Information on EC 2.1.2.1 - glycine hydroxymethyltransferase

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The expected taxonomic range for this enzyme is: Archaea, Bacteria, Eukaryota

EC NUMBER
COMMENTARY
2.1.2.1
-
RECOMMENDED NAME
GeneOntology No.
glycine hydroxymethyltransferase
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
hydroxymethyl group transfer
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Biosynthesis of secondary metabolites
-
Cyanoamino acid metabolism
-
folate polyglutamylation
-
folate transformations I
-
folate transformations II
-
formaldehyde assimilation I (serine pathway)
-
formylTHF biosynthesis
-
glycine betaine degradation
-
glycine biosynthesis I
-
Glycine, serine and threonine metabolism
-
Glyoxylate and dicarboxylate metabolism
-
Metabolic pathways
-
Methane metabolism
-
Microbial metabolism in diverse environments
-
One carbon pool by folate
-
photorespiration
-
purine nucleobases degradation II (anaerobic)
-
SYSTEMATIC NAME
IUBMB Comments
5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase
A pyridoxal-phosphate protein. Also catalyses the reaction of glycine with acetaldehyde to form L-threonine, and with 4-trimethylammoniobutanal to form 3-hydroxy-N6,N6,N6-trimethyl-L-lysine.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
AtSHMT3
Q94JQ3
-
EC 4.1.2.6
-
-
formerly
-
GlyA protein
Q49K94
-
GlyA protein
Q49KA1
-
glycine hydroxymethyltransferrase
O53615
-
hSHMT
-
-
L-serine hydroxymethyltransferase
-
-
-
-
PvSHMT
A5K8L9
-
serine hydroxymethyl transferase
-
-
serine hydroxymethyl transferase
Escherichia coli K-12 MG1655
-
-
-
serine hydroxymethyl transferase
-
-
serine hydroxymethyl transferase
-
-
serine hydroxymethylase hydroxymethyltransferase, serine
-
-
-
-
serine hydroxymethyltransferase
-
-
-
-
serine hydroxymethyltransferase
I7H6W6
-
serine hydroxymethyltransferase
-
-
serine hydroxymethyltransferase
Q94JQ3
-
serine hydroxymethyltransferase
-
-
serine hydroxymethyltransferase
-
-
serine hydroxymethyltransferase
Corynebacterium glutamicum ATCC13032
-
-
-
serine hydroxymethyltransferase
Q2TL58
-
serine hydroxymethyltransferase
Danio rerio AB
Q2TL58
-
-
serine hydroxymethyltransferase
-
-
serine hydroxymethyltransferase
Escherichia coli AB90054
-
-
-
serine hydroxymethyltransferase
-
-
serine hydroxymethyltransferase
-
-
serine hydroxymethyltransferase
-
-
serine hydroxymethyltransferase
Hordeum vulgare Bob
-
-
-
serine hydroxymethyltransferase
-
-
serine hydroxymethyltransferase
-
-
-
serine hydroxymethyltransferase
Q86LS9
-
serine hydroxymethyltransferase
Leishmania donovani MHOM/IN/80/Dd8
Q86LS9
-
-
serine hydroxymethyltransferase
-
-
serine hydroxymethyltransferase
-
-
serine hydroxymethyltransferase
O53441
-
serine hydroxymethyltransferase
-
-
serine hydroxymethyltransferase
-
-
serine hydroxymethyltransferase
-
-
serine hydroxymethyltransferase
Pisum sativum Progress 9
-
-
-
serine hydroxymethyltransferase
-
-
serine hydroxymethyltransferase
Plasmodium falciparum strainTM4
-
-
-
serine hydroxymethyltransferase
-
-
serine hydroxymethyltransferase
A5K8L9
-
serine hydroxymethyltransferase
-
-
serine hydroxymethyltransferase
Q49K94
-
serine hydroxymethyltransferase
-
-
serine hydroxymethyltransferase
Q49KA1
-
serine hydroxymethyltransferase 1
-
-
serine hydroxymethyltransferase 1
-
-
serine hydroxymethyltransferase 2
-
-
serine hydroxymethyltransferase 2alpha
-
-
serine transhydroxymethylase
-
-
-
-
SHMT
Corynebacterium glutamicum ATCC13032
-
-
-
SHMT
Escherichia coli AB90054, Escherichia coli K-12 MG1655
