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Disease on EC 2.1.2.1 - glycine hydroxymethyltransferase

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DISEASE
TITLE OF PUBLICATION
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Acidosis
Increased activity of renal glycine-cleavage-enzyme complex in metabolic acidosis.
Adenocarcinoma
Association of MTHFR C677T and SHMT(1) C1420T with susceptibility to ESCC and GCA in a high incident region of Northern China.
Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-d]pyrimidine Inhibitor Targeting Mitochondrial and Cytosolic One-Carbon Metabolism.
One carbon metabolism in human lung cancer.
[Correlations between Serine Hydroxymethyltransferase1 C1420T Polymorphisms and Susceptibilities to Esophageal Squamous Cell Carcinoma and Gastric Cardiac Adenocarcinoma.]
Adenocarcinoma of Lung
Cytosolic serine hydroxymethyltransferase controls lung adenocarcinoma cells migratory ability by modulating AMP kinase activity.
Identification of SHMT2 as a Potential Prognostic Biomarker and Correlating with Immune Infiltrates in Lung Adenocarcinoma.
miR-198 targets SHMT1 to inhibit cell proliferation and enhance cell apoptosis in lung adenocarcinoma.
MiR-218-5p Suppresses the Killing Effect of Natural Killer Cell to Lung Adenocarcinoma by Targeting SHMT1.
Modelling of SHMT1 riboregulation predicts dynamic changes of serine and glycine levels across cellular compartments.
Adenoma
Dietary intake of B-vitamins, polymorphisms in thymidylate synthase and serine hydroxymethyltransferase 1, and colorectal adenoma risk: a Dutch case-control study.
Adrenocortical Carcinoma
Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism.
Alopecia
Risk genotypes in folate-dependent enzymes and their association with methotrexate-related side effects in rheumatoid arthritis.
Anemia
Disruption of the mouse Shmt2 gene confers embryonic anaemia via foetal liver-specific metabolomic disorders.
Anemia, Hypochromic
Arabidopsis photorespiratory serine hydroxymethyltransferase activity requires the mitochondrial accumulation of ferredoxin-dependent glutamate synthase.
Arthritis, Rheumatoid
Genetic polymorphisms in key methotrexate pathway genes are associated with response to treatment in rheumatoid arthritis patients.
Breast Neoplasms
Aberrations in one-carbon metabolism induce oxidative DNA damage in sporadic breast cancer.
Association of aberrations in one-carbon metabolism with molecular phenotype and grade of breast cancer.
Bioinformatics analysis of the serine and glycine pathway in cancer cells.
Circ_0072995 Promotes Cell Carcinogenesis via Up-Regulating miR-149-5p-Mediated SHMT2 in Breast Cancer.
Clinical significance of SHMT1 rs1979277 polymorphism in Asian solid tumors: evidence from a meta-analysis.
EIF2A promotes cell survival during paclitaxel treatment in vitro and in vivo.
ERR? activates SHMT2 transcription to enhance the resistance of breast cancer to lapatinib via modulating the mitochondrial metabolic adaption.
Folate-mediated one-carbon metabolism: a targeting strategy in cancer therapy.
Genetic polymorphisms in the one-carbon metabolism pathway and breast cancer risk: a population-based case-control study and meta-analyses.
Genetic variants in one-carbon metabolism genes and breast cancer risk in European American and African American women.
In silico analysis of the structural and functional implications of SLC19A1 R27H polymorphism.
Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism.
No association between cSHMT genotypes and the risk of breast cancer in the Nurses' Health Study.
Polymorphism of cytosolic serine hydroxymethyltransferase and breast cancer risk: evidence from a meta-analysis.
Polymorphism of cytosolic serine hydroxymethyltransferase, estrogen and breast cancer risk among Chinese women in Taiwan.
Population-level diversity in the association of genetic polymorphisms of one-carbon metabolism with breast cancer risk.
Positive correlation between expression level of mitochondrial serine hydroxymethyltransferase and breast cancer grade.
Prognostic and therapeutic value of mitochondrial serine hydroxyl-methyltransferase 2 as a breast cancer biomarker.
Proteomic profiling of breast cancer metabolism identifies SHMT2 and ASCT2 as prognostic factors.
Roles of Mitochondrial Serine Hydroxymethyltransferase 2 (SHMT2) in Human Carcinogenesis.
Site-specific metabolic phenotypes in metastatic breast cancer.
[Polymorphic variants of folate metabolizing genes (C677T and A1298C MTHFR, C1420T SHMT1 and G1958A MTHFD) are not associated with the risk of breast cancer in West Siberian Region of Russia].
