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Literature summary for 2.1.2.1 extracted from

  • Lewis, R.M.; Godfrey, K.M.; Jackson, A.A.; Cameron, I.T.; Hanson, M.A.
    Low serine hydroxymethyltransferase activity in the human placenta has important implications for fetal glycine supply (2005), J. Clin. Endocrinol. Metab., 90, 1594-1598.
    View publication on PubMed
Search for more literature for 2.1.2.1

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-Ser + tetrahydrofolate Ovis aries placental conversion of serine to glycine is a major source of fetal glycine Gly + 5,10-methylenetetrahydrofolate
-
 ?
additional information Homo sapiens low activity in placenta suggests that placental conversion of serine to glycine is not a major source of fetal glycine ?
-
 ?
additional information Rattus norvegicus low activity in placenta suggests that placental conversion of serine to glycine is not a major source of fetal glycine ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Ovis aries
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta low activity Rattus norvegicus
-
placenta activity per gram of placenta increases 2.1fold between midgestation and term Ovis aries
-
placenta low activity, activity is similar 8 weeks post conception and at term Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Ser + tetrahydrofolate placental conversion of serine to glycine is a major source of fetal glycine Ovis aries Gly + 5,10-methylenetetrahydrofolate
-
 ?
additional information low activity in placenta suggests that placental conversion of serine to glycine is not a major source of fetal glycine Homo sapiens ?
-
 ?
additional information low activity in placenta suggests that placental conversion of serine to glycine is not a major source of fetal glycine Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
SHMT
-
 Homo sapiens
SHMT
-
 Rattus norvegicus
SHMT
-
 Ovis aries