Cloned (Comment) | Organism |
---|---|
expression of isozyme UGT1A1 in insect cells using the baculovirus infection system | Homo sapiens |
expression of isozyme UGT1A10 in insect cells using the baculovirus infection system | Homo sapiens |
expression of isozyme UGT1A3 in insect cells using the baculovirus infection system | Homo sapiens |
expression of isozyme UGT1A4 in insect cells using the baculovirus infection system | Homo sapiens |
expression of isozyme UGT1A6 in insect cells using the baculovirus infection system | Homo sapiens |
expression of isozyme UGT1A7 in insect cells using the baculovirus infection system | Homo sapiens |
expression of isozyme UGT1A8 in insect cells using the baculovirus infection system | Homo sapiens |
expression of isozyme UGT1A9 in insect cells using the baculovirus infection system | Homo sapiens |
expression of isozyme UGT2B15 in insect cells using the baculovirus infection system | Homo sapiens |
expression of isozyme UGT2B17 in insect cells using the baculovirus infection system | Homo sapiens |
expression of isozyme UGT2B4 in insect cells using the baculovirus infection system | Homo sapiens |
expression of isozyme UGT2B7 in insect cells using the baculovirus infection system | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
diclofenac | inhibition of denopamine glucuroniation | Homo sapiens | |
DMSO | 2% v/v reduces enzyme activity in liver microsomes | Canis lupus familiaris | |
DMSO | 2% v/v reduces enzyme activity in liver microsomes; 2% v/v reduces enzyme activity in liver microsomes; 2% v/v reduces enzyme activity in liver microsomes; 2% v/v reduces enzyme activity in liver microsomes; 2% v/v reduces enzyme activity in liver microsomes; 2% v/v reduces enzyme activity in liver microsomes; 2% v/v reduces enzyme activity in liver microsomes; 2% v/v reduces enzyme activity in liver microsomes; 2% v/v reduces enzyme activity in liver microsomes; 2% v/v reduces enzyme activity in liver microsomes; 2% v/v reduces enzyme activity in liver microsomes | Homo sapiens | |
additional information | no effect by 1% v/v DMSO and 2% v/v methanol on denopamine glucuronidation | Canis lupus familiaris | |
additional information | no effect by 1% v/v DMSO and 2% v/v methanol on denopamine glucuronidation | Homo sapiens | |
additional information | no effect by 1% v/v DMSO and 2% v/v methanol on denopamine glucuronidation | Macaca fascicularis | |
additional information | no effect by 1% v/v DMSO and 2% v/v methanol on denopamine glucuronidation | Oryctolagus cuniculus | |
additional information | no effect by 1% v/v DMSO and 2% v/v methanol on denopamine glucuronidation | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0018 | - |
denopamine | liver microsomes, substrate denopamine, pH 7.5, 37°C | Oryctolagus cuniculus | |
0.0022 | - |
denopamine | liver microsomes, substrate denopamine, pH 7.5, 37°C | Rattus norvegicus | |
1.48 | - |
denopamine | recombinant isozyme UGT2B7, substrate denopamine, pH 7.5, 37°C | Homo sapiens | |
1.84 | - |
denopamine | liver microsomes, substrate denopamine, formation of G2 product, pH 7.5, 37°C | Macaca fascicularis | |
2.87 | - |
denopamine | liver micosomes, substrate denopamine, pH 7.5, 37°C | Homo sapiens | |
2.99 | - |
denopamine | jejunum microsomes, substrate denopamine, pH 7.5, 37°C | Homo sapiens | |
3.51 | - |
denopamine | liver microsomes, substrate denopamine, formation of G2 product, pH 7.5, 37°C | Canis lupus familiaris | |
3.91 | - |
denopamine | liver microsomes, substrate denopamine, formation of G1 product, pH 7.5, 37°C | Macaca fascicularis | |
10.18 | - |
denopamine | liver microsomes, substrate denopamine, formation of G1 product, pH 7.5, 37°C | Canis lupus familiaris |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
microsome | - |
Rattus norvegicus | - |
- |
microsome | - |
Oryctolagus cuniculus | - |
- |
microsome | - |
Canis lupus familiaris | - |
- |
microsome | - |
Macaca fascicularis | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens | |
Mg2+ | - |
Rattus norvegicus | |
Mg2+ | - |
Oryctolagus cuniculus | |
Mg2+ | - |
Canis lupus familiaris | |
Mg2+ | - |
Macaca fascicularis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
male beagles | - |
Homo sapiens | - |
isozyme UGT1A6 | - |
Homo sapiens | - |
isozyme UGT2B4 | - |
Homo sapiens | O60656 | isozyme UGT1A9; isozyme UGT1A9 | - |
Homo sapiens | O75795 | isozyme UGT2B17 | - |
Homo sapiens | P16662 | isozyme UGT2B7; isozyme UGT2B7 | - |
Homo sapiens | P22309 | isozyme UGT1A1; isozyme UGT1A1 | - |
