Reference on EC 2.3.1.26 - sterol O-acyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sgoutas, D.S.
Effect of geometry and position of ethylenic bond upon acyl coenzyme A: cholesterol-O-acyltransferase
Biochemistry
9
1826-1833
1970
Rattus norvegicus
Taketani, S.; Nishino, T.; Katsuki, H.
Characterization of sterol-ester synthetase in Saccharomyces cerevisiae
Biochim. Biophys. Acta
575
148-155
1979
Saccharomyces cerevisiae
Billheimer, J.T.
Cholesterol acyltransferase
Methods Enzymol.
111
286-293
1985
Saccharomyces cerevisiae, Helicoverpa zea, Homo sapiens, Rattus norvegicus, Sus scrofa
Chang, T.Y.; Doolittle, G.M.
Acyl coenzyme A:cholesterol O-acyltransferase
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
16
523-539
1983
Cavia porcellus, Cricetulus griseus, Columba sp., Oryctolagus cuniculus, Homo sapiens, Platyrrhini, Mus musculus, Rattus norvegicus, Sus scrofa
-
Tabas, I.; Chen, L.L.; Clader, J.W.; McPhail, A.T.; Burnett, D.A.; Bartner, P.; Das, P.R.; Pramanik, B.N.; Puar, M.S.; Feinmark, S.J.; Zipkin, R.E.; Boykow, G.; Vita, G.; Tall, A.R.
Rabbit and human liver contain a novel pentacyclic triterpene ester with acyl-CoA:cholesterol acyltransferase inhibitory activity
J. Biol. Chem.
265
8042-8051
1990
Oryctolagus cuniculus, Rattus norvegicus
Simpson, E.R.; Burkhart, M.F.
Acyl CoA:cholesterol acyl transferase activity in human placental microsomes: inhibition by progesterone
Arch. Biochem. Biophys.
200
79-85
1980
Homo sapiens
Miller, L.R.; Needleman, D.H.; Brabson, J.S.; Wang, K.S.; Schroepfer, G.J.
5alpha-Cholest-8(14)-en-3beta-ol-15-one. A competitive substrate for acyl coenzyme A: cholesterol acyl transferase
Biochem. Biophys. Res. Commun.
148
934-940
1987
Rattus norvegicus, Rattus norvegicus male Sprague-Dawley
Tavani, D.M.; Nes, W.R.; Billheimer, J.T.
The sterol substrate specificity of acyl CoA:cholesterol acyltransferase from rat liver
J. Lipid Res.
23
774-781
1982
Rattus norvegicus, Rattus norvegicus male Sprague-Dawley
Doolittle, G.M.; Chang, T.Y.
Solubilization, partial purification, and reconstitution in phosphatidylcholine-cholesterol liposomes of acyl-CoA:cholesterol acyltransferase
Biochemistry
21
674-679
1982
Sus scrofa
Kinnunen, P.M.; DeMichele, A.; Lange, L.G.
Chemical modification of acyl-CoA:cholesterol O-acyltransferase. 1. Identification of acyl-CoA:cholesterol O-acyltransferase subtypes by differential diethyl pyrocarbonate sensitivity
Biochemistry
27
7344-7350
1988
Oryctolagus cuniculus
Helgerud, P.; Saarem, K.; Norum, K.R.
Acyl-CoA:cholesterol acyltransferase in human small intestine: its activity and some properties of the enzymic reaction
J. Lipid Res.
22
271-277
1981
Homo sapiens
Erickson, S.K.; Shrewsbury, M.A.; Brooks, C.; Meyer, D.J.
Rat liver acyl-coenzyme A:cholesterol acyltransferase: its regulation in vivo and some of its properties in vitro
J. Lipid Res.
21
930-941
1980
Rattus norvegicus, Rattus norvegicus male Sprague-Dawley
Balasubramaniam, S.; Venkatesan, S.; Mitropoulos, K.A.; Peters, T.J.
The submicrosomal localization of acyl-coenzyme A-cholesterol acyltransferase and its substrate, and of cholesteryl esters in rat liver
Biochem. J.
174
863-872
1978
Rattus norvegicus, Rattus norvegicus male Wistar
Marco, C.; Morillas, L.G.; Garcia-Peregrin, E.
Acyl coenzyme A:cholesterol acyltransferase in neonatal chick brain
Biochim. Biophys. Acta
875
599-604
1986
Gallus gallus
Brecher, P.; Chan, C.T.
Properties of acyl-CoA:cholesterol O-acyltransferase in aortic microsomes from atherosclerotic rabbits
Biochim. Biophys. Acta
617
458-471
1980
Oryctolagus cuniculus, Rattus norvegicus
Suckling, K.E.; Tocher, D.R.; Smellie, C.G.; Boyd, G.S.
In vitro regulation of bovine adrenal cortical acyl-CoA: cholesterol acyltransferase and comparison with the rat liver enzyme
Biochim. Biophys. Acta
753
422-429
1983
Bos taurus, Rattus norvegicus
Doolittle, G.M.; Chang, T.Y.
Acyl-CoA:cholesterol acyltransferase in Chinese hamster ovary cells. Enzyme activity determined after reconstitution in phospholipid/cholesterol liposomes
Biochim. Biophys. Acta
713
529-537
1982
Cricetulus griseus
Kaduce, T.L.; Schmidt, R.W.; Spector, A.A.
Acylcoenzyme A:cholesterol acyltransferase activity: solubilization and reconstitution in liposomes
Biochem. Biophys. Res. Commun.
81
462-468
1978
Mus musculus
Einarsson, K.; Benthin, L.; Ewerth, S.; Heller, G.; Staehlberg, D.; Angelin, B.
