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6.2.1.12: 4-coumarate-CoA ligase

This is an abbreviated version!
For detailed information about 4-coumarate-CoA ligase, go to the full flat file.

Word Map on EC 6.2.1.12

Reaction

ATP
+
4-coumarate
 +
CoA
=
AMP
 +
diphosphate
 +
4-coumaroyl-CoA

Synonyms

4-CL, 4-coumarate CoA ligase, 4-coumarate coenzyme A ligase, 4-coumarate/coenzyme A ligase, 4-coumarate: CoA ligase, 4-coumarate: coenzyme A ligase, 4-coumarate:CoA ligase, 4-coumarate:CoA-ligase, 4-coumarate:coenzyme A (CoA) ligase, 4-Coumarate:coenzyme A ligase, 4-coumarate:coenzyme-A ligase-1, 4-coumaroyl CoA ligase, 4-coumaroyl coenzyme A ligase, 4-coumaroyl-CoA ligase, 4-coumaroyl-CoA synthase, 4-coumaroyl:CoA ligase, 4-Coumaryl-CoA synthetase, 4CL, 4CL-A1, 4CL-A2, 4CL-B, 4CL1, 4CL10, 4CL2, 4CL3, 4CL4, 4CL5, 4CL7, Ar4CL, At4CL1, Caffeolyl coenzyme A synthetase, caffeoyl-CoA ligase, caffeoyl-CoA synthetase, caffeoyl-coenzyme A synthetase, CarB, Clone 4CL14, Clone 4CL16, coumarate:CoA ligase, Feruloyl CoA ligase, Feruloyl coenzyme A synthetase, Hc4CL, Hydroxy-cinnamate:CoA ligase, Hydroxycinnamate:CoA ligase, Hydroxycinnamoyl CoA synthetase, LJ4CL1, OB4CL_ctg4, OS4CL, Os4Cl1, Os4Cl2, Os4Cl3, Os4Cl4, Os4Cl5, p-Coumaroyl CoA ligase, p-coumaroyl-CoA ligase, p-Coumaryl coenzyme A synthetase, p-Coumaryl-CoA ligase, p-Coumaryl-CoA synthetase, p-Hydroxycinnamic acid:CoA ligase, p-Hydroxycinnamoyl coenzyme A synthetase, Pc4CL2, Pl4CL1, Pl4CL2, Sa4CL1, Sa4CL2, Sa4CL3, Sinapoyl coenzyme A snthetase, Synthetase, p-coumaroyl coenzyme A, type I 4CL

ECTree

     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.12 4-coumarate-CoA ligase

KM Value

KM Value on EC 6.2.1.12 - 4-coumarate-CoA ligase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.09 - 0.18
2-coumarate
0.23
3,4,5-trimethoxycinnamate
-
isoenzyme 1
0.049 - 0.55
3,4-dimethoxycinnamate
0.028 - 0.03
3-coumarate
0.336
3-methoxcinnamate
-
-
-
0.0009 - 0.6149
4-coumarate
0.246
4-coumaric acid
-
-
0.38
4-methoxycinnamate
-
isoenzyme 1
0.5
4-methoxyferulate
-
-
0.012 - 0.34
5-hydroxyferulate
0.064
adenosine 5'-tetraphosphate
-
reverse reaction, M293P/K320L mutant enzyme, pH 7.0, 30°C
0.004 - 1.507
ATP
0.0009 - 0.725
caffeate
0.0094 - 6.63
cinnamate
0.0032 - 0.5
CoA
0.004 - 0.007
CoASH
0.253 - 0.4418
dihydro-4-coumarate
0.0009 - 3.1
ferulate
0.026 - 0.15
isoferulate
0.69
p-methoxycinnamate
-
-
0.005 - 0.0589
sinapate
1.32
sinapinate
wild type enzyme, at pH 7.5 and 25°C
0.001 - 0.022
sinapoate
0.02576 - 0.664
trans-cinnamate
additional information
additional information
-