Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Mus musculus | - |
- |
microsome | - |
Rattus norvegicus | - |
- |
microsome | - |
Sus scrofa | - |
- |
microsome | - |
Canis lupus familiaris | - |
- |
microsome | - |
Macaca fascicularis | - |
- |
microsome | - |
Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Mus musculus | |
Mg2+ | required | Rattus norvegicus | |
Mg2+ | required | Sus scrofa | |
Mg2+ | required | Canis lupus familiaris | |
Mg2+ | required | Macaca fascicularis | |
Mg2+ | required | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
beagle dogs | - |
Homo sapiens | O60656 | gene UGT1A9 | - |
Homo sapiens | P16662 | gene UGT2B7 | - |
Homo sapiens | P19224 | gene UGT1A6 | - |
Homo sapiens | P22309 | gene UGT1A1 | - |
Homo sapiens | P22310 | gene UGT1A4 | - |
Macaca fascicularis | - |
cynomolgus monkeys | - |
Mus musculus | - |
ICR mice | - |
Rattus norvegicus | - |
SD rats | - |
Sus scrofa | - |
Yucatan minipig | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Canis lupus familiaris | - |
liver | - |
Macaca fascicularis | - |
liver | - |
Homo sapiens | - |
liver | UGT activities in the microminipig are similar to those in the minipig | Sus scrofa | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
hepatic UGTactivity with selective substrates of human in the microminipig compared to those in humans and other experimental animals, overview. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and the other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview | Mus musculus |
additional information | - |
hepatic UGTactivity with selective substrates of human in the microminipig compared to those in humans and other experimental animals, overview. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and the other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview | Rattus norvegicus |
additional information | - |
hepatic UGTactivity with selective substrates of human in the microminipig compared to those in humans and other experimental animals, overview. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and the other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview | Canis lupus familiaris |
additional information | - |
hepatic UGTactivity with selective substrates of human in the microminipig compared to those in humans and other experimental animals, overview. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and the other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview | Macaca fascicularis |
additional information | - |
hepatic UGTactivity with selective substrates of human in the microminipig compared to those in humans and other experimental animals, overview. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and the other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview. 3'-Azido-3'-deoxythymidine glucuronidation is approximately 26fold lower in microminipig microsomes than in human microsomes | Sus scrofa |
additional information | - |
hepatic UGTactivity with selective substrates of human in the microminipig compared to those in humans and other experimental animals, overview. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and the other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview. 3'-Azido-3'-deoxythymidine glucuronidation is approximately 26fold lower in microminipig microsomes than in human microsomes | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | 3'-azido-3'-deoxythymidine-glucuronidation activity is low in the microminipig compared with humans, morphine-3-glucuronidation activity in the microminipig is higher than that in humans | Sus scrofa | ? | - |
? | |
additional information | 3'-azido-3'-deoxythymidine-glucuronidation activity is low in the microminipig compared with humans, morphine-3-glucuronidation activity in the microminipig is higher than that in humans | Homo sapiens | ? | - |
? | |
additional information | no activity with imipramine | Canis lupus familiaris | ? | - |
? | |
UDP-glucuronate + 17-beta-estradiol | - |
