Cloned (Comment) | Organism |
---|---|
stable expression of isozymes UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A10, UGT2B4, UGT2B7, UGT2B15, UGT2B17, and UGT2B28 in HEK-293 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
fluconazole | a UGT2B7 selective inhibitor | Homo sapiens | |
Phenylbutazone | a UGT1A selective inhibitor | Homo sapiens | |
sulfinpyrazone | a UGT1A selective inhibitor | Homo sapiens | |
zidovudine | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | frusemide glucuronidation followed MichaelisMenten kinetics in all tissues, kinetics of different microsome types from liver and kidney, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-D-glucuronate + acceptor | Homo sapiens | - |
UDP + acceptor beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + frusemide | Homo sapiens | - |
UDP + frusemide beta-D-glucuronoside | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
diverse isozymes | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | cortex and medulla | Homo sapiens | - |
liver | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
catalytic efficiency of frusemide glucuronidation of different microsome types from liver and kidney, overview | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-D-glucuronate + acceptor | - |
Homo sapiens | UDP + acceptor beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + frusemide | - |
Homo sapiens | UDP + frusemide beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + frusemide | substrate of isozymes UGT 1A1, UGT1A3, UGT1A6, UGT1A7, UGT1A9, UGT1A10 and UGT2B7, with a predominant role of UGT1A9 in liver and kidney | Homo sapiens | UDP + frusemide beta-D-glucuronoside | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UDP-glucuronosyltransferase | - |
Homo sapiens |
UGT | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |