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biotechnology
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the AlkS/PalkB-expression system is shown as an efficient tool for the production of recombinant serine hydroxymethyltransferase in Escherichia coli fed-batch fermentations
degradation
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essential for one-carbon metabolism
pharmacology
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L-serine is required for pharmaceutical purposes, availability of a sugar-based microbial process for its production is desirable, however, SHMT prevents overproduction of L-serine, control of the essential SHMT activity by a novel physiological approach
analysis
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molecular dynamics simulations and interaction energy analysis for compounds designed as potential selective inhibitors of Plasmodium falciparum SHMT based on the conformational and dynamics differences observed between the residues Asp146 and Glu137 in the active sites of human SHMT and Plasmodium falciparum SHMT, respectively
analysis
molecular dynamics simulations and interaction energy analysis for compounds designed as potential selective inhibitors of Plasmodium falciparum SHMT based on the conformational and dynamics differences observed between the residues Asp146 and Glu137 in the active sites of human SHMT and Plasmodium falciparum SHMT, respectively
analysis
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protein sequence of the two isoforms, the short form SHMT-S and the long form SHMT-L, show 59% identity
analysis
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SHMT1 is a zinc-inducible gene, provides first mechanism for the regulation of folate-mediated one-carbon metabolism by zinc
drug development
the enzyme might be a a key target for the development of chemotherapic agents
drug development
the enzyme represents a potential target for chemotherapeutics
drug development
the enzyme represents a potential target for chemotherapeutics
drug development
the enzyme represents a potential target for chemotherapeutics
drug development
the enzyme represents a potential target for chemotherapeutics
drug development
the enzyme represents a potential target for chemotherapeutics
drug development
the enzyme represents a potential target for chemotherapeutics
drug development
the enzyme represents a potential target for chemotherapeutics
drug development
the enzyme represents a potential target for chemotherapeutics
drug development
the enzyme represents a potential target for chemotherapeutics
drug development
the enzyme represents a potential target for chemotherapeutics
drug development
the enzyme represents a potential target for chemotherapeutics
drug development
the human enzyme is a potential target for cancer treatment
drug development
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the enzyme represents a potential target for chemotherapeutics
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drug development
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the enzyme represents a potential target for chemotherapeutics
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drug development
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the enzyme represents a potential target for chemotherapeutics
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drug development
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the enzyme represents a potential target for chemotherapeutics
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drug development
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the enzyme represents a potential target for chemotherapeutics
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drug development
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the enzyme represents a potential target for chemotherapeutics
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medicine
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enzyme is a potential target for cancer chemotherapy
medicine
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enzyme is a potential target for cancer chemotherapy
medicine
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enzyme is a potential target for cancer chemotherapy
medicine
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enzyme is a potential target for cancer chemotherapy
medicine
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enzyme is a potential target for cancer chemotherapy
medicine
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enzyme is a potential target for cancer chemotherapy
medicine
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enzyme is a potential target for cancer chemotherapy
medicine
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enzyme is a target for antibiotics
medicine
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the cytosolic SHMT is a target enzyme for chemotherapy
medicine
animal model for drug screening of SHMT
medicine
drug target in Leishmania
medicine
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enzyme is distinct from its prokaryotic and eukaryotic counterparts, thus is a potential drug target
medicine
ldSHMT is of medical importance as a drug target since ldSHMT is preferentially expressed in the amastigote stage of parasite which resides in human macrophages
medicine
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SHMT is a potential target for antimalarial chemotherapy
medicine
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isozyme SHMT2 is a possible target for anticancer therapies
medicine
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drug target in Leishmania
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medicine
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ldSHMT is of medical importance as a drug target since ldSHMT is preferentially expressed in the amastigote stage of parasite which resides in human macrophages
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medicine
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SHMT is a potential target for antimalarial chemotherapy
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medicine
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animal model for drug screening of SHMT
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synthesis
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improved method for preparation of optically pure beta-hydroxy-alpha-amino acids, catalyzed by serine hydroxymethyl transferase with threonine aldolase activity. Usage of substrates beta-phenylserine, beta-(nitrophenyl) serine and beta-(methylsulfonylphenyl) serine with immobilized recombinant enzyme for SHMT activity, optimal at pH 7.5 and 45°C. The immobilized cells are continuously used 10 times, yielding an average conversion rate of 60.4%
synthesis
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improved method for preparation of optically pure beta-hydroxy-alpha-amino acids, catalyzed by serine hydroxymethyl transferase with threonine aldolase activity. Usage of substrates beta-phenylserine, beta-(nitrophenyl) serine and beta-(methylsulfonylphenyl) serine with immobilized recombinant enzyme for SHMT activity, optimal at pH 7.5 and 45°C. The immobilized cells are continuously used 10 times, yielding an average conversion rate of 60.4%
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additional information
two conserved inserts of 3 and 31 amino acids, distinctive characteristics of the Chlamydiales order, ancient lateral gene transfers from actinobacteria to chlamydiae
additional information
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two conserved inserts of 3 and 31 amino acids, distinctive characteristics of the Chlamydiales order, ancient lateral gene transfers from actinobacteria to chlamydiae
additional information
two conserved inserts of 3 and 31 amino acids, distinctive characteristics of the Chlamydiales order, ancient lateral gene transfers from actinobacteria to chlamydiae
additional information
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two conserved inserts of 3 and 31 amino acids, distinctive characteristics of the Chlamydiales order, ancient lateral gene transfers from actinobacteria to chlamydiae