Studies on acyl-coenzyme A:cholesterol acyltransferase activity in human liver microsomes
J. Lipid Res.
30
739-746
1989
Homo sapiens
Cadigan, K.M.; Chang, T.Y.
A simple method for reconstitution of CHO cell and human fibroblast acyl coenzyme A:cholesterol acyltransferase activity into liposomes
J. Lipid Res.
29
1683-1692
1988
Cricetulus griseus, Homo sapiens
Kwok, C.T.; Smith, J.L.; Pillay, S.P.; Hardie, I.R.
Inactivation of acyl-CoA:cholesterol acyltransferase by magnesium-ATP in rat liver microsomes
Biochem. Int.
8
271-282
1984
Rattus norvegicus
Chang, C.C.Y.; Huh, J.Y.; Cadigan, K.M.; Chang, T.Y.
Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells
J. Biol. Chem.
268
20747-20755
1993
Homo sapiens (P35610), Homo sapiens
Becker, A.; Bttcher, A.; Lackner, K.J.; Fehringer, P.; Notka, F.; Aslanidis, C.; Schmitz, G.
Purification, cloning, and expression of a human enzyme with acyl coenzyme A:cholesterol acyltransferase activity, which is identical to liver carboxylesterase
Arterioscler. Thromb.
14
1346-1355
1994
Homo sapiens, Sus scrofa
Cheng, D.; Chang C.C.Y.; Qu, X.; Chang, T.
Activation of acyl-coenzyme A:cholesterol acyltransferase by cholesterol or by oxysterol in a cell-free system
J. Biol. Chem.
270
685-695
1995
Homo sapiens
Uelmen, P.J.; Oka, K.; Sullivan, M.; Chang, C.C.Y.; Chang, T.Y.; Chan, L.
Tissue-specific expression and cholesterol regulation of acylcoenzyme A:cholesterol acyltransferase (ACAT) in mice
J. Biol. Chem.
270
26192-26201
1995
Mus musculus (Q61263), Mus musculus
Green, S.; Steinberg, D.; Quehenberger, O.
Cloning and expression in Xenopus Oocytes of a mouse homologue of the human acylcoenzyme A:cholesterol acyltransferase and its potential role in metabolism of oxidized LDL
Biochem. Biophys. Res. Commun.
218
924-929
1996
Mus musculus
Yu, C.; Kennedy, N.J.; Chang, C.C.Y.; Rothblatt, J.A.
Molecular cloning and characterization of two isoforms of Saccharomyces cerevisiae acyl-CoA:sterol acyltransferase
J. Biol. Chem.
271
24157-24163
1996
Homo sapiens, Saccharomyces cerevisiae (P53629), Saccharomyces cerevisiae
Bhuvaneswaran, C.; Synouri-Vrettakou, S.; Mitropoulos, K.A.
Activation of acyl-CoA:cholesterol acyltransferase in rat liver microsomes by 25-hydroxycholesterol
Biochem. Pharmacol.
53
27-34
1997
Rattus norvegicus, Rattus norvegicus male Wistar
Kerkhoff, C.; Beuck, M.; Threige-Rasmussen, J.; Spener, F.; Knudsen, J.; Schmitz, G.
Acyl-CoA binding protein (ACBP) regulates acyl-CoA:cholesterol acyltransferase (ACAT) in human mononuclear phagocytes
Biochim. Biophys. Acta
1346
163-172
1997
Homo sapiens
Chang, T.Y.; Chang, C.C.Y.; Cheng, D.
Acyl-coenzyme A:cholesterol acyltransferase
Annu. Rev. Biochem.
66
613-638
1997
Cavia porcellus, Cricetulus griseus, Columba sp., Oryctolagus cuniculus, Homo sapiens, Platyrrhini, Mus musculus, Rattus norvegicus, Sus scrofa
Matsuda, H.; Hakamata, H.; Kawasaki, T.; Sakashita, N.; Miyazaki, A.; Takahashi, K.; Shichiri, M.; Horiuchi, S.
Molecular cloning, functional expression and tissue distribution of rat acyl-coenzyme A:cholesterol acyltransferase
Biochim. Biophys. Acta
1391
193-203
1998
Rattus norvegicus
Khelef, N.; Buton, X.; Beatini, N.; Wang, H.; Meiner, V.; Chang, T.; Farese, R.V.; Maxfield, F.R.; Tabas, I.
Immunolocalization of acyl-coenzyme A:cholesterol O-acyltransferase in macrophages
J. Biol. Chem.
273
11218-11224
1998
Mus musculus
Anderson, R.A.; Joyce, C.; Davis, M.; Reagan, J.W.; Clark, M.; Shelness, G.S.; Rudel, L.L.
Identification of a form of acyl-CoA:cholesterol acyltransferase specific to liver and intestine in nonhuman primates
J. Biol. Chem.
273
26747-26754
1998
Platyrrhini, Rattus norvegicus
Vajda, K.; Ferguson, M.W.J.; Shand, J.H.; Noble, R.C.; Speake, B.K.
Activities of acyl-CoA:cholesterol acyltransferase and cholesteryl ester hydrolase in the yolk sac membrane of the alligator (Alligator mississippiensis) embryo
Comp. Biochem. Physiol. B
122
301-307
1999
Alligator mississippiensis
-
Lee, R.G.; Willingham, M.C.; Davis, M.A.; Skinner, K.A.; Rudel, L.L.
Differential expression of ACAT1 and ACAT2 among cells within liver, intestine, kidney, and adrenal of nonhuman primates
J. Lipid Res.
41
1991-2001
2000
Platyrrhini
Lu, X.; Lin, S.; Chang, C.C.Y.; Chang, T.