Carcinogenesis
Association of MTHFR C677T and SHMT(1) C1420T with susceptibility to ESCC and GCA in a high incident region of Northern China.
Azoxymethane-induced colon carcinogenesis in mice occurs independently of de novo thymidylate synthesis capacity.
Circ_0072995 Promotes Cell Carcinogenesis via Up-Regulating miR-149-5p-Mediated SHMT2 in Breast Cancer.
Cytoplasmic SHMT2 drives the progression and metastasis of colorectal cancer by inhibiting ?-catenin degradation.
Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis.
DNMT3B C46359T and SHMT1 C1420T polymorphisms in the folate pathway in carcinogenesis of head and neck.
Downregulating serine hydroxymethyltransferase 2 (SHMT2) suppresses tumorigenesis in human hepatocellular carcinoma.
Roles of Mitochondrial Serine Hydroxymethyltransferase 2 (SHMT2) in Human Carcinogenesis.
Serine hydroxymethyltransferase 2 expression promotes tumorigenesis in rhabdomyosarcoma with 12q13-q14 amplification.
Carcinoma
Association of MTHFR C677T and SHMT(1) C1420T with susceptibility to ESCC and GCA in a high incident region of Northern China.
Deciphering tissue-based proteome signatures revealed novel subtyping and prognostic markers for thymic epithelial tumors.
Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma.
Increased Expression of SHMT2 Is Associated With Poor Prognosis and Advanced Pathological Grade in Oral Squamous Cell Carcinoma.
Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism.
Molecular cloning, characterization and alternative splicing of the human cytoplasmic serine hydroxymethyltransferase gene.
Polymorphisms and haplotypes of serine hydroxymethyltransferase and risk of squamous cell carcinoma of the head and neck: a case-control analysis.
Regular Multivitamin Supplement Use, Single Nucleotide Polymorphisms in ATIC, SHMT2, and SLC46A1, and Risk of Ovarian Carcinoma.
Silencing SHMT2 inhibits the progression of tongue squamous cell carcinoma through cell cycle regulation.
The effect of L-2-amino-4-methoxy-trans-3-butenoic acid on serine hydroxymethyl transferase.
[Correlations between Serine Hydroxymethyltransferase1 C1420T Polymorphisms and Susceptibilities to Esophageal Squamous Cell Carcinoma and Gastric Cardiac Adenocarcinoma.]
Carcinoma, Hepatocellular
Downregulating serine hydroxymethyltransferase 2 (SHMT2) suppresses tumorigenesis in human hepatocellular carcinoma.
Enzymic imbalance in serine metabolism in rat hepatomas.
Increased Expression of Serine Hydroxymethyltransferase 2 (SHMT2) is a Negative Prognostic Marker in Patients with Hepatocellular Carcinoma and is Associated with Proliferation of HepG2 Cells.
Roles of Mitochondrial Serine Hydroxymethyltransferase 2 (SHMT2) in Human Carcinogenesis.
The modulation of serine metabolism in hepatoma 3924A during different phases of cellular proliferation in culture.
[Serine transhydroxymethylase of cells and subcellular structures of liver and hepatoma]
Carcinoma, Ovarian Epithelial
Genetic variation in the one-carbon transfer pathway and ovarian cancer risk.
Carcinoma, Squamous Cell
Deciphering tissue-based proteome signatures revealed novel subtyping and prognostic markers for thymic epithelial tumors.
Polymorphisms and haplotypes of serine hydroxymethyltransferase and risk of squamous cell carcinoma of the head and neck: a case-control analysis.
Silencing SHMT2 inhibits the progression of tongue squamous cell carcinoma through cell cycle regulation.
Cardiovascular Diseases
Genetic modifiers of folate, vitamin B-12, and homocysteine status in a cross-sectional study of the Canadian population.
Polymorphisms in cytoplasmic serine hydroxymethyltransferase and methylenetetrahydrofolate reductase affect the risk of cardiovascular disease in men.
Polymorphisms in serine hydroxymethyltransferase 1 and methylenetetrahydrofolate reductase interact to increase cardiovascular disease risk in humans.
Cholangiocarcinoma
SHMT2 Overexpression Predicts Poor Prognosis in Intrahepatic Cholangiocarcinoma.
Cleft Lip
A SHMT1 variant decreases the risk of nonsyndromic cleft lip with or without cleft palate in Chile.
