)
Dellinger, R.W.; Fang, J.L.; Chen, G.; Weinberg, R.; Lazarus, P.
Importance of UDP-glucuronosyltransferase 1A10 (UGT1A10) in the detoxification of polycyclic aromatic hydrocarbons: decreased glucuronidative activity of the UGT1A10139Lys isoform
Drug Metab. Dispos.
34
943-949
2006
Homo sapiens (O60656), Homo sapiens (O75795), Homo sapiens (P16662), Homo sapiens (P22309), Homo sapiens (P35503), Homo sapiens (P54855), Homo sapiens (Q9HAW7), Homo sapiens (Q9HAW8), Homo sapiens (Q9HAW9), Homo sapiens
Bowalgaha, K.; Elliot, D.J.; Mackenzie, P.I.; Knights, K.M.; Miners, J.O.
The glucuronidation of DELTA4-3-keto C19- and C21-hydroxysteroids by human liver microsomal and recombinant UDP-glucuronosyltransferases (UGTs): 6alpha- and 21-hydroxyprogesterone are selective substrates for UGT2B7
Drug Metab. Dispos.
35
363-370
2007
Homo sapiens (O60656), Homo sapiens (O75795), Homo sapiens (P16662), Homo sapiens (P22310), Homo sapiens (P54855), Homo sapiens
Wen, Z.; Tallman, M.N.; Ali, S.Y.; Smith, P.C.
UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for etoposide glucuronidation in human liver and intestinal microsomes: structural characterization of phenolic and alcoholic glucuronides of etoposide and estimation of enzyme kinetics
Drug Metab. Dispos.
35
371-380
2007
Homo sapiens (P22309), Homo sapiens (P35503), Homo sapiens (Q9HAW9), Homo sapiens
Katoh, M.; Matsui, T.; Yokoi, T.
Glucuronidation of antiallergic drug, tranilast: identification of human UDP-glucuronosyltransferase isoforms and effect of its phase I metabolite
Drug Metab. Dispos.
35
583-589
2007
Homo sapiens (P22309), Homo sapiens
Kaji, H.; Kume, T.
Identification of human UDP-glucuronosyltransferase isoform(s) responsible for the glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid (TA-1801A)
Drug Metab. Pharmacokinet.
20
212-218
2005
Homo sapiens (O60656), Homo sapiens (P16662), Homo sapiens (P22309), Homo sapiens (P35503), Homo sapiens
Hara, Y.; Nakajima, M.; Miyamoto, K.; Yokoi, T.
Morphine glucuronosyltransferase activity in human liver microsomes is inhibited by a variety of drugs that are co-administered with morphine
Drug Metab. Pharmacokinet.
22
103-112
2007
Homo sapiens (P16662), Homo sapiens
Chouinard, S.; Pelletier, G.; Belanger, A.; Barbier, O.
Isoform-specific regulation of uridine diphosphate-glucuronosyltransferase 2B enzymes in the human prostate: differential consequences for androgen and bioactive lipid inactivation
Endocrinology
147
5431-5442
2006
Homo sapiens (O75310), Homo sapiens (O75795), Homo sapiens (P06133), Homo sapiens (P16662), Homo sapiens (P36537), Homo sapiens (P54855), Homo sapiens
Barre, L.; Fournel-Gigleux, S.; Finel, M.; Netter, P.; Magdalou, J.; Ouzzine, M.
Substrate specificity of the human UDP-glucuronosyltransferase UGT2B4 and UGT2B7. Identification of a critical aromatic amino acid residue at position 33
FEBS J.
274
1256-1264
2007
Homo sapiens (P06133), Homo sapiens (P16662), Homo sapiens
Al-Zoughool, M.; Talaska, G.
4-Aminobiphenyl N-glucuronidation by liver microsomes: optimization of the reaction conditions and characterization of the UDP-glucuronosyltransferase isoforms
J. Appl. Toxicol.
26
524-532
2006
Homo sapiens (O60656), Homo sapiens (P22310), Homo sapiens
Chen, S.; Beaton, D.; Nguyen, N.; Senekeo-Effenberger, K.; Brace-Sinnokrak, E.; Argikar, U.; Remmel, R.P.; Trottier, J.; Barbier, O.; Ritter, J.K.; Tukey, R.H.
Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus
J. Biol. Chem.
280
37547-37557
2005
Homo sapiens (P19224), Homo sapiens (P22309), Homo sapiens (P22310), Homo sapiens
Sorich, M.J.; McKinnon, R.A.; Miners, J.O.; Smith, P.A.
The importance of local chemical structure for chemical metabolism by human uridine 5-diphosphate-glucuronosyltransferase
J. Chem. Inf. Model.
46
2692-2697
2006
Homo sapiens
Bichlmaier, I.; Kurkela, M.; Joshi, T.; Siiskonen, A.; Rueffer, T.; Lang, H.; Suchanova, B.; Vahermo, M.; Finel, M.; Yli-Kauhaluoma, J.
Isoform-selective inhibition of the human UDP-glucuronosyltransferase 2B7 by isolongifolol derivatives
J. Med. Chem.
50
2655-2664
2007
Homo sapiens (P16662), Homo sapiens
Finel, M.; Li, X.; Gardner-Stephen, D.; Bratton, S.; Mackenzie, P.I.; Radominska-Pandya, A.
Human UDP-glucuronosyltransferase 1A5: identification, expression, and activity
J. Pharmacol. Exp. Ther.
315
1143-1149
2005
Homo sapiens (P35504), Homo sapiens
DAndrea, V.; Perez, L.M.; Sanchez Pozzi, E.J.
Inhibition of rat liver UDP-glucuronosyltransferase by silymarin and the metabolite silibinin-glucuronide
Life Sci.
77
683-692
2005
Rattus norvegicus (Q64550)
Gardner-Stephen, D.A.; Gregory, P.A.; Mackenzie, P.I.
Identification and characterization of functional hepatocyte nuclear factor 1-binding sites in UDP-glucuronosyltransferase genes
Methods Enzymol.
400
22-46
2005
Rattus norvegicus (P08430), Homo sapiens (P19224), Homo sapiens
Tian, H.; Ou, J.; Strom, S.C.; Venkataramanan, R.
Activity and expression of various isoforms of uridine diphosphate glucuronosyltransferase are differentially regulated during hepatic regeneration in rats
Pharm. Res.
22
2007-2015
2005
Rattus norvegicus (P08541), Rattus norvegicus (P09875), Rattus norvegicus (P20720), Rattus norvegicus (P36511), Rattus norvegicus (Q62789), Rattus norvegicus (Q64550), Rattus norvegicus (Q64634), Rattus norvegicus (Q64637), Rattus norvegicus (Q64638)
Caspersen, C.S.; Reznik, B.; Weldy, P.L.; Abildskov, K.M.; Stark, R.I.; Garland, M.
