2.1.2.1: glycine hydroxymethyltransferase

This is an abbreviated version!
For detailed information about glycine hydroxymethyltransferase, go to the full flat file.

Reaction

Synonyms

AtSHMT3, bsSHMT, bstSHMT, EC 4.1.2.6, eSHMT, GlyA, GlyA protein, glycine hydroxymethyltransferrase, hSHMT, L-serine hydroxymethyltransferase, mitochondrial serine hydroxymethyltransferase, MJ1597, PvSHMT, Rhg4, serine hydroxymethyl transferase, serine hydroxymethylase hydroxymethyltransferase, serine, serine hydroxymethyltransferase, serine hydroxymethyltransferase 1, serine hydroxymethyltransferase 2, serine hydroxymethyltransferase 2alpha, serine transhydroxymethylase, serine:H4F hydroxymethyltransferase, serine:tetrahydrofolate hydroxymethyltransferase, SHM1, SHM2, SHMT, SHMT-1, SHMT-L, SHMT-S, SHMT08, SHMT1, SHMT2, SHMT2alpha, SHMT3, zcSHMT, zebrafish cytosolic serine hydroxymethyltransferase, zebrafish mitochondiral serine hydroxymethyltransferase, zmSHMT

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.2 Hydroxymethyl-, formyl- and related transferases

                2.1.2.1 glycine hydroxymethyltransferase

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Results	in table
12	Activating Compound
57530	AA Sequence
55	Application
1	CAS Registry Number
84	Cloned(Commentary)
203	Cofactor
22	Crystallization (Commentary)
984	Disease/ Diagnostics
8	Expression
107	General Information
24	General Stability
26	IC50 Value
314	Inhibitors
50	kcat/KM [mM/s]
33	Ki Value [mM]
179	KM Value [mM]
129	Localization
20	Metals/Ions
102	Molecular Weight [Da]
191	Natural Substrates/ Products (Substrates)
571	Organism
28	Pathway
280	PDB ID
44	pH Optimum
16	pH Range
14	pH Stability
1	pI Value
6	Posttranslational Modification
92	Protein Variants
71	Purification (Commentary)
50	Reaction
1	Reaction Type
241	Reference
2	Renatured (Commentary)
95	Source Tissue
69	Specific Activity [micromol/min/mg]
13	Storage Stability
498	Substrates and Products (Substrate)
137	Subunits
345	Synonyms
1	Systematic Name
29	Temperature Optimum [°C]
17	Temperature Range [°C]
49	Temperature Stability [°C]
111	Turnover Number [1/s]

Natural Substrates Products

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of the Enzyme Summary Page.

Natural Substrates Products on EC 2.1.2.1 - glycine hydroxymethyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

(6S)-tetrahydrofolate + D-serine

5,10-methylenetetrahydrofolate + glycine + H2O

2 entries

(6S)-tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

3 entries

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + D-serine

2 entries

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-Ser

Rattus norvegicus

-

the enzyme is a major source of one-carbon units for cellular metabolism. Potential for disruption of SHMT-mediated one-carbon metabolism by inadequate vitamin B-6 intake

659772

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

66 entries

L-Ser + tetrahydrofolate

Gly + 5,10-methylenetetrahydrofolate

Ovis aries

-

placental conversion of serine to glycine is a major source of fetal glycine

659572

-

-

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

50 entries

L-serine + tetrahydropteroylglutamate

glycine + 5,10-methylene-tetrahydropteroylglutamate + H2O

2 entries

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

38 entries

additional information

?

-

18 entries

(6S)-tetrahydrofolate + D-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Plasmodium falciparum

-

-

736084

-

-

r

(6S)-tetrahydrofolate + D-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Plasmodium vivax

-

-

736084

-

-

r

(6S)-tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Homo sapiens

P34896

-

736084

-

-

r

(6S)-tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Plasmodium falciparum

-

-

736084

-

-

r

(6S)-tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Plasmodium vivax

-

-

736084

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + D-serine

Plasmodium falciparum

-

-

736084

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + D-serine

Plasmodium vivax

-

-

736084

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Aedes aegypti

-

-

757905

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Aedes aegypti NIH Rockefeller

-

-

757905

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Alcanivorax sp.

