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2.4.1.17: glucuronosyltransferase

This is an abbreviated version!
For detailed information about glucuronosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.17

Reaction

UDP-alpha-D-glucuronate
+
acceptor
=
UDP
 +
acceptor beta-D-glucuronoside

Synonyms

1-naphthol glucuronyltransferase, 1-naphthol-UDP-glucuronosyltransferase, 17-OH steroid UDPGT, 17beta-hydroxysteroid UDP-glucuronosyltransferase, 1A10, 3,4-catechol estrogen specific UDPGTh-2, 3-OH androgenic UDPGT, 3alpha-hydroxysteroid UDP-glucuronosyltransferase, 4-hydroxybiphenyl UDP-glucuronosyltransferase, 4-methylumbelliferone UDP-glucuronosyltransferase, 4-nitrophenol UDP-glucuronosyltransferase, 4-nitrophenol UDP-glucuronyltransferase, 4-nitrophenol UDPGT, bile acid uridine 5'-diphosphoglucuronyltransferase, bilirubin glucuronyltransferase, bilirubin monoglucuronide glucuronyltransferase, bilirubin UDP-glucuronosyltransferase, bilirubin UDPglucuronosyltransferase, bilirubin UDPGT, bilirubin uridine diphosphoglucuronyltransferase, bilirubin-specific UDPGT isozyme 1, bilirubin-specific UDPGT isozyme 2, ciramadol UDP-glucuronyltransferase, DP-glucuronosyltransferase 1A3, EC 2.4.1.107, EC 2.4.1.108, EC 2.4.1.42, EC 2.4.1.59, EC 2.4.1.61, EC 2.4.1.76, EC 2.4.1.77, EC 2.4.1.84, estriol UDP-glucuronosyltransferase, estrone UDP-glucuronosyltransferase, GlcAT-P, GlcAT-S, glucuronosyltransferase, uridine diphospho-, glucuronosyltransferase, uridine diphosphoglucuronate-1,2-diacylglycerol, glucuronosyltransferase, uridine diphosphoglucuronate-4-hydroxybiphenyl, glucuronosyltransferase, uridine diphosphoglucuronate-bilirubin, glucuronosyltransferase, uridine diphosphoglucuronate-estradiol, glucuronosyltransferase, uridine diphosphoglucuronate-estriol, glucuronosyltransferase, uridine diphosphoglucuronate-estriol 16alpha-, glucuronyltransferase, glucuronyltransferase, uridine diphospho-GT, HUG-BR1, HUG-BR2, inositol phosphorylceramide glucuronosyltransferase1, IPUT1, monUGT1A6, More, morphine glucuronyltransferase, p-hydroxybiphenyl UDP glucuronyltransferase, p-nitrophenol UDP-glucuronosyltransferase, p-nitrophenol UDP-glucuronyltransferase, p-nitrophenylglucuronosyltransferase, p-phenylphenol glucuronyltransferase, phenol-metabolizing UDP-glucuronosyltransferase, phenyl-UDP-glucuronosyltransferase, PNP-UDPGT, UDP glucuronate-estradiol-glucuronosyltransferase, UDP glucuronate-estriol glucuronosyltransferase, UDP glucuronic acid transferase, UDP glucuronosyltransferase, UDP glucuronosyltransferase 1A4, UDP glucuronosyltransferase 2B10, UDP glucuronyltransferase, UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase, UDP-glucuronate-bilirubin glucuronyltransferase, UDP-glucuronosyl-transferase 1A1, UDP-glucuronosyltransferase, UDP-glucuronosyltransferase 1A, UDP-glucuronosyltransferase 1A1, UDP-glucuronosyltransferase 1A10, UDP-glucuronosyltransferase 1A3, UDP-glucuronosyltransferase 1A4, UDP-glucuronosyltransferase 1A5, UDP-glucuronosyltransferase 1A6, UDP-glucuronosyltransferase 1A7, UDP-glucuronosyltransferase 1A8, UDP-glucuronosyltransferase 1A9, UDP-glucuronosyltransferase 2, UDP-glucuronosyltransferase 2A3, UDP-glucuronosyltransferase 2B10, UDP-glucuronosyltransferase 2B15, UDP-glucuronosyltransferase 2B17, UDP-glucuronosyltransferase 2B7, UDP-glucuronosyltransferase-1A10, UDP-glucuronosyltransferases 2B15, UDP-glucuronosyltransferases 2B7, UDP-glucuronyltransferase, UDPGA transferase, UDPGA-glucuronyltransferase, UDPglucuronate