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Literature summary for 2.3.1.26 extracted from

  • Kanome, T.; Watanabe, T.; Nishio, K.; Takahashi, K.; Hongo, S.; Miyazaki, A.
    Angiotensin II upregulates acyl-CoA:cholesterol acyltransferase-1 via the angiotensin II Type 1 receptor in human monocyte-macrophages (2008), Hypertens. Res., 31, 1801-1810.
    View publication on PubMed
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
macrophage
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 Homo sapiens
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monocyte
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 Homo sapiens
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Expression

Organism Comment Expression
Homo sapiens angiotensin II significantly increases ACAT1 protein expression in a time- or concentration-dependent manner. Application of angiotensin II type 1 receptor agonist L162313, but not angiotensin II type 2 receptor agonist CGP42112A, mimicks the effects of angiotensin II treatment in inducing ACAT1 protein expression. ACAT activity and ACAT1 mRNA levels are also significantly increased by angiotensin II. Two-fold increases in ACAT1 protein expression and ACAT activity with angiotensin II treatment are completely inhibited by angiotensin type I receptor antagonists candesartan, [Sar(1),Ile(8)]-angiotensin II up