Mutant acyl-coenzyme A: cholesterol acyltransferase 1 devoid of cysteine residues remains catalytically active
J. Biol. Chem.
277
711-718
2002
Homo sapiens
Yu, C.; Zhang, Y.; Lu, X.; Chen, J.; Chang, C.C.Y.; Chang, T.
Role of the N-terminal hydrophilic domain of acyl-coenzyme A:cholesterol acyltransferase 1 on the enzymes's quaternary structure and catalytic efficiency
Biochemistry
41
3762-3769
2002
Homo sapiens
Kim, D.H.; Han, K.M.; Chung, I.S.; Kim, D.K.; Kim, S.H.; Kwon, B.M.; Jeong, T.S.; Park, M.H.; Ahn, E.M.; Baek, N.I.
Triterpenoids from the flower of Campsis grandiflora K. Schum. as human acyl-CoA: cholesterol acyltransferase inhibitors
Arch. Pharm. Res.
28
550-556
2005
Homo sapiens
Kim, K.Y.; Shin, Y.K.; Park, J.C.; Kim, J.H.; Yang, H.; Han, D.M.; Paik, Y.K.
Molecular cloning and biochemical characterization of Candida albicans acyl-CoA:sterol acyltransferase, a potential target of antifungal agents
Biochem. Biophys. Res. Commun.
319
911-919
2004
Candida albicans
Hori, M.; Miyazaki, A.; Tamagawa, H.; Satoh, M.; Furukawa, K.; Hakamata, H.; Sasaki, Y.; Horiuchi, S.
Up-regulation of acyl-coenzyme A:cholesterol acyltransferase-1 by transforming growth factor-beta1 during differentiation of human monocytes into macrophages
Biochem. Biophys. Res. Commun.
320
501-505
2004
Homo sapiens
Liu, J.; Chang, C.C.; Westover, E.J.; Covey, D.F.; Chang, T.Y.
Investigating the allosterism of acyl coenzyme A: cholesterol acyltransferase (ACAT) by using various sterols: in vitro and intact cell studies
Biochem. J.
391
389-397
2005
Homo sapiens
Zhang, Y.; Yu, C.; Liu, J.; Spencer, T.A.; Chang, C.C.; Chang, T.Y.
Cholesterol is superior to 7-ketocholesterol or 7 alpha-hydroxycholesterol as an allosteric activator for acyl-coenzyme A:cholesterol acyltransferase 1
J. Biol. Chem.
278
11642-11647
2003
Homo sapiens
Temel, R.E.; Gebre, A.K.; Parks, J.S.; Rudel, L.L.
Compared with acyl-CoA:cholesterol O-acyltransferase (ACAT) 1 and lecithin:cholesterol acyltransferase, ACAT2 displays the greatest capacity to differentiate cholesterol from sitosterol
J. Biol. Chem.
278
47594-47601
2003
Chlorocebus aethiops
Liang, J.J.; Oelkers, P.; Guo, C.; Chu, P.C.; Dixon, J.L.; Ginsberg, H.N.; Sturley, S.L.
Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells
J. Biol. Chem.
279
44938-44944
2004
Homo sapiens
Lee, J.Y.; Carr, T.P.
Dietary fatty acids regulate acyl-CoA:cholesterol acyltransferase and cytosolic cholesteryl ester hydrolase in hamsters
J. Nutr.
134
3239-3244
2004
Mesocricetus auratus
Kushwaha, R.S.; Vandeberg, J.F.; Rodriguez, R.; Vandeberg, J.L.
Cholesterol absorption and hepatic acyl-coenzyme A:cholesterol acyltransferase activity play major roles in lipemic response to dietary cholesterol and fat in laboratory opossums
Metabolism
53
817-822
2004
Monodelphis domestica
Lin, S.; Lu, X.; Chang, C.C.; Chang, T.Y.
Human acyl-coenzyme A:cholesterol acyltransferase expressed in chinese hamster ovary cells: membrane topology and active site location
Mol. Biol. Cell
14
2447-2460
2003
Homo sapiens
Gelain, A.; Barlocco, D.; Kwon, B.M.; Jeong, T.S.; Im, K.R.; Legnani, L.; Toma, L.
3-Heptylamino-5-phenylpyridazine derivatives as analogues of acyl-CoA: cholesterol acyltransferase inhibitors containing the N-heptyl-N-arylureidic moiety
Arch. Pharm.
339
645-651
2006
Rattus norvegicus
Im, K.R.; Jeong, T.S.; Kwon, B.M.; Baek, N.I.; Kim, S.H.; Kim, D.K.
Acyl-CoA: cholesterol acyltransferase inhibitors from Ilex macropoda
Arch. Pharm. Res.
29
191-194
2006
Homo sapiens (O75908), Homo sapiens (P35610)
Bell, T.A.; Brown, J.M.; Graham, M.J.; Lemonidis, K.M.; Crooke, R.M.; Rudel, L.L.
Liver-specific inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 with antisense oligonucleotides limits atherosclerosis development in apolipoprotein B100-only low-density lipoprotein receptor-/- mice
Arterioscler. Thromb. Vasc. Biol.
26
1814-1820
2006
Mus musculus (O88908)
Suguro, T.; Watanabe, T.; Kanome, T.; Kodate, S.; Hirano, T.; Miyazaki, A.; Adachi, M.
