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Literature summary for 2.4.1.17 extracted from
- Evaluation of 5-hydroxytryptophol and other endogenous serotonin (5-hydroxytryptamine) analogs as substrates for UDP-glucuronosyltransferase 1A6 (2004), Drug Metab. Dispos., 32, 862-869.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of diverse isozymes in a lymphoblast expression system, overview | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5-hydroxytryptophol | competitive inhibition of serotonin glucuronidation | Homo sapiens |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.135 | - |
5-hydroxytryptophol | isozyme UGT1A6, pH 7.5, 37°C | Homo sapiens | |
| 3.674 | - |
5-hydroxytryptophol | isozyme UGT1A9, pH 7.5, 37°C | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P19224 | isozyme UGT1A6; isozymes UGT1A6 and UGT1A9 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
activity of diverse recombinant isozymes with the different substrates | Homo sapiens |
| 0.0016 | - |
liver microsomes, substrate morphine 3-glucuronide | Homo sapiens |
| 0.0044 | - |
liver microsomes, substrate serotonin | Homo sapiens |
| 0.0052 | - |
liver microsomes, substrate N-acetylserotonin | Homo sapiens |
| 0.0072 | - |
liver microsomes, substrate 6-hydroxymelatonin | Homo sapiens |
| 0.008 | 4 | liver microsomes, substrate 5-hydroxytryptophol | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-glucuronate + 5-hydroxytryptophol | isozymes UGT1A6 and UGT1A9, the latter shows over 20fold lower activity | Homo sapiens | UDP + 5-hydroxytryptophol beta-D-glucuronide | - |
? | |
| UDP-glucuronate + 6-hydroxymelatonin | - |
Homo sapiens | UDP + 6-hydroxymelatonin beta-D-glucuronide | - |
? | |
| UDP-glucuronate + morphine 3-glucuronide | - |
Homo sapiens | UDP + ? | - |
? | |
| UDP-glucuronate + N-acetylserotonin | - |
Homo sapiens | UDP + N-acetylserotonin beta-D-glucuronide | - |
? | |
| UDP-glucuronate + serotonin | - |
Homo sapiens | UDP + serotonin beta-D-glucuronide | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| UDP-glucuronosyltransferase 1A6 | - |
Homo sapiens |
| UGT1A6 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.2 | - |
5-hydroxytryptophol | isozyme UGT1A6, pH 7.5, 37°C | Homo sapiens | |
| 0.29 | - |
5-hydroxytryptophol | liver microsomes, pH 7.5, 37°C | Homo sapiens | |
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