Reference on EC 2.1.2.1 - glycine hydroxymethyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bourguignon, J.; Neuburger, M.; Douce, R.
Resolution and characterization of the glycine-cleavage reaction in pea leaf mitochondria. Properties of the forward reaction catalysed by glycine decarboxylase and serine hydroxymethyltransferase
Biochem. J.
255
169-178
1988
Pisum sativum
Ide, H.; Hamaguchi, K.; Kobata, S.; Murakami, A.; Kimura, Y.; Makino, K.; Kamada, M.; Miyamoto, S.; Nagaya, T.; et al.
Purification of serine hydroxymethyltransferase from Bacillus stearothermophilus with ion-exchange high-performance liquid chromatography
J. Chromatogr.
596
203-209
1992
Geobacillus stearothermophilus
Henricson, D.; Ericson, I.
Serine hydroxymethyltransferase from spinach leaf mitochondria. Purification and characterization
Physiol. Plant.
74
602-606
1988
Spinacia oleracea
-
Manohar, R.; Ramesh, K.S.; Rao, N.A.
Purification, physicochemical and regulatory properties of serine hydroxymethyltransferase from sheep liver
J. Biosci.
4
31-50
1982
Ovis aries
-
Schirch, L.; Peterson, D.
Purification and properties of mitochondrial serine hydroxymethyltransferase
J. Biol. Chem.
255
7801-7806
1980
Oryctolagus cuniculus
Masuda, T.; Sakamoto, M.; Nishizaki, I.; Hayashi, H.; Yamamoto, M.; Wada, H.
Affinity purification and characterization of serine hydroxymethyltransferases from rat liver
J. Biochem.
101
643-652
1987
Rattus norvegicus
Ogawa, H.; Fujioka, M.
Purification and characterization of cytosolic and mitochondrial serine hydroxymethyltransferases from rat liver
J. Biochem.
90
381-390
1981
Rattus norvegicus, Rattus norvegicus Wistar
Schirch, L.; Gross, T.
Serine transhydroxymethylase. Identification as the threonine and allothreonine aldolases
J. Biol. Chem.
243
5651-5655
1968
Oryctolagus cuniculus
Fujioka, M.
Purification and properties of serine hydroxymethylase from soluble and mitochondrial fractions of rabbit liver
Biochim. Biophys. Acta
185
338-349
1969
Oryctolagus cuniculus
Akhtar, M.; El-Obeid, H.A.
Interaction of serine transhydroxymethylase and threonine aldolase activities
Biochim. Biophys. Acta
791
791-799
1972
Oryctolagus cuniculus
-
Ramesh, K.S.; Rao, N.A.
Purification and physicochemical, kinetic and immunological properties of allosteric serine hydroxymethyltransferase from monkey liver
Biochem. J.
187
623-636
1980
Macaca radiata
Ramesh, K.S.; Rao, N.A.
Inhibition of monkey liver serine hydroxymethyltransferase by Cibacron Blue 3G-A
Biochem. J.
187
249-252
1980
Macaca radiata
Strong, W.B.; Tendler, S.J.; Seither, R.L.; Goldman, I.D.; Schirch, V.
Purification and properties of serine hydroxymethyltransferase and C1-tetrahydrofolate synthase from L1210 cells
J. Biol. Chem.
265
12149-12155
1990
Mus musculus
Mitchell, M.K.; Reynolds, P.H.S.; Blevins, D.G.
Serine hydroxymethyltransferase from soybean root nodules
Plant Physiol.
81
553-557
1986
Glycine max, Glycine max L. Merr. cv. Williams
Rao, D.N.; Rao, N.A.
Purification and regulatory properties of mung bean (Vigna Radiata L.) serine hydroxymethyltransferase
Plant Physiol.
69
11-18
1982
Vigna radiata
Sakamoto, M.; Masuda, T.; Yanagimoto, Y.; Nakano, Y.; Kitaoka, S.
Purification and characterization of cytosolic serine hydroxymethyltransferase from Euglena gracilis z
Agric. Biol. Chem.
55
2243-2249
1991
Euglena gracilis, Euglena gracilis Z
-
Miyazaki, S.S.; Toki, S.; Izumi, Y.; Yamada, H.
Purification and characterization of a serine hydroxymethyltransferase from an obligate methylotroph, Hyphomicrobium methylovorum GM2
Eur. J. Biochem.
162
533-540
1987
Hyphomicrobium methylovorum
Miyazaki, S.S.; Toki, S.; Izumi, Y.; Yamada, H.
Futher characterization of serine hydroxymethyltransferase from a serine-producing methylotroph, Hyphomicrobium methylovorum
Agric. Biol. Chem.
51
2587-2589
1987
Hyphomicrobium methylovorum
-
Schirch, V.; Hopkins, S.; Villar, E.; Angelaccio, S.
Serine hydroxymethyltransferase from Escherichia coli: purification and properties
J. Bacteriol.
163
1-7
1985
Escherichia coli
Nakamura, K.D.; Trewyn, R.W.; Parks, L.W.
Purification and characterization of serine transhydroxy-methylase from Saccharomyces cerevisiae
Biochim. Biophys. Acta
327
328-335
1973
Saccharomyces cerevisiae, Saccharomyces cerevisiae 3701B
El-Obeid, H.A.; Akhtar, M.
Glycidaldehyde, an inhibitor directed towards the C1-units-binding site of serine transhydoxymethylase
Biochem. Soc. Trans.
1
1274-1276
1973
Oryctolagus cuniculus
-
Manohar, R.; Rao, A.G.A.; Rao, N.A.
Kinetic mechanism of the interaction of D-cycloserine with serine hydroxymethyltransferase
Biochemistry
23
4116-4122
1984
Ovis aries
Malthouse, J.P.G.; Milne, J.J.; Gariani, L.S.