Serotonin acts as an up-regulator of acyl-coenzyme A:cholesterol acyltransferase-1 in human monocyte-macrophages
Atherosclerosis
186
275-281
2006
Homo sapiens (P35610), Homo sapiens
Song, B.L.; Wang, C.H.; Yao, X.M.; Yang, L.; Zhang, W.J.; Wang, Z.Z.; Zhao, X.N.; Yang, J.B.; Qi, W.; Yang, X.Y.; Inoue, K.; Lin, Z.X.; Zhang, H.Z.; Kodama, T.; Chang, C.C.; Liu, Y.K.; Chang, T.Y.; Li, B.L.
Human acyl-CoA:cholesterol acyltransferase 2 gene expression in intestinal Caco-2 cells and in hepatocellular carcinoma
Biochem. J.
394
617-626
2006
Homo sapiens (O75908), Homo sapiens
Guo, Z.Y.; Chang, C.C.; Lu, X.; Chen, J.; Li, B.L.; Chang, T.Y.
The disulfide linkage and the free sulfhydryl accessibility of acyl-coenzyme A:cholesterol acyltransferase 1 as studied by using mPEG5000-maleimide
Biochemistry
44
6537-6546
2005
Homo sapiens (P35610), Homo sapiens
Park, Y.D.; Lee, W.S.; An, S.; Jeong, T.S.
Human acyl-CoA: cholesterol acyltransferase inhibitory activities of aliphatic acid amides from Zanthoxylum piperitum DC
Biol. Pharm. Bull.
30
205-207
2007
Homo sapiens, Homo sapiens (O75908), Homo sapiens (P35610)
Jeong, T.; Kim, K.S.; Yu, H.; Kim, M.J.; Cho, K.; Choi, Y.; Kim, H.; Park, H.; Lee, W.S.
Saucerneol B derivatives as human acyl-CoA: cholesterol acyltransferase inhibitors
Bioorg. Med. Chem. Lett.
15
385-388
2005
Homo sapiens (O75908), Homo sapiens (P35610), Homo sapiens
Ban, H.; Muraoka, M.; Ioriya, K.; Ohashi, N.
Synthesis and biological activity of novel 4-phenyl-1,8-naphthyridin-2(1H)-on-3-yl ureas: potent acyl-CoA:cholesterol acyltransferase inhibitor with improved aqueous solubility
Bioorg. Med. Chem. Lett.
16
44-48
2006
Rattus norvegicus
Benfatti, F.; Cardillo, G.; Gentilucci, L.; Tolomelli, A.
Synthesis and biological evaluation of unprecedented classes of spiro-beta-lactams and azido-beta-lactams as acyl-CoA:cholesterol acyltransferase inhibitors
Bioorg. Med. Chem. Lett.
17
1946-1950
2007
Oryctolagus cuniculus, Mammalia
Kharbanda, R.K.; Wallace, S.; Walton, B.; Donald, A.; Cross, J.M.; Deanfield, J.
Systemic Acyl-CoA:cholesterol acyltransferase inhibition reduces inflammation and improves vascular function in hypercholesterolemia
Circulation
111
804-807
2005
Homo sapiens
An, S.; Cho, K.H.; Lee, W.S.; Lee, J.O.; Paik, Y.K.; Jeong, T.S.
A critical role for the histidine residues in the catalytic function of acyl-CoA:cholesterol acyltransferase catalysis: evidence for catalytic difference between ACAT1 and ACAT2
FEBS Lett.
580
2741-2749
2006
Homo sapiens (O75908), Homo sapiens (P35610)
Ohshiro, T.; Rudel, L.L.; Omura, S.; Tomoda, H.
Selectivity of microbial acyl-CoA: cholesterol acyltransferase inhibitors toward isozymes
J. Antibiot.
60
43-51
2007
Chlorocebus aethiops, Cricetulus griseus, Mus musculus, Rattus norvegicus
Zamorano-Leon, J.J.; Fernandez-Sanchez, R.; Lopez Farre, A.J.; Lapuente-Tiana, L.; Alonso-Orgaz, S.; Sacristan, D.; Junquera, D.; Delhon, A.; Conesa, A.; Mateos-Caceres, P.J.; Macaya, C.
Direct effect of F12511, a systemic inhibitor of acyl-CoA cholesterol acyltransferase on bovine aortic endothelial cells
J. Cardiovasc. Pharmacol.
48
128-134
2006
Bos taurus
Freeman, N.E.; Rusinol, A.E.; Linton, M.; Hachey, D.L.; Fazio, S.; Sinensky, M.S.; Thewke, D.
Acyl-coenzyme A:cholesterol acyltransferase promotes oxidized LDL/oxysterol-induced apoptosis in macrophages
J. Lipid Res.
46
1933-1943
2005
Mus musculus
Gelain, A.; Bettinelli, I.; Barlocco, D.; Kwon, B.M.; Jeong, T.S.; Cho, K.H.; Toma, L.
Mono- or diphenylpyridazines connected to N-(2,4-difluorophenyl)-N-heptylurea as acyl-CoA:cholesterol acyltransferase inhibitors
J. Med. Chem.
48
7708-7713
2005
Rattus norvegicus
Bose, C.; Bhuvaneswaran, C.; Udupa, K.B.
Age-related alteration in hepatic acyl-CoA: cholesterol acyltransferase and its relation to LDL receptor and MAPK
Mech. Ageing Dev.
126
740-751
2005
Mus musculus, Mus musculus C57/BL6
Song, M.C.; Yang, H.J.; Jeong, T.S.; Kim, K.T.; Baek, N.I.
Heterocyclic compounds from Chrysanthemum coronarium L. and their inhibitory activity on hACAT-1, hACAT-2, and LDL-oxidation
Arch. Pharm. Res.
31
573-578
2008
Homo sapiens
Fujiwara, Y.; Kiyota, N.; Hori, M.; Matsushita, S.; Iijima, Y.; Aoki, K.; Shibata, D.; Takeya, M.; Ikeda, T.; Nohara, T.; Nagai, R.
