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2.1.2.1: glycine hydroxymethyltransferase

This is an abbreviated version!
For detailed information about glycine hydroxymethyltransferase, go to the full flat file.

Word Map on EC 2.1.2.1

Reaction

5,10-methylenetetrahydrofolate
+
glycine
 +
H2O
=
tetrahydrofolate
 +
L-serine

Synonyms

AtSHMT3, bsSHMT, bstSHMT, EC 4.1.2.6, eSHMT, GlyA, GlyA protein, glycine hydroxymethyltransferrase, hSHMT, L-serine hydroxymethyltransferase, mitochondrial serine hydroxymethyltransferase, MJ1597, PvSHMT, Rhg4, serine hydroxymethyl transferase, serine hydroxymethylase hydroxymethyltransferase, serine, serine hydroxymethyltransferase, serine hydroxymethyltransferase 1, serine hydroxymethyltransferase 2, serine hydroxymethyltransferase 2alpha, serine transhydroxymethylase, serine:H4F hydroxymethyltransferase, serine:tetrahydrofolate hydroxymethyltransferase, SHM1, SHM2, SHMT, SHMT-1, SHMT-L, SHMT-S, SHMT08, SHMT1, SHMT2, SHMT2alpha, SHMT3, zcSHMT, zebrafish cytosolic serine hydroxymethyltransferase, zebrafish mitochondiral serine hydroxymethyltransferase, zmSHMT

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.2 Hydroxymethyl-, formyl- and related transferases
                2.1.2.1 glycine hydroxymethyltransferase

pH Range

pH Range on EC 2.1.2.1 - glycine hydroxymethyltransferase

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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2 - 4
-
about 60% activity at pH 2.0, 100% activity at pH 3.0, about 20% activity at pH 4.0
4 - 10
-
activity range
5.5 - 9.5
5.8 - 9
almost inactive at pH 5.8, less than 10% of maximal activity at pH 6.0, maximal activity at pH 8.0, 80% of maximal activity at pH 7.5 and pH 8.5, inactive at pH 9.5
6 - 8.5
-
cytosol: about 60% of maximal activity at pH 6, about 70% at 8.5, mitochondria: about 40% of maximal activity at pH 6.0 and 8.5
6.5 - 10
-
-
6.5 - 9.5
-
about half-maximal activity at pH 6.5 and 9.5
6.6 - 8.4
-
the catalytic efficiency of the enzyme for tetrahydrofolate is about 29fold greater at pH 6.6 than at pH 8.3
7 - 10
-
about 20% activity at pH 6.5, about 85% activity at pH 7.0, about 95% activity at pH 8.0, about 75% activity at pH 9.0, about 45% activity at pH 10.0
7 - 8
the enzyme shows more than 40% activity between pH 7.0 and 8.0. The enzyme displays less than 20% of its maximal activity at pH 5.5 and nearly no activity is detected below pH 2.5
7 - 9
-
serine synthesis: about 80% of maximal activity at pH 7.0 and 9.0
7.2 - 8.6
-
3-phenylserine degradation: about half-maximal activity at pH 7.2 and 8.6
7.3 - 9.5
-
about half-maximal activity at pH 7.3 and about 60% of maximal activity at 9.5
9.5
-
no activity above