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2.1.2.1: glycine hydroxymethyltransferase

This is an abbreviated version!
For detailed information about glycine hydroxymethyltransferase, go to the full flat file.

Word Map on EC 2.1.2.1

Reaction

5,10-methylenetetrahydrofolate
+
glycine
 +
H2O
=
tetrahydrofolate
 +
L-serine

Synonyms

AtSHMT3, bsSHMT, bstSHMT, EC 4.1.2.6, eSHMT, GlyA, GlyA protein, glycine hydroxymethyltransferrase, hSHMT, L-serine hydroxymethyltransferase, mitochondrial serine hydroxymethyltransferase, MJ1597, PvSHMT, Rhg4, serine hydroxymethyl transferase, serine hydroxymethylase hydroxymethyltransferase, serine, serine hydroxymethyltransferase, serine hydroxymethyltransferase 1, serine hydroxymethyltransferase 2, serine hydroxymethyltransferase 2alpha, serine transhydroxymethylase, serine:H4F hydroxymethyltransferase, serine:tetrahydrofolate hydroxymethyltransferase, SHM1, SHM2, SHMT, SHMT-1, SHMT-L, SHMT-S, SHMT08, SHMT1, SHMT2, SHMT2alpha, SHMT3, zcSHMT, zebrafish cytosolic serine hydroxymethyltransferase, zebrafish mitochondiral serine hydroxymethyltransferase, zmSHMT

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.2 Hydroxymethyl-, formyl- and related transferases
                2.1.2.1 glycine hydroxymethyltransferase

Temperature Range

Temperature Range on EC 2.1.2.1 - glycine hydroxymethyltransferase

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TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25 - 35
-
the enzyme shows about 35% activity at 25 or 35°C
25 - 75
-
about half-maximal activity at 25°C and 75°C
29 - 42
-
serine synthesis, about half-maximal activity at 28.5°C and 90% of maximal activity at 42°C
3 - 43
activity range
30 - 42
-
2-phenylserine degradation, about half-maximal activity at 29.5°C and 80% of maximal activity at 42°C
30 - 60
-
activity range, profile overview
30 - 65
the enzyme retains over 50% of the maximal activity at 30-65°C
35 - 60
-
more than 45% activity between 35 and 60°C
5 - 30
-
the catalytic activity increases upon temperature increment
5 - 45
60% of maximal activity at 30°C and 45°C, rapid loss of activity above
additional information