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Literature summary for 2.4.1.17 extracted from

  • Soars, M.G.; Fettes, M.; O'Sullivan, A.C.; Riley, R.J.; Ethell, B.T.; Burchell, B.
    Cloning and characterisation of the first drug-metabolising canine UDP-glucuronosyltransferase of the 2B subfamily (2003), Biochem. Pharmacol., 65, 1251-1259.
    View publication on PubMed
Search for more literature for 2.4.1.17

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and analysis, expression in chinese hamster lung fibroblast V79 cells, sequence comparison, phylogenetic analysis Homo sapiens
DNA and amino acid sequence determination and analysis, screening of dog cDNA library, expression in chinese hamster lung fibroblast V79 cells, sequence comparison, phylogenetic analysis Canis lupus familiaris

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetics Homo sapiens
additional information
-
 additional information kinetics Canis lupus familiaris
0.013
-
 androstanediol pH 7.4, 37°C Canis lupus familiaris
0.0175
-
 androstanediol pH 7.4, 37°C Homo sapiens
0.0195
-
 gemfibrozil pH 7.4, 37°C Homo sapiens
0.139
-
 gemfibrozil pH 7.4, 37°C Canis lupus familiaris
0.22
-
 1-naphthol pH 7.4, 37°C Canis lupus familiaris
0.25
-
 naproxen pH 7.4, 37°C Homo sapiens
0.265
-
 1-naphthol pH 7.4, 37°C Homo sapiens
0.48
-
 Ketoprofen pH 7.4, 37°C Homo sapiens
0.58
-
 naproxen pH 7.4, 37°C Canis lupus familiaris
1.15
-
 morphine 3-glucuronide pH 7.4, 37°C Homo sapiens
1.425
-
 morphine 3-glucuronide pH 7.4, 37°C Canis lupus familiaris
1.695
-
 Ketoprofen pH 7.4, 37°C Canis lupus familiaris

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-
microsome
-
 Canis lupus familiaris
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens
Mg2+
-
 Canis lupus familiaris

