Information on EC 2.1.2.1 - glycine hydroxymethyltransferase

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The expected taxonomic range for this enzyme is: Archaea, Bacteria, Eukaryota

EC NUMBER
COMMENTARY hide
2.1.2.1
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RECOMMENDED NAME
GeneOntology No.
glycine hydroxymethyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydroxymethyl group transfer
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of antibiotics
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Biosynthesis of secondary metabolites
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Cyanoamino acid metabolism
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folate polyglutamylation
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folate transformations I
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folate transformations II
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formaldehyde assimilation I (serine pathway)
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glycine betaine degradation I
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glycine betaine degradation II (mammalian)
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glycine biosynthesis I
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Glycine, serine and threonine metabolism
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Glyoxylate and dicarboxylate metabolism
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Metabolic pathways
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Methane metabolism
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Microbial metabolism in diverse environments
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N10-formyl-tetrahydrofolate biosynthesis
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One carbon pool by folate
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photorespiration
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purine nucleobases degradation II (anaerobic)
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folate polyglutamylation
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glycine metabolism
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purine metabolism
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SYSTEMATIC NAME
IUBMB Comments
5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase
A pyridoxal-phosphate protein. Also catalyses the reaction of glycine with acetaldehyde to form L-threonine, and with 4-trimethylammoniobutanal to form 3-hydroxy-N6,N6,N6-trimethyl-L-lysine.
CAS REGISTRY NUMBER
COMMENTARY hide
9029-83-8
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
gene glyA
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
gene glyA
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Manually annotated by BRENDA team
gene glyA
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
gene glyA
UniProt
Manually annotated by BRENDA team
gene glyA
UniProt
Manually annotated by BRENDA team
gene glyA
UniProt
Manually annotated by BRENDA team
gene glyA
UniProt
Manually annotated by BRENDA team
strain ATCC13032
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Manually annotated by BRENDA team
AB strain
SwissProt
Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
strain AB90054
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Manually annotated by BRENDA team
strain L. Merr. cv. Williams, soybean
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Manually annotated by BRENDA team
strain L. Merr. cv. Williams, soybean
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
gene HTH1832
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Manually annotated by BRENDA team
gene HTH1832
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Manually annotated by BRENDA team
; strain MHOM/IN/80/Dd8
SwissProt
Manually annotated by BRENDA team
strain MHOM/IN/80/Dd8
SwissProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Bonnet monkey
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Manually annotated by BRENDA team
gene glyA
UniProt
Manually annotated by BRENDA team
gene glyA
UniProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Wistar strain
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Manually annotated by BRENDA team
gene glyA
UniProt
Manually annotated by BRENDA team
strain 3701B
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Manually annotated by BRENDA team
gene glyA
UniProt
Manually annotated by BRENDA team
strain ATCC VR1471
SwissProt
Manually annotated by BRENDA team
cv. Solara, antisense lines G310-10, G310-16, G310-76, G310-101 and G310-106
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
gene glyA
UniProt
Manually annotated by BRENDA team
gene glyA
UniProt
Manually annotated by BRENDA team
strain PCC 6803
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Manually annotated by BRENDA team
gene glyA
UniProt
Manually annotated by BRENDA team
gene glyA
UniProt
Manually annotated by BRENDA team
strains T1 and G3
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Manually annotated by BRENDA team
strain ATCC 1470
SwissProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
malfunction
metabolism
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(6S)-tetrahydrofolate + D-serine
5,10-methylenetetrahydrofolate + glycine + H2O
show the reaction diagram
(6S)-tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
show the reaction diagram
5,10-methenyl-tetrahydropteroyl pentaglutamate + glycine + H2O
5-formyl-tetrahydropteroyl pentaglutamate + L-serine
show the reaction diagram
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + D-serine
show the reaction diagram
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-Ser
show the reaction diagram
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the enzyme is a major source of one-carbon units for cellular metabolism. Potential for disruption of SHMT-mediated one-carbon metabolism by inadequate vitamin B-6 intake
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r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
show the reaction diagram
5,6,7,8-tetrahydrofolate + L-Ser
5,10-methylenetetrahydrofolate + glycine + H2O
show the reaction diagram
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r
alpha-methylserine + tetrahydrofolate
D-alanine + 5,10-methylenetetrahydrofolate
show the reaction diagram
D-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
show the reaction diagram
L-Ser + tetrahydrofolate
Gly + 5,10-methylenetetrahydrofolate
show the reaction diagram
L-Ser + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
show the reaction diagram
L-serine + modified folate
glycine + modified methylenefolate
show the reaction diagram
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
show the reaction diagram
L-serine + tetrahydropteroylglutamate
glycine + 5,10-methylene-tetrahydropteroylglutamate + H2O
show the reaction diagram
NADH + coenzyme Q10
?
show the reaction diagram
tetrahydrofolate + L-Ser
5,10-methylenetetrahydrofolate + glycine
show the reaction diagram
tetrahydrofolate + L-Ser
? + glycine + H2O
show the reaction diagram
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tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
show the reaction diagram
tetrahydromethanopterin + L-Ser
glycine + ?
show the reaction diagram
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?
tetrahydropteroylglutamate + L-Ser
glycine + ?
show the reaction diagram
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?
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(6S)-tetrahydrofolate + D-serine
5,10-methylenetetrahydrofolate + glycine + H2O
show the reaction diagram
(6S)-tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
show the reaction diagram
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + D-serine
show the reaction diagram
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-Ser
show the reaction diagram
-
the enzyme is a major source of one-carbon units for cellular metabolism. Potential for disruption of SHMT-mediated one-carbon metabolism by inadequate vitamin B-6 intake
-
-
r
5,10-methylenetetrahydrofolate + glycine + H2O
tetrahydrofolate + L-serine
show the reaction diagram
L-Ser + tetrahydrofolate
Gly + 5,10-methylenetetrahydrofolate
show the reaction diagram
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placental conversion of serine to glycine is a major source of fetal glycine
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?
L-serine + tetrahydrofolate
glycine + 5,10-methylenetetrahydrofolate + H2O
show the reaction diagram
L-serine + tetrahydropteroylglutamate
glycine + 5,10-methylene-tetrahydropteroylglutamate + H2O
show the reaction diagram
tetrahydrofolate + L-serine
5,10-methylenetetrahydrofolate + glycine + H2O
show the reaction diagram
additional information
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5,10-methylenetetrahydrofolate
pyridoxal 5'-phosphate
tetrahydrofolate
Tetrahydrofolate derivatives
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requirement, if L-serine is substrate
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