A comparative study of the kinetics and stereochemistry of the serine hydroxymethyltransferase- and tryptophan synthase-catalysed exchange of the pro-2R and pro-2S protons of glycine
Biochem. J.
274
807-812
1991
Bos taurus
Stover, P.; Schirch, V.
5-Formyltetrahydrofolate polyglutamates are slow tight binding inhibitors of serine hydroxymethyltransferase
J. Biol. Chem.
266
1543-1550
1991
Oryctolagus cuniculus, Escherichia coli
Akhtar, M.; El-Obeida, H.A.; Jordan, P.M.
Mechanistic, inhibitory and stereochemical studies on cytoplasmic and mitochondrial serine transhydorxymethylases
Biochem. J.
145
159-168
1975
Oryctolagus cuniculus
Schirch, L.
Serine hydroxymethyltransferase
Adv. Enzymol. Relat. Areas Mol. Biol.
53
83-112
1982
Bos taurus, Saccharomyces cerevisiae, Cricetulus griseus, Oryctolagus cuniculus, Ovis aries, Neurospora crassa, Salmonella enterica subsp. enterica serovar Typhimurium
Kruschwitz, H.; Ren, S.; Di Salvo, M.; Schifch, V.
Expression, purification, and characterization of human cytosolic serine hydroxymethyltransferase
Protein Expr. Purif.
6
411-416
1995
Homo sapiens
Fratte, S.D.; White, R.H.; Maras, B.; Bossa, F.; Schirch, V.
Purification and properties of serine hydroxymethyltransferase from Sulfolobus solfataricus
J. Bacteriol.
179
7456-7461
1997
Saccharolobus solfataricus (Q9UWT5), Saccharolobus solfataricus, Saccharolobus solfataricus P2 (Q9UWT5)
Di Salvo, M.L.; Delle Fratte, S.; De Biase, D.; Bossa, F.; Schirch, V.
Purification and characterization of recombinant rabbit cytosolic serine hydroxymethyltransferase
Protein Expr. Purif.
13
177-183
1998
Oryctolagus cuniculus
Contestabile, R.; Paiardini, A.; Pascarella, S.; Di Salvo, M.L.; D'Aguanno, S.; Bossa, F.
L-Threonine aldolase, serine hydroxymethyltransferase and fungal alanine racemase. A subgroup of strictly related enzymes specialized for different functions
Eur. J. Biochem.
268
6508-6525
2001
Escherichia coli (P0A825), Escherichia coli
Jagath-Reddy, J.; Ganesan, K.; Savithri, H.S.; Datta, A.; Rao, N.A.
cDNA cloning, overexpression in Escherichia coli, purification and characterization of sheep liver cytosolic serine hydroxymethyltransferase
Eur. J. Biochem.
230
533-537
1995
Ovis aries
Brahatheeswaran, B.; Prakash, V.; Savithri, H.S.; Rao, N.A.
Interaction of sheep liver apo-serine hydroxymethyltransferase with pyridoxal-5'-phosphate: a physicochemical, kinetic, and thermodynamic study
Arch. Biochem. Biophys.
330
363-372
1996
Ovis aries
Appaji Rao, N.; Talwar, R.; Savithri, H.S.
Molecular organization, catalytic mechanism and function of serine hydroxymethyltransferase - a potential target for cancer chemotherapy
Int. J. Biochem. Cell Biol.
32
405-416
2000
Saccharomyces cerevisiae, Oryctolagus cuniculus, Escherichia coli, Ovis aries, Homo sapiens, Pisum sativum
Talwar, R.; Leelavathy, V.; Rao, J.V.K.; Rao, N.A.; Savithri, H.S.
Role of Pro-297 in the catalytic mechanism of sheep liver serine hydroxymethyltransferase
Biochem. J.
350
849-853
2000
Ovis aries
-
Talwar, R.; Appaji Rao, N.; Savithri, H.S.
A change in reaction specificity of sheep liver serine hydroxymethyltransferase: induction of NADH oxidation upon mutation of His230 to Tyr
Eur. J. Biochem.
267
929-934
2000
Ovis aries
Rao, J.V.K.; Prakash, V.; Appaji Rao, N.; Savithri, H.S.
The role of Glu74 and Tyr82 in the reaction catalyzed by sheep liver cytosolic serine hydroxymethyltransferase
Eur. J. Biochem.
267
5967-5976
2000
Ovis aries
Trivedi, V.; Gupta, A.; Jala, V.R.; Saravanan, P.; Rao, G.S.J.; Rao, N.A.; Savithri, H.S.; Subramanya, H.S.
Crystal structure of binary and ternary complexes of serine hydroxymethyltransferase from Bacillus stearothermophilus: insights into the catalytic mechanism
J. Biol. Chem.
277
17161-17169
2002
Geobacillus stearothermophilus
Jala, V.R.; Prakash, V.; Rao, N.A.; Savithri, H.S.
Overexpression and characterization of dimeric and tetrameric forms of recombinant serine hydroxymethyltransferase from Bacillus stearothermophilus
J. Biosci.
27
233-242
2002
Geobacillus stearothermophilus
Liu, J.Q.; Ito, S.; Dairi, T.; Itoh, N.; Kataoka, M.; Shimizu, S.; Yamada, H.
Gene cloning, nucleotide sequencing, and purification and characterization of the low-specificity L-threonine aldolase from Pseudomonas sp. strain NCIMB 10558
Appl. Environ. Microbiol.
64
549-554
1998
Escherichia coli
Ogawa, H.; Gomi, T.; Fujioka, M.
Serine hydroxymethyltransferase and threonine aldolase: are they identical?
Int. J. Biochem. Cell Biol.
32
289-301
2000
Cricetulus griseus, Oryctolagus cuniculus, Escherichia coli, Ovis aries, Homo sapiens, Neurospora crassa, Vigna radiata, Pisum sativum, Rattus norvegicus
Chave, K.J.; Snell, K.; Sanders, P.G.