-

-

736645

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Aphanothece halophytica

-

-

755912

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Aphanothece halophytica

I7H6W6

-

719529

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Arabidopsis thaliana

Q94JQ3

-

718775

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Arthrobacter sp.

-

-

735436

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Arthrobacter sp. MCCC 1A05493

-

-

735436

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Bombyx mori

-

-

755905

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Bombyx mori p50T

-

-

755905

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Burkholderia cenocepacia

B4ECY9

-

737188

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Burkholderia pseudomallei

A0A069BAT4

-

737188

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Burkholderia pseudomallei ATCC 23343

A0A069BAT4

-

737188

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Campylobacter jejuni

Q9S6K1

-

737188

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Campylobacter jejuni ATCC 33560

Q9S6K1

-

737188

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Escherichia coli

P0A825

-

736646, 737188

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Geobacillus stearothermophilus

-

-

719472

-

-

?

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Geobacillus stearothermophilus

Q7SIB6

-

737188, 758412

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Glutamicibacter nicotianae

U5TRK6

-

756288

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Glycine max

-

-

758045

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Helicobacter pylori

P56089

-

758178

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Helicobacter pylori 26695

P56089

-

758178

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Homo sapiens

-

-

755894, 756477

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Homo sapiens

P34896

-

736084, 756058

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Homo sapiens

P34897

-

756058

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Homo sapiens

P34896, P34897

-

756098

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Homo sapiens

P34896, P34897

-

756695

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Homo sapiens

P34896

-

756705

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Homo sapiens

P34897

-

756725

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Hordeum vulgare

-

-

718775

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Hordeum vulgare Bob

-

-

718775

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Hydrogenobacter thermophilus

-

-

719472

-

-

?

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Hydrogenobacter thermophilus TK-6 / IAM 12695

-

-

719472

-

-

?

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Idiomarina loihiensis

-

-

756948

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Komagataella pastoris

F2QZA4

-

755964

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Komagataella pastoris X-33

F2QZA4

-

755964

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Medicago truncatula

G7ILW0

-

756837

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Mycobacterium tuberculosis

P9WGI9

-

737188

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Mycobacterium tuberculosis H37Rv

P9WGI9

-

737188

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Oryctolagus cuniculus

-

-

719472

-

-

?

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Oryza sativa Japonica Group

-

-

757362

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Ovis aries

-

-

719472

-

-

?

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Pisum sativum

-

-

718775

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Pisum sativum Progress 9

-

-

718775

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Plasmodium berghei

-

-

757384

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Plasmodium falciparum

-

-

720362

-

-

?

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Plasmodium falciparum

-

-

736084, 757384

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Plasmodium vivax

-

-

736084, 736499, 755894

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Plasmodium vivax

A5K8L9

-

757384

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Plasmodium vivax Salvador I

A5K8L9

-

757384

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Pseudomonas plecoglossicida

L7Y8B0

-

737301

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Pseudomonas plecoglossicida MCCC 1K00022

L7Y8B0

-

737301

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Psychromonas ingrahamii

A1SUU0

-

736646, 737188, 737212

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Psychromonas ingrahamii

-

-

737212

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Psychromonas ingrahamii 37

A1SUU0

-

736646, 737188

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Rickettsia rickettsii

A8GTI9

-

737188

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Rickettsia rickettsii Sheila Smith

A8GTI9

-

737188

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Saccharomyces cerevisiae

-

-

756534

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Saccharomyces cerevisiae BY4741

-

-

756534

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Salmonella enterica subsp. enterica serovar Typhimurium