Cleft Palate
A SHMT1 variant decreases the risk of nonsyndromic cleft lip with or without cleft palate in Chile.
Colonic Neoplasms
Azoxymethane-induced colon carcinogenesis in mice occurs independently of de novo thymidylate synthesis capacity.
Long noncoding RNA LINC01234 promotes serine hydroxymethyltransferase 2 expression and proliferation by competitively binding miR-642a-5p in colon cancer.
Polymorphisms in methionine synthase, methionine synthase reductase and serine hydroxymethyltransferase, folate and alcohol intake, and colon cancer risk.
SHMT1 1420 and MTHFR 677 variants are associated with rectal but not colon cancer.
[RETRACTED: Serine hydroxymethyl transferase 2 regulates the AMPK/mTOR pathway and induces autophagy to promote chemotherapy resistance in colon cancer cells].
[Serine hydroxymethyl transferase 2 regulates the AMPK/mTOR pathway and induces autophagy to promote chemotherapy resistance in colon cancer cells].
Colorectal Neoplasms
A meta-analysis of the C1420T polymorphism in cytosolic serine hydroxymethyltransferase (SHMT1) among Caucasian colorectal cancer populations.
Association between cytosolic serine hydroxymethyltransferase (SHMT1) gene polymorphism and cancer risk: a meta-analysis.
Cytoplasmic SHMT2 drives the progression and metastasis of colorectal cancer by inhibiting ?-catenin degradation.
Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis.
Genetic modifiers of folate, vitamin B-12, and homocysteine status in a cross-sectional study of the Canadian population.
High expression of SHMT2 is correlated with tumor progression and predicts poor prognosis in gastrointestinal tumors.
Impact of SHMT1 polymorphism on the clinical outcome of patients with metastatic colorectal cancer treated with first-line FOLFIRI+bevacizumab.
The importance of mitochondrial folate enzymes in human colorectal cancer.
The loss of SHMT2 mediates 5-fluorouracil chemoresistance in colorectal cancer by upregulating autophagy.
Communicable Diseases
Cloning and characterization of Plasmodium vivax serine hydroxymethyltransferase.
Coronary Artery Disease
Oxidative Stress is Associated with Genetic Polymorphisms in One-Carbon Metabolism in Coronary Artery Disease.
Cysts
Engineered resistance and hypersusceptibility through functional metabolic studies of 100 genes in soybean to its major pathogen, the soybean cyst nematode.
Genome reorganization of the GmSHMT gene family in soybean showed a lack of functional redundancy in resistance to soybean cyst nematode.
Impaired folate binding of serine hydroxymethyltransferase 8 from soybean underlies resistance to the soybean cyst nematode.
Soybean Cyst Nematode Resistance Emerged via Artificial Selection of Duplicated Serine Hydroxymethyltransferase Genes.
Down Syndrome
Polymorphism C1420T of Serine hydroxymethyltransferase gene on maternal risk for Down syndrome.
Epilepsy
A high frequency of the MTHFR 677C>T polymorphism in Scottish women with epilepsy: possible role in pathogenesis.
Esophageal Neoplasms
High expression of SHMT2 is correlated with tumor progression and predicts poor prognosis in gastrointestinal tumors.
Esophageal Squamous Cell Carcinoma
Association of MTHFR C677T and SHMT(1) C1420T with susceptibility to ESCC and GCA in a high incident region of Northern China.
[Correlations between Serine Hydroxymethyltransferase1 C1420T Polymorphisms and Susceptibilities to Esophageal Squamous Cell Carcinoma and Gastric Cardiac Adenocarcinoma.]
Essential Hypertension
Serine hydroxymethyltransferase 1 promoter hypermethylation increases the risk of essential hypertension.
Fatty Liver
Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease.
Folic Acid Deficiency
Effect of dietary folic acid deficiency on serine-glycine interconversion and the activity of liver serine hydroxymethyl transferase in the chick.
Glioblastoma
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.
Glioma
Effect of methionine, glycine and serine on serine hydroxymethyltransferase activity in rat glioma and human neuroblastoma cells.
Mitochondrial serine hydroxymethyltransferase 2 is a potential diagnostic and prognostic biomarker for human glioma.
Overexpression of mitochondrial serine hydroxyl-methyltransferase 2 is associated with poor prognosis and promotes cell proliferation and invasion in gliomas.
Serine-dependent redox homeostasis regulates glioblastoma cell survival.
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.
glycine hydroxymethyltransferase deficiency
Disruption of the mouse Shmt2 gene confers embryonic anaemia via foetal liver-specific metabolomic disorders.