beta-D-glucuronosyltransferase, UDPglucuronosyltransferase, UDPGT, UFT1A9, UGT, UGT 1A1, UGT 1A10, UGT 1A3, UGT 1A4, UGT 1A6, UGT 1A7, UGT 1A8, UGT 1A9, UGT 2B15, UGT 2B17, UGT 2B4, UGT 2B7, UGT-1A, UGT-1D, UGT-1F, UGT-1J, UGT1-01, UGT1-03, UGT1-04, UGT1-06, UGT1-10, UGT1-9, UGT1.1, UGT1.10, UGT1.3, UGT1.4, UGT1.6, UGT1.9, UGT1A, UGT1A1, UGT1A10, UGT1A10A, UGT1A10B, UGT1A11, UGT1A2, UGT1A2A, UGT1A3, UGT1A4, UGT1A5, UGT1A5A, UGT1A5B, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1D, UGT1E, UGT1F, UGT1J, UGT2A1, UGT2A2, UGT2A3, UGT2B1, UGT2B10, UGT2B11, UGT2B12, UGT2B15, UGT2B17, UGT2B18, UGT2B19, UGT2B2, UGT2B20, UGT2B23, UGT2B28, UGT2B3, UGT2B30, UGT2B31, UGT2B33, Ugt2b34, Ugt2b36, Ugt2b37, UGT2B39, UGT2B4, UGT2B40, UGT2B41, UGT2B42, UGT2B43, UGT2B44, UGT2B45, UGT2B46, UGT2B7, UGT2B8, UGT2B9, UGT330A3, UGT339A2, UGT341A6, UGT342B3, UGT343C3, UGT344D5, UGT344D8, UGT348A3, UGT349A3, UGT350A3, UGT3A1, UGT3A2, uridine 5'-diphospho-glucuronosyltransferase, uridine 5'-diphosphoglucuronyltransferase, uridine diphosphate glucuronosyltransferase, uridine diphosphate glucuronyltransferase, uridine diphosphate-glucuronosyltransferase, uridine diphosphate-glucuronosyltransferase 2 B15, uridine diphosphate-glucuronosyltransferase 2B10, uridine diphosphate-glucuronosyltransferase 2B11, uridine diphosphate-glucuronosyltransferase 2B15, uridine diphosphate-glucuronosyltransferase 2B17, uridine diphosphate-glucuronosyltransferase 2B4, uridine diphosphate-glucuronosyltransferase 2B7, uridine diphosphoglucuronate-bilirubin glucuronosyltransferase, uridine diphosphoglucuronosyltransferase, uridine diphosphoglucuronyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.17 glucuronosyltransferase

Natural Substrates Products

Natural Substrates Products on EC 2.4.1.17 - glucuronosyltransferase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
11alpha-hydroxyprogesterone + UDP-glucuronate
UDP + 11alpha-hydroxyprogesterone-11-O-D-glucuronate
show the reaction diagram
-
-
-
?
16alpha-hydroxyprogesterone + UDP-glucuronate
?
show the reaction diagram
UGT2B15 and UGT2B17 are the major enzyme forms involved in the high-affinity component of 16alpha-hydroxyprogesterone glucuronidation
-
-
?
16alpha-hydroxyprogesterone + UDP-glucuronate
UDP + 16alpha-hydroxyprgesterone-16-O-D-glucuronate
show the reaction diagram
2 UDP-D-glucuronate + 2 dexmedetomidine
2 UDP + dexmedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
show the reaction diagram
the major metabolic pathway of dexmedetomidine, i.e. (4S)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, in humans is N-glucuronidation at the imidazolate nitrogens to N3- and N1-glucuronides
-
-
?
2 UDP-D-glucuronate + 2 levomedetomidine
2 UDP + levomedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
show the reaction diagram
the major metabolic pathway of levomedetomidine, i.e. (4R)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, in humans is N-glucuronidation at the imidazolate nitrogens to N3-glucuronide
-
-
?
2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDP-glucuronate
?
show the reaction diagram
2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid + UDPglucuronate
?
show the reaction diagram
glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid is mainly catalyzed by UGT1A1, UGT1A9, and UGT2B7 in the liver, and by UGT1A1, UGT1A3, and UGT2B7 in the intestine in humans
-
-
?
21-hydroxyprogesterone + UDP-glucuronate
UDP + 21-hydroxyprogesterone-21-O-D-glucuronate
show the reaction diagram
-
-
-
?