-
-
-
SHMT
Hordeum vulgare Bob
-
-
-
SHMT
Q86LS9
-
SHMT
Leishmania donovani MHOM/IN/80/Dd8
Q86LS9
-
-
SHMT
Pisum sativum Progress 9
-
-
-
SHMT
Plasmodium falciparum strainTM4
-
-
-
SHMT
Q49K94
-
SHMT-1
Q2TL58
-
SHMT-1
Danio rerio AB
Q2TL58
-
-
SHMT1
Arabidopsis thaliana C24
-
-
-
SHMT2
-
-
SHMT2alpha
-
-
zcSHMT
Q7SXN1
-
zebrafish cytosolic serine hydroxymethyltransferase
Q7SXN1
-
zebrafish mitochondiral serine hydroxymethyltransferase
A9LDD9
-
zmSHMT
A9LDD9
-
CAS REGISTRY NUMBER
COMMENTARY
9029-83-8
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
ecotype Columbia
UniProt
Manually annotated by BRENDA team
Arabidopsis thaliana C24
C24
-
-
Manually annotated by BRENDA team
strain ATCC 13032
-
-
Manually annotated by BRENDA team
strain ATCC13032
-
-
Manually annotated by BRENDA team
Corynebacterium glutamicum ATCC13032
strain ATCC13032
-
-
Manually annotated by BRENDA team
AB strain
SwissProt
Manually annotated by BRENDA team
Danio rerio AB
AB strain
SwissProt
Manually annotated by BRENDA team
strain AB90054
-
-
Manually annotated by BRENDA team
Escherichia coli AB90054
strain AB90054
-
-
Manually annotated by BRENDA team
Escherichia coli K-12 MG1655
-
-
-
Manually annotated by BRENDA team
Euglena gracilis Z
-
-
-
Manually annotated by BRENDA team
strain L. Merr. cv. Williams, soybean
-
-
Manually annotated by BRENDA team
Glycine max L.
strain L. Merr. cv. Williams, soybean
-
-
Manually annotated by BRENDA team
Hordeum vulgare Bob
-
-
-
Manually annotated by BRENDA team
strain GM2, a glycine resistant mutant derived from strain KM146
-
-
Manually annotated by BRENDA team
; strain MHOM/IN/80/Dd8
SwissProt
Manually annotated by BRENDA team
Leishmania donovani MHOM/IN/80/Dd8
strain MHOM/IN/80/Dd8
SwissProt
Manually annotated by BRENDA team
Bonnet monkey
-
-
Manually annotated by BRENDA team
Pisum sativum Progress 9
-
-
-
Manually annotated by BRENDA team
one enzymatically functional SHMT isozyme, PfSHMTc, and one related, apparently inactive isoform, PfSHMTm, encoded by different genes pfshmt and PF14_ 0534, respectively
-
-
Manually annotated by BRENDA team
Plasmodium falciparum strainTM4
strainTM4
-
-
Manually annotated by BRENDA team
putative
UniProt
Manually annotated by BRENDA team
Wistar strain
-
-
Manually annotated by BRENDA team
Rattus norvegicus Wistar
Wistar strain
-
-
Manually annotated by BRENDA team
strain 3701B
-
-
Manually annotated by BRENDA team
Saccharomyces cerevisiae 3701B
strain 3701B
-
-
Manually annotated by BRENDA team
strain ATCC VR1471
SwissProt
Manually annotated by BRENDA team
cv. Solara, antisense lines G310-10, G310-16, G310-76, G310-101 and G310-106
-
-
Manually annotated by BRENDA team
strain PCC 6803
-
-
Manually annotated by BRENDA team
strains T1 and G3
-
-
Manually annotated by BRENDA team
mung bean
-
-
Manually annotated by BRENDA team
strain ATCC 1470
SwissProt
Manually annotated by BRENDA team
pI VALUE
pI VALUE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
8.9
-
-, Q86LS9
-
PDB
SCOP
CATH
ORGANISM
Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610)
Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610)
Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610)
Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610)
Burkholderia pseudomallei (strain 1710b)
Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Rickettsia rickettsii (strain Sheila Smith)
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Staphylococcus aureus (strain COL)
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)