4.1.1.7: benzoylformate decarboxylase
This is an abbreviated version!
For detailed information about benzoylformate decarboxylase, go to the full flat file.
Word Map on EC 4.1.1.7
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4.1.1.7
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thiamin
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putida
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thdp-dependent
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diphosphate-dependent
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carboligation
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carboligase
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acyloin
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r-benzoin
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synthesis
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s-mandelate
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2-keto
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biotechnology
- 4.1.1.7
- thiamin
- putida
-
thdp-dependent
-
diphosphate-dependent
-
carboligation
-
carboligase
- acyloin
-
r-benzoin
- synthesis
- s-mandelate
-
2-keto
- biotechnology
Reaction
Synonyms
benzoylformate decarboxylase, BFD, BfdB, BFDC, BfdM, Decarboxylase, benzoylformate, MdlC, Phenylglyoxylate decarboxylase
ECTree
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Cofactor
Cofactor on EC 4.1.1.7 - benzoylformate decarboxylase
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additional information
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the addition of thiamine thiazolone diphosphate has no effect on the activity of BFD in the presence of thiamine diphosphate
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thiamine diphosphate
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the 4'-aminopyrimidine ring of the thiamine diphosphate coenzyme participates in catalysis, likely as an intramolecular general acid-base catalyst via the unusual 1',4'-iminopyrimidine tautomer
thiamine diphosphate
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the enzyme avoids formation of a benzoyl anion by addition of enzyme-bound thiamine diphosphate to the carbonyl group of benzoylformate, producing enzyme-bound 2-(2-mandelyl)thiamine diphosphate
thiamine diphosphate
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dependent on, structural binding environment, overview. The V-conformation is assisted by the presence of a fulcrum residue, Leu403, located directly below the cofactor, the V-conformation results in a N4'-C2 distance of 3.1 A