6alpha-hydroxyprogesterone + UDP-glucuronate
UDP + 6alpha-hydroxyprogesteron-6-O-alpha-D-glucuronate
show the reaction diagram
-
-
-
?
bilirubin + UDPglucuronate
UDP + bilirubin O-glucuronide
show the reaction diagram
estrogen + UDP-glucuronate
?
show the reaction diagram
UDP-glucuronosyltransferase 1A10 has been identified as the major isoform involved in the biotransformation of a wide range of phenolic substrates, including native estrogens and their oxidized metabolites
-
-
?
etoposide + UDP-glucuronate
UDP + etoposide glucuronide
show the reaction diagram
UGT1A1 is principally responsible for the formation of etoposide glucuronides, mainly in the form of phenolic glucuronide
-
-
?
testosterone + UDP-glucuronate
UDP + testosterone beta-D-glucuronoside
show the reaction diagram
UGT2B15 and UGT2B17 are the major enzyme forms involved in human liver microsomal testosterone 17beta-glucuronidation
-
-
?
UDP-alpha-D-glucuronate + (S)-naproxen
UDP + beta-D-glucuronosyl (S)-naproxen
show the reaction diagram
-
-
-
-
?
UDP-alpha-D-glucuronate + 3-hydroxyflavone
UDP + 3-[(beta-D-glucopyranurnosyl)oxy]-flavone
show the reaction diagram
isozyme UGT1A1
-
-
?
UDP-alpha-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + 17beta-estradiol
UDP + 17beta-estradiol 3-O-beta-D-glucuronoside
show the reaction diagram
-
-
-
?
UDP-D-glucuronate + 3-hydroxydesloratadine
UDP + 3-hydroxydesloratadine beta-O-D-glucuronoside
show the reaction diagram
specific substrate of isozyme UGT1A8
-
-
?
UDP-D-glucuronate + 4'-hydroxy-warfarin
UDP + 4'-hydroxy-warfarin beta-D-glucuronoside
show the reaction diagram
substrate of isozyme UGT1A10
-
-
?
UDP-D-glucuronate + 4-hydroxy-N-desmethyl-tamoxifen
UDP + 4-hydroxy-N-desmethyl-tamoxifen beta-D-glucuronoside
show the reaction diagram
the enzyme is involved in metabolism and elimination of tamoxifen, TAM, and its major active metabolites 4-hydroxytamoxifen and 4-hydroxy-N-desmethyl-tamoxifen, i.e. endoxifen, by glucuronidation, overview
-
-
?
UDP-D-glucuronate + 4-nitrophenol
UDP + 4-nitrophenyl O-beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + 6-hydroxy-warfarin
UDP + 6-hydroxy-warfarin beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + 7-hydroxy-warfarin
UDP + 7-hydroxy-warfarin beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + 8-hydroxy-warfarin
UDP + 8-hydroxy-warfarin beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + androstane-3alpha,17beta-diol
UDP + ?
show the reaction diagram
UDP-D-glucuronate + androsterone
UDP + androsterone 3-O-beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + bilirubin
UDP + bilirubin beta-D-glucuronoside
show the reaction diagram
isozyme UGT1A1
-
-
?
UDP-D-glucuronate + bisdemethoxy-curcumin
UDP + bisdemethoxy-curcumin phenolic beta-D-monoglucuronide
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + chenodeoxycholic acid
UDP + hyodeoxycholic acid 6-O-glucuronoside
show the reaction diagram
isozyme UGT2A3
-
-
?
UDP-D-glucuronate + cis-4-hydroxytamoxifen
UDP + 4-hydroxytamoxifen beta-D-glucuronoside
show the reaction diagram
the enzyme is involved in metabolism and elimination of tamoxifen, TAM, and its major active metabolites 4-hydroxytamoxifen and 4-hydroxy-N-desmethyl-tamoxifen, i.e. endoxifen, by glucuronidation, overview
-
-
?
UDP-D-glucuronate + cotinine
UDP + ?
show the reaction diagram
isozyme UGT2B10, cotinine is exclusively glucuronized in liver, no activity in intestinal microsomes
-
-
?
UDP-D-glucuronate + curcumin
UDP + curcumin phenolic beta-D-monoglucuronide
show the reaction diagram
-
glucuronidation is an important pathway in the metabolism of curcumin
-
-
?
