2.1.2.1: glycine hydroxymethyltransferase

This is an abbreviated version!
For detailed information about glycine hydroxymethyltransferase, go to the full flat file.

Word Map on EC 2.1.2.1

2.1.2.1

one-carbon

pyridoxal

thymidylate

purine

5'-phosphate

homocysteine

dihydrofolate

folate-dependent

photorespiratory

photorespiration

folate-mediated

pyridoxal-5'-phosphate

thf

dtmp

mthfd1

plp-dependent

remethylation

aldimine

phgdh

medicine

folate-metabolizing

5,10-methenyltetrahydrofolate

5'-phosphate-dependent

antifolate

hydroxypyruvate

quinonoid

5-methyltetrahydrofolate

glycerate

5-formyltetrahydrofolate

drug development

folate-related

d-alanine

c1-tetrahydrofolate

1-carbon

5-formyl

polyglutamate

l-threonine

alpha-protons

slc19a1

retro-aldol

degradation

analysis

synthesis

biotechnology

pharmacology

Reaction

Synonyms

AtSHMT3, bsSHMT, bstSHMT, EC 4.1.2.6, eSHMT, GlyA, GlyA protein, glycine hydroxymethyltransferrase, hSHMT, L-serine hydroxymethyltransferase, mitochondrial serine hydroxymethyltransferase, MJ1597, PvSHMT, Rhg4, serine hydroxymethyl transferase, serine hydroxymethylase hydroxymethyltransferase, serine, serine hydroxymethyltransferase, serine hydroxymethyltransferase 1, serine hydroxymethyltransferase 2, serine hydroxymethyltransferase 2alpha, serine transhydroxymethylase, serine:H4F hydroxymethyltransferase, serine:tetrahydrofolate hydroxymethyltransferase, SHM1, SHM2, SHMT, SHMT-1, SHMT-L, SHMT-S, SHMT08, SHMT1, SHMT2, SHMT2alpha, SHMT3, zcSHMT, zebrafish cytosolic serine hydroxymethyltransferase, zebrafish mitochondiral serine hydroxymethyltransferase, zmSHMT

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.2 Hydroxymethyl-, formyl- and related transferases

2.1.2.1 glycine hydroxymethyltransferase

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Results	in table
12	Activating Compound
57530	AA Sequence
55	Application
1	CAS Registry Number
84	Cloned(Commentary)
203	Cofactor
22	Crystallization (Commentary)
984	Disease/ Diagnostics
8	Expression
107	General Information
24	General Stability
26	IC50 Value
314	Inhibitors
50	kcat/KM [mM/s]
33	Ki Value [mM]
179	KM Value [mM]
129	Localization
20	Metals/Ions
102	Molecular Weight [Da]
191	Natural Substrates/ Products (Substrates)
571	Organism
28	Pathway
280	PDB ID
44	pH Optimum
16	pH Range
14	pH Stability
1	pI Value
6	Posttranslational Modification
92	Protein Variants
71	Purification (Commentary)
50	Reaction
1	Reaction Type
241	Reference
2	Renatured (Commentary)
95	Source Tissue
69	Specific Activity [micromol/min/mg]
13	Storage Stability
498	Substrates and Products (Substrate)
137	Subunits
345	Synonyms
1	Systematic Name
29	Temperature Optimum [°C]
17	Temperature Range [°C]
49	Temperature Stability [°C]
111	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 2.1.2.1 - glycine hydroxymethyltransferase

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0.000009

(+/-)-methyl 5-[3-(6-amino-5-cyano-4-isopropyl-3-methyl-1,4-dihydropyrano[2,3-c]pyrazol-4-yl)-5-cyanophenyl]thiophene-2-carboxylate

Plasmodium berghei

at pH 7.0, temperature not specified in the publication

757384

0.00037

(4R)-6-amino-4-(5-cyano-3'-fluoro[1,1'-biphenyl]-3-yl)-3-methyl-4-(propan-2-yl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

Plasmodium falciparum

at pH 7.0, temperature not specified in the publication

757384

0.00047

(4S)-6-amino-4-(5-cyano-3'-fluoro[1,1'-biphenyl]-3-yl)-3-methyl-4-(propan-2-yl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

Plasmodium falciparum

at pH 7.0, temperature not specified in the publication

757384

0.15

1843U89

Plasmodium falciparum

in 50 mM Tris-HCl pH 8.0, at 37°C

705603

0.00022

3'-[6-amino-5-cyano-3-methyl-4-(propan-2-yl)-2,4-dihydropyrano[2,3-c]pyrazol-4-yl]-5'-cyano[1,1'-biphenyl]-3-carboxylic acid