Molecular cloning of the baboon UDP-glucuronosyltransferase 1A gene family: evolution of the primate UGT1 locus and relevance for models of human drug metabolism
Pharmacogenet. Genomics
17
11-24
2007
Homo sapiens, Papio anubis (Q20CK6), Papio anubis (Q20CK7), Papio anubis (Q20CK8), Papio anubis (Q20CK9), Papio anubis (Q20CL0), Papio anubis (Q20CL1), Papio anubis (Q20CL2), Papio anubis (Q20CL3), Papio anubis (Q20CL4), Papio anubis (Q20CL5), Papio anubis (Q20CL6), Papio anubis
Kurkela, M.; Patana, A.S.; Mackenzie, P.I.; Court, M.H.; Tate, C.G.; Hirvonen, J.; Goldman, A.; Finel, M.
Interactions with other human UDP-glucuronosyltransferases attenuate the consequences of the Y485D mutation on the activity and substrate affinity of UGT1A6
Pharmacogenet. Genomics
17
115-126
2007
Homo sapiens (P19224), Homo sapiens (P22309), Homo sapiens
Basu, N.K.; Kovarova, M.; Garza, A.; Kubota, S.; Saha, T.; Mitra, P.S.; Banerjee, R.; Rivera, J.; Owens, I.S.
Phosphorylation of a UDP-glucuronosyltransferase regulates substrate specificity
Proc. Natl. Acad. Sci. USA
102
6285-6290
2005
Homo sapiens (Q9HAW7), Homo sapiens (Q9HAW8)
Starlard-Davenport, A.; Xiong, Y.; Bratton, S.; Gallus-Zawada, A.; Finel, M.; Radominska-Pandya, A.
Phenylalanine(90) and phenylalanine(93) are crucial amino acids within the estrogen binding site of the human UDP-glucuronosyltransferase 1A10
Steroids
72
85-94
2007
Homo sapiens (Q9HAW8), Homo sapiens
Mano, Y.; Usui, T.; Kamimura, H.
Substrate-dependent modulation of UDP-glucuronosyltransferase 1A1 (UGT1A1) by propofol in recombinant human UGT1A1 and human liver microsomes
Basic Clin. Pharmacol. Toxicol.
101
211-214
2007
Homo sapiens (P22309), Homo sapiens
Lewis, B.C.; Mackenzie, P.I.; Elliot, D.J.; Burchell, B.; Bhasker, C.R.; Miners, J.O.
Amino terminal domains of human UDP-glucuronosyltransferases (UGT) 2B7 and 2B15 associated with substrate selectivity and autoactivation
Biochem. Pharmacol.
73
1463-1473
2007
Homo sapiens (P16662), Homo sapiens (P54855), Homo sapiens
Hashizume, T.; Xu, Y.; Mohutsky, M.A.; Alberts, J.; Hadden, C.; Kalhorn, T.F.; Isoherranen, N.; Shuhart, M.C.; Thummel, K.E.
Identification of human UDP-glucuronosyltransferases catalyzing hepatic 1alpha,25-dihydroxyvitamin D3 conjugation
Biochem. Pharmacol.
75
1240-1250
2008
Homo sapiens (P22310), Homo sapiens
Kerdpin, O.; Knights, K.M.; Elliot, D.J.; Miners, J.O.
In vitro characterisation of human renal and hepatic frusemide glucuronidation and identification of the UDP-glucuronosyltransferase enzymes involved in this pathway
Biochem. Pharmacol.
76
249-257
2008
Homo sapiens
Alonen, A.; Finel, M.; Kostiainen, R.
The human UDP-glucuronosyltransferase UGT1A3 is highly selective towards N2 in the tetrazole ring of losartan, candesartan, and zolarsartan
Biochem. Pharmacol.
76
763-772
2008
Homo sapiens
Banerjee, R.; Pennington, M.W.; Garza, A.; Owens, I.S.
Mapping the UDP-glucuronic acid binding site in UDP-glucuronosyltransferase-1A10 by homology-based modeling: confirmation with biochemical evidence
Biochemistry
47
7385-7392
2008
Homo sapiens (Q9HAW8)
Nishimura, Y.; Maeda, S.; Ikushiro, S.; Mackenzie, P.I.; Ishii, Y.; Yamada, H.
Inhibitory effects of adenine nucleotides and related substances on UDP-glucuronosyltransferase: Structure-effect relationships and evidence for an allosteric mechanism
Biochim. Biophys. Acta
1770
1557-1566
2007
Rattus norvegicus
Bichlmaier, I.; Finel, M.; Sippl, W.; Yli-Kauhaluoma, J.
Stereochemical and steric control of the UDP-glucuronosyltransferase-catalyzed conjugation reaction: a rational approach for the design of inhibitors for the human UGT2B7
ChemMedChem
2
1730-1740
2007
Homo sapiens
Bichlmaier, I.; Kurkela, M.; Joshi, T.; Siiskonen, A.; Rueffer, T.; Lang, H.; Finel, M.; Yli-Kauhaluoma, J.
Potent inhibitors of the human UDP-glucuronosyltransferase 2B7 derived from the sesquiterpenoid alcohol longifolol
ChemMedChem
2
881-889
2007
Homo sapiens (P16662), Homo sapiens
Sorich, M.J.; Smith, P.A.; Miners, J.O.; Mackenzie, P.I.; McKinnon, R.A.
Recent advances in the in silico modelling of UDP glucuronosyltransferase substrates
Curr. Drug Metab.
9
60-69
2008
Rattus norvegicus, Homo sapiens (P22309)
Finel, M.; Kurkela, M.
The UDP-glucuronosyltransferases as oligomeric enzymes
Curr. Drug Metab.
9
70-76
2008
Rattus norvegicus, Homo sapiens (O60656), Homo sapiens (P16662), Homo sapiens (P19224), Homo sapiens (P22310)
Fujiwara, R.; Nakajima, M.; Yamanaka, H.; Katoh, M.; Yokoi, T.
Interactions between human UGT1A1, UGT1A4, and UGT1A6 affect their enzymatic activities
Drug Metab. Dispos.
35
1781-1787
2007
Homo sapiens, Homo sapiens (P22310)
Sun, D.; Sharma, A.K.; Dellinger, R.W.; Blevins-Primeau, A.S.; Balliet, R.M.; Chen, G.; Boyiri, T.; Amin, S.; Lazarus, P.
Glucuronidation of active tamoxifen metabolites by the human UDP glucuronosyltransferases
Drug Metab. Dispos.
35
2006-2014
2007
Homo sapiens (O75795), Homo sapiens (P22309), Homo sapiens (P35503), Homo sapiens (P54855), Homo sapiens (Q9HAW7), Homo sapiens (Q9HAW8), Homo sapiens (Q9HAW9), Homo sapiens
Mano, Y.; Usui, T.; Kamimura, H.
The UDP-glucuronosyltransferase 2B7 isozyme is responsible for gemfibrozil glucuronidation in the human liver
Drug Metab. Dispos.