Esculeogenin A, a new tomato sapogenol, ameliorates hyperlipidemia and atherosclerosis in ApoE-deficient mice by inhibiting ACAT
Arterioscler. Thromb. Vasc. Biol.
27
2400-2406
2007
Homo sapiens, Mus musculus
Parini, P.; Gustafsson, U.; Davis, M.A.; Larsson, L.; Einarsson, C.; Wilson, M.; Rudling, M.; Tomoda, H.; Omura, S.; Sahlin, S.; Angelin, B.; Rudel, L.L.; Eriksson, M.
Cholesterol synthesis inhibition elicits an integrated molecular response in human livers including decreased ACAT2
Arterioscler. Thromb. Vasc. Biol.
28
1200-1206
2008
Homo sapiens
Terasaka, N.; Miyazaki, A.; Kasanuki, N.; Ito, K.; Ubukata, N.; Koieyama, T.; Kitayama, K.; Tanimoto, T.; Maeda, N.; Inaba, T.
ACAT inhibitor pactimibe sulfate (CS-505) reduces and stabilizes atherosclerotic lesions by cholesterol-lowering and direct effects in apolipoprotein E-deficient mice
Atherosclerosis
190
239-247
2007
Homo sapiens, Mus musculus, Rattus norvegicus
Ikenoya, M.; Yoshinaka, Y.; Kobayashi, H.; Kawamine, K.; Shibuya, K.; Sato, F.; Sawanobori, K.; Watanabe, T.; Miyazaki, A.
A selective ACAT-1 inhibitor, K-604, suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels
Atherosclerosis
191
290-297
2007
Homo sapiens
Pramfalk, C.; Angelin, B.; Eriksson, M.; Parini, P.
Cholesterol regulates ACAT2 gene expression and enzyme activity in human hepatoma cells
Biochem. Biophys. Res. Commun.
364
402-409
2007
Homo sapiens
An, S.; Park, Y.; Paik, Y.; Jeong, T.; Lee, W.S.
Human ACAT inhibitory effects of shikonin derivatives from Lithospermum erythrorhizon
Bioorg. Med. Chem. Lett.
17
1112-1116
2007
Homo sapiens
Kitamura, A.; Imai, S.; Yabuki, M.; Komuro, S.
The new acyl-CoA cholesterol acyltransferase inhibitor SMP-797 does not interact with statins via OATP1B1 in human cryopreserved hepatocytes and oocytes expressing systems
Biopharm. Drug Dispos.
28
517-525
2007
Homo sapiens
Lee, J.H.; Ryu, Y.B.; Lee, B.W.; Kim, J.H.; Lee, W.S.; Park, Y.; Jeong, T.; Park, K.H.
Human acyl-CoA:cholesterol acyltransferase (hACAT) inhibitory activities of triterpenoids from roots of Glycine max (L.) merr
Bull. Korean Chem. Soc.
29
615-619
2008
Homo sapiens
-
Hans, C.P.; Zerfaoui, M.; Naura, A.S.; Catling, A.; Boulares, A.H.
Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability
Cardiovasc. Res.
78
429-439
2008
Mus musculus
Adameova, A.; Ravingerova, T.; Svec, P.; Faberova, V.; Kuzelova, M.
The myocardial infarct size-limiting and antiarrhythmic effects of acyl-CoA:cholesterol acyltransferase inhibitor VULM 1457 protect the hearts of diabetic-hypercholesterolaemic rats against ischaemia/reperfusion injury both in vitro and in vivo
Eur. J. Pharmacol.
576
114-121
2007
Rattus norvegicus
An, S.; Jang, Y.S.; Park, J.S.; Kwon, B.M.; Paik, Y.K.; Jeong, T.S.
Inhibition of acyl-coenzyme A:cholesterol acyltransferase stimulates cholesterol efflux from macrophages and stimulates farnesoid X receptor in hepatocytes
Exp. Mol. Med.
40
407-417
2008
Homo sapiens
Vojtassakova, E.; Synekova, M.; Tazka, D.; Matyas, S.; Hozova, R.; Sadlonova, I.; Svec, P.
Effect of VULM 1457, an ACAT inhibitor, on serum lipid levels and on real time red blood cell flow in diabetic and non-diabetic hamsters fed high cholesterol-lipid diet
Gen. Physiol. Biophys.
26
254-259
2007
Mesocricetus auratus
Das, A.; Davis, M.A.; Tomoda, H.; Omura, S.; Rudel, L.L.
Identification of the interaction site within acyl-CoA:cholesterol acyltransferase 2 for the isoform-specific inhibitor pyripyropene A
J. Biol. Chem.
283
10453-10460
2008
Chlorocebus aethiops
Choi, J.H.; Rho, M.; Lee, S.W.; Kwon, O.E.; Park, H.R.; Kang, J.Y.; Lee, S.H.; Lee, H.S.; Bae, K.H.; Kim, Y.K.
Glabrol, an acyl-coenzyme A: cholesterol acyltransferase inhibitor from licorice roots
J. Ethnopharmacol.
110
563-566
2007
Homo sapiens, Rattus norvegicus
He, P.; Cheng, B.; Wang, Y.; Wang, H.
Effect of tumor necrosis factor-alpha on acyl coenzyme A: cholesteryl acyltransferase activity and ACAT1 gene expression in THP-1 macrophages
J. Huazhong Univ. Sci. Technol. Med. Sci.
27
170-172
2007
Homo sapiens
Das, A.; Davis, M.A.; Rudel, L.L.