Plasmodium falciparum

at pH 7.0, temperature not specified in the publication

757384

0.00027

5-[3-[6-amino-5-cyano-3-methyl-4-(propan-2-yl)-2,4-dihydropyrano[2,3-c]pyrazol-4-yl]-5-cyanophenyl]-N,N-dimethylthiophene-2-carboxamide

Plasmodium falciparum

at pH 7.0, temperature not specified in the publication

757384

0.00048

6-amino-3-methyl-4-[3-(morpholin-4-yl)-5-(trifluoromethyl)phenyl]-4-(propan-2-yl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

Plasmodium falciparum

at pH 7.0, temperature not specified in the publication

757384

0.00029

6-amino-4-(3,5-dichlorophenyl)-3-methyl-4-(propan-2-yl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

Plasmodium falciparum

at pH 7.0, temperature not specified in the publication

757384

0.00021

6-amino-4-(5-cyano-3'-fluoro[1,1'-biphenyl]-3-yl)-3-methyl-4-(propan-2-yl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

Plasmodium falciparum

at pH 7.0, temperature not specified in the publication

757384

0.15

AG331

Plasmodium falciparum

in 50 mM Tris-HCl pH 8.0, at 37°C

705603

0.2

AG337

Plasmodium falciparum

in 50 mM Tris-HCl pH 8.0, at 37°C

705603

0.00017

benzyl 5-[3-[(4S)-6-amino-5-cyano-3-methyl-4-(propan-2-yl)-2,4-dihydropyrano[2,3-c]pyrazol-4-yl]-5-cyanophenyl]thiophene-2-carboxylate

Plasmodium falciparum

at pH 7.0, temperature not specified in the publication

757384

0.00042

benzyl 5-[3-[6-amino-5-cyano-3-methyl-4-(propan-2-yl)-2,4-dihydropyrano[2,3-c]pyrazol-4-yl]-5-cyanophenyl]thiophene-2-carboxylate

Plasmodium falciparum

at pH 7.0, temperature not specified in the publication

757384

0.5

D1694

Plasmodium falciparum

IC50 above 0.5 mM, in 50 mM Tris-HCl pH 8.0, at 37°C

705603

0.00056

ethyl 4-[[3-[6-amino-5-cyano-3-methyl-4-(propan-2-yl)-2,4-dihydropyrano[2,3-c]pyrazol-4-yl]-5-cyanophenyl](methyl)amino]butanoate

Plasmodium falciparum

at pH 7.0, temperature not specified in the publication

757384

0.15

GR1

Plasmodium falciparum

in 50 mM Tris-HCl pH 8.0, at 37°C

705603

30 - 70

leucovorin

2 entries

0.5

methotrexate

Plasmodium falciparum

IC50 above 0.5 mM, in 50 mM Tris-HCl pH 8.0, at 37°C

705603

0.00021

methyl 3'-[6-amino-5-cyano-3-methyl-4-(propan-2-yl)-2,4-dihydropyrano[2,3-c]pyrazol-4-yl]-5'-chloro[1,1'-biphenyl]-4-carboxylate

Plasmodium falciparum

at pH 7.0, temperature not specified in the publication

757384

0.00542

methyl 5-[3-[(4R)-6-amino-5-cyano-3-methyl-4-(propan-2-yl)-2,4-dihydropyrano[2,3-c]pyrazol-4-yl]-5-cyanophenyl]thiophene-2-carboxylate

Plasmodium falciparum

at pH 7.0, temperature not specified in the publication

757384

0.00006

methyl 5-[3-[(4S)-6-amino-5-cyano-3-methyl-4-(propan-2-yl)-2,4-dihydropyrano[2,3-c]pyrazol-4-yl]-5-cyanophenyl]thiophene-2-carboxylate

Plasmodium falciparum

at pH 7.0, temperature not specified in the publication

757384

0.00037

methyl 5-[3-[6-amino-5-cyano-3-methyl-4-(propan-2-yl)-2,4-dihydropyrano[2,3-c]pyrazol-4-yl]-5-cyanophenyl]thiophene-2-carboxylate

Plasmodium falciparum

at pH 7.0, temperature not specified in the publication

757384

0.5

permetrexed

Plasmodium falciparum

IC50 above 0.5 mM, in 50 mM Tris-HCl pH 8.0, at 37°C

705603

0.5

pyrimethamine

Plasmodium falciparum

IC50 above 0.5 mM, in 50 mM Tris-HCl pH 8.0, at 37°C

705603

0.125

WR99210

Plasmodium falciparum

in 50 mM Tris-HCl pH 8.0, at 37°C

705603