Homo sapiens | P22310 | isozyme UGT1A4; isozyme UGT1A4 | - |
Homo sapiens | P35503 | isozyme UGT1A3; isozyme UGT1A3 | - |
Homo sapiens | P54855 | isozyme UGT2B15; isozyme UGT2B15 | - |
Homo sapiens | Q9HAW7 | isozyme UGT1A7; isozyme UGT1A7 | - |
Homo sapiens | Q9HAW8 | isozyme UGT1A10; isozyme UGT1A10 | - |
Homo sapiens | Q9HAW9 | isozyme UGT1A8; isozyme UGT1A8 | - |
Macaca fascicularis | - |
cynomolgus monkey | - |
Oryctolagus cuniculus | - |
male New Zealand White | - |
Rattus norvegicus | - |
male Sprague-Dawley | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
jejunum | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Oryctolagus cuniculus | - |
liver | - |
Canis lupus familiaris | - |
liver | - |
Macaca fascicularis | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Rattus norvegicus |
additional information | - |
- |
Oryctolagus cuniculus |
additional information | - |
- |
Canis lupus familiaris |
additional information | - |
- |
Macaca fascicularis |
0.00011 | - |
recombinant isozyme UGT2B17, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C | Homo sapiens |
0.0002 | - |
recombinant isozyme UGT1A10, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C | Homo sapiens |
0.0005 | - |
recombinant isozyme UGT2B4, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C | Homo sapiens |
0.0007 | - |
recombinant isozyme UGT1A8, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C | Homo sapiens |
0.0014 | - |
recombinant isozyme UGT1A4, substrate trifluoperazine, pH 7.5, 37°C | Homo sapiens |
0.0015 | - |
recombinant isozyme UGT1A1, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C | Homo sapiens |
0.0022 | - |
recombinant isozyme UGT1A3, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C | Homo sapiens |
0.0037 | - |
recombinant isozyme UGT2B15, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C | Homo sapiens |
0.0037 | - |
recombinant isozyme UGT2B7, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C | Homo sapiens |
0.0044 | - |
recombinant isozyme UGT1A6, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C | Homo sapiens |
0.0065 | - |
recombinant isozyme UGT1A9, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C | Homo sapiens |
0.0126 | - |
recombinant isozyme UGT1A7, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C | Homo sapiens |
0.0191 | - |
jejunum microsomes, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C | Homo sapiens |
0.0622 | - |
liver microsomes, substrate 7-hydroxy-4-trifluoromethylcoumarin, pH 7.5, 37°C | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-alpha-D-glucuronate + diclofenac | - |
Homo sapiens | UDP + diclofenac O-beta-D-glucuronide | - |
? | |
UDP-glucuronate + 7-hydroxy-4-trifluoromethylcoumarin | - |
Homo sapiens | UDP + 4-trifluoromethylcoumarin 7-O-beta-D-glucuronide | - |
? | |
UDP-glucuronate + denopamine | - |
Rattus norvegicus | UDP + denopamine beta-D-glucuronide | formation of 1 product metabolite termed G1 | ? | |
UDP-glucuronate + denopamine | - |
Oryctolagus cuniculus | UDP + denopamine beta-D-glucuronide | formation of 1 product metabolite termed G1 | ? | |
UDP-glucuronate + denopamine | - |
Homo sapiens | UDP + denopamine beta-D-glucuronide | formation of 1 product metabolite termed G2 | ? | |
UDP-glucuronate + denopamine | - |
Canis lupus familiaris | UDP + denopamine beta-D-glucuronide | formation of 2 product metabolites termed G1 and G2 | ? | |
UDP-glucuronate + denopamine | - |
Macaca fascicularis | UDP + denopamine beta-D-glucuronide | formation of 2 product metabolites termed G1 and G2 | ? | |
UDP-glucuronate + trifluoperazine | isozyme UGT1A4 | Homo sapiens | UDP + trifluoperazine beta-D-glucuronide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UDP-glucuronosyltransferase | - |
Homo sapiens |
UDP-glucuronosyltransferase | - |
Rattus norvegicus |
UDP-glucuronosyltransferase | - |
Oryctolagus cuniculus |
UDP-glucuronosyltransferase | - |
Canis lupus familiaris |
UDP-glucuronosyltransferase | - |
Macaca fascicularis |
UGT | - |
Homo sapiens |
UGT | - |
Rattus norvegicus |
UGT | - |
Oryctolagus cuniculus |
UGT | - |
Canis lupus familiaris |
UGT | - |
Macaca fascicularis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
37 | - |
assay at | Rattus norvegicus |
37 | - |
assay at | Oryctolagus cuniculus |
37 | - |
assay at | Canis lupus familiaris |
37 | - |
assay at | Macaca fascicularis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
7.5 | - |
assay at | Rattus norvegicus |
7.5 | - |
assay at | Oryctolagus cuniculus |
7.5 | - |
assay at | Canis lupus familiaris |
7.5 | - |
assay at | Macaca fascicularis |