UDP-D-glucuronate + dehydrotestosterone
UDP + dehydrotestosterone 17-O-beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + demethoxy-curcumin
UDP + demethoxy-curcumin phenolic beta-D-monoglucuronide
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + deoxycholic acid
UDP + hyodeoxycholic acid 6-O-glucuronoside
show the reaction diagram
isozyme UGT2A3
-
-
?
UDP-D-glucuronate + dihydrotestosterone
UDP + dihydrotestosterone 17-O-beta-D-glucuronoside
show the reaction diagram
in epithelial cells of the human prostate
-
-
?
UDP-D-glucuronate + estradiol
UDP + estradiol 3-O-beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + estradiol
UDP + estradiol-3-beta-D-glucuronoside
show the reaction diagram
liver microsomes
-
-
?
UDP-D-glucuronate + flurbiprofen
UDP + flurbiprofen beta-D-glucuronoside
show the reaction diagram
-
isozyme UGT2B7
-
-
?
UDP-D-glucuronate + frusemide
UDP + frusemide beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-D-glucuronate + gemfibrozil
UDP + gemfibrozil beta-D-glucuronoside
show the reaction diagram
-
gemfibrozil is a fibrate hypolipidemic agent, isozyme UGT2B7 in the liver
-
-
?
UDP-D-glucuronate + hyodeoxycholic acid
UDP + hyodeoxycholic acid 6-O-glucuronoside
show the reaction diagram
isozyme UGT2A3
-
-
?
UDP-D-glucuronate + labetalol
UDP + ?
show the reaction diagram
UDP-D-glucuronate + morphine
UDP + morphine 3-O-beta-D-glucuronoside
show the reaction diagram
UDP-D-glucuronate + morphine
UDP + morphine 6-beta-D-glucuronoside
show the reaction diagram
the metabolic conversion of morphine to morphine-6-glucuronide plays a significant role in mediation of the clinical effect of morphine because of the superior analgesic effect of morphine-6-glucuronide
-
-
?
UDP-D-glucuronate + mycophenolate
UDP + ?
show the reaction diagram
UDP-D-glucuronate + nicotine
UDP + ?
show the reaction diagram
isozyme UGT2B10, nicotine is mainly glucuronized in liver, very low activity in intestinal microsomes
-
-
?
UDP-D-glucuronate + propofol
UDP + propofol beta-D-glucuronoside
show the reaction diagram
-
isozymes UGT1A1 and UGT1A9
-
-
?
UDP-D-glucuronate + protocatechuic aldehyde
UDP + ?
show the reaction diagram
-
-
-
?
UDP-D-glucuronate + serotonin
UDP + serotonin beta-D-glucuronoside
show the reaction diagram
isozyme UGT1A6
-
-
?
UDP-D-glucuronate + tamoxifen + H+
UDP + tamoxifen beta-D-glucuronoside
show the reaction diagram
the enzyme is involved in metabolism and elimination of tamoxifen, TAM, and its major active metabolites 4-hydroxytamoxifen and 4-hydroxy-N-desmethyl-tamoxifen, i.e. endoxifen, by glucuronidation, overview
-
-
?
UDP-D-glucuronate + thyroxine
UDP + thyroxine beta-D-glucuronoside
show the reaction diagram
-
glucuronidation of the thyroid hormone thyroxine, T4, in the human liver, the T4 glucuronidation activities of recombinant human UGT isoforms and microsomes
-
-
?
UDP-D-glucuronate + trans-4-hydroxytamoxifen
UDP + 4-hydroxytamoxifen beta-D-glucuronoside
show the reaction diagram
the enzyme is involved in metabolism and elimination of tamoxifen, TAM, and its major active metabolites 4-hydroxytamoxifen and 4-hydroxy-N-desmethyl-tamoxifen, i.e. endoxifen, by glucuronidation, overview
-
-
?
UDP-D-glucuronate + ursodeoxycholic acid
UDP + hyodeoxycholic acid 6-O-glucuronoside
show the reaction diagram
isozyme UGT2A3
-
-
?
UDP-glucuronate + (E)-2,4-dimethoxy-6-(4-methoxystyryl)benzaldehyde oxime
UDP + 1-O-[(E)-2,4-dimethoxy-6-(4-methoxystyryl)benzaldehyde oxime]-beta-D-glucuronate
show the reaction diagram
-
i.e. NI-ST-05, low activity, NI-ST-05 forms a distinct N-O-glucuronide. NI-ST-05 is primarily metabolized by an extrahepatic enzyme, UGT1A10
-
-
?