35
2040-2044
2007
Homo sapiens
Rowland, A.; Knights, K.M.; Mackenzie, P.I.; Miners, J.O.
The albumin effect and drug glucuronidation: bovine serum albumin and fatty acid-free human serum albumin enhance the glucuronidation of UDP-glucuronosyltransferase (UGT) 1A9 substrates but not UGT1A1 and UGT1A6 activities
Drug Metab. Dispos.
36
1056-1062
2008
Homo sapiens (O60656), Homo sapiens
Kaivosaari, S.; Toivonen, P.; Aitio, O.; Sipilae, J.; Koskinen, M.; Salonen, J.S.; Finel, M.
Regio- and stereospecific N-glucuronidation of medetomidine: the differences between UDP glucuronosyltransferase (UGT) 1A4 and UGT2B10 account for the complex kinetics of human liver microsomes
Drug Metab. Dispos.
36
1529-1537
2008
Homo sapiens, Homo sapiens (P36537)
Liu, H.X.; Liu, Y.; Zhang, J.W.; Li, W.; Liu, H.T.; Yang, L.
UDP-glucuronosyltransferase 1A6 is the major isozyme responsible for protocatechuic aldehyde glucuronidation in human liver microsomes
Drug Metab. Dispos.
36
1562-1569
2008
Homo sapiens (P19224), Homo sapiens
Shiratani, H.; Katoh, M.; Nakajima, M.; Yokoi, T.
Species differences in UDP-glucuronosyltransferase activities in mice and rats
Drug Metab. Dispos.
36
1745-1752
2008
Mus musculus, Rattus norvegicus
Fujiwara, R.; Nakajima, M.; Yamanaka, H.; Katoh, M.; Yokoi, T.
Product inhibition of UDP-glucuronosyltransferase (UGT) enzymes by UDP obfuscates the inhibitory effects of UGT substrates
Drug Metab. Dispos.
36
361-367
2008
Homo sapiens, Homo sapiens (P19224), Homo sapiens (P22310)
Kato, Y.; Ikushiro, S.; Emi, Y.; Tamaki, S.; Suzuki, H.; Sakaki, T.; Yamada, S.; Degawa, M.
Hepatic UDP-glucuronosyltransferases responsible for glucuronidation of thyroxine in humans
Drug Metab. Dispos.
36
51-55
2008
Homo sapiens
Ohno, S.; Kawana, K.; Nakajin, S.
Contribution of UDP-glucuronosyltransferase 1A1 and 1A8 to morphine-6-glucuronidation and its kinetic properties
Drug Metab. Dispos.
36
688-694
2008
Homo sapiens, Homo sapiens (P22309)
Fujiwara, R.; Nakajima, M.; Yamanaka, H.; Yokoi, T.
Key amino acid residues responsible for the differences in substrate specificity of human UDP-glucuronosyltransferase (UGT) 1A9 and UGT1A8
Drug Metab. Dispos.
37
41-46
2009
Homo sapiens, Homo sapiens (O60656), Homo sapiens (Q9HAW7), Homo sapiens (Q9HAW8), Homo sapiens (Q9HAW9)
Nishimura, M.; Koeda, A.; Shimizu, T.; Nakayama, M.; Satoh, T.; Narimatsu, S.; Naito, S.
Comparison of inducibility of sulfotransferase and UDP-glucuronosyltransferase mRNAs by prototypical microsomal enzyme inducers in primary cultures of human and cynomolgus monkey hepatocytes
Drug Metab. Pharmacokinet.
23
45-53
2008
Homo sapiens, Macaca fascicularis (Q9TSL7), Macaca fascicularis (Q9TSL9), Macaca fascicularis (Q9TSM0), Macaca fascicularis
Hanioka, N.; Takeda, Y.; Tanaka-Kagawa, T.; Hayashi, K.; Jinno, H.; Narimatsu, S.
Interaction of bisphenol A with human UDP-glucuronosyltransferase 1A6 enzyme
Environ. Toxicol.
23
407-412
2008
Homo sapiens (P19224), Homo sapiens
Davis, B.D.; Brodbelt, J.S.
Regioselectivity of human UDP-glucuronosyl-transferase 1A1 in the synthesis of flavonoid glucuronides determined by metal complexation and tandem mass spectrometry
J. Am. Soc. Mass Spectrom.
19
246-256
2008
Homo sapiens
Chouinard, S.; Barbier, O.; Belanger, A.
UDP-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 enzymes are major determinants of the androgen response in prostate cancer LNCaP cells
J. Biol. Chem.
282
33466-33474
2007
Homo sapiens (O75795), Homo sapiens (P54855), Homo sapiens
Li, D.; Fournel-Gigleux, S.; Barre, L.; Mulliert, G.; Netter, P.; Magdalou, J.; Ouzzine, M.
Identification of aspartic acid and histidine residues mediating the reaction mechanism and the substrate specificity of the human UDP-glucuronosyltransferases 1A
J. Biol. Chem.
282
36514-36524
2007
Homo sapiens (P19224), Homo sapiens (P22309), Homo sapiens (P22310), Homo sapiens (P35503), Homo sapiens
Operana, T.N.; Tukey, R.H.
Oligomerization of the UDP-glucuronosyltransferase 1A proteins: Homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation
J. Biol. Chem.
282
4821-4829
2007
Homo sapiens (O60656), Homo sapiens (P19224), Homo sapiens (P22309), Homo sapiens (P22310), Homo sapiens (P35503), Homo sapiens (Q9HAW7), Homo sapiens (Q9HAW8), Homo sapiens (Q9HAW9)
Basu, N.K.; Kole, L.; Basu, M.; Chakraborty, K.; Mitra, P.S.; Owens, I.S.
The major chemical-detoxifying system of UDP-glucuronosyltransferases requires regulated phosphorylation supported by protein kinase C
J. Biol. Chem.
283
23048-23061
2008
Homo sapiens
Liu, H.; He, Y.; Hu, Y.; Liu, Y.; Zhang, J.; Li, W.; Wang, Z.; Yang, L.
Determination of UDP-glucuronosyltransferase UGT2B7 activity in human liver microsomes by ultra-performance liquid chromatography with MS detection
J. Chromatogr. B
870
84-90
2008
Homo sapiens (P16662), Homo sapiens
Gaganis, P.; Miners, J.O.; Brennan, J.S.; Thomas, A.; Knights, K.M.
Human renal cortical and medullary UDP-glucuronosyltransferases (UGTs): immunohistochemical localization of UGT2B7 and UGT1A enzymes and kinetic characterization of S-naproxen glucuronidation
J. Pharmacol. Exp. Ther.
323
422-430
2007
Homo sapiens
Zielinska, A.; Lichti, C.F.; Bratton, S.; Mitchell, N.C.; Gallus-Zawada, A.; Le, V.H.; Finel, M.; Miller, G.P.; Radominska-Pandya, A.; Moran, J.H.
