Application | Comment | Organism |
---|---|---|
medicine | enzyme is a potential target for cancer chemotherapy | Escherichia coli |
medicine | enzyme is a potential target for cancer chemotherapy | Homo sapiens |
medicine | enzyme is a potential target for cancer chemotherapy | Oryctolagus cuniculus |
medicine | enzyme is a potential target for cancer chemotherapy | Ovis aries |
medicine | enzyme is a potential target for cancer chemotherapy | Pisum sativum |
Cloned (Comment) | Organism |
---|---|
- |
Escherichia coli |
- |
Homo sapiens |
- |
Neurospora crassa |
- |
Vigna radiata |
Crystallization (Comment) | Organism |
---|---|
- |
Homo sapiens |
- |
Oryctolagus cuniculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-chloro-L-threonine | - |
Cricetulus griseus | |
4-chloro-L-threonine | - |
Escherichia coli | |
4-chloro-L-threonine | - |
Homo sapiens | |
4-chloro-L-threonine | - |
Neurospora crassa | |
4-chloro-L-threonine | - |
Oryctolagus cuniculus | |
4-chloro-L-threonine | - |
Ovis aries | |
4-chloro-L-threonine | - |
Pisum sativum | |
4-chloro-L-threonine | - |
Rattus norvegicus | |
4-chloro-L-threonine | - |
Vigna radiata |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
additional information | - |
review | Escherichia coli |
additional information | - |
review | Homo sapiens |
additional information | - |
review | Rattus norvegicus |
additional information | - |
review | Oryctolagus cuniculus |
additional information | - |
review | Ovis aries |
additional information | - |
review | Pisum sativum |
additional information | - |
review | Vigna radiata |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-serine + tetrahydrofolate | Cricetulus griseus | - |
glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
L-serine + tetrahydrofolate | Oryctolagus cuniculus | - |
glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
L-serine + tetrahydrofolate | Neurospora crassa | - |
glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
L-serine + tetrahydrofolate | Ovis aries | - |
glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
L-serine + tetrahydrofolate | Pisum sativum | - |
glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
L-serine + tetrahydrofolate | Vigna radiata | - |
glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
L-serine + tetrahydrofolate | Escherichia coli | major pathway for production of C1-units of 5,10-methylenetetrahydrofolate | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
L-serine + tetrahydrofolate | Homo sapiens | major pathway for production of C1-units of 5,10-methylenetetrahydrofolate | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
L-serine + tetrahydrofolate | Rattus norvegicus | major pathway for production of C1-units of 5,10-methylenetetrahydrofolate | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cricetulus griseus | - |
- |
- |
Escherichia coli | - |
- |
- |
Homo sapiens | - |
- |
- |
Neurospora crassa | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Ovis aries | - |
- |
- |
Pisum sativum | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Vigna radiata | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine | mechanism | Cricetulus griseus | |
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine | mechanism | Escherichia coli | |
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine | mechanism | Homo sapiens | |
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine | mechanism | Oryctolagus cuniculus | |
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine | mechanism | Neurospora crassa | |
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine | mechanism | Ovis aries | |
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine | enzyme exhibits threonine aldolase activity (EC 4.1.2.5), but the two enzymes are distinct | Cricetulus griseus | |
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine | enzyme exhibits threonine aldolase activity (EC 4.1.2.5), but the two enzymes are distinct | Escherichia coli | |
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine | enzyme exhibits threonine aldolase activity (EC 4.1.2.5), but the two enzymes are distinct | Homo sapiens | |
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine | enzyme exhibits threonine aldolase activity (EC 4.1.2.5), but the two enzymes are distinct | Rattus norvegicus | |
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine | enzyme exhibits threonine aldolase activity (EC 4.1.2.5), but the two enzymes are distinct | Oryctolagus cuniculus | |
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine | enzyme exhibits threonine aldolase activity (EC 4.1.2.5), but the two enzymes are distinct | Neurospora crassa | |
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine | enzyme exhibits threonine aldolase activity (EC 4.1.2.5), but the two enzymes are distinct | Ovis aries | |
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine | enzyme exhibits threonine aldolase activity (EC 4.1.2.5), but the two enzymes are distinct | Pisum sativum | |
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine | enzyme exhibits threonine aldolase activity (EC 4.1.2.5), but the two enzymes are distinct | Vigna radiata |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
review | Escherichia coli |
additional information | - |
review | Homo sapiens |
