Literature summary for 2.3.1.26 extracted from

An, S.; Cho, K.H.; Lee, W.S.; Lee, J.O.; Paik, Y.K.; Jeong, T.S.
A critical role for the histidine residues in the catalytic function of acyl-CoA:cholesterol acyltransferase catalysis: evidence for catalytic difference between ACAT1 and ACAT2 (2006), FEBS Lett., 580, 2741-2749.

Search for more literature for 2.3.1.26

Cloned(Commentary)

Cloned (Comment)	Organism
mutants generated by baculovirus expression technology	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
H360A	complete loss of activity	Homo sapiens
H386A	complete loss of activity. Enzymatic activity is restored to values below 37% of the level of the wild-type activity when cholesterol is replaced by 25-hydroxycholesterol as substrate	Homo sapiens
H399A	complete loss of activity	Homo sapiens
H425A	59% of the wild-type activity, inhibitory sensitivity against oleic acid anilide ias decreased about 3fold	Homo sapiens
H460A	complete loss of activity	Homo sapiens
H501A	75% of the wild-type activity, inhibitory sensitivity against oleic acid anilide ias decreased about 10fold	Homo sapiens
H527A	96% of the wild-type activity, inhibitory sensitivity against oleic acid anilide ias decreased about 10fold	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O75908	-	-
Homo sapiens	P35610	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
oleoyl-CoA + cholesterol	-	Homo sapiens	CoA + cholesteryl oleate	-	?

Synonyms

Synonyms	Comment	Organism
ACAT1	-	Homo sapiens
ACAT2	-	Homo sapiens

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Release 2023.1 (January 2023)