Mus musculus | UDP + 17-beta-estradiol 3-beta-D-glucuronoside | - |
? | |
UDP-glucuronate + 17-beta-estradiol | - |
Rattus norvegicus | UDP + 17-beta-estradiol 3-beta-D-glucuronoside | - |
? | |
UDP-glucuronate + 17-beta-estradiol | - |
Canis lupus familiaris | UDP + 17-beta-estradiol 3-beta-D-glucuronoside | - |
? | |
UDP-glucuronate + 17-beta-estradiol | - |
Macaca fascicularis | UDP + 17-beta-estradiol 3-beta-D-glucuronoside | - |
? | |
UDP-glucuronate + 17-beta-estradiol | - |
Homo sapiens | UDP + 17-beta-estradiol 3-beta-D-glucuronoside | - |
? | |
UDP-glucuronate + 17-beta-estradiol | high levels of estradiol-3-glucuronidation in microsomes of 1-day-old microminipigs | Sus scrofa | UDP + 17-beta-estradiol 3-beta-D-glucuronoside | - |
? | |
UDP-glucuronate + 3'-azido-3'-deoxythymidine | - |
Mus musculus | UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronoside | - |
? | |
UDP-glucuronate + 3'-azido-3'-deoxythymidine | - |
Rattus norvegicus | UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronoside | - |
? | |
UDP-glucuronate + 3'-azido-3'-deoxythymidine | - |
Sus scrofa | UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronoside | - |
? | |
UDP-glucuronate + 3'-azido-3'-deoxythymidine | - |
Canis lupus familiaris | UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronoside | - |
? | |
UDP-glucuronate + 3'-azido-3'-deoxythymidine | - |
Macaca fascicularis | UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronoside | - |
? | |
UDP-glucuronate + 3'-azido-3'-deoxythymidine | - |
Homo sapiens | UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronoside | - |
? | |
UDP-glucuronate + imipramine | - |
Sus scrofa | UDP + imipramine N-beta-D-glucuronoside | - |
? | |
UDP-glucuronate + imipramine | specific substrate of UGT1A4 | Homo sapiens | UDP + imipramine N-beta-D-glucuronoside | - |
? | |
UDP-glucuronate + morphine | - |
Mus musculus | UDP + morphine 3-beta-D-glucuronoside | - |
? | |
UDP-glucuronate + morphine | - |
Rattus norvegicus | UDP + morphine 3-beta-D-glucuronoside | - |
? | |
UDP-glucuronate + morphine | - |
Sus scrofa | UDP + morphine 3-beta-D-glucuronoside | - |
? | |
UDP-glucuronate + morphine | - |
Canis lupus familiaris | UDP + morphine 3-beta-D-glucuronoside | - |
? | |
UDP-glucuronate + morphine | - |
Macaca fascicularis | UDP + morphine 3-beta-D-glucuronoside | - |
? | |
UDP-glucuronate + morphine | - |
Homo sapiens | UDP + morphine 3-beta-D-glucuronoside | - |
? | |
UDP-glucuronate + morphine | morphine-3-glucuronidation is a marker of conjugation by human UGT2B7 | Homo sapiens | UDP + morphine 3-beta-D-glucuronoside | - |
? | |
UDP-glucuronate + propofol | - |
Mus musculus | UDP + propofol beta-D-glucuronoside | - |
? | |
UDP-glucuronate + propofol | - |
Rattus norvegicus | UDP + propofol beta-D-glucuronoside | - |
? | |
UDP-glucuronate + propofol | - |
Sus scrofa | UDP + propofol beta-D-glucuronoside | - |
? | |
UDP-glucuronate + propofol | - |
Canis lupus familiaris | UDP + propofol beta-D-glucuronoside | - |
? | |
UDP-glucuronate + propofol | - |
Macaca fascicularis | UDP + propofol beta-D-glucuronoside | - |
? | |
UDP-glucuronate + propofol | - |
Homo sapiens | UDP + propofol beta-D-glucuronoside | - |
? | |
UDP-glucuronate + serotonin | - |
Mus musculus | UDP + serotonin beta-D-glucuronoside | - |
? | |
UDP-glucuronate + serotonin | - |
Rattus norvegicus | UDP + serotonin beta-D-glucuronoside | - |
? | |
UDP-glucuronate + serotonin | - |
Sus scrofa | UDP + serotonin beta-D-glucuronoside | - |
? | |
UDP-glucuronate + serotonin | - |
Canis lupus familiaris | UDP + serotonin beta-D-glucuronoside | - |
? | |
UDP-glucuronate + serotonin | - |
Macaca fascicularis | UDP + serotonin beta-D-glucuronoside | - |
? | |
UDP-glucuronate + serotonin | - |
Homo sapiens | UDP + serotonin beta-D-glucuronoside | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UDP-glucuronosyltransferase | - |
Mus musculus |
UDP-glucuronosyltransferase | - |
Rattus norvegicus |
UDP-glucuronosyltransferase | - |