Identification of putative active site residues of ACAT enzymes
J. Lipid Res.
49
1770-1781
2008
Chlorocebus aethiops, Chlorocebus sabaeus
Takahashi, K.; Kasai, M.; Ohta, M.; Shoji, Y.; Kunishiro, K.; Kanda, M.; Kurahashi, K.; Shirahase, H.
Novel indoline-based acyl-CoA:cholesterol acyltransferase inhibitor with antiperoxidative activity: improvement of physicochemical properties and biological activities by introduction of carboxylic acid
J. Med. Chem.
51
4823-4833
2008
Oryctolagus cuniculus
Miike, T.; Shirahase, H.; Jino, H.; Kunishiro, K.; Kanda, M.; Kurahashi, K.
Effects of an anti-oxidative ACAT inhibitor on apoptosis/necrosis and cholesterol accumulation under oxidative stress in THP-1 cell-derived foam cells
Life Sci.
82
79-84
2008
Homo sapiens
Rho, M.; Lee, S.W.; Park, H.R.; Choi, J.; Kang, J.Y.; Kim, K.; Lee, H.S.; Kim, Y.K.
ACAT inhibition of alkamides identified in the fruits of Piper nigrum
Phytochemistry
68
899-903
2007
Homo sapiens, Rattus norvegicus
Lam, C.; Chen, J.; Cao, Y.; Yang, L.; Wong, Y.; Yeung, S.; Yao, X.; Huang, Y.; Chen, Z.
Conjugated and non-conjugated octadecaenoic acids affect differently intestinal acyl coenzyme A: Cholesterol acyltransferase activity
Atherosclerosis
198
85-93
2008
Mesocricetus auratus
Thewke, D.; Freeman-Anderson, N.; Pickle, T.; Netherland, C.; Chilton, C.
AM-251 and SR144528 are acyl CoA:cholesterol acyltransferase inhibitors
Biochem. Biophys. Res. Commun.
381
181-186
2009
Mus musculus
Asano, S.; Ban, H.; Kino, K.; Ioriya, K.; Muraoka, M.
Novel 1,4-diarylpiperidine-4-methylureas as anti-hyperlipidemic agents: dual effectors on acyl-CoA:cholesterol O-acyltransferase and low-density lipoprotein receptor expression
Bioorg. Med. Chem. Lett.
19
1062-1065
2009
Rattus norvegicus
Asano, S.; Ban, H.; Kino, K.; Ioriya, K.; Muraoka, M.
Synthesis and structure-activity relationships of N-(4-amino-2,6-diisopropylphenyl)-N-(1,4-diarylpiperidine-4-yl)methylureas as anti-hyperlipidemic agents
Bioorg. Med. Chem.
17
4636-4646
2009
Rattus norvegicus
Jin, Y.; Rho, M.; Gajulapati, K.; Jung, H.; Boovanahalli, S.; Lee, J.; Song, G.; Choi, J.; Kim, Y.; Lee, K.; Choi, Y.
Synthesis of a novel series of imidazo[1,2-alpha]pyridines as acyl-CoA: Cholesterol acyltransferase (ACAT) inhibitors
Bull. Korean Chem. Soc.
30
1297-1304
2009
Homo sapiens
-
Xin, C.; Yan-Fu, W.; Ping, H.; Jing, G.; Jing-Jing, W.; Chun-Li, M.; Wei, L.; Bei, C.
Study of the insulin signaling pathways in the regulation of ACAT1 expression in cultured macrophages
Cell Biol. Int.
33
602-606
2009
Homo sapiens
Ohshiro, T.; Matsuda, D.; Nagai, K.; Doi, T.; Sunazuka, T.; Takahashi, T.; Rudel, L.L.; Omura, S.; Tomoda, H.
The selectivity of beauveriolide derivatives in inhibition toward the two isozymes of acyl-CoA: cholesterol acyltransferase
Chem. Pharm. Bull.
57
377-381
2009
Chlorocebus aethiops (O77759), Chlorocebus aethiops (O77760)
Kanome, T.; Watanabe, T.; Nishio, K.; Takahashi, K.; Hongo, S.; Miyazaki, A.
Angiotensin II upregulates acyl-CoA:cholesterol acyltransferase-1 via the angiotensin II Type 1 receptor in human monocyte-macrophages
Hypertens. Res.
31
1801-1810
2008
Homo sapiens
Ohshiro, T.; Ohte, S.; Matsuda, D.; Ohtawa, M.; Nagamitsu, T.; Sunazuka, T.; Harigaya, Y.; Rudel, L.L.; Omura, S.; Tomoda, H.
Selectivity of pyripyropene derivatives in inhibition toward acyl-CoA:cholesterol acyltransferase 2 isozyme
J. Antibiot.
61
503-508
2008
Chlorocebus aethiops (O77759), Chlorocebus aethiops (O77760)
Sakai, K.; Ohte, S.; Ohshiro, T.; Matsuda, D.; Masuma, R.; Rudel, L.L.; Tomoda, H.
Selective inhibition of acyl-CoA:cholesterol acyltransferase 2 isozyme by flavasperone and sterigmatocystin from Aspergillus species
J. Antibiot.
61
568-572
2008
Chlorocebus aethiops (O77759), Chlorocebus aethiops (O77760)
Choi, J.H.; Rho, M.C.; Lee, S.W.; Choi, J.N.; Lee, H.J.; Bae, K.S.; Kim, K.; Kim, Y.K.
Penicillium griseofulvum F1959, high-production strain of pyripyropene a, specific inhibitor of acyl-CoA: cholesterol acyltransferase 2
J. Microbiol. Biotechnol.
18
1663-1665
2008
Rattus norvegicus
Chen, L.; Lafond, J.; Pelletier, R.M.