P0A2E1

-

737188

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Shewanella algae

R9YJZ9

-

736753

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Staphylococcus aureus

Q5HE87

-

737188

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Staphylococcus aureus COL

Q5HE87

-

737188

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Streptococcus thermophilus

Q5M0B4

-

755784

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Streptococcus thermophilus CNRZ 1066

Q5M0B4

-

755784

-

-

r

5,10-methylenetetrahydrofolate + glycine + H2O

tetrahydrofolate + L-serine

Thermus thermophilus

Q5SI56

-

737188

-

-

r

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Bacillus subtilis

-

-

704347

-

-

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Bos taurus

-

may play important role in central nervous system

441420

-

441420

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Cricetulus griseus

-

-

441434

-

441434

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Cricetulus griseus

-

may play important role in central nervous system

441420

-

441420

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Escherichia coli

-

major pathway for production of C1-units of 5,10-methylenetetrahydrofolate

441412

-

441412

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Escherichia coli

-

major pathway for production of C1-units of 5,10-methylenetetrahydrofolate

441434

-

441434

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Escherichia coli

-

catalyzes interconversion of serine and glycine

441433

-

441433

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Escherichia coli

-

enzyme plays a pivotal role in channelling metabolites between amino acid and nucleotide metabolism

441427

-

441427

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Geobacillus stearothermophilus

-

-

441431

-

441431

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Geobacillus stearothermophilus

-

-

441432

-

441432

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Glycine max

-

main glycine source for purine biosynthetic pathway in ureide biogenesis

441407

-

441407

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Glycine max L. Merr. cv. Williams

-

main glycine source for purine biosynthetic pathway in ureide biogenesis

441407

-

441407

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Homo sapiens

-

-

703863, 704565

-

-

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Homo sapiens

-

major pathway for production of C1-units of 5,10-methylenetetrahydrofolate

441434

-

441434

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Homo sapiens

-

major pathway for production of C1-units of 5,10-methylenetetrahydrofolate

441436

-

441436

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Homo sapiens

-

main glycine source for purine biosynthetic pathway in ureide biogenesis

441435

-

441435

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Homo sapiens

-

enzyme plays a pivotal role in channelling metabolites between amino acid and nucleotide metabolism

441427

-

441427

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Hyphomicrobium methylovorum

-

key enzyme of serine pathway for assimilation of C1-compounds

441410

-

441410

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Hyphomicrobium methylovorum

-

key enzyme of serine pathway for assimilation of C1-compounds

441411

-

441411

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Macaca radiata

-

regulatory protein

441403

-

441403

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Mus musculus

-

main glycine source for purine biosynthetic pathway in ureide biogenesis

441405

-

441405

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Mus musculus

-

key enzyme of serine pathway for assimilation of C1-compounds

441405

-

441405

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Neurospora crassa

-

-

441434

-

441434

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Neurospora crassa

-

may play important role in central nervous system

441420

-

441420

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Oryctolagus cuniculus

-

-

441415

-

441415

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Oryctolagus cuniculus

-

-

441434

-

441434

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Oryctolagus cuniculus

-

enzyme is a component of thymidylate cycle

441423

-

441423

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Oryctolagus cuniculus

-

may play important role in central nervous system

441420

-

441420

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Oryctolagus cuniculus

-

catalyzes interconversion of serine and glycine

441423

-

441423

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Oryctolagus cuniculus

-

enzyme plays a pivotal role in channelling metabolites between amino acid and nucleotide metabolism

441427

-

441427

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Ovis aries

-

-

441430

-

441430

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Ovis aries

-

-

441434

-

441434

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Ovis aries

-

enzyme is a component of thymidylate cycle

441425

-

441425

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Ovis aries

-

may play important role in central nervous system

441420

-

441420

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Ovis aries

-

enzyme plays a pivotal role in channelling metabolites between amino acid and nucleotide metabolism

441427

-

441427

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Pisum sativum

-

-

441434

-

441434

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Pisum sativum

-

enzyme plays a pivotal role in channelling metabolites between amino acid and nucleotide metabolism

