3.4.21.68: t-Plasminogen activator

This is an abbreviated version!
For detailed information about t-Plasminogen activator, go to the full flat file.

Reaction

Specific cleavage of Arg-/-Val bond in plasminogen to form plasmin =

Synonyms

Alteplase, BAT-PA, desmoteplase, DSPA beta, DSPA gamma, EC 3.4.21.31, EC 3.4.99.26, human tissue-type plasminogen activator, IV t-PA, IV tissue plasminogen activator, More, plasminogen activator, Plasminogen activator, tissue-type, PLAT, r-tPA, recombinant tissue plasminogen activator, Reteplase, rt-PA, rtPA, sc-tPA, sctPA, single chain enzyme tPA, t-PA, t-PA protein, t-plasminogen activator, tc-tPA, tctPA, Tissue plasminogen activator, tissue type plasminogen activator, tissue-plasminogen activator, Tissue-type plasminogen activator, tissue-type plasmiongen activator, tPA, two chain tPA

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.68 t-Plasminogen activator

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Results	in table
36	Activating Compound
1259	AA Sequence
47	Application
1	CAS Registry Number
41	Cloned(Commentary)
1	Cofactor
5	Crystallization (Commentary)
75764	Disease/ Diagnostics
11	Expression
59	General Information
27	IC50 Value
118	Inhibitors
5	kcat/KM [mM/s]
6	Ki Value [mM]
210	KM Value [mM]
15	Localization
32	Molecular Weight [Da]
48	Natural Substrates/ Products (Substrates)
965	Organism
15	PDB ID
11	pH Optimum
1	pH Range
2	pH Stability
7	Posttranslational Modification
49	Protein Variants
20	Purification (Commentary)
1	Reaction
3	Reaction Type
155	Reference
164	Source Tissue
9	Specific Activity [micromol/min/mg]
2	Storage Stability
224	Substrates and Products (Substrate)
19	Subunits
261	Synonyms
14	Temperature Optimum [°C]
4	Temperature Stability [°C]
185	Turnover Number [1/s]

KI Value

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KI Value on EC 3.4.21.68 - t-Plasminogen activator

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Ki VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.000035

2,7-bis-(4-amidinobenzylidene)-cycloheptanone-(1)dihydrochloride

2 entries

0.0318

6-carbamimidoyl-N-phenyl-2-naphthamide

Homo sapiens

P00750

pH 7.4-8.3, 37°C

731467

0.0049

ethyl 4-(3-carbamimidoyl-N-[[2,4,6-tri(propan-2-yl)phenyl]sulfonyl]-L-phenylalanyl)piperazine-1-carboxylate

Homo sapiens

P00750

pH 7.4-8.3, 37°C

731467

0.0584

N-(4-(aminomethyl)phenyl)-6-carbamimidoyl-2-naphthamide trifluoro acetate

Homo sapiens

P00750

pH 7.4-8.3, 37°C

731467

0.0074

N-(benzylsulfonyl)-D-seryl-N-(4-carbamimidoylbenzyl)-L-alaninamide

Homo sapiens

P00750

pH 7.4-8.3, 37°C

731467

0.000035

2,7-bis-(4-amidinobenzylidene)-cycloheptanone-(1)dihydrochloride

Mus musculus

P11214

-

664749

0.000035

2,7-bis-(4-amidinobenzylidene)-cycloheptanone-(1)dihydrochloride

Rattus norvegicus

P19637

-

664749