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Literature summary for 2.4.1.17 extracted from

  • Barbier, O.; Girard, C.; Breton, R.; Belanger, A.; Hum, D.W.
    N-Glycosylation and Residue 96 Are Involved in the Functional Properties of UDP-Glucuronosyltransferase Enzymes (2000), Biochemistry, 39, 11540-11552.
    View publication on PubMed
Search for more literature for 2.4.1.17

Protein Variants

Protein Variants Comment Organism
I96R UGT2B20 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone Platyrrhini
I96R UGT2B20 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone Homo sapiens
I96R/T98I UGT2B20 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone Platyrrhini
I96R/T98I UGT2B20 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone Homo sapiens
I98T UGT2B15 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone Platyrrhini
I98T UGT2B15 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone Homo sapiens
L93I UGT2B20 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone Platyrrhini
L93I UGT2B20 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone Homo sapiens
R96I UGT2B15 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone Platyrrhini
R96I UGT2B15 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone Homo sapiens
R96I/I98T UGT2B15 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone Platyrrhini
R96I/I98T UGT2B15 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone Homo sapiens
S100G UGT2B20 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone Platyrrhini
S100G UGT2B20 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone Homo sapiens
T98I UGT2B20 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone Platyrrhini
T98I UGT2B20 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone Homo sapiens
T98I UGT2B17 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone Platyrrhini
T98I UGT2B17 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetic analysis of UGT2B15, UGT2B17 and UGT2B20 mutant proteins for 5 alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone Platyrrhini
additional information
-
 additional information kinetic analysis of UGT2B15, UGT2B17 and UGT2B20 mutant proteins for 5 alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Platyrrhini
-
-
microsome
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens O75795
-
-
Platyrrhini
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein UGT2B7 UGT2B15, UGT2B17 and UGT2B20 Platyrrhini
glycoprotein UGT2B7 UGT2B15, UGT2B17 and UGT2B20 Homo sapiens

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 activities of wild-type and glycosylation mutant of UGT2B15 and UGT2B20 on 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone Platyrrhini
additional information
-
 activities of wild-type and glycosylation mutant of UGT2B15 and UGT2B20 on 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone Homo sapiens