Head and Neck Neoplasms
DNMT3B C46359T and SHMT1 C1420T polymorphisms in the folate pathway in carcinogenesis of head and neck.
Gene Polymorphisms Involved in Folate Metabolism and DNA Methylation with the Risk of Head and Neck Cancer.
Heart Defects, Congenital
Maternal and infant genetic variants, maternal periconceptional use of selective serotonin reuptake inhibitors, and risk of congenital heart defects in offspring: population based study.
Hepatitis B
Increased Expression of Serine Hydroxymethyltransferase 2 (SHMT2) is a Negative Prognostic Marker in Patients with Hepatocellular Carcinoma and is Associated with Proliferation of HepG2 Cells.
Hodgkin Disease
Nutrients and Genetic Variation Involved in One-Carbon Metabolism and Hodgkin Lymphoma Risk: A Population-based Case-Control Study.
Hyperglycemia
Loss of PYCR2 Causes Neurodegeneration by Increasing Cerebral Glycine Levels via SHMT2.
Hyperhomocysteinemia
Serine hydroxymethyltransferase 1 promoter hypermethylation increases the risk of essential hypertension.
Hyperphosphatemia
Role of Cytosolic Serine Hydroxymethyl Transferase 1 (SHMT1) in Phosphate-Induced Vascular Smooth Muscle Cell Calcification.
Hypertension
Impact of SHMT1 polymorphism on the clinical outcome of patients with metastatic colorectal cancer treated with first-line FOLFIRI+bevacizumab.
Serine hydroxymethyltransferase 1 promoter hypermethylation increases the risk of essential hypertension.
Infections
Increased Expression of Serine Hydroxymethyltransferase 2 (SHMT2) is a Negative Prognostic Marker in Patients with Hepatocellular Carcinoma and is Associated with Proliferation of HepG2 Cells.
Intestinal Neoplasms
Shmt1 heterozygosity impairs folate-dependent thymidylate synthesis capacity and modifies risk of apcmin-mediated intestinal cancer risk.
SHMT1 inhibits the metastasis of HCC by repressing NOX1-mediated ROS production.
Ischemic Stroke
Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17 genes involved in methionine metabolism.
The association between serine hydroxymethyl transferase 1 gene hypermethylation and ischemic stroke.
Kidney Neoplasms
Evaluating the clinical significance of SHMT2 and its co-expressed gene in human kidney cancer.
Leukemia
Association of Thymidylate Synthase 5'-UTR 28bp Tandem Repeat and Serine Hydroxymethyltransfarase C1420T Polymorphisms with Susceptibility to Acute Leukemia.
C1420T Polymorphism of Cytosolic Serine Hydroxymethyltransferase and Risk of Cancer: a Meta-analysis.
Inhibition of glycinamide ribonucleotide formyltransferase and other folate enzymes by homofolate polyglutamates in human lymphoma and murine leukemia cell extracts.
Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy.
Thymidylate synthetase and serine transhydroxymethylase activities in preleukemic disorders of erythropoiesis and acute leukemia.
Leukemia, Experimental
[Study of serine hydroxymethyltransferase in experimental leukemias]
Leukemia, Myeloid, Acute
Evaluation of LKB1 and Serine-Glycine Metabolism Pathway Genes (SHMT1 and GLDC) Expression in AML.
Genetic variation in the folate metabolic pathway and risk of childhood leukemia.
Liver Neoplasms
Downregulating serine hydroxymethyltransferase 2 (SHMT2) suppresses tumorigenesis in human hepatocellular carcinoma.
Increased Expression of Serine Hydroxymethyltransferase 2 (SHMT2) is a Negative Prognostic Marker in Patients with Hepatocellular Carcinoma and is Associated with Proliferation of HepG2 Cells.
The RFC1 80G>A, among Common One-Carbon Polymorphisms, Relates to Survival Rate According to DNA Global Methylation in Primary Liver Cancers.
Lung Neoplasms
A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic serine hydroxymethyltransferase and induces cell death in lung cancer cells.
Comprehensive evaluation of the response of genes to the administration of the antitumor drug S-1 using a low density array.
Differential inhibitory effect of a pyrazolopyran compound on human serine hydroxymethyltransferase-amino acid complexes.
Modelling of SHMT1 riboregulation predicts dynamic changes of serine and glycine levels across cellular compartments.
One carbon metabolism in human lung cancer.
Polymorphisms of cytosolic serine hydroxymethyltransferase and risk of lung cancer: a case-control analysis.