Glucuronidation of monohydroxylated warfarin metabolites by human liver microsomes and human recombinant UDP-glucuronosyltransferases
J. Pharmacol. Exp. Ther.
324
139-148
2008
Homo sapiens, Homo sapiens (P22309), Homo sapiens (Q9HAW8), Homo sapiens (Q9HAW9)
Chouinard, S.; Yueh, M.F.; Tukey, R.H.; Giton, F.; Fiet, J.; Pelletier, G.; Barbier, O.; Belanger, A.
Inactivation by UDP-glucuronosyltransferase enzymes: the end of androgen signaling
J. Steroid Biochem. Mol. Biol.
109
247-253
2008
Homo sapiens, Homo sapiens (P16662), Homo sapiens (P54855)
Hoehle, S.I.; Pfeiffer, E.; Metzler, M.
Glucuronidation of curcuminoids by human microsomal and recombinant UDP-glucuronosyltransferases
Mol. Nutr. Food Res.
51
932-938
2007
Homo sapiens
Patana, A.S.; Kurkela, M.; Goldman, A.; Finel, M.
The human UDP-glucuronosyltransferase: identification of key residues within the nucleotide-sugar binding site
Mol. Pharmacol.
72
604-611
2007
Homo sapiens
Kaivosaari, S.; Toivonen, P.; Hesse, L.M.; Koskinen, M.; Court, M.H.; Finel, M.
Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10
Mol. Pharmacol.
72
761-768
2007
Homo sapiens (P22310), Homo sapiens (P36537), Homo sapiens
Uchaipichat, V.; Galetin, A.; Houston, J.B.; Mackenzie, P.I.; Williams, J.A.; Miners, J.O.
Kinetic modeling of the interactions between 4-methylumbelliferone, 1-naphthol, and zidovudine glucuronidation by UDP-glucuronosyltransferase 2B7 (UGT2B7) provides evidence for multiple substrate binding and effector sites
Mol. Pharmacol.
74
1152-1162
2008
Homo sapiens (P16662)
Court, M.H.; Hazarika, S.; Krishnaswamy, S.; Finel, M.; Williams, J.A.
Novel polymorphic human UDP-glucuronosyltransferase 2A3: cloning, functional characterization of enzyme variants, comparative tissue expression, and gene induction
Mol. Pharmacol.
74
744-754
2008
Homo sapiens (Q6UWM9), Homo sapiens
Starlard-Davenport, A.; Lyn-Cook, B.; Radominska-Pandya, A.
Identification of UDP-glucuronosyltransferase 1A10 in non-malignant and malignant human breast tissues
Steroids
73
611-620
2008
Homo sapiens, Homo sapiens (P36537)
Locuson, C.W.; Tracy, T.S.
Comparative modelling of the human UDP-glucuronosyltransferases: insights into structure and mechanism
Xenobiotica
37
155-168
2007
Homo sapiens
Jeong, H.; Choi, S.; Song, J.W.; Chen, H.; Fischer, J.H.
Regulation of UDP-glucuronosyltransferase (UGT) 1A1 by progesterone and its impact on labetalol elimination
Xenobiotica
38
62-75
2008
Homo sapiens (O60656), Homo sapiens (P06133), Homo sapiens (P16662), Homo sapiens (P19224), Homo sapiens (P22309), Homo sapiens (P22310), Homo sapiens
Nishiyama, T.; Ohnuma, T.; Inoue, Y.; Kishi, T.; Ogura, K.; Hiratsuka, A.
UDP-glucuronosyltransferases 1A6 and 1A10 catalyze reduced menadione glucuronidation
Biochem. Biophys. Res. Commun.
371
247-250
2008
Homo sapiens
Mitra, P.S.; Basu, N.K.; Owens, I.S.
Src supports UDP-glucuronosyltransferase-2B7 detoxification of catechol estrogens associated with breast cancer
Biochem. Biophys. Res. Commun.
382
651-656
2009
Homo sapiens
Blevins-Primeau, A.S.; Sun, D.; Chen, G.; Sharma, A.K.; Gallagher, C.J.; Amin, S.; Lazarus, P.
Functional significance of UDP-glucuronosyltransferase variants in the metabolism of active tamoxifen metabolites
Cancer Res.
69
1892-1900
2009
Homo sapiens
Guo, J.; Liu, A.; Cao, H.; Luo, Y.; Pezzuto, J.M.; van Breemen, R.B.
Biotransformation of the chemopreventive agent 2,4,4-trihydroxychalcone (isoliquiritigenin) by UDP-glucuronosyltransferases
Drug Metab. Dispos.
36
2104-2112
2008
Homo sapiens
Miller, G.P.; Lichti, C.F.; Zielinska, A.K.; Mazur, A.; Bratton, S.M.; Gallus-Zawada, A.; Finel, M.; Moran, J.H.; Radominska-Pandya, A.
Identification of hydroxywarfarin binding site in human UDP glucuronosyltransferase 1A10: phenylalanine90 is crucial for the glucuronidation of 6- and 7-hydroxywarfarin but not 8-hydroxywarfarin
Drug Metab. Dispos.
36
2211-2218
2008
Homo sapiens
Mazur, A.; Lichti, C.F.; Prather, P.L.; Zielinska, A.K.; Bratton, S.M.; Gallus-Zawada, A.; Finel, M.; Miller, G.P.; Radominska-Pandya, A.; Moran, J.H.
Characterization of human hepatic and extrahepatic UDP-glucuronosyltransferase enzymes involved in the metabolism of classic cannabinoids
Drug Metab. Dispos.
37
1496-1504
2009
Homo sapiens
Kerdpin, O.; Mackenzie, P.I.; Bowalgaha, K.; Finel, M.; Miners, J.O.
Influence of N-terminal domain histidine and proline residues on the substrate selectivities of human UDP-glucuronosyltransferase 1A1, 1A6, 1A9, 2B7, and 2B10
Drug Metab. Dispos.
37
1948-1955
2009
Homo sapiens
Ohno, S.; Nakajin, S.
Determination of mRNA expression of human UDP-glucuronosyltransferases and application for localization in various human tissues by real-time reverse transcriptase-polymerase chain reaction
Drug Metab. Dispos.
37
32-40
2009
Homo sapiens (O75310), Homo sapiens
Benoit-Biancamano, M.O.; Connelly, J.; Villeneuve, L.; Caron, P.; Guillemette, C.
Deferiprone glucuronidation by human tissues and recombinant UDP glucuronosyltransferase 1A6: an in vitro investigation of genetic and splice variants
Drug Metab. Dispos.
37
322-329
2009
Homo sapiens
Sten, T.; Bichlmaier, I.; Kuuranne, T.; Leinonen, A.; Yli-Kauhaluoma, J.; Finel, M.
UDP-glucuronosyltransferases (UGTs) 2B7 and UGT2B17 display converse specificity in testosterone and epitestosterone glucuronidation, whereas UGT2A1 conjugates both androgens similarly
Drug Metab. Dispos.
