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3.1.4.1: phosphodiesterase I

This is an abbreviated version!
For detailed information about phosphodiesterase I, go to the full flat file.

Word Map on EC 3.1.4.1

Reaction

[nucleotide]n
+
H2O
=
[nucleotide]m
 +
Nucleotide

Synonyms

5' nucleotide phosphodiesterase/alkaline phosphodiesterase I, 5'-exonuclease, 5'-NPDase, 5'-nucleotide phosphodiesterase, 5'-PDase, 5'-PDE, 5'-phosphodiesterase, 5'NPDE, alkaline phosphodiesterase, Ap3A (Ap4A) hydrolase, autotaxin, B10, calcium-dependent phosphodiesterase 1C, cleavage/polyadenylation specificity factor, CPSF-73, cRNPMase-5'-PDase, cyclic nucleotide phosphodiesterase 1, cyclic-ribonucleotide phosphomutase-5'-phosphodiesterase I, ecto-NPPase, ecto-nucleotide pyrophosphatase/phosphodiesterase 1, ectonucleotide pyrophosphatase phosphodiesterase 1, ectonucleotide pyrophosphatase/phosphodiesterase 1, ectonucleotide pyrophosphate/phosphodiesterase-1, ENPP-1, ENPP1, exonuclease I, exophosphodiesterase, gp130RB13-6, liver alkaline phosphodiesterase 1, liver nucleotide phosphodiesterase, More, NPP, NPP-1, NPP/PDE, NPP1, NPP2, NPP3, nucleotide phosphodiesterase, nucleotide phosphodiesterase/pyrophosphatase, nucleotide pyrophosphatase/alkaline phosphodiesterase I, nucleotide pyrophosphatase/phosphodiesterase 1, nucleotide pyrophosphatase/phosphodiesterase I, nucleotide pyrophosphatase/phosphodiesterase-1, nucleotide pyrophosphatase/phosphodiesterase-2, nucleotide pyrophosphatase/phosphodiesterase-3, orthophosphoric diester phosphohydrolase, PC-1, PDase, PDE, PDE 1A, PDE I, PDE1, PDE1A, PDE1C, PDE4A, PDEase, phosphodiesterase, phosphodiesterase 1, phosphodiesterase 1A, phosphodiesterase 1C, phosphonate monoester hydrolase/phosphodiesterase, phosphoric diester hydrolase, plant exonuclease I, plasma cell antigen 1, plasma cell membrane glycoprotein, plasma cell membrane protein-1, PMH, RNase J1, SMPDL3A, sphingomyelin phosphodiesterase, acid-like 3A, SVPD, Tdp 1, TDP1, tRNase Z, tyrosyl DNA phosphodiesterase 1, tyrosyl-DNA phosphodiesterase 1, tyrosyl-DNA phosphodiesterase I, tyrosyl-DNA-phosphodiesterase I, yfcE

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.1 phosphodiesterase I

Specific Activity

Specific Activity on EC 3.1.4.1 - phosphodiesterase I

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0015
-
wild-type protein, in the absence of Ca2+, reflecting the basal PDE activity in the cilia, 37°C, pH not specified in the publication
0.0034
-
wild-type cilial PDE, supplemented with Ca2+ and calmodulin, 2.3fold increased compared compared to the assay without Ca2+, 37°C, pH not specified in the publication
0.03
-
cytoplasmic membrane of mammary gland
0.103
-
-
0.183
-
-
0.23
-
liver microsomes, substrate: p-nitrophenylthymidine 5'-phosphate
0.3
-
liver microsomes, substrate: p-nitrophenylthymidine 5'-phosphate
0.47
-
kidney microsomes, substrate: p-nitrophenylthymidine 5'-phosphate
0.48
-
substrate: NAD+
0.63
-
kidney microsomes, substrate: p-nitrophenylthymidine 5'-phosphate
1.2
-
substrate: p-nitrophenyluridine 5'-phosphate
1.88
-
substrate: ApU
125.2
-
-
13
-
nucleotide pyrophosphatase/phosphodiesterase I
15.5 - 29
-
-
16
-
calf
2.16
-
pH 5.0, 60°C
253.3
-
-
3230
-
FS-44: 5'-PDase activity of bifunctional enzyme: cyclic-ribonucleotide phosphomutase-5'-phosphodiesterase
411
-
PC-1, phosphodiesterase I activity, substrate: p-nitrophenylthymidine 5'-phosphate
47.7
-
-
5.08
-
-
8570
-
pH 5.0, 60°C
additional information