A novel technical approach for the measurement of individual ACAT-1 and ACAT-2 enzymatic activity in the testis
Methods Mol. Biol.
550
169-177
2009
Mus musculus (O88908), Mus musculus (Q61263), Mus musculus
Antalis, C.J.; Arnold, T.; Lee, B.; Buhman, K.K.; Siddiqui, R.A.
Docosahexaenoic acid is a substrate for ACAT1 and inhibits cholesteryl ester formation from oleic acid in MCF-10A cells
Prostaglandins Leukot. Essent. Fatty Acids
80
165-171
2009
Homo sapiens
Locke, J.; Wasan, K.; Nelson, C.; Guns, E.; Leon, C.
Androgen-mediated cholesterol metabolism in LNCaP and PC-3 cell lines is regulated through two different isoforms of acyl-coenzyme A:cholesterol acyltransferase (ACAT)
Prostate
68
20-33
2008
Homo sapiens
Chang, C.C.; Miyazaki, A.; Dong, R.; Kheirollah, A.; Yu, C.; Geng, Y.; Higgs, H.N.; Chang, T.Y.
Purification of recombinant acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) from H293 cells and binding studies between the enzyme and substrates using difference intrinsic fluorescence spectroscopy
Biochemistry
49
9957-9963
2010
Homo sapiens
Hu, H.; Liao, H.; Zhang, J.; Wu, W.; Yan, J.; Yan, Y.; Zhao, Q.; Zou, Y.; Chai, X.; Yu, S.; Wu, Q.
First identification of xanthone sulfonamides as potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors
Bioorg. Med. Chem. Lett.
20
3094-3097
2010
Homo sapiens
Ohta, M.; Takahashi, K.; Kasai, M.; Shoji, Y.; Kunishiro, K.; Miike, T.; Kanda, M.; Mukai, C.; Shirahase, H.
Novel tetrahydroisoquinoline derivatives with inhibitory activities against acyl-CoA: cholesterol acyltransferase and lipid peroxidation
Chem. Pharm. Bull.
58
1066-1076
2010
Oryctolagus cuniculus
Rogers, M.A.; Liu, J.; Kushnir, M.M.; Bryleva, E.; Rockwood, A.L.; Meikle, A.W.; Shapiro, D.; Vaisman, B.L.; Remaley, A.T.; Chang, C.C.; Chang, T.Y.
Cellular pregnenolone esterification by acyl-CoA:cholesterol acyltransferase
J. Biol. Chem.
287
17483-17492
2012
Homo sapiens (O75908), Homo sapiens (P35610)
Ohtawa, M.; Yamazaki, H.; Ohte, S.; Matsuda, D.; Ohshiro, T.; Rudel, L.L.; Omura, S.; Tomoda, H.; Nagamitsu, T.
Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 1
Bioorg. Med. Chem. Lett.
23
1285-1287
2013
Homo sapiens (O75908), Homo sapiens (P35610)
Ohtawa, M.; Yamazaki, H.; Matsuda, D.; Ohshiro, T.; Rudel, L.L.; Omura, S.; Tomoda, H.; Nagamitsu, T.
Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 2
Bioorg. Med. Chem. Lett.
23
2659-2662
2013
Homo sapiens (O75908), Homo sapiens (P35610)
Ohtawa, M.; Yamazaki, H.; Ohte, S.; Matsuda, D.; Ohshiro, T.; Rudel, L.L.; Omura, S.; Tomoda, H.; Nagamitsu, T.
Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 3
Bioorg. Med. Chem. Lett.
23
3798-3801
2013
Homo sapiens (O75908), Homo sapiens (P35610)
Zhang, J.; Sawyer, J.K.; Marshall, S.M.; Kelley, K.L.; Davis, M.A.; Wilson, M.D.; Brown, J.M.; Rudel, L.L.
Cholesterol esters (CE) derived from hepatic sterol O-acyltransferase 2 (SOAT2) are associated with more atherosclerosis than CE from intestinal SOAT2
Circ. Res.
115
826-833
2014
Mus musculus (O88908)
He, X.; Leow, K.Y.; Yang, H.; Heng, C.K.
Functional characterization of two single nucleotide polymorphisms of acyl-coenzyme A:cholesterol acyltransferase 2
Gene
566
236-241
2015
Homo sapiens (O75908), Homo sapiens
Tomita, K.; Teratani, T.; Suzuki, T.; Shimizu, M.; Sato, H.; Narimatsu, K.; Usui, S.; Furuhashi, H.; Kimura, A.; Nishiyama, K.; Maejima, T.; Okada, Y.; Kurihara, C.; Shimamura, K.; Ebinuma, H.; Saito, H.; Yokoyama, H.; Watanabe, C.; Komoto, S.; Nagao, S.; Sugiyama, K.; Aosasa, S.; Hatsuse, K.; Yamamoto, J.; Hibi, T.; Miura, S.; Hokari, R.; Kanai, T.
Acyl-CoA:cholesterol acyltransferase 1 mediates liver fibrosis by regulating free cholesterol accumulation in hepatic stellate cells
J. Hepatol.
61
98-106
2014
Homo sapiens (P35610), Mus musculus (Q61263), Mus musculus C57BL/6 (Q61263)
Rogers, M.A.; Liu, J.; Song, B.L.; Li, B.L.; Chang, C.C.; Chang, T.Y.