37
417-423
2009
Homo sapiens
Itaeaho, K.; Court, M.H.; Uutela, P.; Kostiainen, R.; Radominska-Pandya, A.; Finel, M.
Dopamine is a low-affinity and high-specificity substrate for the human UDP-glucuronosyltransferase 1A10
Drug Metab. Dispos.
37
768-775
2009
Homo sapiens
Abildskov, K.; Weldy, P.; Garland, M.
Molecular cloning of the baboon UDP-glucuronosyltransferase 2B gene family and their activity in conjugating morphine
Drug Metab. Dispos.
38
545-553
2010
Papio anubis (D2SML9), Papio anubis (D2SMM0), Papio anubis (D2SMM1), Papio anubis (D2SMM2), Papio anubis (D2SMM3), Papio anubis (D2SMM4), Papio anubis (D2SMM5), Papio anubis (D2SMM6), Papio anubis
Fujiwara, R.; Nakajima, M.; Yamamoto, T.; Nagao, H.; Yokoi, T.
In silico and in vitro approaches to elucidate the thermal stability of human UDP-glucuronosyltransferase (UGT) 1A9
Drug Metab. Pharmacokinet.
24
235-244
2009
Homo sapiens (O60656), Homo sapiens
Hanioka, N.; Hayashi, K.; Shimizudani, T.; Nagaoka, K.; Koeda, A.; Naito, S.; Narimatsu, S.
Stereoselective glucuronidation of propranolol in human and cynomolgus monkey liver microsomes: role of human hepatic UDP-glucuronosyltransferase isoforms, UGT1A9, UGT2B4 and UGT2B7
Pharmacology
82
293-303
2008
Homo sapiens
Patana, A.; Kurkela, M.; Finel, M.; Goldman, A.
Mutation analysis in UGT1A9 suggests a relationship between substrate and catalytic residues in UDP-glucuronosyltransferases
Protein Eng. Des. Sel.
21
537-543
2008
Homo sapiens
Korprasertthaworn, P.; Rowland, A.; Lewis, B.C.; Mackenzie, P.I.; Yoovathaworn, K.; Miners, J.O.
Effects of amino acid substitutions at positions 33 and 37 on UDP-glucuronosyltransferase 1A9 (UGT1A9) activity and substrate selectivity
Biochem. Pharmacol.
84
1511-1521
2012
Homo sapiens
Zhou, J.; Tracy, T.; Remmel, R.
Glucuronidation of dihydrotestosterone and trans-androsterone by recombinant UDP-glucuronosyltransferase (UGT) 1A4: Evidence for multiple UGT1A4 aglycone binding sites
Drug Metab. Dispos.
38
431-440
2010
Homo sapiens
He, Y.Q.; Liu, Y.; Zhang, B.F.; Liu, H.X.; Lu, Y.L.; Yang, L.; Xiong, A.Z.; Xu, L.L.; Wang, C.H.; Yang, L.; Wang, Z.T.
Identification of the UDP-glucuronosyltransferase isozyme involved in senecionine glucuronidation in human liver microsomes
Drug Metab. Dispos.
38
626-634
2010
Homo sapiens
Bourcier, K.; Hyland, R.; Kempshall, S.; Jones, R.; Maximilien, J.; Irvine, N.; Jones, B.
Investigation into UDP-glucuronosyltransferase (UGT) enzyme kinetics of imidazole- and triazole-containing antifungal drugs in human liver microsomes and recombinant UGT enzymes
Drug Metab. Dispos.
38
923-929
2010
Homo sapiens
Fedejko-Kap, B.; Bratton, S.M.; Finel, M.; Radominska-Pandya, A.; Mazerska, Z.
Role of human UDP-glucuronosyltransferases in the biotransformation of the triazoloacridinone and imidazoacridinone antitumor agents C-1305 and C-1311: highly selective substrates for UGT1A10
Drug Metab. Dispos.
40
1736-1743
2012
Homo sapiens
Zhang, H.; Patana, A.S.; Mackenzie, P.I.; Ikushiro, S.; Goldman, A.; Finel, M.
Human UDP-glucuronosyltransferase expression in insect cells: ratio of active to inactive recombinant proteins and the effects of a C-terminal his-tag on glucuronidation kinetics
Drug Metab. Dispos.
40
1935-1944
2012
Homo sapiens
Ma, L.; Sun, J.; Peng, Y.; Zhang, R.; Shao, F.; Hu, X.; Zhu, J.; Wang, X.; Cheng, X.; Zhu, Y.; Wan, P.; Feng, D.; Wu, H.; Wang, G.
Glucuronidation of edaravone by human liver and kidney microsomes: biphasic kinetics and identification of UGT1A9 as the major UDP-glucuronosyltransferase isoform
Drug Metab. Dispos.
40
734-741
2012
Homo sapiens
Takaoka, Y.; Ohta, M.; Takeuchi, A.; Miura, K.; Matsuo, M.; Sakaeda, T.; Sugano, A.; Nishio, H.
Ligand orientation governs conjugation capacity of UDP-glucuronosyltransferase 1A1
J. Biochem.
148
25-28
2010
Homo sapiens
Liu, Y.; She, M.; Wu, Z.; Dai, R.
The inhibition study of human UDP-glucuronosyltransferases with cytochrome P450 selective substrates and inhibitors
J. Enzyme Inhib. Med. Chem.
26
386-393
2011
Homo sapiens
Bratton, S.M.; Mosher, C.M.; Khallouki, F.; Finel, M.; Court, M.H.; Moran, J.H.; Radominska-Pandya, A.
Analysis of R- and S-hydroxywarfarin glucuronidation catalyzed by human liver microsomes and recombinant UDP-glucuronosyltransferases
J. Pharmacol. Exp. Ther.
340
46-55
2012
Homo sapiens
Sneitz, N.; Krishnan, K.; Covey, D.F.; Finel, M.
Glucuronidation of the steroid enantiomers ent-17beta-estradiol, ent-androsterone and ent-etiocholanolone by the human UDP-glucuronosyltransferases
J. Steroid Biochem. Mol. Biol.
127
282-288
2011
Homo sapiens
Hanioka, N.; Tanabe, N.; Jinno, H.; Tanaka-Kagawa, T.; Nagaoka, K.; Naito, S.; Koeda, A.; Narimatsu, S.
Functional characterization of human and cynomolgus monkey UDP-glucuronosyltransferase 1A1 enzymes
Life Sci.
87
261-268
2010
Homo sapiens (P22309), Homo sapiens, Macaca fascicularis (Q9TSL7), Macaca fascicularis
Zhang, Y.; Yuan, J.; Fang, Z.; Tu, Y.; Hu, C.; Li, G.; Wang, L.; Deng, J.; Yao, J.; Li, H.
Gossypol exhibits a strong influence towards UDP-glucuronosyltransferase (UGT) 1A1, 1A9 and 2B7-mediated metabolism of xenobiotics and endogenous substances
Molecules
17
4896-4903
2012
Homo sapiens
Bushey, R.T.; Chen, G.; Blevins-Primeau, A.S.; Krzeminski, J.; Amin, S.; Lazarus, P.