UDP-glucuronate + (E)-3-(3-hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)acrylic acid
UDP + ?
show the reaction diagram
-
i.e. NI-12a, low activity, NI-12a is glucuronidated at both the -COOH and -OH functions. NI-12a is primarily metabolized by the hepatic and renal enzyme UGT1A9
-
-
?
UDP-glucuronate + 10-gingerol
UDP + 10-gingerol 4'-O-beta-D-glucuronoside
show the reaction diagram
-
-
-
?
UDP-glucuronate + 10-gingerol
UDP + 10-gingerol 5-O-beta-D-glucuronoside
show the reaction diagram
-
-
-
?
UDP-glucuronate + 3-epideacetycinobufagin
UDP + 3-epideacetycinobufagin 3-beta-D-glucuronoside
show the reaction diagram
3-epideacetycinobufagin is a highly isoform-specific probe substrate for 3-glucuronidation mediated by UDP-glucuronosyltransferase 2B7 determined in recombinant UGT supersomes, overview
-
-
?
UDP-glucuronate + 4-hydroxy-estrone
UDP + ?
show the reaction diagram
glucuronidation of 4-hydroxylated estrone is significantly reduced in breast carcinomas compared to healthy
-
-
?
UDP-glucuronate + 6-gingerol
UDP + 6-gingerol 4'-O-beta-D-glucuronoside
show the reaction diagram
-
-
-
?
UDP-glucuronate + 6-gingerol
UDP + 6-gingerol 5-O-beta-D-glucuronoside
show the reaction diagram
-
-
-
?
UDP-glucuronate + 7-ethyl-10-hydroxycamptothecin
UDP + 7-ethyl-10-hydroxycamptothecin 10-O-beta-D-glucuronoside
show the reaction diagram
i.e. SN-38, an active metabolite of irinotecan
-
-
?
UDP-glucuronate + 8-gingerol
UDP + 8-gingerol 4'-O-beta-D-glucuronoside
show the reaction diagram
-
-
-
?
UDP-glucuronate + 8-gingerol
UDP + 8-gingerol 5-O-beta-D-glucuronoside
show the reaction diagram
-
-
-
?
UDP-glucuronate + acceptor
UDP + acceptor beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + acceptor
UDP + acceptor beta-glucuronoside
show the reaction diagram
UDP-glucuronate + estriol
UDP + estriol beta-D-glucuronoside
show the reaction diagram
-
-
-
?
UDP-glucuronate + ethanol
UDP + ethyl beta-D-glucuronoside
show the reaction diagram
-
-
-
?
UDP-glucuronate + genistein
UDP + genistein beta-D-glucuronoside
show the reaction diagram
-
-
-
?
UDP-glucuronate + gingerol
UDP + gingerol 4'-O-beta-D-glucuronoside
show the reaction diagram
-
-
-
?
UDP-glucuronate + morphine
UDP + morphine-3-beta-D-glucuronide
show the reaction diagram
UDP-glucuronate + morphine
UDP + morphine-6-beta-D-glucuronide
show the reaction diagram
-
-
-
?
UDP-glucuronate + mycophenolic acid
UDP + mycophenolic acid-acyl-glucuronide
show the reaction diagram
-
mycophenolic acid is the active metabolite of immunosuppressant mycophenolate mofetil
-
-
?
UDP-glucuronate + mycophenolic acid
UDP + mycophenolic acid-phenyl-glucuronide
show the reaction diagram
-
mycophenolic acid is the active metabolite of immunosuppressant mycophenolate mofetil
-
-
?
UDP-glucuronate + propofol
UDP + propofol beta-D-glucuronoside
show the reaction diagram
UDP-glucuronate + serotonin
UDP + serotonin beta-glucuronoside
show the reaction diagram
isozyme UGT2B7
-
-
?
UDP-glucuronate + tamoxifen
UDP + tamoxifen N-beta-D-glucuronoside
show the reaction diagram
-
-
-
?
UDP-glucuronate + trans-resveratrol
UDP + trans-resveratrol beta-D-glucuronoside
show the reaction diagram
-
-
-
-
?
UDP-glucuronate + zidovudine
UDP + zidovudine beta-D-glucuronoside
show the reaction diagram
UDP-glucuronic acid + bilirubin
UDP + bilirubin-glucuronoside
show the reaction diagram
UDPglucuronate + naproxen
?
show the reaction diagram
UGT2B7 is responsible for human hepatic naproxen acyl glucuronidation, which is the primary elimination pathway for this drug
-
-
?
additional information
?
-