Roles of Mitochondrial Serine Hydroxymethyltransferase 2 (SHMT2) in Human Carcinogenesis.
SHMT1 inhibits the metastasis of HCC by repressing NOX1-mediated ROS production.
SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation.
The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells.
Lymphatic Metastasis
High expression of SHMT2 is correlated with tumor progression and predicts poor prognosis in gastrointestinal tumors.
Lymphoma
Associations between polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and susceptibility to malignant lymphoma.
Inhibition of glycinamide ribonucleotide formyltransferase and other folate enzymes by homofolate polyglutamates in human lymphoma and murine leukemia cell extracts.
The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing.
Lymphoma, Non-Hodgkin
Genetic polymorphisms in the one-carbon metabolism pathway genes and susceptibility to non-Hodgkin lymphoma.
SHMT1 C1420T polymorphism contributes to the risk of non-Hodgkin lymphoma: evidence from 7309 patients.
Lymphoma, T-Cell
Therapeutic targeting of the mitochondrial one-carbon pathway: perspectives, pitfalls, and potential.
Malaria
Plasmodium serine hydroxymethyltransferase: indispensability and display of distinct localization.
Possible selection of host folate pathway gene polymorphisms in patients with malaria from a malaria endemic region in North East India.
Vitamin B6-dependent enzymes in the human malaria parasite Plasmodium falciparum: a druggable target?
Multiple Sclerosis
Association of SHMT1, MAZ, ERG, and L3MBTL3 Gene Polymorphisms with Susceptibility to Multiple Sclerosis.
Neoplasm Metastasis
Cytoplasmic SHMT2 drives the progression and metastasis of colorectal cancer by inhibiting ?-catenin degradation.
Cytosolic serine hydroxymethyltransferase controls lung adenocarcinoma cells migratory ability by modulating AMP kinase activity.
Gene expression signatures of primary and metastatic uterine leiomyosarcoma.
High expression of SHMT2 is correlated with tumor progression and predicts poor prognosis in gastrointestinal tumors.
Overexpression of SHMT2 Predicts a Poor Prognosis and Promotes Tumor Cell Growth in Bladder Cancer.
Prognostic and therapeutic value of mitochondrial serine hydroxyl-methyltransferase 2 as a breast cancer biomarker.
SHMT1 inhibits the metastasis of HCC by repressing NOX1-mediated ROS production.
Neoplasms
A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic serine hydroxymethyltransferase and induces cell death in lung cancer cells.
A Review of Small-Molecule Inhibitors of One-Carbon Enzymes: SHMT2 and MTHFD2 in the Spotlight.
Activities of serine hydroxymethyltransferase in murine tissues and tumours.
An amphiphilic graft copolymer-based nanoparticle platform for reduction-responsive anticancer and antimalarial drug delivery.
Arsenic trioxide targets MTHFD1 and SUMO-dependent nuclear de novo thymidylate biosynthesis.
Association between cytosolic serine hydroxymethyltransferase (SHMT1) gene polymorphism and cancer risk: a meta-analysis.
Azoxymethane-induced colon carcinogenesis in mice occurs independently of de novo thymidylate synthesis capacity.
C1420T Polymorphism of Cytosolic Serine Hydroxymethyltransferase and Risk of Cancer: a Meta-analysis.
Cancer cell resistance to aurora kinase inhibitors: identification of novel targets for cancer therapy.
Cancer proteome and metabolite changes linked to SHMT2.
Circ_0072995 Promotes Cell Carcinogenesis via Up-Regulating miR-149-5p-Mediated SHMT2 in Breast Cancer.
Clinical significance of SHMT1 rs1979277 polymorphism in Asian solid tumors: evidence from a meta-analysis.
Cloning and characterization of Plasmodium vivax serine hydroxymethyltransferase.
Cloning, expression, activity and folding studies of serine hydroxymethyltransferase: a target enzyme for cancer chemotherapy.
Comparative oncogenomics identifies PSMB4 and SHMT2 as potential cancer driver genes.
Cooperative interactions of tetrahydrofolate with purified pig kidney serine transhydroxymethylase and loss of this cooperativity in L1210 tumors and in tissues of mice bearing these tumors.
Cytoplasmic SHMT2 drives the progression and metastasis of colorectal cancer by inhibiting ?-catenin degradation.
Cytosolic serine hydroxymethyltransferase controls lung adenocarcinoma cells migratory ability by modulating AMP kinase activity.
Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis.
