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6.2.1.12: 4-coumarate-CoA ligase

This is an abbreviated version!
For detailed information about 4-coumarate-CoA ligase, go to the full flat file.

Word Map on EC 6.2.1.12

Reaction

ATP
+
4-coumarate
 +
CoA
=
AMP
 +
diphosphate
 +
4-coumaroyl-CoA

Synonyms

4-CL, 4-coumarate CoA ligase, 4-coumarate coenzyme A ligase, 4-coumarate/coenzyme A ligase, 4-coumarate: CoA ligase, 4-coumarate: coenzyme A ligase, 4-coumarate:CoA ligase, 4-coumarate:CoA-ligase, 4-coumarate:coenzyme A (CoA) ligase, 4-Coumarate:coenzyme A ligase, 4-coumarate:coenzyme-A ligase-1, 4-coumaroyl CoA ligase, 4-coumaroyl coenzyme A ligase, 4-coumaroyl-CoA ligase, 4-coumaroyl-CoA synthase, 4-coumaroyl:CoA ligase, 4-Coumaryl-CoA synthetase, 4CL, 4CL-A1, 4CL-A2, 4CL-B, 4CL1, 4CL10, 4CL2, 4CL3, 4CL4, 4CL5, 4CL7, Ar4CL, At4CL1, Caffeolyl coenzyme A synthetase, caffeoyl-CoA ligase, caffeoyl-CoA synthetase, caffeoyl-coenzyme A synthetase, CarB, Clone 4CL14, Clone 4CL16, coumarate:CoA ligase, Feruloyl CoA ligase, Feruloyl coenzyme A synthetase, Hc4CL, Hydroxy-cinnamate:CoA ligase, Hydroxycinnamate:CoA ligase, Hydroxycinnamoyl CoA synthetase, LJ4CL1, OB4CL_ctg4, OS4CL, Os4Cl1, Os4Cl2, Os4Cl3, Os4Cl4, Os4Cl5, p-Coumaroyl CoA ligase, p-coumaroyl-CoA ligase, p-Coumaryl coenzyme A synthetase, p-Coumaryl-CoA ligase, p-Coumaryl-CoA synthetase, p-Hydroxycinnamic acid:CoA ligase, p-Hydroxycinnamoyl coenzyme A synthetase, Pc4CL2, Pl4CL1, Pl4CL2, Sa4CL1, Sa4CL2, Sa4CL3, Sinapoyl coenzyme A snthetase, Synthetase, p-coumaroyl coenzyme A, type I 4CL

ECTree

     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.12 4-coumarate-CoA ligase

Specific Activity

Specific Activity on EC 6.2.1.12 - 4-coumarate-CoA ligase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.008 - 4
mutant enzyme M247Y/A251S, with dihydro-4-coumarate as substrate, at pH 7.5 and 30°C
0.0093
mutant enzyme A251S, with dihydro-4-coumarate as substrate, at pH 7.5 and 30°C
0.013
-
purified leaf enzyme, room temperature
0.0135
mutant enzyme A251S, with caffeate as substrate, at pH 7.5 and 30°C
0.0152
mutant enzyme M247Y/A251S, with cinnamate as substrate, at pH 7.5 and 30°C
0.0161
mutant enzyme M247Y/A251S, with caffeate as substrate, at pH 7.5 and 30°C
0.0204
wild type enzyme, with dihydro-4-coumarate as substrate, at pH 7.5 and 30°C
0.0231
mutant enzyme A251S, with cinnamate as substrate, at pH 7.5 and 30°C
0.0344
mutant enzyme M247Y, with dihydro-4-coumarate as substrate, at pH 7.5 and 30°C
0.0378
wild type enzyme, with cinnamate as substrate, at pH 7.5 and 30°C
0.0409
wild type enzyme, with caffeate as substrate, at pH 7.5 and 30°C
0.0577
mutant enzyme M247Y/A251S, with 4-coumarate as substrate, at pH 7.5 and 30°C
0.0706
mutant enzyme A251S, with 4-coumarate as substrate, at pH 7.5 and 30°C
0.1079
mutant enzyme M247Y, with cinnamate as substrate, at pH 7.5 and 30°C
0.1136
wild type enzyme, with 4-coumarate as substrate, at pH 7.5 and 30°C
0.13
-
purified cell culture enzyme, room temperature
0.1309
mutant enzyme M247Y, with caffeate as substrate, at pH 7.5 and 30°C
0.33
-
purified xylem enzyme, room temperature
0.34
-
K211S mutant enzyme with caffeate as substrate
0.37
-
R449Q mutant enzyme with caffeate as substrate
0.4561
mutant enzyme M247Y, with 4-coumarate as substrate, at pH 7.5 and 30°C
0.46
-
K457S mutant enzyme with caffeate as substrate
12.5
-
wild type with caffeate as substrate
2.64
-
E401Q mutant enzyme with caffeate as substrate
3.624
-
purified recombinnat enzyme, substrate 4-coumaric acid
5.64
-
C403A mutant enzyme with caffeate as substrate
additional information