Isolation and characterization of human genomic sequences encoding cytosolic serine hydroxymethyltransferase
Biochem. Soc. Trans.
25
53S
1997
Homo sapiens
Liu, X.; Reig, B.; Nasrallah, I.M.; Stover, P.J.
Human cytoplasmic serine hydroxymethyltransferase is an mRNA binding protein
Biochemistry
39
11523-11531
2000
Homo sapiens
Sakamoto, M.; Masuda, T.; Yanagimoto, Y.; Nakano, Y.; Kitaoka, S.; Tanigawa, Y.
Purification and characterization of serine hydroxymethyltransferase from mitochondria of Euglena gracilis z
Biosci. Biotechnol. Biochem.
60
1941-1944
1996
Euglena gracilis, Euglena gracilis Z
-
Vatcher, G.P.; Barbazuk, W.B.; O'Neil, N.J.; Marra, M.A.; Ha, T.; Baillie, D.L.
Identification and characterization of a serine hydroxymethyltransferase isoform in Caenorhabditis briggsae
Gene
230
137-144
1999
Caenorhabditis briggsae, Caenorhabditis elegans
Schlpen, C.; Santos, M.A.; Weber, U.; de Graaf, A.; Revuelta, J.L.; Stahmann, K.P.
Disruption of the SHM2 gene, encoding one of two serine hydroxymethyltransferase isoenzymes, reduces the flux from glycine to serine in Ashbya gossypii
Biochem. J.
369
263-273
2003
Eremothecium gossypii (Q75BQ6), Eremothecium gossypii
Jala, V.R.; Appaji Rao, N.; Savithri, H.S.
Identification of amino acid residues, essential for maintaining the tetrameric structure of sheep liver cytosolic serine hydroxymethyltransferase, by targeted mutagenesis
Biochem. J.
369
469-476
2003
Ovis aries
Szebenyi, D.M.; Musayev, F.N.; di Salvo, M.L.; Safo, M.K.; Schirch, V.
Serine hydroxymethyltransferase: role of Glu75 and evidence that serine is cleaved by a retroaldol mechanism
Biochemistry
43
6865-6876
2004
Oryctolagus cuniculus (P07511)
Bhavani, S.; Trivedi, V.; Jala, V.R.; Subramanya, H.S.; Kaul, P.; Prakash, V.; Appaji Rao, N.; Savithri, H.S.
Role of Lys-226 in the catalytic mechanism of Bacillus stearothermophilus serine hydroxymethyltransferase--crystal structure and kinetic studies
Biochemistry
44
6929-6937
2005
Geobacillus stearothermophilus
Jala, V.R.; Ambili, M.; Prakash, V.; Rao, N.A.; Savithri, H.S.
Disruption of distal interactions of Arg262 and of substrate binding to Ser52 affect catalysis of sheep liver cytosolic serine hydroxymethyltransferase
Indian J. Biochem. Biophys.
40
226-237
2003
Ovis aries
Fu, T.F.; Scarsdale, J.N.; Kazanina, G.; Schirch, V.; Wright, H.T.
Location of the pteroylpolyglutamate-binding site on rabbit cytosolic serine hydroxymethyltransferase
J. Biol. Chem.
278
2645-2653
2003
Oryctolagus cuniculus
Fu, T.F.; Boja, E.S.; Safo, M.K.; Schirch, V.
Role of proline residues in the folding of serine hydroxymethyltransferase
J. Biol. Chem.
278
31088-31094
2003
Escherichia coli
Chaturvedi, S.; Bhakuni, V.
Unusual structural, functional, and stability properties of serine hydroxymethyltransferase from Mycobacterium tuberculosis
J. Biol. Chem.
278
40793-40805
2003
Mycobacterium tuberculosis (P9WGI7), Mycobacterium tuberculosis (P9WGI9), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WGI7), Mycobacterium tuberculosis H37Rv (P9WGI9)
Angelaccio, S.; Chiaraluce, R.; Consalvi, V.; Buchenau, B.; Giangiacomo, L.; Bossa, F.; Contestabile, R.
Catalytic and thermodynamic properties of tetrahydromethanopterin-dependent serine hydroxymethyltransferase from Methanococcus jannaschii
J. Biol. Chem.
278
41789-41797
2003
Methanocaldococcus jannaschii
Lewis, R.M.; Godfrey, K.M.; Jackson, A.A.; Cameron, I.T.; Hanson, M.A.
Low serine hydroxymethyltransferase activity in the human placenta has important implications for fetal glycine supply
J. Clin. Endocrinol. Metab.
90
1594-1598
2005
Ovis aries, Homo sapiens, Rattus norvegicus
Agrawal, S.; Kumar, A.; Srivastava, V.; Mishra, B.N.
Cloning, expression, activity and folding studies of serine hydroxymethyltransferase: a target enzyme for cancer chemotherapy
J. Mol. Microbiol. Biotechnol.
6
67-75
2003
Escherichia coli, Homo sapiens
Scheer, J.B.; Mackey, A.D.; Gregory, J.F., 3rd
Activities of hepatic cytosolic and mitochondrial forms of serine hydroxymethyltransferase and hepatic glycine concentration are affected by vitamin B-6 intake in rats
J. Nutr.
135
233-238
2005
Rattus norvegicus
Moreno, J.I.; Martin, R.; Castresana, C.
Arabidopsis SHMT1, a serine hydroxymethyltransferase that functions in the photorespiratory pathway influences resistance to biotic and abiotic stress
Plant J.
41
451-463
2005
Arabidopsis thaliana, Arabidopsis thaliana C24
Bhatt, A.N.; Khan, M.Y.; Bhakuni, V.
The C-terminal domain of dimeric serine hydroxymethyltransferase plays a key role in stabilization of the quaternary structure and cooperative unfolding of protein: domain swapping studies with enzymes having high sequence identity
Protein Sci.
