Literature summary for 2.3.1.26 extracted from

Kim, K.Y.; Shin, Y.K.; Park, J.C.; Kim, J.H.; Yang, H.; Han, D.M.; Paik, Y.K.
Molecular cloning and biochemical characterization of Candida albicans acyl-CoA:sterol acyltransferase, a potential target of antifungal agents (2004), Biochem. Biophys. Res. Commun., 319, 911-919.

Search for more literature for 2.3.1.26

Cloned(Commentary)

Cloned (Comment)	Organism
-	Candida albicans

Inhibitors

Inhibitors	Comment	Organism	Structure
CI-976	50% inhibition at 0.0116 mM	Candida albicans
HWY-289	50% inhibition at 0.0132 mM	Candida albicans
miconazole	50% inhibition at 0.0224 mM	Candida albicans
additional information	not inhibitory: polyoxin D, amphotericin B, nikkomycin Z	Candida albicans

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.00163	-	cholesterol	-	Candida albicans

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
71000	-	x * 71300, calculated, x * 71000, SDS-PAGE	Candida albicans
71300	-	x * 71300, calculated, x * 71000, SDS-PAGE	Candida albicans

Organism

Organism	UniProt	Comment	Textmining
Candida albicans	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
oleoyl-CoA + cholesterol	-	Candida albicans	CoA + cholesteryl oleate	-	?
oleoyl-CoA + ergosterol	53% of the activity with cholesterol	Candida albicans	CoA + ergosteryl oleate	-	?

Subunits

Subunits	Comment	Organism
?	x * 71300, calculated, x * 71000, SDS-PAGE	Candida albicans

Synonyms

Synonyms	Comment	Organism
AsAT	-	Candida albicans

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00515	-	HWY-289	-	Candida albicans
0.026	-	CI-976	-	Candida albicans
0.039	-	miconazole	-	Candida albicans

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)