Dietary Uridine Decreases Tumorigenesis in the ApcMin/+ Model of Intestinal Cancer.
Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming.
Differential inhibitory effect of a pyrazolopyran compound on human serine hydroxymethyltransferase-amino acid complexes.
DNMT3B C46359T and SHMT1 C1420T polymorphisms in the folate pathway in carcinogenesis of head and neck.
Downregulating serine hydroxymethyltransferase 2 (SHMT2) suppresses tumorigenesis in human hepatocellular carcinoma.
Drosha-independent miR-6778-5p strengthens gastric cancer stem cell stemness via regulation of cytosolic one-carbon folate metabolism.
EIF2A promotes cell survival during paclitaxel treatment in vitro and in vivo.
Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma.
Evaluating the clinical significance of SHMT2 and its co-expressed gene in human kidney cancer.
Expression of Glucose Metabolism-Related Proteins in Adrenal Neoplasms.
Expression of metabolism-related proteins in invasive lobular carcinoma: comparison to invasive ductal carcinoma.
Expression of serine and glycine-related enzymes in phyllodes tumor.
Folate-mediated one-carbon metabolism: a targeting strategy in cancer therapy.
Genetic variation in the folate metabolic pathway and risk of childhood leukemia.
Genetic variation in the one-carbon transfer pathway and ovarian cancer risk.
Glycine by MR spectroscopy is an imaging biomarker of glioma aggressiveness.
Glycine consumption and mitochondrial serine hydroxymethyltransferase in cancer cells: The heme connection.
Glycine supplementation in vitro enhances porcine preimplantation embryo cell number and decreases apoptosis but does not lead to live births.
High Expression of Serine Hydroxymethyltransferase 2 Indicates Poor Prognosis of Gastric Cancer Patients.
High expression of SHMT2 is correlated with tumor progression and predicts poor prognosis in gastrointestinal tumors.
How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state.
Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma.
HybridSucc: A Hybrid-learning Architecture for General and Species-specific Succinylation Site Prediction.
Identification of three new compounds that directly target human serine hydroxymethyltransferase 2.
Implication of the folate-methionine metabolism pathways in susceptibility to follicular lymphomas.
In vivo MR studies of glycine and glutathione metabolism in a rat mammary tumor.
Increased expression of cSHMT, Tbx3 and utrophin in plasma of ovarian and breast cancer patients.
Increased Expression of Serine Hydroxymethyltransferase 2 (SHMT2) is a Negative Prognostic Marker in Patients with Hepatocellular Carcinoma and is Associated with Proliferation of HepG2 Cells.
Increased Expression of SHMT2 Is Associated With Poor Prognosis and Advanced Pathological Grade in Oral Squamous Cell Carcinoma.
Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism.
Metformin Is a Pyridoxal-5'-phosphate (PLP)-Competitive Inhibitor of SHMT2.
MiR-218-5p Suppresses the Killing Effect of Natural Killer Cell to Lung Adenocarcinoma by Targeting SHMT1.
Mitochondrial serine hydroxymethyltransferase 2 is a potential diagnostic and prognostic biomarker for human glioma.
Modelling of SHMT1 riboregulation predicts dynamic changes of serine and glycine levels across cellular compartments.
Molecular organization, catalytic mechanism and function of serine hydroxymethyltransferase--a potential target for cancer chemotherapy.
Mouse genetics suggests cell-context dependency for Myc-regulated metabolic enzymes during tumorigenesis.
NAD- and NADPH-Contributing Enzymes as Therapeutic Targets in Cancer: An Overview.
New Mechanism of Bone Cancer Pain: Tumor Tissue-Derived Endogenous Formaldehyde Induced Bone Cancer Pain via TRPV1 Activation.
Novel pyrrolo[3,2-d]pyrimidine compounds target mitochondrial and cytosolic one-carbon metabolism with broad-spectrum antitumor efficacy.
Nucleotide biosynthesis arrest by silencing SHMT1 function via vitamin B6-coupled vector and effects on tumor growth inhibition.
One-carbon genetic variants and the role of MTHFD1 1958G>A in liver and colon cancer risk according to global DNA methylation.
Overexpression of mitochondrial serine hydroxyl-methyltransferase 2 is associated with poor prognosis and promotes cell proliferation and invasion in gliomas.
Overexpression of SHMT2 Predicts a Poor Prognosis and Promotes Tumor Cell Growth in Bladder Cancer.
Polymorphisms of cytosolic serine hydroxymethyltransferase and risk of lung cancer: a case-control analysis.
