3.4.21.68: t-Plasminogen activator

This is an abbreviated version!
For detailed information about t-Plasminogen activator, go to the full flat file.

Reaction

Specific cleavage of Arg-/-Val bond in plasminogen to form plasmin =

Synonyms

Alteplase, BAT-PA, desmoteplase, DSPA beta, DSPA gamma, EC 3.4.21.31, EC 3.4.99.26, human tissue-type plasminogen activator, IV t-PA, IV tissue plasminogen activator, More, plasminogen activator, Plasminogen activator, tissue-type, PLAT, r-tPA, recombinant tissue plasminogen activator, Reteplase, rt-PA, rtPA, sc-tPA, sctPA, single chain enzyme tPA, t-PA, t-PA protein, t-plasminogen activator, tc-tPA, tctPA, Tissue plasminogen activator, tissue type plasminogen activator, tissue-plasminogen activator, Tissue-type plasminogen activator, tissue-type plasmiongen activator, tPA, two chain tPA

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.68 t-Plasminogen activator

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Results	in table
36	Activating Compound
1259	AA Sequence
47	Application
1	CAS Registry Number
41	Cloned(Commentary)
1	Cofactor
5	Crystallization (Commentary)
75764	Disease/ Diagnostics
11	Expression
59	General Information
27	IC50 Value
118	Inhibitors
5	kcat/KM [mM/s]
6	Ki Value [mM]
210	KM Value [mM]
15	Localization
32	Molecular Weight [Da]
48	Natural Substrates/ Products (Substrates)
965	Organism
15	PDB ID
11	pH Optimum
1	pH Range
2	pH Stability
7	Posttranslational Modification
49	Protein Variants
20	Purification (Commentary)
1	Reaction
3	Reaction Type
155	Reference
164	Source Tissue
9	Specific Activity [micromol/min/mg]
2	Storage Stability
224	Substrates and Products (Substrate)
19	Subunits
261	Synonyms
14	Temperature Optimum [°C]
4	Temperature Stability [°C]
185	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.4.21.68 - t-Plasminogen activator

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

N-methyl-D-aspartate receptor NR1 subunit + H2O

?

2 entries

plasminogen + H2O

?

2 entries

plasminogen + H2O

plasmin + ?

30 entries

plasminogen + H2O

plasminon + ?

Homo sapiens

-

-

707127

-

-

?

additional information

?

-

6 entries

N-methyl-D-aspartate receptor NR1 subunit + H2O

?

Mus musculus

-

-

718402

-

-

?

N-methyl-D-aspartate receptor NR1 subunit + H2O

?

Mus musculus Swiss

-

-

718402

-

-

?

plasminogen + H2O

?

Homo sapiens

-

responsible for practically all vascular fibrinolysis through activation of plasminogen

29578

-

-

?

plasminogen + H2O

?

Homo sapiens

-

participation in the destruction of the follicle wall

29572

-

-

?

plasminogen + H2O

plasmin + ?

Homo sapiens

-

-

649828

-

649828

?

plasminogen + H2O

plasmin + ?

Homo sapiens

-

-

649831

-

649831

?

plasminogen + H2O

plasmin + ?

Homo sapiens

-

-

650069

-

650069

?

plasminogen + H2O

plasmin + ?

Homo sapiens

-

-

651864

-

651864

?

plasminogen + H2O

plasmin + ?

Homo sapiens

-

-

651869

-

651869

?

plasminogen + H2O

plasmin + ?

Homo sapiens

-

-

651918

-

651918

?

plasminogen + H2O

plasmin + ?

Homo sapiens

-

-

717121, 717411, 717425

-

-

?

plasminogen + H2O

plasmin + ?

Homo sapiens

P00750

-

663857, 664221

-

-

?

plasminogen + H2O

plasmin + ?

Homo sapiens

-

-

664221

-

-

?

plasminogen + H2O

plasmin + ?

Homo sapiens

P00750

-

665068, 665516

-

-

?

plasminogen + H2O

plasmin + ?

