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Literature summary for 2.3.1.26 extracted from

  • Zhang, J.; Sawyer, J.K.; Marshall, S.M.; Kelley, K.L.; Davis, M.A.; Wilson, M.D.; Brown, J.M.; Rudel, L.L.
    Cholesterol esters (CE) derived from hepatic sterol O-acyltransferase 2 (SOAT2) are associated with more atherosclerosis than CE from intestinal SOAT2 (2014), Circ. Res., 115, 826-833.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.26

Protein Variants

Protein Variants Comment Organism
additional information generation of tissue-specific SOAT2 knockouts in liver and small intestine, i.e. SOAT2L-/L- and SOAT2SI-/SI- mice, phenotypes, overview. Floxed mice (LoxP sites flanked exons 11 through 13 of the SOAT2 gene on chromosome 15) are designated as SOAT2fl/fl. SOAT2 wild-type control mice (SOAT2+/+LDLr?/?) and SOAT2 floxed mice (SOAT2fl/flLDLr?/?) have similar levels of cholesterol absorption. SOAT2 total body knockout mice (SOAT2?/?LDLr?/?) and intestinal SOAT2 knockout mice (SOAT2SI?/SI?LDLr?/?) have significantly decreased levels of cholesterol absorption, overview. SOAT2 knockout mice have lower plasma VLDL and LDL cholesterol concentrations Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + cholesterol Mus musculus
-
 CoA + cholesterol ester
-
 ?
oleoyl-CoA + cholesterol Mus musculus
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 CoA + cholesterol oleate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus O88908
-
-

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
 Mus musculus
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liver
-
 Mus musculus
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additional information tissue-specific expression and physiological function of the isozyme SOAT2 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + cholesterol
-
 Mus musculus CoA + cholesterol ester
-
 ?
oleoyl-CoA + cholesterol
-
 Mus musculus CoA + cholesterol oleate
-
 ?

Synonyms

Synonyms Comment Organism
Soat2
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 Mus musculus
sterol O-acyltransferase 2
-
 Mus musculus

General Information

General Information Comment Organism
malfunction aortic atherosclerosis development is significantly lower in all mice with global or tissue-restricted SOAT2 gene deletions. Nevertheless, liver-specific and complete SOAT2-/-LDLr-/- knockout mice have less aortic cholesterol esters accumulation and smaller aortic lesions than intestine-specific SOAT2SI-/SI-LDLr-/- mice Mus musculus
physiological function cholesterol esters, especially cholesterol oleate, generated by hepatic and intestinal sterol O-acyltransferase 2 (SOAT2) play a critical role in cholesterol homeostasis. SOAT2-derived cholesterol esters from both the intestine and liver significantly contribute to the development of atherosclerosis, although the cholesterol esters from the hepatic enzyme appear to promote more atherosclerosis development. Intestinal SOAT2, but not liver SOAT2, is a critical determinant of cholesterol absorption and of biliary cholesterol levels Mus musculus