Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.1.4.1: phosphodiesterase I

This is an abbreviated version!
For detailed information about phosphodiesterase I, go to the full flat file.

Word Map on EC 3.1.4.1

Reaction

[nucleotide]n
+
H2O
=
[nucleotide]m
 +
Nucleotide

Synonyms

5' nucleotide phosphodiesterase/alkaline phosphodiesterase I, 5'-exonuclease, 5'-NPDase, 5'-nucleotide phosphodiesterase, 5'-PDase, 5'-PDE, 5'-phosphodiesterase, 5'NPDE, alkaline phosphodiesterase, Ap3A (Ap4A) hydrolase, autotaxin, B10, calcium-dependent phosphodiesterase 1C, cleavage/polyadenylation specificity factor, CPSF-73, cRNPMase-5'-PDase, cyclic nucleotide phosphodiesterase 1, cyclic-ribonucleotide phosphomutase-5'-phosphodiesterase I, ecto-NPPase, ecto-nucleotide pyrophosphatase/phosphodiesterase 1, ectonucleotide pyrophosphatase phosphodiesterase 1, ectonucleotide pyrophosphatase/phosphodiesterase 1, ectonucleotide pyrophosphate/phosphodiesterase-1, ENPP-1, ENPP1, exonuclease I, exophosphodiesterase, gp130RB13-6, liver alkaline phosphodiesterase 1, liver nucleotide phosphodiesterase, More, NPP, NPP-1, NPP/PDE, NPP1, NPP2, NPP3, nucleotide phosphodiesterase, nucleotide phosphodiesterase/pyrophosphatase, nucleotide pyrophosphatase/alkaline phosphodiesterase I, nucleotide pyrophosphatase/phosphodiesterase 1, nucleotide pyrophosphatase/phosphodiesterase I, nucleotide pyrophosphatase/phosphodiesterase-1, nucleotide pyrophosphatase/phosphodiesterase-2, nucleotide pyrophosphatase/phosphodiesterase-3, orthophosphoric diester phosphohydrolase, PC-1, PDase, PDE, PDE 1A, PDE I, PDE1, PDE1A, PDE1C, PDE4A, PDEase, phosphodiesterase, phosphodiesterase 1, phosphodiesterase 1A, phosphodiesterase 1C, phosphonate monoester hydrolase/phosphodiesterase, phosphoric diester hydrolase, plant exonuclease I, plasma cell antigen 1, plasma cell membrane glycoprotein, plasma cell membrane protein-1, PMH, RNase J1, SMPDL3A, sphingomyelin phosphodiesterase, acid-like 3A, SVPD, Tdp 1, TDP1, tRNase Z, tyrosyl DNA phosphodiesterase 1, tyrosyl-DNA phosphodiesterase 1, tyrosyl-DNA phosphodiesterase I, tyrosyl-DNA-phosphodiesterase I, yfcE

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.1 phosphodiesterase I

Posttranslational Modification

Posttranslational Modification on EC 3.1.4.1 - phosphodiesterase I

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
glycoprotein
phosphoprotein
poly(ADP-ribosyl)ation
the N-terminal region is posttranslationally modified by parylation, i.e. addition of polyadenosylribose units at an undefined site. Parylation of the enzyme stimulates Tdp1 translocation to sites of DNA damage, not only increases Tdp1 protein stability but also facilitates Tdp1 interaction/complex formation with XRCC1
proteolytic modification
sumoylation
the N-terminal region is posttranslationally modified by sumoylation, i.e. addition of small ubiquitin-like protein to Lys111, the sumoylation may be involved in regulating Tdp1 recruitment to DNA lesions. The enzyme is conjugated to all three SUMO isoforms, SUMO-1, SUMO-2 and SUMO-3