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Canis lupus familiaris enzyme UGT2B31 plays a crucial role in drug detoxificiation ?
-
 ?
additional information Homo sapiens enzyme UGT2B7 plays a crucial role in drug detoxificiation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris Q6K1J1
-
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-
liver
-
 Canis lupus familiaris
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.000008
-
 microsomes, substrate codeine Homo sapiens
0.000009
-
 microsomes, substrate ketoprofen Canis lupus familiaris
0.000011
-
 microsomes, substrate naproxen Canis lupus familiaris
0.000013
-
 microsomes, substrate naproxen Homo sapiens
0.000028
-
 microsomes, substrate morphine 3-glucuronide Canis lupus familiaris
0.000032
-
 microsomes, substrate 4-nitrophenol Canis lupus familiaris
0.000037
-
 microsomes, substrate androstanediol Canis lupus familiaris
0.000058
-
 microsomes, substrates hydromorphone and morphine 3-glucuronide Homo sapiens
0.00006
-
 microsomes, substrate ketoprofen Homo sapiens
0.00006
-
 microsomes, substrate lorazepam Canis lupus familiaris
0.00007
-
 microsomes, substrate ethylphenol Canis lupus familiaris
0.00007
-
 microsomes, substrate gemfibrozil Canis lupus familiaris
0.000075
-
 microsomes, substrate 4-methylumbelliferone Canis lupus familiaris
0.00008
-
 microsomes, substrate 1-naphthol Canis lupus familiaris
0.000082
-
 microsomes, substrate eugenol Canis lupus familiaris
0.000102
-
 microsomes, substrate valproic acid Homo sapiens
0.000105
-
 microsomes, substrate ibuprofen Homo sapiens
0.0002
-
 microsomes, substrate ethylphenol Homo sapiens
0.000215
-
 microsomes, substrate 4-methylumbelliferone Homo sapiens
0.00022
-
 microsomes, substrate androstanediol Homo sapiens
0.00023
-
 microsomes, substrate 1-naphthol Homo sapiens
0.00027
-
 microsomes, substrate gemfibrozil Homo sapiens
0.00028
-
 microsomes, substrate diclofenac Homo sapiens
0.0004
-
 microsomes, substrate 4-nitrophenol Homo sapiens
0.00103
-
 microsomes, substrate eugenol Homo sapiens
0.00124
-
 microsomes, substrate hyodeoxycholic acid Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme UGT2B31 plays a crucial role in drug detoxificiation Canis lupus familiaris ?
-
 ?
additional information enzyme UGT2B7 plays a crucial role in drug detoxificiation Homo sapiens ?
-
 ?
additional information substrate specificity, no substrates are hyodeoxycholic acid, lithocholic acid, diclofenac, furosemide, ibuprofen, valproic acid, codeine, hydromorphone, morphine 6-glucuronide, propofol, ethinylestradiol, and testosterone Canis lupus familiaris ?
-
 ?
additional information substrate specificity, no substrates are lorazepam, lithocholic acid, furosemide, propofol, ethinylestradiol, and testosterone Homo sapiens ?
-
 ?
naproxen + UDP-glucuronate
-
 Homo sapiens naproxen glucuronide + UDP
-
 ?
naproxen + UDP-glucuronate
-
 Canis lupus familiaris naproxen glucuronide + UDP
-
 ?
UDP-alpha-D-glucuronate + (S)-naproxen
-
 Homo sapiens UDP + beta-D-glucuronosyl (S)-naproxen
-
 ?
UDP-alpha-D-glucuronate + (S)-naproxen
-
 Canis lupus familiaris UDP + beta-D-glucuronosyl (S)-naproxen low activity ?
UDP-alpha-glucuronate + diclofenac
-
 Homo sapiens UDP + beta-D-glucuronosyl-diclofenac
-
 ?
UDP-glucuronate + 1-naphthol
-
 Homo sapiens UDP + beta-D-glucuronosyl-(1-naphthol)
-
 ?
UDP-glucuronate + 1-naphthol
-
 Canis lupus familiaris UDP + beta-D-glucuronosyl-(1-naphthol)
-
 ?
UDP-glucuronate + 4-ethylphenol
-
 Homo sapiens UDP + beta-D-glucuronosyl-(4-ethylphenol)
-
 ?
UDP-glucuronate + 4-ethylphenol
-
 Canis lupus familiaris UDP + beta-D-glucuronosyl-(4-ethylphenol)
-
 ?
UDP-glucuronate + 4-methylumbelliferone
-
 Homo sapiens UDP + beta-D-glucuronosyl-(4-methylumbelliferone)
-
 ?
UDP-glucuronate + 4-methylumbelliferone
-
 Canis lupus familiaris UDP + beta-D-glucuronosyl-(4-methylumbelliferone)
-
 ?
UDP-glucuronate + 4-nitrophenol
-
 Homo sapiens UDP + beta-D-glucuronosyl-(4-nitrophenol)
-
 ?
UDP-glucuronate + 4-nitrophenol
-
 Canis lupus familiaris UDP + beta-D-glucuronosyl-(4-nitrophenol)
-
 ?
UDP-glucuronate + androstane-3,17-diol
-
 Homo sapiens UDP + beta-D-glucuronosyl-androstane-3,17-diol
-
 ?
UDP-glucuronate + androstane-3,17-diol
-
 Canis lupus familiaris UDP + beta-D-glucuronosyl-androstane-3,17-diol
-
 ?
UDP-glucuronate + codeine low activity Homo sapiens UDP + beta-D-glucuronosyl-codeine
-
 ?
UDP-glucuronate + eugenol
-
 Canis lupus familiaris UDP + beta-D-glucuronosyl-eugenol
-
 ?
UDP-glucuronate + eugenol high activity Homo sapiens UDP + beta-D-glucuronosyl-eugenol
-
 ?
UDP-glucuronate + gemfibrozil
-
 Homo sapiens UDP + beta-D-glucuronosyl-gemfibrozil
-
 ?
UDP-glucuronate + gemfibrozil
-
 Canis lupus familiaris UDP + beta-D-glucuronosyl-gemfibrozil
-
 ?
UDP-glucuronate + hydromorphone
-
 Homo sapiens UDP + beta-D-glucuronosyl-hydromorphone
-
 ?
UDP-glucuronate + hyodeoxycholic acid high activity Homo sapiens UDP + beta-D-glucuronosyl-hyodeoxycholic acid
-
 ?
UDP-glucuronate + ibuprofen
-
 Homo sapiens UDP + beta-D-glucuronosyl-ibuprofen
-
 ?
UDP-glucuronate + ketoprofen
-
 Homo sapiens UDP + beta-D-glucuronosyl-ketoprofen
-
 ?
UDP-glucuronate + ketoprofen
-
 Canis lupus familiaris UDP + beta-D-glucuronosyl-ketoprofen low activity ?
UDP-glucuronate + lorazepam
-
 Canis lupus familiaris UDP + beta-D-glucuronosyl-lorazepam
-
 ?
UDP-glucuronate + morphine 3-glucuronide
-
 Homo sapiens UDP + morphine 3,6-diglucuronide
-
 ?
UDP-glucuronate + morphine 3-glucuronide
-
 Canis lupus familiaris UDP + morphine 3,6-diglucuronide
-
 ?
UDP-glucuronate + valproic acid
-
 Homo sapiens UDP + beta-D-glucuronosyl-valproic acid
-
 ?

Synonyms

Synonyms Comment Organism
More enzyme belongs to the 2B subfamily Homo sapiens
More enzyme belongs to the 2B subfamily Canis lupus familiaris
UDP-glucuronosyltransferase
-
 Homo sapiens
UDP-glucuronosyltransferase
-
 Canis lupus familiaris
UGT
-
 Homo sapiens
UGT
-
 Canis lupus familiaris
UGT2B31
-
 Canis lupus familiaris
UGT2B7
-
 Homo sapiens
uridine diphosphate glucuronosyltransferase
-
 Homo sapiens
uridine diphosphate glucuronosyltransferase
-
 Canis lupus familiaris

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens
37
-
 assay at Canis lupus familiaris

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens
7.4
-
 assay at Canis lupus familiaris