13
2184-2195
2004
Geobacillus stearothermophilus, Bacillus subtilis
Paiardini, A.; Gianese, G.; Bossa, F.; Pascarella, S.
Structural plasticity of thermophilic serine hydroxymethyltransferases
Proteins
50
122-134
2003
Aeropyrum pernix, Aquifex aeolicus, Archaeoglobus fulgidus, Methanothermobacter thermautotrophicus, Methanocaldococcus jannaschii, Pyrococcus abyssi, Pyrococcus horikoshii, Saccharolobus solfataricus, Thermotoga maritima, Methanothermobacter marburgensis
Goyer, A.; Collakova, E.; Diaz de la Garza, R.; Quinlivan, E.P.; Williamson, J.; Gregory, J.F., 3rd; Shachar-Hill, Y.; Hanson, A.D.
5-Formyltetrahydrofolate is an inhibitory but well tolerated metabolite in Arabidopsis leaves
J. Biol. Chem.
280
26137-26142
2005
Arabidopsis thaliana
Stolz, M.; Peters-Wendisch, P.; Etterich, H.; Gerharz, T.; Faurie, R.; Sahm, H.; Fersterra, H.; Eggeling, L.
Reduced folate supply as a key to enhanced L-serine production by Corynebacterium glutamicum
Appl. Environ. Microbiol.
73
750-755
2007
Corynebacterium glutamicum
Fu, T.F.; Hunt, S.; Schirch, V.; Safo, M.K.; Chen, B.H.
Properties of human and rabbit cytosolic serine hydroxymethyltransferase are changed by single nucleotide polymorphic mutations
Arch. Biochem. Biophys.
442
92-101
2005
Homo sapiens, Oryctolagus cuniculus (P07511), Oryctolagus cuniculus
Zuo, Z.; Zheng, Z.; Liu, Z.; Yi, Q.; Zou, G.
Cloning, DNA shuffling and expression of serine hydroxymethyltransferase gene from Escherichia coli strain AB90054
Enzyme Microb. Technol.
40
569-577
2007
Escherichia coli, Escherichia coli AB90054
-
Mukherjee, M.; Sievers, S.A.; Brown, M.T.; Johnson, P.J.
Identification and biochemical characterization of serine hydroxymethyl transferase in the hydrogenosome of Trichomonas vaginalis
Eukaryot. Cell
5
2072-2078
2006
Trichomonas vaginalis
Perry, C.; Sastry, R.; Nasrallah, I.M.; Stover, P.J.
Mimosine attenuates serine hydroxymethyltransferase transcription by chelating zinc: implications for inhibition of DNA replication
J. Biol. Chem.
280
396-400
2005
Homo sapiens
Franca, T.C.; Wilter, A.; Ramalho, T.C.; Pascutti, P.G.; Figueroa-Villar, J.D.
Molecular dynamics of the interaction of Plasmodium falciparum and human serine hydroxymethyltransferase with 5-formyl-6-hydrofolic acid analogues: design of new potential antimalarials
J. Braz. Chem. Soc.
17
1383-1392
2006
Plasmodium falciparum, Homo sapiens (P34896)
-
Griffiths, E.; Gupta, R.S.
Lateral transfers of serine hydroxymethyltransferase (glyA) and UDP-N-acetylglucosamine enolpyruvyl transferase (murA) genes from free-living Actinobacteria to the parasitic chlamydiae
J. Mol. Evol.
63
283-296
2006
Simkania negevensis (Q49K94), Simkania negevensis, Waddlia chondrophila (Q49KA1), Waddlia chondrophila
Gagnon, D.; Foucher, A.; Girard, I.; Ouellette, M.
Stage specific gene expression and cellular localization of two isoforms of the serine hydroxymethyltransferase in the protozoan parasite Leishmania
Mol. Biochem. Parasitol.
150
63-71
2006
Leishmania infantum, Leishmania major
Schjoerring, J.K.; Maeck, G.; Nielsen, K.H.; Husted, S.; Suzuki, A.; Driscoll, S.; Boldt, R.; Bauwe, H.
Antisense reduction of serine hydroxymethyltransferase results in diurnal displacement of NH4+ assimilation in leaves of Solanum tuberosum
Plant J.
45
71-82
2006
Solanum tuberosum
Eisenhut, M.; Kahlon, S.; Hasse, D.; Ewald, R.; Lieman-Hurwitz, J.; Ogawa, T.; Ruth, W.; Bauwe, H.; Kaplan, A.; Hagemann, M.
The plant-like C2 glycolate cycle and the bacterial-like glycerate pathway cooperate in phosphoglycolate metabolism in cyanobacteria
Plant Physiol.
142
333-342
2006
Synechocystis sp.
Chang, W.N.; Tsai, J.N.; Chen, B.H.; Fu, T.F.
Cloning, expression, purification, and characterization of zebrafish cytosolic serine hydroxymethyltransferase
Protein Expr. Purif.
46
212-220
2006
Danio rerio (Q2TL58), Danio rerio, Danio rerio AB (Q2TL58)
Vatsyayan, R.; Roy, U.
Molecular cloning and biochemical characterization of Leishmania donovani serine hydroxymethyltransferase
Protein Expr. Purif.
52
433-440
2007
Leishmania donovani (Q86LS9), Leishmania donovani, Leishmania donovani MHOM/IN/80/Dd8 (Q86LS9)
Makart Stefa, M.S.; Heinemann Matthia, H.M.; Panke Sve, P.S.
Characterization of the AlkS/P(alkB)-expression system as an efficient tool for the production of recombinant proteins in Escherichia coli fed-batch fermentations
Biotechnol. Bioeng.
96
326-336
2007
Escherichia coli
Chang, W.N.; Tsai, J.N.; Chen, B.H.; Huang, H.S.; Fu, T.F.