441427

-

441427

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Rattus norvegicus

-

major pathway for production of C1-units of 5,10-methylenetetrahydrofolate

441398

-

441398

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Rattus norvegicus

-

major pathway for production of C1-units of 5,10-methylenetetrahydrofolate

441434

-

441434

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Rattus norvegicus

-

catalyzes interconversion of serine and glycine

441399

-

441399

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Saccharolobus solfataricus

Q9UWT5

key enzyme of serine pathway for assimilation of C1-compounds

441422

-

441422

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Saccharolobus solfataricus P2

Q9UWT5

key enzyme of serine pathway for assimilation of C1-compounds

441422

-

441422

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Saccharomyces cerevisiae

-

-

441420

-

441420

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Saccharomyces cerevisiae

-

key enzyme of serine pathway for assimilation of C1-compounds

441413

-

441413

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Saccharomyces cerevisiae

-

enzyme plays a pivotal role in channelling metabolites between amino acid and nucleotide metabolism

441427

-

441427

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Saccharomyces cerevisiae 3701B

-

key enzyme of serine pathway for assimilation of C1-compounds

441413

-

441413

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Salmonella enterica subsp. enterica serovar Typhimurium

-

may play important role in central nervous system

441420

-

441420

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Vigna radiata

-

-

441434

-

441434

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Vigna radiata

-

regulatory protein

441408

-

441408

?

L-serine + tetrahydrofolate

glycine + 5,10-methylenetetrahydrofolate + H2O

Vigna radiata

-

key enzyme of serine pathway for assimilation of C1-compounds

441408

-

441408

?

L-serine + tetrahydropteroylglutamate

glycine + 5,10-methylene-tetrahydropteroylglutamate + H2O

Bacillus subtilis

-

-

718984

-

-

r

L-serine + tetrahydropteroylglutamate

glycine + 5,10-methylene-tetrahydropteroylglutamate + H2O

Escherichia coli

-

-

718984

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Aedes aegypti

-

-

757905

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Aedes aegypti NIH Rockefeller

-

-

757905

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Aphanothece halophytica

-

-

755912

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Arthrobacter sp.

-

-

735436

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Arthrobacter sp. MCCC 1A05493

-

-

735436

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Bombyx mori

-

-

755905

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Bombyx mori p50T

-

-

755905

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Escherichia coli

P0A825

-

736646

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Geobacillus stearothermophilus

Q7SIB6

-

758412

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Glutamicibacter nicotianae

U5TRK6

-

756288

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Glycine max

-

-

758045

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Helicobacter pylori

P56089

-

758178

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Helicobacter pylori 26695

P56089

-

758178

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Homo sapiens

-

-

755894, 756477

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Homo sapiens

P34896, P34897

-

756058

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Homo sapiens

P34896, P34897

-

756098

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Homo sapiens

P34896, P34897

-

756695

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Homo sapiens

P34896

-

756705

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Homo sapiens

P34897

-

756725

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Idiomarina loihiensis

-

-

756948

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Komagataella pastoris

F2QZA4

-

755964

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Komagataella pastoris X-33

F2QZA4

-

755964

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Medicago truncatula

G7ILW0

-

756837

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Oryza sativa Japonica Group

-

-

757362

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Plasmodium berghei

-

-

757384

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Plasmodium falciparum

-

-

757384

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Plasmodium vivax

-

-

736499, 755894

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Plasmodium vivax

A5K8L9

-

757384

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Plasmodium vivax Salvador I

A5K8L9

-

757384

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Pseudomonas plecoglossicida

L7Y8B0

-

737301

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Pseudomonas plecoglossicida MCCC 1K00022

L7Y8B0

-

737301

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Psychromonas ingrahamii

A1SUU0

-

736646

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Psychromonas ingrahamii 37

A1SUU0

-

736646

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Saccharomyces cerevisiae

-

-

756534

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Saccharomyces cerevisiae BY4741

-

-

756534

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Shewanella algae

R9YJZ9

-

736753

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Streptococcus thermophilus

Q5M0B4

-

755784

-

-

r

tetrahydrofolate + L-serine

5,10-methylenetetrahydrofolate + glycine + H2O

Streptococcus thermophilus CNRZ 1066

Q5M0B4

-

755784

-

-

r

additional information

?

