4.1.1.7: benzoylformate decarboxylase
This is an abbreviated version!
For detailed information about benzoylformate decarboxylase, go to the full flat file.
Word Map on EC 4.1.1.7
-
4.1.1.7
-
thiamin
-
putida
-
thdp-dependent
-
diphosphate-dependent
-
carboligation
-
carboligase
-
acyloin
-
r-benzoin
-
synthesis
-
s-mandelate
-
2-keto
-
biotechnology
- 4.1.1.7
- thiamin
- putida
-
thdp-dependent
-
diphosphate-dependent
-
carboligation
-
carboligase
- acyloin
-
r-benzoin
- synthesis
- s-mandelate
-
2-keto
- biotechnology
Reaction
Synonyms
benzoylformate decarboxylase, BFD, BfdB, BFDC, BfdM, Decarboxylase, benzoylformate, MdlC, Phenylglyoxylate decarboxylase
ECTree
Advanced search results
General Information
General Information on EC 4.1.1.7 - benzoylformate decarboxylase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
metabolism
-
penultimate enzyme in the mandelate pathway, that catalyzes the non-oxidative decarboxylation of benzoylformate to yield carbon dioxide and benzaldehyde
physiological function
additional information
-
the first step in catalysis by all ThDP-dependent enzymes is the deprotonation of the C2 carbon by the 4'-imino group to form the ylide. Both active sites contain two histidine residues in the catalytic dimer, three ionizable residues in the active site of the enzyme are Ser26, His70 and His281. His281 is the donor for the protonation of the enamine intermediate, Ser26 forms a hydrogen bond with the carboxylate of the substrate
-
the enzyme enables the organism to utilize R-mandelate as their sole carbon source
physiological function
-
the enzyme functions in decarboxylation of benzoylformate to benzaldehyde in the mandalate pathway