Characterization of UDP-glucuronosyltransferase 2A1 (UGT2A1) variants and their potential role in tobacco carcinogenesis
Pharmacogenet. Genomics
21
55-65
2011
Homo sapiens
Gradinaru, D.; Minn, A.L.; Artur, Y.; Minn, A.; Heydel, J.M.
Effect of oxidative stress on UDP-glucuronosyltransferases in rat astrocytes
Toxicol. Lett.
213
316-324
2012
Rattus norvegicus
Dong, R.H.; Fang, Z.Z.; Zhu, L.L.; Ge, G.B.; Yang, L.; Liu, Z.Y.
Identification of UDP-glucuronosyltransferase isoforms involved in hepatic and intestinal glucuronidation of phytochemical carvacrol
Xenobiotica
42
1009-1016
2012
Homo sapiens
Schwab, N.; Skopp, G.
Identification and preliminary characterization of UDP-glucuronosyltransferases catalyzing formation of ethyl glucuronide
Anal. Bioanal. Chem.
406
2325-2332
2014
Homo sapiens (O60656), Homo sapiens (P16662), Homo sapiens (P19224), Homo sapiens (P22309), Homo sapiens (P22310), Homo sapiens (P35503), Homo sapiens (P36537), Homo sapiens (P54855), Homo sapiens
Yuan, L.; Qian, S.; Xiao, Y.; Sun, H.; Zeng, S.
Homo- and hetero-dimerization of human UDP-glucuronosyltransferase 2B7 (UGT2B7) wild type and its allelic variants affect zidovudine glucuronidation activity
Biochem. Pharmacol.
95
58-70
2015
Homo sapiens (P16662), Homo sapiens
Bock, K.W.
Roles of human UDP-glucuronosyltransferases in clearance and homeostasis of endogenous substrates, and functional implications
Biochem. Pharmacol.
96
77-82
2015
Homo sapiens, Homo sapiens (O60656), Homo sapiens (O75310), Homo sapiens (O75795), Homo sapiens (P06133), Homo sapiens (P16662), Homo sapiens (P19224), Homo sapiens (P22309), Homo sapiens (P22310), Homo sapiens (P35503), Homo sapiens (P35504), Homo sapiens (P36537), Homo sapiens (P54855), Homo sapiens (Q6UWM9), Homo sapiens (Q9BY64), Homo sapiens (Q9HAW7), Homo sapiens (Q9HAW8), Homo sapiens (Q9HAW9), Homo sapiens (Q9Y4X1)
Higashi, E.; Ando, A.; Iwano, S.; Murayama, N.; Yamazaki, H.; Miyamoto, Y.
Hepatic microsomal UDP-glucuronosyltransferase (UGT) activities in the microminipig
Biopharm. Drug Dispos.
35
313-320
2014
Canis lupus familiaris, Macaca fascicularis, Mus musculus, Rattus norvegicus, Sus scrofa, Homo sapiens (O60656), Homo sapiens (P16662), Homo sapiens (P19224), Homo sapiens (P22309), Homo sapiens (P22310), Homo sapiens
Greer, A.K.; Madadi, N.R.; Bratton, S.M.; Eddy, S.D.; Mazerska, Z.; Hendrickson, H.P.; Crooks, P.A.; Radominska-Pandya, A.
Novel resveratrol-based substrates for human hepatic, renal, and intestinal UDP-glucuronosyltransferases
Chem. Res. Toxicol.
27
536-545
2014
Homo sapiens
Kato, Y.; Izukawa, T.; Oda, S.; Fukami, T.; Finel, M.; Yokoi, T.; Nakajima, M.
Human UDP-glucuronosyltransferase (UGT) 2B10 in drug N-glucuronidation: substrate screening and comparison with UGT1A3 and UGT1A4
Drug Metab. Dispos.
41
1389-1397
2013
Homo sapiens (P22310), Homo sapiens (P35503), Homo sapiens (P36537), Homo sapiens
Perreault, M.; Gauthier-Landry, L.; Trottier, J.; Verreault, M.; Caron, P.; Finel, M.; Barbier, O.
The human UDP-glucuronosyltransferase UGT2A1 and UGT2A2 enzymes are highly active in bile acid glucuronidation
Drug Metab. Dispos.
41
1616-1620
2013
Homo sapiens, Homo sapiens (Q6UWM9), Homo sapiens (Q9Y4X1)
Collier, A.C.; Yamauchi, Y.; Sato, B.L.; Rougee, L.R.; Ward, M.A.
UDP-glucuronosyltransferase 1a enzymes are present and active in the mouse blastocyst
Drug Metab. Dispos.
42
1921-1925
2014
Mus musculus (Q64435), Mus musculus, Mus musculus B6D2F1 (Q64435)
Troberg, J.; Jaervinen, E.; Muniz, M.; Sneitz, N.; Mosorin, J.; Hagstroem, M.; Finel, M.
Dog UDP-glucuronosyltransferase enzymes of subfamily 1A: cloning, expression, and activity
Drug Metab. Dispos.
43
107-118
2015
Canis lupus familiaris, Canis lupus familiaris (Q95M37), Homo sapiens (O60656), Homo sapiens (P19224), Homo sapiens (P22309), Homo sapiens (P22310), Homo sapiens (P35503), Homo sapiens (P35504), Homo sapiens (Q9HAW7), Homo sapiens (Q9HAW8), Homo sapiens (Q9HAW9), Homo sapiens
Pattanawongsa, A.; Nair, P.C.; Rowland, A.; Miners, J.O.
Human UDP-glucuronosyltransferase (UGT) 2B10: validation of cotinine as a selective probe substrate, inhibition by UGT enzyme-selective inhibitors and antidepressant and antipsychotic drugs, and structural determinants of enzyme inhibition
Drug Metab. Dispos.
44
378-388
2016
Homo sapiens (P36537), Homo sapiens
Tripathi, S.P.; Bhadauriya, A.; Patil, A.; Sangamwar, A.T.
Substrate selectivity of human intestinal UDP-glucuronosyltransferases (UGTs): in silico and in vitro insights
Drug Metab. Rev.
45
231-252
2013
Homo sapiens
Niemeyer, E.D.; Brodbelt, J.S.
Regiospecificity of human UDP-glucuronosyltransferase isoforms in chalcone and flavanone glucuronidation determined by metal complexation and tandem mass spectrometry
J. Nat. Prod.
76
1121-1132
2013
Homo sapiens
Wu, Z.; Liu, H.; Wu, B.