Serine hydroxymethyltransferase isoforms are differentially inhibited by leucovorin: characterization and comparison of recombinant zebrafish serine hydroxymethyltransferases
Drug Metab. Dispos.
35
2127-2137
2007
Danio rerio (A9LDD9), Danio rerio (Q7SXN1), Danio rerio
Leartsakulpanich, U.; Kongkasuriyachai, D.; Imwong, M.; Chotivanich, K.; Yuthavong, Y.
Cloning and characterization of Plasmodium vivax serine hydroxymethyltransferase
Parasitol. Int.
57
223-228
2008
Plasmodium vivax (A5K8L9), Plasmodium vivax
Jamai, A.; Salome, P.A.; Schilling, S.H.; Weber, A.P.; McClung, C.R.
Arabidopsis photorespiratory serine hydroxymethyltransferase activity requires the mitochondrial accumulation of ferredoxin-dependent glutamate synthase
Plant Cell
21
595-606
2009
Arabidopsis thaliana
Pai, V.R.; Rajaram, V.; Bisht, S.; Bhavani, B.S.; Rao, N.A.; Murthy, M.R.; Savithri, H.S.
Structural and functional studies of Bacillus stearothermophilus serine hydroxymethyltransferase: the role of Asn(341), Tyr(60) and Phe(351) in tetrahydrofolate binding
Biochem. J.
418
635-642
2009
Geobacillus stearothermophilus (Q7SIB6), Geobacillus stearothermophilus
Bhavani, B.S.; Rajaram, V.; Bisht, S.; Kaul, P.; Prakash, V.; Murthy, M.R.; Appaji Rao, N.; Savithri, H.S.
Importance of tyrosine residues of Bacillus stearothermophilus serine hydroxymethyltransferase in cofactor binding and L-allo-Thr cleavage
FEBS J.
275
4606-4619
2008
Geobacillus stearothermophilus
Florio, R.; Chiaraluce, R.; Consalvi, V.; Paiardini, A.; Catacchio, B.; Bossa, F.; Contestabile, R.
The role of evolutionarily conserved hydrophobic contacts in the quaternary structure stability of Escherichia coli serine hydroxymethyltransferase
FEBS J.
276
132-143
2009
Escherichia coli (P0A825), Escherichia coli
Sopitthummakhun, K.; Maenpuen, S.; Yuthavong, Y.; Leartsakulpanich, U.; Chaiyen, P.
Serine hydroxymethyltransferase from Plasmodium vivax is different in substrate specificity from its homologues
FEBS J.
276
4023-4036
2009
Plasmodium vivax
Florio, R.; Chiaraluce, R.; Consalvi, V.; Paiardini, A.; Catacchio, B.; Bossa, F.; Contestabile, R.
Structural stability of the cofactor binding site in Escherichia coli serine hydroxymethyltransferase - the role of evolutionarily conserved hydrophobic contacts
FEBS J.
276
7319-7328
2009
Escherichia coli (P0A825), Escherichia coli
Choi, M.
Human serine hydroxymethyltransferase 2 (SHMT2) interacts with hnRNP D
Genes Genomics
30
541-548
2008
Homo sapiens
-
Siglioccolo, A.; Bossa, F.; Pascarella, S.
Structural adaptation of serine hydroxymethyltransferase to low temperatures
Int. J. Biol. Macromol.
46
37-46
2010
Geobacillus stearothermophilus, Oryctolagus cuniculus, Escherichia coli, Homo sapiens, Mus musculus
Bhatt, A.N.; Bhakuni, V.
Characterization of pyridoxal 5'-phosphate-binding domain and folding intermediate of Bacillus subtilis serine hydroxymethyltransferase: an autonomous folding domain
J. Biochem.
144
295-303
2008
Bacillus subtilis
MacFarlane, A.J.; Liu, X.; Perry, C.A.; Flodby, P.; Allen, R.H.; Stabler, S.P.; Stover, P.J.
Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice
J. Biol. Chem.
283
25846-25853
2008
Mus musculus
Fox, J.T.; Stover, P.J.
Mechanism of the internal ribosome entry site-mediated translation of serine hydroxymethyltransferase 1
J. Biol. Chem.
284
31085-31096
2009
Homo sapiens
Fox, J.T.; Shin, W.K.; Caudill, M.A.; Stover, P.J.
A UV-responsive internal ribosome entry site enhances serine hydroxymethyltransferase 1 expression for DNA damage repair
J. Biol. Chem.
284
31097-31108
2009
Homo sapiens
Schweitzer, J.E.; Stolz, M.; Diesveld, R.; Etterich, H.; Eggeling, L.
The serine hydroxymethyltransferase gene glyA in Corynebacterium glutamicum is controlled by GlyR
J. Biotechnol.
139
214-221
2009
Corynebacterium glutamicum, Corynebacterium glutamicum ATCC 13032
Maenpuen, S.; Sopitthummakhun, K.; Yuthavong, Y.; Chaiyen, P.; Leartsakulpanich, U.
Characterization of Plasmodium falciparum serine hydroxymethyltransferase-A potential antimalarial target
Mol. Biochem. Parasitol.
168
63-73
2009
Plasmodium falciparum, Plasmodium falciparum TM4
Pang, C.K.; Hunter, J.H.; Gujjar, R.; Podutoori, R.; Bowman, J.; Mudeppa, D.G.; Rathod, P.K.
Catalytic and ligand-binding characteristics of Plasmodium falciparum serine hydroxymethyltransferase
Mol. Biochem. Parasitol.
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Plasmodium falciparum
Zhao, G.H.; Li, H.; Liu, W.; Zhang, W.G.; Zhang, F.; Liu, Q.; Jiao, Q.C.
Preparation of optically active beta-hydroxy-alpha-amino acid by immobilized Escherichia coli cells with serine hydroxymethyl transferase activity
Amino Acids
40
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2011
Escherichia coli, Escherichia coli K-12 MG1655
Zhang, Y.; Sun, K.; Sandoval, F.J.; Santiago, K.; Roje, S.
