3.4.21.68: t-Plasminogen activator

This is an abbreviated version!
For detailed information about t-Plasminogen activator, go to the full flat file.

Reaction

Specific cleavage of Arg-/-Val bond in plasminogen to form plasmin =

Synonyms

Alteplase, BAT-PA, desmoteplase, DSPA beta, DSPA gamma, EC 3.4.21.31, EC 3.4.99.26, human tissue-type plasminogen activator, IV t-PA, IV tissue plasminogen activator, More, plasminogen activator, Plasminogen activator, tissue-type, PLAT, r-tPA, recombinant tissue plasminogen activator, Reteplase, rt-PA, rtPA, sc-tPA, sctPA, single chain enzyme tPA, t-PA, t-PA protein, t-plasminogen activator, tc-tPA, tctPA, Tissue plasminogen activator, tissue type plasminogen activator, tissue-plasminogen activator, Tissue-type plasminogen activator, tissue-type plasmiongen activator, tPA, two chain tPA

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.68 t-Plasminogen activator

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Results	in table
36	Activating Compound
1259	AA Sequence
47	Application
1	CAS Registry Number
41	Cloned(Commentary)
1	Cofactor
5	Crystallization (Commentary)
75764	Disease/ Diagnostics
11	Expression
59	General Information
27	IC50 Value
118	Inhibitors
5	kcat/KM [mM/s]
6	Ki Value [mM]
210	KM Value [mM]
15	Localization
32	Molecular Weight [Da]
48	Natural Substrates/ Products (Substrates)
965	Organism
15	PDB ID
11	pH Optimum
1	pH Range
2	pH Stability
7	Posttranslational Modification
49	Protein Variants
20	Purification (Commentary)
1	Reaction
3	Reaction Type
155	Reference
164	Source Tissue
9	Specific Activity [micromol/min/mg]
2	Storage Stability
224	Substrates and Products (Substrate)
19	Subunits
261	Synonyms
14	Temperature Optimum [°C]
4	Temperature Stability [°C]
185	Turnover Number [1/s]

Posttranslational Modification

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Posttranslational Modification on EC 3.4.21.68 - t-Plasminogen activator

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POSTTRANSLATIONAL MODIFICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

glycoprotein

5 entries

proteolytic modification

Homo sapiens

P00750

Pichia pastoris Kex2p protease can cleave the secreted tPA-serine protease domain

754119

glycoprotein

Homo sapiens

-

-

29593, 649779

glycoprotein

Homo sapiens

-

glycosylated at three of the four potential glycosylation sites

29578

glycoprotein

Homo sapiens

-

3 major N-linked sites and one O-linked site are identified: site-specific N-glycosylation at typical Asn-Xaa-Ser/Thr motifs are due to asparagine glycosylation at sequence positions 117, 184, and 448, glycosylation at each individual site is heterogeneous: Asn117 glycosylation site contains high-mannose structures, whereas Asn184 and Asn448 are modified by complex/hybrid oligosaccharide structures. 2 further glycosylation site are identified in low abundance: the major oligosaccharides modifying Asn142 are biantennary monosialo and asialo hybrid and mannose-5-type structures, the other glycosylation site is at Thr61, elongation of O-fucose to bi-, tri-, and tetrasaccharides at Thr61 is identified at levels of about 0.7%

707127

glycoprotein

Mammalia

-

the multimolecular interaction of tRNA with plasminogen and fibrin is modulated by glycosylation

29584

glycoprotein

Mammalia

-

the rate of activation of plasminogen is glycosylation dependent

29584