Positive correlation between expression level of mitochondrial serine hydroxymethyltransferase and breast cancer grade.
Prognostic and therapeutic value of mitochondrial serine hydroxyl-methyltransferase 2 as a breast cancer biomarker.
Pyruvate kinase is a dosage-dependent regulator of cellular amino acid homeostasis.
Roles of Mitochondrial Serine Hydroxymethyltransferase 2 (SHMT2) in Human Carcinogenesis.
Serine catabolism regulates mitochondrial redox control during hypoxia.
Serine hydroxymethyl transferase 1 stimulates pro-oncogenic cytokine expression through sialic acid to promote ovarian cancer tumor growth and progression.
Serine hydroxymethyltransferase 2: a novel target for human cancer therapy.
SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia.
SHMT1 1420 and MTHFR 677 variants are associated with rectal but not colon cancer.
SHMT1 C1420T polymorphism contributes to the risk of non-Hodgkin lymphoma: evidence from 7309 patients.
SHMT1 inhibits the metastasis of HCC by repressing NOX1-mediated ROS production.
SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation.
SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation.
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.
SHMT2 expression as a diagnostic and prognostic marker for thyroid cancer.
SHMT2 Overexpression Predicts Poor Prognosis in Intrahepatic Cholangiocarcinoma.
Silencing SHMT2 inhibits the progression of tongue squamous cell carcinoma through cell cycle regulation.
Study of SHMT2 Inhibitors and Their Binding Mechanism by Computational Alanine Scanning.
Succinate Anaplerosis Has an Onco-Driving Potential in Prostate Cancer Cells.
The crystal structure of human cytosolic serine hydroxymethyltransferase: a target for cancer chemotherapy.
The effect of L-2-amino-4-methoxy-trans-3-butenoic acid on serine hydroxymethyl transferase.
The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism.
The one-carbon metabolism pathway highlights therapeutic targets for gastrointestinal cancer (Review).
The role of the folate pathway in pancreatic cancer risk.
The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing.
Therapeutic Targeting of Mitochondrial One-Carbon Metabolism in Cancer.
Therapeutic targeting of the mitochondrial one-carbon pathway: perspectives, pitfalls, and potential.
Tumor Reliance on Cytosolic versus Mitochondrial One-Carbon Flux Depends on Folate Availability.
[Polymorphic variants of folate metabolizing genes (C677T and A1298C MTHFR, C1420T SHMT1 and G1958A MTHFD) are not associated with the risk of breast cancer in West Siberian Region of Russia].
[Regulation of serine hydroxymethyltransferase activity in normal, tumor, and host cells]
Neural Tube Defects
Dietary folate, but not choline, modifies neural tube defect risk in Shmt1 knockout mice.
Dietary Uridine Decreases Tumorigenesis in the ApcMin/+ Model of Intestinal Cancer.
Genetic modifiers of folate, vitamin B-12, and homocysteine status in a cross-sectional study of the Canadian population.
Interaction between Maternal and Paternal SHMT1 C1420T Predisposes to Neural Tube Defects in the Fetus: Evidence from Case-Control and Family-Based Triad Approaches.
Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice.
Neuroblastoma
Effect of methionine, glycine and serine on serine hydroxymethyltransferase activity in rat glioma and human neuroblastoma cells.
Molecular cloning, characterization and alternative splicing of the human cytoplasmic serine hydroxymethyltransferase gene.
Serine catabolism regulates mitochondrial redox control during hypoxia.
Ovarian Neoplasms
Genetic variation in the one-carbon transfer pathway and ovarian cancer risk.
Serine hydroxymethyl transferase 1 stimulates pro-oncogenic cytokine expression through sialic acid to promote ovarian cancer tumor growth and progression.
SHMT1 inhibits the metastasis of HCC by repressing NOX1-mediated ROS production.
Pancreatic Neoplasms
Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-d]pyrimidine Inhibitor Targeting Mitochondrial and Cytosolic One-Carbon Metabolism.
Papilledema
Association of Genetics and B Vitamin Status With the Magnitude of Optic Disc Edema During 30-Day Strict Head-Down Tilt Bed Rest.
Parkinson Disease
The role of the one-carbon cycle in neuropsychiatric disease.
Phyllodes Tumor
Expression of serine and glycine-related enzymes in phyllodes tumor.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Association Between SHMT1 rs1979277 Polymorphism and Risk of Acute Lymphoblastic Leukemia: A Systematic Review and Meta-analysis.