One-carbon metabolism in plants: characterization of a plastid serine hydroxymethyltransferase
Biochem. J.
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2010
Hordeum vulgare, Pisum sativum, Arabidopsis thaliana (Q94JQ3), Arabidopsis thaliana, Hordeum vulgare Bob, Pisum sativum Progress 9
Bhatt, A.N.; Bhakuni, V.; Kumar, A.; Khan, M.Y.; Siddiqi, M.I.
Alkaline pH-dependent differential unfolding characteristics of mesophilic and thermophilic homologs of dimeric serine hydroxymethyltransferase
Biochim. Biophys. Acta
1804
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2010
Geobacillus stearothermophilus, Bacillus subtilis
Florio, R.; di Salvo, M.L.; Vivoli, M.; Contestabile, R.
Serine hydroxymethyltransferase: a model enzyme for mechanistic, structural, and evolutionary studies
Biochim. Biophys. Acta
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2011
Bacillus subtilis, Escherichia coli
Chiba, Y.; Terada, T.; Kameya, M.; Shimizu, K.; Arai, H.; Ishii, M.; Igarashi, Y.
Mechanism for folate-independent aldolase reaction catalyzed by serine hydroxymethyltransferase
FEBS J.
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Geobacillus stearothermophilus, Oryctolagus cuniculus, Ovis aries, Hydrogenobacter thermophilus, Hydrogenobacter thermophilus TK-6 / IAM 12695
Waditee-Sirisattha, R.; Sittipol, D.; Tanaka, Y.; Takabe, T.
Overexpression of serine hydroxymethyltransferase from halotolerant cyanobacterium in Escherichia coli results in increased accumulation of choline precursors and enhanced salinity tolerance
FEMS Microbiol. Lett.
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2012
Aphanothece halophytica (I7H6W6), Aphanothece halophytica
Anderson, D.D.; Woeller, C.F.; Chiang, E.P.; Shane, B.; Stover, P.J.
Serine hydroxymethyltransferase anchors de novo thymidylate synthesis pathway to nuclear lamina for DNA synthesis
J. Biol. Chem.
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Homo sapiens
Read, M.; Mueller, I.B.; Mitchell, S.L.; Sims, P.F.; Hyde, J.E.
Dynamic subcellular localization of isoforms of the folate pathway enzyme serine hydroxymethyltransferase (SHMT) through the erythrocytic cycle of Plasmodium falciparum
Malar. J.
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Plasmodium falciparum
Engel, N.; Ewald, R.; Gupta, K.J.; Zrenner, R.; Hagemann, M.; Bauwe, H.
The presequence of Arabidopsis serine hydroxymethyltransferase SHM2 selectively prevents import into mesophyll mitochondria
Plant Physiol.
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Arabidopsis thaliana
Buchenau, B.; Thauer, R.K.
Tetrahydrofolate-specific enzymes in Methanosarcina barkeri and growth dependence of this methanogenic archaeon on folic acid or p-aminobenzoic acid
Arch. Microbiol.
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Methanosarcina barkeri (Q46A52), Methanosarcina barkeri DSM 804 (Q46A52)
Lin, Z.; Sparling, R.
Investigation of serine hydroxymethyltransferase in methanogens
Can. J. Microbiol.
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1998
Methanospirillum hungatei, Methanothrix soehngenii, Methanolobus tindarius, Methanosarcina barkeri (Q46A52), Methanosarcina barkeri, Methanospirillum hungatei GP1, Methanosarcina barkeri DSM 804 (Q46A52)
Angelucci, F.; Morea, V.; Angelaccio, S.; Saccoccia, F.; Contestabile, R.; Ilari, A.
The crystal structure of archaeal serine hydroxymethyltransferase reveals idiosyncratic features likely required to withstand high temperatures
Proteins
82
3437-3449
2014
Methanocaldococcus jannaschii (Q58992), Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661 (Q58992)
Chitnumsub, P.; Jaruwat, A.; Riangrungroj, P.; Ittarat, W.; Noytanom, K.; Oonanant, W.; Vanichthanankul, J.; Chuankhayan, P.; Maenpuen, S.; Chen, C.J.; Chaiyen, P.; Yuthavong, Y.; Leartsakulpanich, U.
Structures of Plasmodium vivax serine hydroxymethyltransferase: implications for ligand-binding specificity and functional control
Acta Crystallogr. Sect. D
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2014
Plasmodium vivax (A5K8L9), Plasmodium vivax
Huang, J.; Chen, L.; Hu, N.; Jiang, W.; Wu, G.; Liu, Z.
Characterization of a novel serine hydroxymethyltransferase isolated from marine bacterium Arthrobacter sp. and its application on L-serine production
Ann. Microbiol.
65
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2015
Arthrobacter sp., Arthrobacter sp. MCCC 1A05493
Pinthong, C.; Maenpuen, S.; Amornwatcharapong, W.; Yuthavong, Y.; Leartsakulpanich, U.; Chaiyen, P.
Distinct biochemical properties of human serine hydroxymethyltransferase compared with the Plasmodium enzyme: implications for selective inhibition
FEBS J.
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Plasmodium falciparum, Plasmodium vivax, Homo sapiens (P34896), Homo sapiens
Maenpuen, S.; Amornwatcharapong, W.; Krasatong, P.; Sucharitakul, J.; Palfey, B.A.; Yuthavong, Y.; Chitnumsub, P.; Leartsakulpanich, U.; Chaiyen, P.
Kinetic mechanism and the rate-limiting step of Plasmodium vivax serine hydroxymethyltransferase
J. Biol. Chem.
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2015
Plasmodium vivax
Yuan, S.; Jiang, W.; Chen, L.; Guo, Y.; Liu, Z.
