6.2.1.12: 4-coumarate-CoA ligase

This is an abbreviated version!
For detailed information about 4-coumarate-CoA ligase, go to the full flat file.

Word Map on EC 6.2.1.12

Reaction

ATP
+
4-coumarate
+
CoA
=
AMP
+
diphosphate
+
4-coumaroyl-CoA

Synonyms

4-Coumaryl-CoA synthetase, Synthetase, p-coumaroyl coenzyme A, p-Coumaroyl CoA ligase, p-Coumaryl coenzyme A synthetase, p-Coumaryl-CoA synthetase, p-Coumaryl-CoA ligase, Feruloyl CoA ligase, Hydroxycinnamoyl CoA synthetase, Sinapoyl coenzyme A snthetase, Feruloyl coenzyme A synthetase, p-Hydroxycinnamoyl coenzyme A synthetase, Caffeolyl coenzyme A synthetase, p-Hydroxycinnamic acid:CoA ligase, 4-Coumarate:coenzyme A ligase, Hydroxy-cinnamate:CoA ligase, Hydroxycinnamate:CoA ligase, 4CL, 4-coumaroyl-CoA synthase, Clone 4CL14, Clone 4CL16, 4-coumarate:coenzyme A (CoA) ligase, coumarate:CoA ligase, CarB, 4-coumarate:coenzyme-A ligase-1, 4-coumarate:CoA ligase, 4-coumarate coenzyme A ligase, 4-coumaroyl:CoA ligase, 4-coumarate:CoA-ligase, 4CL1, 4-coumarate: coenzyme A ligase, 4CL-A1, 4CL-A2, 4CL-B, 4CL2, p-coumaroyl-CoA ligase, 4-coumarate: CoA ligase, 4CL4, 4CL3, 4-coumarate/coenzyme A ligase, 4-CL, Os4Cl1, Os4Cl2, Os4Cl3, Os4Cl4, Os4Cl5, 4-coumaroyl-CoA ligase, At4CL1, LJ4CL1, OS4CL, OB4CL_ctg4, Ar4CL, Pl4CL1, Pl4CL2, Hc4CL, Sa4CL1, Sa4CL2, Sa4CL3, type I 4CL, caffeoyl-coenzyme A synthetase, caffeoyl-CoA synthetase, caffeoyl-CoA ligase, 4CL10, 4CL7, 4-coumaroyl CoA ligase, 4-coumaroyl coenzyme A ligase, 4-coumarate CoA ligase, 4CL5, Pc4CL2

ECTree

     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.12 4-coumarate-CoA ligase

Crystallization

Crystallization on EC 6.2.1.12 - 4-coumarate-CoA ligase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
purified recombinant isozyme At4CL1 and engineered isozyme At4CL1-VvSTS fusion enzyme, X-ray diffraction structure determination and analysis
isoform 4CL2 in complex with Mg2+ and ATP or with AMP and coenzyme A or with three different hydroxycinnamate-AMP intermediates: 4-coumaroyl-AMP, caffeoyl-AMP, and feruloyl-AMP, hanging drop vapor diffusion method, using 20% (w/v) PEG 3350 and 0.2 M potassium nitrate or 4.4% (w/v) PEG 8000, 0.08 M sodium cacodylate (pH 6.5), 0.16 M calcium acetate, and 20% (v/v) glycerol or 25.5% (w/v) PEG 8000, 0.085 M sodium cacodylate (pH 6.5), 0.17 M sodium acetate, and 15% (v/v) glycerol or 25% (w/v) PEG 3350, 0.2 M ammonium acetate, and 0.1 M Tris (pH 8.5)