Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-nitrophenol | inhibits the etoposide glucuronosyltransferase activity in liver microsomes | Homo sapiens | |
beta-estradiol | completely inhibits the etoposide glucuronosyltransferase activity in liver microsomes at 0.5 mM | Homo sapiens | |
bilirubin | completely inhibits the etoposide glucuronosyltransferase activity in liver microsomes at 0.5 mM | Homo sapiens | |
imipramine | inhibits the etoposide glucuronosyltransferase activity in liver microsomes | Homo sapiens | |
morphine | inhibits the etoposide glucuronosyltransferase activity in liver microsomes | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.44 | - |
etoposide | liver microsomes, pH 7.4, 37°C | Homo sapiens | |
0.5 | - |
etoposide | recombinant isozyme UGT1A1, pH 7.4, 37°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P22309 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-glucuronate + etoposide | isozyme UGT1A1 is specific for etoposide | Homo sapiens | UDP + etoposide beta-D-glucuronide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UDP-glucuronosyltransferase | - |
Homo sapiens |
UDP-glucuronosyltransferase 1A1 | - |
Homo sapiens |
UGT | - |
Homo sapiens |
UGT1A1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Homo sapiens |