A novel serine hydroxymethyltransferase from marine bacterium Alcanivorax sp. and its application on enzymatic synthesis of L-serine
J. Mol. Catal. B
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2014
Alcanivorax sp.
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Angelaccio, S.; Di Salvo, M.; Parroni, A.; Di Bello, A.; Contestabile, R.; Pascarella, S.
Structural stability of cold-adapted serine hydroxymethyltransferase, a tool for beta-hydroxy-alpha-amino acid biosynthesis
J. Mol. Catal. B
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2014
Psychromonas ingrahamii (A1SUU0), Escherichia coli (P0A825), Psychromonas ingrahamii 37 (A1SUU0)
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di Salvo, M.L.; Contestabile, R.; Paiardini, A.; Maras, B.
Glycine consumption and mitochondrial serine hydroxymethyltransferase in cancer cells: the heme connection
Med. Hypotheses
80
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2013
Homo sapiens (P34897)
Jiang, W.; Xia, B.; Liu, Z.
A serine hydroxymethyltransferase from marine bacterium Shewanella algae: Isolation, purification, characterization and l-serine production
Microbiol. Res.
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Shewanella algae (R9YJZ9), Shewanella algae
Kim, D.; Fiske, B.P.; Birsoy, K.; Freinkman, E.; Kami, K.; Possemato, R.L.; Chudnovsky, Y.; Pacold, M.E.; Chen, W.W.; Cantor, J.R.; Shelton, L.M.; Gui, D.Y.; Kwon, M.; Ramkissoon, S.H.; Ligon, K.L.; Kang, S.W.; Snuderl, M.; Vander Heiden, M.G.; Sabatini, D.M.
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance
Nature
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2015
Homo sapiens (P34897), Homo sapiens
Yin, K.
Positive correlation between expression level of mitochondrial serine hydroxymethyltransferase and breast cancer grade
OncoTargets Ther.
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2015
Homo sapiens
Milano, T.; Di Salvo, M.L.; Angelaccio, S.; Pascarella, S.
Conserved water molecules in bacterial serine hydroxymethyltransferases
Protein Eng. Des. Sel.
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2015
Burkholderia pseudomallei (A0A069BAT4), Psychromonas ingrahamii (A1SUU0), Rickettsia rickettsii (A8GTI9), Burkholderia cenocepacia (B4ECY9), Salmonella enterica subsp. enterica serovar Typhimurium (P0A2E1), Escherichia coli (P0A825), Mycobacterium tuberculosis (P9WGI9), Staphylococcus aureus (Q5HE87), Thermus thermophilus (Q5SI56), Geobacillus stearothermophilus (Q7SIB6), Campylobacter jejuni (Q9S6K1), Campylobacter jejuni ATCC 33560 (Q9S6K1), Psychromonas ingrahamii 37 (A1SUU0), Mycobacterium tuberculosis H37Rv (P9WGI9), Staphylococcus aureus COL (Q5HE87), Burkholderia pseudomallei ATCC 23343 (A0A069BAT4), Rickettsia rickettsii Sheila Smith (A8GTI9)
Angelaccio, S.; Dworkowski, F.; Di Bello, A.; Milano, T.; Capitani, G.; Pascarella, S.
Conformational transitions driven by pyridoxal-5-phosphate uptake in the psychrophilic serine hydroxymethyltransferase from Psychromonas ingrahamii
Proteins
82
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2014
Psychromonas ingrahamii (A1SUU0), Psychromonas ingrahamii
Jiang, W.; Xia, B.; Huang, J.; Liu, Z.
Characterization of a serine hydroxymethyltransferase for L-serine enzymatic production from Pseudomonas plecoglossicida
World J. Microbiol. Biotechnol.
29
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2013
Pseudomonas plecoglossicida (L7Y8B0), Pseudomonas plecoglossicida, Pseudomonas plecoglossicida MCCC 1K00022 (L7Y8B0)
Hernandez, K.; Zelen, I.; Petrillo, G.; Uson, I.; Wandtke, C.M.; Bujons, J.; Joglar, J.; Parella, T.; Clapes, P.
Engineered L-serine hydroxymethyltransferase from Streptococcus thermophilus for the synthesis of alpha,alpha-dialkyl-alpha-amino acids
Angew. Chem. Int. Ed. Engl.
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2015
Streptococcus thermophilus (Q5M0B4), Streptococcus thermophilus, Streptococcus thermophilus CNRZ 1066 (Q5M0B4)
Amornwatcharapong, W.; Maenpuen, S.; Chitnumsub, P.; Leartsakulpanich, U.; Chaiyen, P.
Human and Plasmodium serine hydroxymethyltransferases differ in rate-limiting steps and pH-dependent substrate inhibition behavior
Arch. Biochem. Biophys.
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2017
Homo sapiens, Plasmodium vivax
Haque, M.; Hirowatari, A.; Nai, N.; Furuya, S.; Yamamoto, K.
Serine hydroxymethyltransferase from the silkworm Bombyx mori Identification, distribution, and biochemical characterization
Arch. Insect Biochem. Physiol.
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Bombyx mori, Bombyx mori p50T
Waditee-Sirisattha, R.; Kageyama, H.; Tanaka, Y.; Fukaya, M.; Takabe, T.
Overexpression of halophilic serine hydroxymethyltransferase in fresh water cyanobacterium Synechococcus elongatus PCC7942 results in increased enzyme activities of serine biosynthetic pathways and enhanced salinity tolerance
Arch. Microbiol.
199
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Aphanothece halophytica
Zhang, M.; Wu, W.; Chen, Z.
Structure and function of cytoplasmic serine hydroxymethyltransferase from Pichia pastoris
Biochem. Biophys. Res. Commun.
496
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2018
Komagataella pastoris (F2QZA4), Komagataella pastoris, Komagataella pastoris X-33 (F2QZA4)
Tramonti, A.; Nardella, C.; di Salvo, M.L.; Barile, A.; Cutruzzola, F.; Contestabile, R.