Regioselective glucuronidation of gingerols by human liver microsomes and expressed UDP-glucuronosyltransferase enzymes: reaction kinetics and activity correlation analyses for UGT1A9 and UGT2B7
J. Pharm. Pharmacol.
67
583-596
2015
Homo sapiens (O60656), Homo sapiens (O75795), Homo sapiens (P06133), Homo sapiens (P16662), Homo sapiens (P19224), Homo sapiens (P22309), Homo sapiens (P22310), Homo sapiens (P35503), Homo sapiens (P54855), Homo sapiens (Q9HAW7), Homo sapiens (Q9HAW8), Homo sapiens (Q9HAW9), Homo sapiens
Chau, N.; Elliot, D.J.; Lewis, B.C.; Burns, K.; Johnston, M.R.; Mackenzie, P.I.; Miners, J.O.
Morphine glucuronidation and glucosidation represent complementary metabolic pathways that are both catalyzed by UDP-glucuronosyltransferase 2B7: kinetic, inhibition, and molecular modeling studies
J. Pharmacol. Exp. Ther.
349
126-137
2014
Homo sapiens (P16662), Homo sapiens
Zhang, Q.; Cao, Y.F.; Ran, R.X.; Li, R.S.; Wu, X.; Dong, P.P.; Zhang, Y.Y.; Hu, C.M.; Wang, W.M.
Strong specific inhibition of UDP-glucuronosyltransferase 2B7 by atractylenolide I and III
Phytother. Res.
30
25-30
2016
Homo sapiens (P16662)
Lu, L.; Zhou, J.; Shi, J.; Peng, X.J.; Qi, X.X.; Wang, Y.; Li, F.Y.; Zhou, F.Y.; Liu, L.; Liu, Z.Q.
Drug-metabolizing activity, protein and gene expression of UDP-glucuronosyltransferases are significantly altered in hepatocellular carcinoma patients
PLoS ONE
10
e0127524
2015
Homo sapiens (O60656), Homo sapiens (P16662), Homo sapiens (P22309), Homo sapiens (P22310), Homo sapiens
Tian, X.; Wang, C.; Ge, G.; Ning, J.; Ai, C.; Hong, J.; Cai, Y.; Huo, X.; Hou, J.; Liu, K.; Sun, H.; Ma, X.
A highly selective probe for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human microsomes: Isoform specificity, kinetic characterization, and applications
RSC Adv.
5
5924-5927
2015
Homo sapiens (P16662)
-
Miners, J.O.; Chau, N.; Rowland, A.; Burns, K.; McKinnon, R.A.; Mackenzie, P.I.; Tucker, G.T.; Knights, K.M.; Kichenadasse, G.
Inhibition of human UDP-glucuronosyltransferase enzymes by lapatinib, pazopanib, regorafenib and sorafenib Implications for hyperbilirubinemia
Biochem. Pharmacol.
129
85-95
2017
Homo sapiens
Uno, Y.; Takahira, R.; Murayama, N.; Onozeki, S.; Kawamura, S.; Uehara, S.; Ikenaka, Y.; Ishizuka, M.; Ikushiro, S.; Yamazaki, H.
Functional and molecular characterization of UDP-glucuronosyltransferase 2 family in cynomolgus macaques
Biochem. Pharmacol.
163
335-344
2019
Macaca fascicularis, Macaca fascicularis (A0A4Y1K7J9), Macaca fascicularis (A0A4Y1KAF7)
Korprasertthaworn, P.; Chau, N.; Nair, P.; Rowland, A.; Miners, J.
Inhibition of human UDP-glucuronosyltransferase (UGT) enzymes by kinase inhibitors Effects of dabrafenib, ibrutinib, nintedanib, trametinib and BIBF 1202
Biochem. Pharmacol.
169
113616
2019
Homo sapiens (A0A0G2JMZ5), Homo sapiens (D6RH08), Homo sapiens (O60656), Homo sapiens (P06133), Homo sapiens (P16662), Homo sapiens (P19224), Homo sapiens (P22309), Homo sapiens (P22310), Homo sapiens (P35503), Homo sapiens (Q9HAW7), Homo sapiens (Q9HAW8), Homo sapiens (Q9HAW9), Homo sapiens
Shi, X.; Zhang, G.; Ge, G.; Guo, Z.; Song, Y.; Su, D.; Shan, L.
In Vitro metabolism of auriculasin and its inhibitory effects on human cytochrome P450 and UDP-glucuronosyltransferase enzymes
Chem. Res. Toxicol.
32
2125-2134
2019
Homo sapiens
Du, Z.; Cao, Y.F.; Li, S.N.; Hu, C.M.; Fu, Z.W.; Huang, C.T.; Sun, X.Y.; Liu, Y.Z.; Yang, K.; Fang, Z.Z.
Inhibition of UDP-glucuronosyltransferases (UGTs) by phthalate monoesters
Chemosphere
197
7-13
2018
Homo sapiens
Li, S.N.; Cao, Y.F.; Sun, X.Y.; Yang, K.; Liang, Y.J.; Gao, S.S.; Fu, Z.W.; Liu, Y.Z.; Yang, K.; Fang, Z.Z.
Hydroxy metabolites of polychlorinated biphenyls (OH-PCBs) exhibit inhibitory effects on UDP-glucuronosyltransferases (UGTs)
Chemosphere
212
513-522
2018
Homo sapiens
Wang, F.; Wang, S.; Yang, K.; Liu, Y.Z.; Yang, K.; Chen, Y.; Fang, Z.Z.
Inhibition of UDP-glucuronosyltransferases (UGTs) by bromophenols (BPs)
Chemosphere
238
124645
2020
Homo sapiens (O60656), Homo sapiens (P16662), Homo sapiens (P19224), Homo sapiens (P22309), Homo sapiens (P35503), Homo sapiens (Q9HAW7), Homo sapiens (Q9HAW9)
Kawai, Y.K.; Shinya, S.; Ikenaka, Y.; Saengtienchai, A.; Kondo, T.; Darwish, W.S.; Nakayama, S.M.M.; Mizukawa, H.; Ishizuka, M.
Characterization of function and genetic feature of UDP-glucuronosyltransferase in avian species
Comp. Biochem. Physiol. C
217
5-14
2019
Gallus gallus, Meleagris gallopavo, Struthio camelus, Rattus norvegicus, Serinus canaria, Bubo virginianus, Haliaeetus albicilla, Spheniscus humboldti
Kim, K.; Zheng, F.; Zhan, C.G.
Oligomerization and catalytic parameters of human UDP-glucuronosyltransferase 1A10 expression and characterization of the recombinant protein
Drug Metab. Dispos.
46
1446-1452
2018
Homo sapiens
Koyama, M.; Shirahata, T.; Hirashima, R.; Kobayashi, Y.; Itoh, T.; Fujiwara, R.
Inhibition of UDP-glucuronosyltransferase (UGT)-mediated glycyrrhetinic acid 3-O-glucuronidation by polyphenols and triterpenoids
Drug Metab. Pharmacokinet.
32
218-223
2017
Homo sapiens
Neumann, E.; Mehboob, H.; Ramrez, J.; Mirkov, S.; Zhang, M.; Liu, W.
