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6.2.1.12: 4-coumarate-CoA ligase

This is an abbreviated version!
For detailed information about 4-coumarate-CoA ligase, go to the full flat file.

Word Map on EC 6.2.1.12

Reaction

ATP
+
4-coumarate
 +
CoA
=
AMP
 +
diphosphate
 +
4-coumaroyl-CoA

Synonyms

4-CL, 4-coumarate CoA ligase, 4-coumarate coenzyme A ligase, 4-coumarate/coenzyme A ligase, 4-coumarate: CoA ligase, 4-coumarate: coenzyme A ligase, 4-coumarate:CoA ligase, 4-coumarate:CoA-ligase, 4-coumarate:coenzyme A (CoA) ligase, 4-Coumarate:coenzyme A ligase, 4-coumarate:coenzyme-A ligase-1, 4-coumaroyl CoA ligase, 4-coumaroyl coenzyme A ligase, 4-coumaroyl-CoA ligase, 4-coumaroyl-CoA synthase, 4-coumaroyl:CoA ligase, 4-Coumaryl-CoA synthetase, 4CL, 4CL-A1, 4CL-A2, 4CL-B, 4CL1, 4CL10, 4CL2, 4CL3, 4CL4, 4CL5, 4CL7, Ar4CL, At4CL1, Caffeolyl coenzyme A synthetase, caffeoyl-CoA ligase, caffeoyl-CoA synthetase, caffeoyl-coenzyme A synthetase, CarB, Clone 4CL14, Clone 4CL16, coumarate:CoA ligase, Feruloyl CoA ligase, Feruloyl coenzyme A synthetase, Hc4CL, Hydroxy-cinnamate:CoA ligase, Hydroxycinnamate:CoA ligase, Hydroxycinnamoyl CoA synthetase, LJ4CL1, OB4CL_ctg4, OS4CL, Os4Cl1, Os4Cl2, Os4Cl3, Os4Cl4, Os4Cl5, p-Coumaroyl CoA ligase, p-coumaroyl-CoA ligase, p-Coumaryl coenzyme A synthetase, p-Coumaryl-CoA ligase, p-Coumaryl-CoA synthetase, p-Hydroxycinnamic acid:CoA ligase, p-Hydroxycinnamoyl coenzyme A synthetase, Pc4CL2, Pl4CL1, Pl4CL2, Sa4CL1, Sa4CL2, Sa4CL3, Sinapoyl coenzyme A snthetase, Synthetase, p-coumaroyl coenzyme A, type I 4CL

ECTree

     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.12 4-coumarate-CoA ligase

Expression

Expression on EC 6.2.1.12 - 4-coumarate-CoA ligase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
CarE and CarD (and thus the caffeate reduction operon) are induced in cells grown in the presence of cinnamate, sinapate, caffeate, ferulate, or 4-coumarate
enzyme gene transcription is induced when Plagiochasma appendiculatum thallus is treated with either salicylic acid or methyl jasmonate
exposure of tea shoots to 50-100 microM catechins leads to down-regulation of the expression of 4CL
expression of Pl4CL1 is increased more than 3fold in the 24 h methyl jasmonate-treated samples
expression of Pl4CL2 is not significantly influenced in methyl jasmonate-treated samples
Hc4CL is upregulated by NaCl treatment, reaching its maximum level at 24 h after treatment. The enzyme is induced by cold and drought treatment. The Hc4CL gene is downregulated at early time points and then upregulated 24 h after H2O2 treatment, after which the transcript level returns to a negative level relative to the control. The enzyme also shows biphasic expression in response to wounding. Specifically, the transcript is highly expressed at 6 h and then decreases sharply at 12 h with a second induction at 24 h
isozyme Os4CL1 is downregulated by UV radiation when dark-adapted rice plants are illuminated with UV-containing white light
isozyme Os4CL3 is downregulated by UV radiation when dark-adapted rice plants are illuminated with UV-containing white light
isozyme Os4CL4 is downregulated by UV radiation when dark-adapted rice plants are illuminated with UV-containing white light
isozyme Os4CL5 is downregulated by UV radiation when dark-adapted rice plants are illuminated with UV-containing white light
Os4CL2 is strongly activated by UV irradiation, the isozyme is induced by up to 16fold at 12 h after the onset of irradiation, and expression remains high at 24 h after treatment
strong positive correlation coefficient between catechins content and the expression of Cs4Cl throughout a variety of environmental conditions such as drought stress, abscisic acid and gibberellic acid treatments, and wounding. Tea clones with high levels of catechins have higher expression of 4CL whereas tea clones with lower catechins exhibit lower expression of this gene
the enzyme expression in the leave and stem is increased significantly with the growth of seedlings of Angelica sinensis
the enzyme expression is reduced by abscisic acid treatment. The Hc4CL gene is downregulated at early time points and then upregulated 24 h after H2O2 treatment, after which the transcript level returns to a negative level relative to the control. The enzyme also shows biphasic expression in response to wounding. Specifically, the transcript is highly expressed at 6 h and then decreases sharply at 12 h with a second induction at 24 h
the expression level of isoform 4CL10 is clearly enhanced under PEG treatment
transcript abundance of isoform 4CL7 is up-regulated under heat treatment
upon PEG, NaCl, CuSO4, heat and cold treatments, the expression level of isoform 4CL1 significantly decreases