-

Arabidopsis thaliana

-

SHMT1 functions in the photorespiratory pathway and plays a critical role in controlling the cell damage provoked by abiotic stresses such as high light and salt and in restricting pathogen induced cell death

660180

-

-

?

additional information

?

-

Arabidopsis thaliana C24

-

SHMT1 functions in the photorespiratory pathway and plays a critical role in controlling the cell damage provoked by abiotic stresses such as high light and salt and in restricting pathogen induced cell death

660180

-

-

?

additional information

?

-

Bacillus subtilis

-

SHMT also catalyzes the hydrolysis of 5,10-methenyl-tetrahydropteroylglutamate to 5-formyl-tetrahydropteroylglutamate

718984

-

-

?

additional information

?

-

Eremothecium gossypii

Q75BQ6

disruption of the SHM2 gene, encoding one of two serine hydroxymethyltransferase isoenzymes, reduces the flux from glycine to serine

657809

-

-

?

additional information

?

-

Eremothecium gossypii

-

disruption of the SHM2 gene, encoding one of two serine hydroxymethyltransferase isoenzymes, reduces the flux from glycine to serine

657809

-

-

?

additional information

?

-

Escherichia coli

-

SHMT also catalyzes the hydrolysis of 5,10-methenyl-tetrahydropteroylglutamate to 5-formyl-tetrahydropteroylglutamate

718984

-

-

?

additional information

?

-

Homo sapiens

-

low activity in placenta suggests that placental conversion of serine to glycine is not a major source of fetal glycine

659572

-

-

?

additional information

?

-

Homo sapiens

-

the enzyme plays an indispensable role in nucleic acid biosynthesis

659754

-

-

?

additional information

?

-

Plasmodium falciparum

-

Plasmodium SHMT can use D-serine and L-serine as a substrate

736084

-

-

?

additional information

?

-

Plasmodium vivax

-

Plasmodium SHMT can use D-serine and L-serine as a substrate

736084

-

-

?

additional information

?

-

Plasmodium vivax

-

serine hydroxymethyltransferase is a pyridoxal 5'-phosphate-dependent enzyme that catalyzes a hydroxymethyl group transfer from L-serine to tetrahydrofolate to yield glycine and 5,10-methylenetetrahydrofolate

736499

-

-

?

additional information

?

-

Plasmodium vivax

A5K8L9

the enzyme catalyzes the conversion of L- and D-serine to glycine in a THFdependent reaction

735367

-

-

?

additional information

?

-

Plasmodium vivax

-

the enzyme catalyzes the conversion of L- and D-serine to glycine in a THFdependent reaction

735367

-

-

?

additional information

?

-

Psychromonas ingrahamii

A1SUU0

SHMT catalyses the reversible cleavage of several beta-hydroxy amino acids varying in substituent and stereochemistry at Cbeta. The enzyme also has L-threo-beta-phenylserine aldolase activity

736646

-

-

?

additional information

?

-

Psychromonas ingrahamii 37

A1SUU0

SHMT catalyses the reversible cleavage of several beta-hydroxy amino acids varying in substituent and stereochemistry at Cbeta. The enzyme also has L-threo-beta-phenylserine aldolase activity

736646

-

-

?

additional information

?

-

Rattus norvegicus

-

low activity in placenta suggests that placental conversion of serine to glycine is not a major source of fetal glycine

659572

-

-

?

additional information

?

-

Shewanella algae

R9YJZ9

the enzyme shows high serine hydroxymethyltransferase activity and L-serine production

736753

-

-

?

additional information

?

-

Shewanella algae

-

the enzyme shows high serine hydroxymethyltransferase activity and L-serine production

736753

-

-

?