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Literature summary for 2.3.1.26 extracted from

  • Jeong, T.; Kim, K.S.; Yu, H.; Kim, M.J.; Cho, K.; Choi, Y.; Kim, H.; Park, H.; Lee, W.S.
    Saucerneol B derivatives as human acyl-CoA: cholesterol acyltransferase inhibitors (2005), Bioorg. Med. Chem. Lett., 15, 385-388.
    View publication on PubMed
Search for more literature for 2.3.1.26

Inhibitors

Inhibitors Comment Organism Structure
5-(1-butoxy-2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}propyl)-1,3-benzodioxole 0.125 mM, 28% inhibition; IC50: 0.017 mM Homo sapiens
5-(2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-ethoxypropyl)-1,3-benzodioxole 0.125 mM, 29% inhibition; IC50: 0.031 mM Homo sapiens
5-(2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-methoxypropyl)-1,3-benzodioxole 0.125 mM, 45% inhibition; IC50: 0.035 mM Homo sapiens
5-(2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-propoxypropyl)-1,3-benzodioxole 0.125 mM, 33% inhibition; IC50: 0.014 mM Homo sapiens
5-[2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-(heptyloxy)propyl]-1,3-benzodioxole 0.125 mM, 26% inhibition; IC50: 0.05 mM Homo sapiens
5-[2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-(hexyloxy)propyl]-1,3-benzodioxole 0.125 mM, 33% inhibition; IC50: 0.034 mM Homo sapiens
5-[2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-(nonyloxy)propyl]-1,3-benzodioxole 0.125 mM, 10% inhibition; 0.125 mM, 25% inhibition Homo sapiens
5-[2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-(octyloxy)propyl]-1,3-benzodioxole 0.125 mM: 19% inhibition; 0.125 mM: 44% inhibition Homo sapiens
5-[2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-(pentyloxy)propyl]-1,3-benzodioxole 0.125 mM, 33% inhibition; IC50: 0.02 mM Homo sapiens
saucemeol B 0.125 mM, 57% inhibition; IC50: 0.043 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O75908
-
-
Homo sapiens P35610
-
-

Synonyms

Synonyms Comment Organism
hACAT-1
-
 Homo sapiens
hACAT-2
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.014
-
 IC50: 0.014 mM Homo sapiens 5-(2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-propoxypropyl)-1,3-benzodioxole
0.017
-
 IC50: 0.017 mM Homo sapiens 5-(1-butoxy-2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}propyl)-1,3-benzodioxole
0.02
-
 IC50: 0.02 mM Homo sapiens 5-[2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-(pentyloxy)propyl]-1,3-benzodioxole
0.031
-
 IC50: 0.031 mM Homo sapiens 5-(2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-ethoxypropyl)-1,3-benzodioxole
0.034
-
 IC50: 0.034 mM Homo sapiens 5-[2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-(hexyloxy)propyl]-1,3-benzodioxole
0.035
-
 IC50: 0.035 mM Homo sapiens 5-(2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-methoxypropyl)-1,3-benzodioxole
0.043
-
 IC50: 0.043 mM Homo sapiens saucemeol B
0.05
-
 IC50: 0.05 mM Homo sapiens 5-[2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-(heptyloxy)propyl]-1,3-benzodioxole