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Literature summary for 3.1.4.1 extracted from
- Glycine-enhanced inhibition of rat liver nucleotide pyrophosphatase/phosphodiesterase-I by EDTA: a full account of the reported inhibition by commercial preparations of acidic fibroblast growth factor (FGF-1) (1998), FEBS Lett., 421, 77-79.
General Stability
| General Stability | Organism |
|---|---|
| PC-1, nucleotide pyrophosphatase/phosphodiesterase I, divalent cations protect from thermal inactivation | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| EDTA | PC-1, nucleotide pyrophosphatase/phosphodiesterase I: glycine-enhanced inhibition, reversed by Mg2+ | Rattus norvegicus |  |
| glycine | PC-1, nucleotide pyrophosphatase/phosphodiesterase I: at high concentrations, 100 mM; PC-1, nucleotide pyrophosphatase/phosphodiesterase I: glycine-enhanced inhibition by EDTA, by itself, up to 25 mM, is not inhibitory | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
PC-1, nucleotide pyrophosphatase/phosphodiesterase I | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| PC-1, NPP/PDE, nucleotide pyrophosphatase/phosphodiesterase I | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | PC-1, nucleotide pyrophosphatase/phosphodiesterase I | Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 13 | - |
nucleotide pyrophosphatase/phosphodiesterase I | Rattus norvegicus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| nucleotide pyrophosphatase/phosphodiesterase I, -20øC, 1 mg/ml bovine serum albumin, stable for at least 1 year | Rattus norvegicus |
| nucleotide pyrophosphatase/phosphodiesterase I, once thawed, 4øC, 1 mg/ml bovine serum albumin, stable for at least 1 month | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5'-p-nitrophenyl deoxythymidine 5'-phosphate + H2O | nucleotide pyrophosphatase/phosphodiesterase I | Rattus norvegicus | 5'-dTMP + p-nitrophenol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| NPP/PDE | nucleotide pyrophosphatase/phosphodiesterase I | Rattus norvegicus |
| nucleotide pyrophosphatase/phosphodiesterase I | EC 3.6.1.9 /EC 3.1.4.1 | Rattus norvegicus |
| PC-1 | PC-1, plasma-cell differentiation antigen-1, membrane glycoprotein, has 5'-nucleotide phosphodiesterase and nucleotide pyrophosphatase activity | Rattus norvegicus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| additional information | - |
PC-1, nucleotide pyrophosphatase/phosphodiesterase I: EDTA favors thermal inactivation, divalent cations protect from thermal inactivation | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9 | 9.1 | nucleotide pyrophosphatase/phosphodiesterase I | Rattus norvegicus |
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Release 2023.1 (January 2023)
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