Literature summary for 2.3.1.26 extracted from

Asano, S.; Ban, H.; Kino, K.; Ioriya, K.; Muraoka, M.
Novel 1,4-diarylpiperidine-4-methylureas as anti-hyperlipidemic agents: dual effectors on acyl-CoA:cholesterol O-acyltransferase and low-density lipoprotein receptor expression (2009), Bioorg. Med. Chem. Lett., 19, 1062-1065.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1-[4-amino-2,6-di(propan-2-yl)phenyl]-3-{[1-(2-butoxyphenyl)-4-(3-methoxyphenyl)piperidin-4-yl]methyl}urea	poor solubility	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
macrophage	-	Rattus norvegicus	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0000532	-	pH 7.4	Rattus norvegicus	N-(4-amino-2,6-diisopropylphenyl)-N'-([1-(2-butoxyphenyl)-4-(3-methoxyphenyl)piperidin-4-yl]-methyl)urea

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Release 2023.1 (January 2023)