Human cytosolic and mitochondrial serine hydroxymethyltransferase isoforms in comparison full kinetic characterization and substrate inhibition properties
Biochemistry
57
6984-6996
2018
Homo sapiens (P34896), Homo sapiens (P34897), Homo sapiens
Paiardini, A.; Tramonti, A.; Schirch, D.; Guiducci, G.; di Salvo, M.L.; Fiascarelli, A.; Giorgi, A.; Maras, B.; Cutruzzola, F.; Contestabile, R.
Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming
Biochim. Biophys. Acta
1864
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2016
Homo sapiens (P34896), Homo sapiens (P34897), Homo sapiens
Jiang, W.; Chen, L.; Hu, N.; Yuan, S.; Li, B.; Liu, Z.
A novel serine hydroxymethyltransferase from Arthrobacter nicotianae Characterization and improving catalytic efficiency by rational design
BMC Biotechnol.
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Glutamicibacter nicotianae (U5TRK6), Glutamicibacter nicotianae
Paiardini, A.; Fiascarelli, A.; Rinaldo, S.; Daidone, F.; Giardina, G.; Koes, D.R.; Parroni, A.; Montini, G.; Marani, M.; Paone, A.; McDermott, L.A.; Contestabile, R.; Cutruzzola, F.
Screening and in vitro testing of antifolate inhibitors of human cytosolic serine hydroxymethyltransferase
ChemMedChem
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490-497
2015
Homo sapiens
Saint-Marc, C.; Huerlimann, H.C.; Daignan-Fornier, B.; Pinson, B.
Serine hydroxymethyltransferase a key player connecting purine, folate and methionine metabolism in Saccharomyces cerevisiae
Curr. Genet.
61
633-640
2015
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
Giardina, G.; Brunotti, P.; Fiascarelli, A.; Cicalini, A.; Costa, M.G.; Buckle, A.M.; di Salvo, M.L.; Giorgi, A.; Marani, M.; Paone, A.; Rinaldo, S.; Paiardini, A.; Contestabile, R.; Cutruzzola, F.
How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state
FEBS J.
282
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2015
Homo sapiens (P34896), Homo sapiens (P34897), Homo sapiens
Giardina, G.; Paone, A.; Tramonti, A.; Lucchi, R.; Marani, M.; Magnifico, M.C.; Bouzidi, A.; Pontecorvi, V.; Guiducci, G.; Zamparelli, C.; Rinaldo, S.; Paiardini, A.; Contestabile, R.; Cutruzzola, F.
The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells
FEBS J.
285
3238-3253
2018
Homo sapiens (P34896)
Scaletti, E.; Jemth, A.S.; Helleday, T.; Stenmark, P.
Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs
FEBS Lett.
593
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2019
Homo sapiens (P34897), Homo sapiens
Ruszkowski, M.; Sekula, B.; Ruszkowska, A.; Dauter, Z.
Chloroplastic serine hydroxymethyltransferase from Medicago truncatula A structural characterization
Front. Plant Sci.
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584
2018
Medicago truncatula (G7ILW0), Medicago truncatula
Kumar, A.; Wu, G.; Wu, Z.; Kumar, N.; Liu, Z.
Improved catalytic properties of a serine hydroxymethyl transferase from Idiomarina loihiensis by site directed mutagenesis
Int. J. Biol. Macromol.
117
1216-1223
2018
Idiomarina loihiensis
Wang, D.; Liu, H.; Li, S.; Zhai, G.; Shao, J.; Tao, Y.
Characterization and molecular cloning of a serine hydroxymethyltransferase 1 (OsSHM1) in rice
J. Integr. Plant Biol.
57
745-756
2015
Oryza sativa Japonica Group
Witschel, M.C.; Rottmann, M.; Schwab, A.; Leartsakulpanich, U.; Chitnumsub, P.; Seet, M.; Tonazzi, S.; Schwertz, G.; Stelzer, F.; Mietzner, T.; McNamara, C.; Thater, F.; Freymond, C.; Jaruwat, A.; Pinthong, C.; Riangrungroj, P.; Oufir, M.; Hamburger, M.; Maeser, P.; Sanz-Alonso, L.M.; Charman, S.
Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT) cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activities
J. Med. Chem.
58
3117-3130
2015
Plasmodium berghei, Plasmodium falciparum, Plasmodium vivax (A5K8L9), Plasmodium vivax, Plasmodium vivax Salvador I (A5K8L9)
Li, X.; Yang, J.; Pu, Q.; Peng, X.; Xu, L.; Liu, S.
Serine hydroxymethyltransferase controls blood-meal digestion in the midgut of Aedes aegypti mosquitoes
Parasit. Vectors
12
460
2019
Aedes aegypti, Aedes aegypti NIH Rockefeller
Kandoth, P.K.; Liu, S.; Prenger, E.; Ludwig, A.; Lakhssassi, N.; Heinz, R.; Zhou, Z.; Howland, A.; Gunther, J.; Eidson, S.; Dhroso, A.; LaFayette, P.; Tucker, D.; Johnson, S.; Anderson, J.; Alaswad, A.; Cianzio, S.R.; Parrott, W.A.; Korkin, D.; Meksem, K.; Mitchum, M.G.
Systematic mutagenesis of serine hydroxymethyltransferase reveals an essential role in nematode resistance
Plant Physiol.
175
1370-1380
2017
Glycine max
Sodolescu, A.; Dian, C.; Terradot, L.; Bouzhir-Sima, L.; Lestini, R.; Myllykallio, H.; Skouloubris, S.; Liebl, U.
Structural and functional insight into serine hydroxymethyltransferase from Helicobacter pylori
PLoS ONE
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2018
Helicobacter pylori (P56089), Helicobacter pylori, Helicobacter pylori 26695 (P56089)
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