Association of SHMT1 gene polymorphisms with the risk of childhood acute lymphoblastic leukemia in a sample of Iranian population.
Associations between polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and susceptibility to malignant lymphoma.
Genetic variation in the folate metabolic pathway and risk of childhood leukemia.
Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy.
Prostatic Neoplasms
Associations of Folate, Vitamin B12, Homocysteine, and Folate-Pathway Polymorphisms with Prostate-Specific Antigen Velocity in Men with Localized Prostate Cancer.
Folate and B12 in prostate cancer.
Identification of TWIST-interacting genes in prostate cancer.
Role of polymorphic variants of MTR gene A2756G and SHMT1 gene C1420T in the development of prostatic cancer in residents of the Western Siberian Region of Russia.
Shmt2: A Stat3 Signaling New Player in Prostate Cancer Energy Metabolism.
Rectal Neoplasms
Candidate pathway polymorphisms in one-carbon metabolism and risk of rectal tumor mutations.
SHMT1 1420 and MTHFR 677 variants are associated with rectal but not colon cancer.
Renal Insufficiency, Chronic
Role of Cytosolic Serine Hydroxymethyl Transferase 1 (SHMT1) in Phosphate-Induced Vascular Smooth Muscle Cell Calcification.
Reperfusion Injury
Downregulating Serine Hydroxymethyltransferase 2 Deteriorates Hepatic Ischemia-Reperfusion Injury through ROS/JNK/P53 Signaling in Mice.
[Protective effect of serine methyltransferase against hepatic ischemia-reperfusion injury in mice].
Rhabdomyosarcoma
Serine hydroxymethyltransferase 2 expression promotes tumorigenesis in rhabdomyosarcoma with 12q13-q14 amplification.
Sarcoma
Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma.
Sheep gene mapping: additional DNA markers included (CASB, CASK, LALBA, IGF-1 and AMH).
Scrapie
2-Aminoacrylate Stress Induces a Context-Dependent Glycine Requirement in ridA Strains of Salmonella enterica.
Decreased coenzyme A levels in ridA mutant strains of Salmonella enterica result from inactivated serine hydroxymethyltransferase.
Proton Nuclear Magnetic Resonance Metabolomics Corroborates Serine Hydroxymethyltransferase as the Primary Target of 2-Aminoacrylate in a ridA Mutant of Salmonella enterica.
Small Cell Lung Carcinoma
One carbon metabolism in human lung cancer.
Smith-Magenis Syndrome
Haploinsufficiency of cytosolic serine hydroxymethyltransferase in the Smith-Magenis syndrome.
Squamous Cell Carcinoma of Head and Neck
Gene Polymorphisms Involved in Folate Metabolism and DNA Methylation with the Risk of Head and Neck Cancer.
Increased Expression of SHMT2 Is Associated With Poor Prognosis and Advanced Pathological Grade in Oral Squamous Cell Carcinoma.
Stomach Neoplasms
Drosha-independent miR-6778-5p strengthens gastric cancer stem cell stemness via regulation of cytosolic one-carbon folate metabolism.
High Expression of Serine Hydroxymethyltransferase 2 Indicates Poor Prognosis of Gastric Cancer Patients.
High expression of SHMT2 is correlated with tumor progression and predicts poor prognosis in gastrointestinal tumors.
Thyroid Cancer, Papillary
SHMT2 expression as a diagnostic and prognostic marker for thyroid cancer.
Thyroid Carcinoma, Anaplastic
SHMT2 expression as a diagnostic and prognostic marker for thyroid cancer.
Thyroid Neoplasms
SHMT2 expression as a diagnostic and prognostic marker for thyroid cancer.
Tuberculosis
Unusual structural, functional, and stability properties of serine hydroxymethyltransferase from Mycobacterium tuberculosis.
Urinary Bladder Neoplasms
Involvement of glycogen debranching enzyme in bladder cancer.
Overexpression of SHMT2 Predicts a Poor Prognosis and Promotes Tumor Cell Growth in Bladder Cancer.
Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer.
Vascular Calcification
Role of Cytosolic Serine Hydroxymethyl Transferase 1 (SHMT1) in Phosphate-Induced Vascular Smooth Muscle Cell Calcification.
Vitamin B 6 Deficiency
Elevations of serum cystathionine and total homocysteine in pyridoxine-, folate-, and cobalamin-deficient rats.
Wilms Tumor
Serine hydroxymethyl transferase 1 stimulates pro-oncogenic cytokine expression through sialic acid to promote ovarian cancer tumor growth and progression.