Acyl-CoA:cholesterol acyltransferases (ACATs/SOATs): enzymes with multiple sterols as substrates and as activators
J. Steroid Biochem. Mol. Biol.
151
102-107
2015
Homo sapiens (O75908), Homo sapiens (P35610), Homo sapiens, Mus musculus (O88908), Mus musculus (Q61263)
Warrier, M.; Zhang, J.; Bura, K.; Kelley, K.; Wilson, M.D.; Rudel, L.L.; Brown, J.M.
Sterol O-acyltransferase 2-driven cholesterol esterification opposes liver X receptor-stimulated fecal neutral sterol loss
Lipids
51
151-157
2016
Mus musculus (O88908), Mus musculus
Toledo, J.D.; Garda, H.A.; Cabaleiro, L.V.; Cuellar, A.; Pellon-Maison, M.; Gonzalez-Baro, M.R.; Gonzalez, M.C.
Apolipoprotein A-I Helsinki promotes intracellular acyl-CoA cholesterol acyltransferase (ACAT) protein accumulation
Mol. Cell. Biochem.
377
197-205
2013
Mus musculus (Q61263)
Zhan, Y.; Zhang, X.W.; Xiong, Y.; Li, B.L.; Nan, F.J.
Design and synthesis of simple, yet potent and selective non-ring-A pyripyropene A-based inhibitors of acyl-coenzyme A: cholesterol acyltransferase 2 (ACAT2)
Org. Biomol. Chem.
14
747-751
2015
Homo sapiens
Lopez, A.M.; Jones, R.D.; Repa, J.J.; Turley, S.D.
Niemann-Pick C1-deficient mice lacking sterol O-acyltransferase 2 have less hepatic cholesterol entrapment and improved liver function
Am. J. Physiol. Gastrointest. Liver Physiol.
315
G454-G463
2018
Mus musculus (O88908)
Neumann, B.; Chang, C.C.Y.; Chang, T.Y.
Triton X-100 or octyl glucoside inactivates acyl-CoA cholesterol acyltransferase 1 by dissociating it from a two-fold dimer to a two-fold monomer
Arch. Biochem. Biophys.
671
103-110
2019
Homo sapiens (P35610)
Shibuya, K.; Kawamine, K.; Miura, T.; Ozaki, C.; Edano, T.; Mizuno, K.; Yoshinaka, Y.; Tsunenari, Y.
Design, synthesis and pharmacology of aortic-selective acyl-CoA Cholesterol O-acyltransferase (ACAT/SOAT) inhibitors
Bioorg. Med. Chem.
26
4001-4013
2018
Oryctolagus cuniculus (G1SUQ0)
Lin, H.; Lin, C.; Mersmann, H.; Ding, S.
Sterol-O acyltransferase 1 is inhibited by gga-miR-181a-5p and gga-miR-429-3p through the TGFbeta pathway in endodermal epithelial cells of Japanese quail
Comp. Biochem. Physiol. B Biochem. Mol. Biol.
240
110376
2020
Coturnix coturnix
Smith, D.C.; Kroiss, M.; Kebebew, E.; Habra, M.A.; Chugh, R.; Schneider, B.J.; Fassnacht, M.; Jafarinasabian, P.; Ijzerman, M.M.; Lin, V.H.; Mohideen, P.; Naing, A.
A phase 1 study of nevanimibe HCl, a novel adrenal-specific sterol O-acyltransferase 1 (SOAT1) inhibitor, in adrenocortical carcinoma
Invest. New Drugs
38
1421-1429
2020
Homo sapiens (P35610), Homo sapiens
Ohshiro, T.; Seki, R.; Fukuda, T.; Uchida, R.; Tomoda, H.
Celludinones, new inhibitors of sterol O-acyltransferase, produced by Talaromyces cellulolyticus BF-0307
J. Antibiot.
71
1000-1007
2018
Homo sapiens (O75908), Homo sapiens (P35610), Chlorocebus aethiops (O77759), Chlorocebus aethiops (O77760)
Xu, Y.; Du, X.; Turner, N.; Brown, A.J.; Yang, H.
Enhanced acyl-CoA cholesterol acyltransferase activity increases cholesterol levels on the lipid droplet surface and impairs adipocyte function
J. Biol. Chem.
294
19306-19321
2019
Mus musculus (O88908), Mus musculus (Q61263)
Iwasaki, A.; Tadenuma, T.; Sumimoto, S.; Ohshiro, T.; Ozaki, K.; Kobayashi, K.; Teruya, T.; Tomoda, H.; Suenaga, K.
Biseokeaniamides A, B, and C, sterol O-Acyltransferase inhibitors from an Okeania sp. marine cyanobacterium
J. Nat. Prod.
80
1161-1166
2017
Homo sapiens (O75908), Homo sapiens (P35610), Homo sapiens
Zhan, Y.; Zhang, X.; Xiong, Y.; Li, B.; Nan, F.
Design and synthesis of simple, yet potent and selective non-ring-A pyripyropene A-based inhibitors of acyl-coenzyme A Cholesterol acyltransferase 2 (ACAT2)
Org. Biomol. Chem.
14
747-751
2016
Homo sapiens (O75908)
Chang, N.Y.; Chan, Y.J.; Ding, S.T.; Lee, Y.H.; HuangFu, W.C.; Liu, I.H.
Sterol O-acyltransferase 2 contributes to the yolk cholesterol trafficking during zebrafish embryogenesis
PLoS ONE
11
e0167644
2016
Danio rerio, Danio rerio (B0UYE4)
Ayyagari, V.N.; Wang, X.; Diaz-Sylvester, P.L.; Groesch, K.; Brard, L.
Assessment of acyl-CoA cholesterol acyltransferase (ACAT-1) role in ovarian cancer progression - An in vitro study
PLoS ONE
15
e0228024
2020
Homo sapiens (P35610)
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