Age-dependent hepatic UDP-glucuronosyltransferase gene expression and activity in children
Front. Pharmacol.
7
437
2016
Homo sapiens (O60656), Homo sapiens (O75795), Homo sapiens (P06133), Homo sapiens (P16662), Homo sapiens (P19224), Homo sapiens (P22309), Homo sapiens (P22310), Homo sapiens (P35503), Homo sapiens (P35504), Homo sapiens (P36537), Homo sapiens (P54855), Homo sapiens
Pan, Y.; Xu, P.; Zeng, X.; Liu, X.; Shang, Q.
Characterization of UDP-glucuronosyltransferases and the potential contribution to nicotine tolerance in Myzus persicae
Int. J. Mol. Sci.
20
3637
2019
Myzus persicae nicotianae
Kurita, A.; Miyauchi, Y.; Ikushiro, S.; Mackenzie, P.I.; Yamada, H.; Ishii, Y.
Comprehensive Characterization of mouse UDP-glucuronosyltransferase (Ugt) belonging to the Ugt2b subfamily identification of Ugt2b36 as the predominant isoform involved in morphine glucuronidation
J. Pharmacol. Exp. Ther.
361
199-208
2017
Mus musculus (Q3UEP4), Mus musculus (Q63886), Mus musculus (Q8K154), Mus musculus (Q8VCN3), Mus musculus
Xie, Y.; Miranda, S.R.; Hoskins, J.M.; Hawke, R.L.
Role of UDP-glucuronosyltransferase 1A1 in the metabolism and pharmacokinetics of silymarin flavonolignans in patients with HCV and NAFLD
Molecules
22
142
2017
Homo sapiens (P22309), Homo sapiens
You, B.H.; Gong, E.C.; Choi, Y.H.
Inhibitory effect of sauchinone on UDP-glucuronosyltransferase (UGT) 2B7 activity
Molecules
23
366
2018
Homo sapiens (P16662), Homo sapiens (P19224), Homo sapiens (P22309), Homo sapiens (P35503)
Mroz, A.; Ryska, I.; Sominko, H.; Bejrowska, A.; Mazerska, Z.
Drug-drug interaction potential of antitumor acridine agent C-1748 The substrate of UDP-glucuronosyltransferases 2B7, 2B17 and the inhibitor of 1A9 and 2B7
Pharmacol. Rep.
70
972-980
2018
Homo sapiens (O60656), Homo sapiens (O75795), Homo sapiens (P16662), Homo sapiens (P22309), Homo sapiens (P22310), Homo sapiens
Zhang, H.; Zhao, Z.; Wang, T.; Wang, Y.; Cui, X.; Zhang, H.; Fang, Z.Z.
Inhibition of UDP-glucuronosyltransferase (UGT) isoforms by arctiin and arctigenin
Phytother. Res.
30
1189-1196
2016
Homo sapiens (O60656), Homo sapiens (O75795), Homo sapiens (P06133), Homo sapiens (P16662), Homo sapiens (P19224), Homo sapiens (P22309), Homo sapiens (P35503), Homo sapiens (P54855), Homo sapiens (Q9HAW7), Homo sapiens (Q9HAW9), Homo sapiens
Yuan, L.M.; Gao, Z.Z.; Sun, H.Y.; Qian, S.N.; Xiao, Y.S.; Sun, L.L.; Zeng, S.
Inter-isoform hetero-dimerization of human UDP-glucuronosyltransferases (UGTs) 1A1, 1A9, and 2B7 and impacts on glucuronidation activity
Sci. Rep.
6
34450
2016
Homo sapiens (O60656), Homo sapiens (P16662), Homo sapiens (P22309), Homo sapiens
Kim, D.; Zheng, Y.F.; Min, J.S.; Park, J.B.; Bae, S.H.; Yoon, K.D.; Chin, Y.W.; Oh, E.; Bae, S.K.
In vitro stereoselective inhibition of ginsenosides toward UDP-glucuronosyltransferase (UGT) isoforms
Toxicol. Lett.
259
1-10
2016
Homo sapiens (O60656), Homo sapiens (P16662), Homo sapiens (P19224), Homo sapiens (P22309), Homo sapiens (P22310), Homo sapiens (P35503), Homo sapiens (P54855), Homo sapiens (Q9HAW7), Homo sapiens (Q9HAW8), Homo sapiens (Q9HAW9), Homo sapiens
Li, F.; Wang, S.; Lu, D.; Wang, Y.; Dong, D.; Wu, B.
Identification of UDP-glucuronosyltransferases 1A1, 1A3 and 2B15 as the main contributors to glucuronidation of bakuchiol, a natural biologically active compound
Xenobiotica
47
369-375
2017
Homo sapiens (P22309), Homo sapiens (P35503), Homo sapiens (P54855), Homo sapiens
He, G.; Troberg, J.; Lv, X.; Xia, Y.L.; Zhu, L.L.; Ning, J.; Ge, G.B.; Finel, M.; Yang, L.
Identification and characterization of human UDP-glucuronosyltransferases responsible for xanthotoxol glucuronidation
Xenobiotica
48
109-116
2018
Homo sapiens (P16662), Homo sapiens (P19224), Homo sapiens (P22309), Homo sapiens (P35503), Homo sapiens (Q9HAW8), Homo sapiens (Q9HAW9), Homo sapiens
Vergara, A.G.; Watson, C.J.W.; Chen, G.; Lazarus, P.
UDP-glycosyltransferase 3A metabolism of polycyclic aromatic hydrocarbons potential importance in aerodigestive tract tissues
Drug Metab. Dispos.
48
160-168
2020
Homo sapiens (Q3SY77), Homo sapiens (Q6NUS8), Homo sapiens
Liu, Y.; Badee, J.; Takahashi, R.H.; Schmidt, S.; Parrott, N.; Fowler, S.; Mackenzie, P.I.; Coughtrie, M.W.H.; Collier, A.C.
Coexpression of human hepatic uridine diphosphate glucuronosyltransferase proteins implications for ontogenetic mechanisms and isoform coregulation
J. Clin. Pharm.
60
722-733
2020
Homo sapiens (O60656), Homo sapiens (P16662), Homo sapiens (P19224), Homo sapiens (P22309), Homo sapiens (P22310), Homo sapiens (P35503), Homo sapiens (Q3SY77), Homo sapiens (Q6NUS8), Homo sapiens
Rennie, E.A.; Ebert, B.; Miles, G.P.; Cahoon, R.E.; Christiansen, K.M.; Stonebloom, S.; Khatab, H.; Twell, D.; Petzold, C.J.; Adams, P.D.; Dupree, P.; Heazlewood, J.L.; Cahoon, E.B.; Scheller, H.V.
Identification of a sphingolipid alpha-glucuronosyltransferase that is essential for pollen function in Arabidopsis
Plant Cell
26
3314-3325
2014
Arabidopsis thaliana (Q8GWB7), Arabidopsis thaliana, Nicotiana benthamiana
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