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Literature summary for 2.3.1.26 extracted from
- Serotonin acts as an up-regulator of acyl-coenzyme A:cholesterol acyltransferase-1 in human monocyte-macrophages (2006), Atherosclerosis, 186, 275-281.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + cholesterol | Homo sapiens | ACAT-1 plays an important role in the formation of macrophage-derived foam cells in atherosclerotic lesions | CoA + cholesterol ester | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P35610 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| monocyte | serotonin upregiulates ACAT-1 expression in human monocyte-macrophages | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + cholesterol | ACAT-1 plays an important role in the formation of macrophage-derived foam cells in atherosclerotic lesions | Homo sapiens | CoA + cholesterol ester | - |
? | |
| oleoyl-CoA + cholesterol | - |
Homo sapiens | CoA + cholesteryl oleate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ACAT-1 | - |
Homo sapiens |
| acyl-coenzyme A:cholesterol acyltransferase-1 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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