Homo sapiens

-

-

665516

-

-

?

plasminogen + H2O

plasmin + ?

Homo sapiens

P00750

-

666406

-

-

?

plasminogen + H2O

plasmin + ?

Homo sapiens

P00750

-

710061

plasmin is a potent broad-spectrum protease that cleaves fibrin and is able to degrade several components of the extracellular matrix by activating procollagenases and matrix metalloproteinases

-

?

plasminogen + H2O

plasmin + ?

Homo sapiens

-

cleavage of the Arg561-Val562 bond of plasminogen, converting the zymogen into the active serine protease plasmin

650935

-

650935

?

plasminogen + H2O

plasmin + ?

Homo sapiens

-

single-chain tPA mediated activation

649835

-

649835

?

plasminogen + H2O

plasmin + ?

Homo sapiens

-

critical role in fibrinolysis

649779

-

649779

?

plasminogen + H2O

plasmin + ?

Homo sapiens

-

activation

732200

-

-

?

plasminogen + H2O

plasmin + ?

Homo sapiens

P00750

activation

731733, 732063

-

-

?

plasminogen + H2O

plasmin + ?

Homo sapiens

-

activation

732063

-

-

?

plasminogen + H2O

plasmin + ?

Homo sapiens

P00750

activation

732325

-

-

?

plasminogen + H2O

plasmin + ?

Mus musculus

-

-

707932, 717304, 718064, 718403

-

-

?

plasminogen + H2O

plasmin + ?

Mus musculus

P11214

-

664747, 664749, 665722

-

-

?

plasminogen + H2O

plasmin + ?

Mus musculus

-

-

665722

-

-

?

plasminogen + H2O

plasmin + ?

Mus musculus

P11214

-

755364

-

-

?

plasminogen + H2O

plasmin + ?

Mus musculus C57/BL6J

-

-

718064

-

-

?

plasminogen + H2O

plasmin + ?

Mus musculus C57BL/6

-

-

718403

-

-

?

plasminogen + H2O

plasmin + ?

Mus musculus CD-1

P11214

-

755364

-

-

?

plasminogen + H2O

plasmin + ?

Rattus norvegicus

-

-

710120, 717679

-

-

?

plasminogen + H2O

plasmin + ?

Rattus norvegicus

P19637

-

664749, 665722

-

-

?

plasminogen + H2O

plasmin + ?

Rattus norvegicus Sprague-Dawley

-

-

717679

-

-

?

additional information

?

-

Homo sapiens

-

the kringle domains 1 and 2 of tissue-type plasminogen activator, TK1–2, interact with endothelial vein cells via integrin and the kringle domain DGDA amino acid sequence, overview

717182

-

-

?

additional information

?

-

Homo sapiens

-

both plasminogen activation and fibrin lysis by tPA. Lysis of fibrin clots performed using confocal microscopy in conjunction with tPA-GFP added to clots formed of fibrin100 and fibrin5. The front of the fibrin clot moves faster in fibrin5 than in fibrin100. There are also morphologic differences that develop in the 2 fibrins as indicated by the pattern of fluorescence, which reflects tPA distribution. Specifically, it can be seen that a granular pattern develops in the fibrin5 lysis series in contrast to the homogeneous fluorescence pattern that is maintained in the fibrin100 series. Binding analysis of tPA to aggregates formed in fibrin5, using orange fluorescent fibrinogen converted to fluorescent fibrin100 and fibrin5

717425

-

-

?

additional information

?

-

Homo sapiens

P00750

the enzyme converts plasminogen into plasmin

753083

-

-

?

additional information

?

-

Homo sapiens

-

the enzyme converts plasminogen into plasmin

753083

-

-

?

additional information

?

-

Mus musculus

-

ZIP4 physically interacts with tPA, immunohistochemic analysis, overview

718020

-

-

?

additional information

?

-

Mus musculus C57BL/6

-

ZIP4 physically interacts with tPA, immunohistochemic analysis, overview

718020

-

-

?