additional information | - |
review | Rattus norvegicus |
additional information | - |
review | Oryctolagus cuniculus |
additional information | - |
review | Ovis aries |
additional information | - |
review | Pisum sativum |
additional information | - |
review | Vigna radiata |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-methylserine + tetrahydrofolate | - |
Cricetulus griseus | D-alanine + 5,10-methylenetetrahydrofolate | - |
? | |
alpha-methylserine + tetrahydrofolate | - |
Escherichia coli | D-alanine + 5,10-methylenetetrahydrofolate | - |
? | |
alpha-methylserine + tetrahydrofolate | - |
Homo sapiens | D-alanine + 5,10-methylenetetrahydrofolate | - |
? | |
alpha-methylserine + tetrahydrofolate | - |
Oryctolagus cuniculus | D-alanine + 5,10-methylenetetrahydrofolate | - |
? | |
alpha-methylserine + tetrahydrofolate | - |
Neurospora crassa | D-alanine + 5,10-methylenetetrahydrofolate | - |
? | |
alpha-methylserine + tetrahydrofolate | - |
Ovis aries | D-alanine + 5,10-methylenetetrahydrofolate | - |
? | |
alpha-methylserine + tetrahydrofolate | - |
Pisum sativum | D-alanine + 5,10-methylenetetrahydrofolate | - |
? | |
L-serine + tetrahydrofolate | - |
Cricetulus griseus | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
L-serine + tetrahydrofolate | - |
Escherichia coli | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
L-serine + tetrahydrofolate | - |
Homo sapiens | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
L-serine + tetrahydrofolate | - |
Rattus norvegicus | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
L-serine + tetrahydrofolate | - |
Oryctolagus cuniculus | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
L-serine + tetrahydrofolate | - |
Neurospora crassa | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
L-serine + tetrahydrofolate | - |
Ovis aries | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
L-serine + tetrahydrofolate | - |
Pisum sativum | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
L-serine + tetrahydrofolate | - |
Vigna radiata | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
L-serine + tetrahydrofolate | major pathway for production of C1-units of 5,10-methylenetetrahydrofolate | Escherichia coli | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
L-serine + tetrahydrofolate | major pathway for production of C1-units of 5,10-methylenetetrahydrofolate | Homo sapiens | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
L-serine + tetrahydrofolate | major pathway for production of C1-units of 5,10-methylenetetrahydrofolate | Rattus norvegicus | glycine + 5,10-methylenetetrahydrofolate + H2O | - |
? | |
additional information | review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources | Cricetulus griseus | ? | - |
? | |
additional information | review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources | Escherichia coli | ? | - |
? | |
additional information | review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources | Homo sapiens | ? | - |
? | |
additional information | review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources | Rattus norvegicus | ? | - |
? | |
additional information | review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources | Oryctolagus cuniculus | ? | - |
? | |
additional information | review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources | Neurospora crassa | ? | - |
? | |
additional information | review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources | Ovis aries | ? | - |
? | |
additional information | review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources | Pisum sativum | ? | - |
? | |
additional information | review and comparison of enzyme activity, threonine aldolase and allothreonine aldolase activity from various sources | Vigna radiata | ? | - |
? | |
additional information | enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate | Cricetulus griseus | ? | - |
? | |
additional information | enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate | Escherichia coli | ? | - |
? | |
additional information | enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate | Rattus norvegicus | ? | - |
? | |
additional information | enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate | Oryctolagus cuniculus | ? | - |
? | |
additional information | enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate | Neurospora crassa | ? | - |
? | |
additional information | enzyme transaminates D-alanine to pyruvate and pyridoxamine phosphate | Ovis aries | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
homotetramer | - |
Cricetulus griseus |
homotetramer | review | Escherichia coli |
homotetramer | review | Homo sapiens |
homotetramer | review | Rattus norvegicus |
homotetramer | review | Oryctolagus cuniculus |
homotetramer | review | Ovis aries |
homotetramer | review | Pisum sativum |
homotetramer | review | Vigna radiata |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Cricetulus griseus | |
pyridoxal 5'-phosphate | - |
Escherichia coli | |
pyridoxal 5'-phosphate | - |
Homo sapiens | |
pyridoxal 5'-phosphate | - |
Rattus norvegicus | |
pyridoxal 5'-phosphate | - |
Oryctolagus cuniculus | |
pyridoxal 5'-phosphate | - |
Ovis aries | |
pyridoxal 5'-phosphate | - |
Pisum sativum | |
pyridoxal 5'-phosphate | - |
Vigna radiata |