Sus scrofa |
UDP-glucuronosyltransferase | - |
Canis lupus familiaris |
UDP-glucuronosyltransferase | - |
Macaca fascicularis |
UDP-glucuronosyltransferase | - |
Homo sapiens |
UGT | - |
Mus musculus |
UGT | - |
Rattus norvegicus |
UGT | - |
Sus scrofa |
UGT | - |
Canis lupus familiaris |
UGT | - |
Macaca fascicularis |
UGT | - |
Homo sapiens |
UGT1A1 | - |
Homo sapiens |
UGT1A4 | - |
Homo sapiens |
UGT1A6 | - |
Homo sapiens |
UGT1A9 | - |
Homo sapiens |
UGT2B7 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
37 | - |
assay at | Rattus norvegicus |
37 | - |
assay at | Sus scrofa |
37 | - |
assay at | Canis lupus familiaris |
37 | - |
assay at | Macaca fascicularis |
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |
7.4 | - |
assay at | Rattus norvegicus |
7.4 | - |
assay at | Sus scrofa |
7.4 | - |
assay at | Canis lupus familiaris |
7.4 | - |
assay at | Macaca fascicularis |
7.4 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
evolution | UGTs have been divided into two families: UGT1 and UGT2, based on similarities between their amino acid sequences and gene organization. Hepatic UGTactivity in the microminipig compared to those in humans and other experimental animals. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview | Mus musculus |
evolution | UGTs have been divided into two families: UGT1 and UGT2, based on similarities between their amino acid sequences and gene organization. Hepatic UGTactivity in the microminipig compared to those in humans and other experimental animals. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview | Rattus norvegicus |
evolution | UGTs have been divided into two families: UGT1 and UGT2, based on similarities between their amino acid sequences and gene organization. Hepatic UGTactivity in the microminipig compared to those in humans and other experimental animals. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview | Sus scrofa |
evolution | UGTs have been divided into two families: UGT1 and UGT2, based on similarities between their amino acid sequences and gene organization. Hepatic UGTactivity in the microminipig compared to those in humans and other experimental animals. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview | Canis lupus familiaris |
evolution | UGTs have been divided into two families: UGT1 and UGT2, based on similarities between their amino acid sequences and gene organization. Hepatic UGTactivity in the microminipig compared to those in humans and other experimental animals. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview | Macaca fascicularis |
evolution | UGTs have been divided into two families: UGT1 and UGT2, based on similarities between their amino acid sequences and gene organization. Hepatic UGTactivity in the microminipig compared to those in humans and other experimental animals. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview | Homo sapiens |
physiological function | glucuronidation catalysed by UDP-glucuronosyltransferase is an important pathway in the metabolism of xenobiotics and endogenous compounds | Mus musculus |
physiological function | glucuronidation catalysed by UDP-glucuronosyltransferase is an important pathway in the metabolism of xenobiotics and endogenous compounds | Rattus norvegicus |
physiological function | glucuronidation catalysed by UDP-glucuronosyltransferase is an important pathway in the metabolism of xenobiotics and endogenous compounds | Sus scrofa |
physiological function | glucuronidation catalysed by UDP-glucuronosyltransferase is an important pathway in the metabolism of xenobiotics and endogenous compounds | Canis lupus familiaris |
physiological function | glucuronidation catalysed by UDP-glucuronosyltransferase is an important pathway in the metabolism of xenobiotics and endogenous compounds | Macaca fascicularis |
physiological function | glucuronidation catalysed by UDP-glucuronosyltransferase is an important pathway in the metabolism of xenobiotics and endogenous compounds | Homo sapiens |