Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ADP | PC-1 | Rattus norvegicus | |
AMP | PC-1 | Rattus norvegicus | |
ATP | PC-1 | Rattus norvegicus | |
dithiothreitol | PC-1 | Rattus norvegicus | |
EDTA | PC-1 | Rattus norvegicus | |
additional information | PC-1, no inhibition by MgCl2 and /or CaCl2 | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasmic membrane | PC-1 | Rattus norvegicus | - |
- |
extracellular | PC-1, active site of plasma-membrane-associated PC-1 appears to be located extracellularly | Rattus norvegicus | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
118000 | - |
x * 118000 + x * 128000, PC-1, SDS-PAGE | Rattus norvegicus |
128000 | - |
x * 118000 + x * 128000, PC-1, SDS-PAGE | Rattus norvegicus |
500000 | - |
PC-1, gel filtration | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | PC-1, plasma-membrane-associated enzyme with nucleotide pyrophosphatase/phosphodiesterase I activity is probably involved in the clearance of extracellular nucleotides such as ATP and diadenosine polyphosphates | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
PC-1, nucleotide pyrophosphatase/phosphodiesterase I | - |
Purification (Comment) | Organism |
---|---|
PC-1, NPP/PDE, nucleotide pyrophosphatase/phosphodiesterase I | Rattus norvegicus |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
[nucleotide]n + H2O = [nucleotide]m + nucleotide | PC-1, enzymic activities and regulation of PC-1 | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | PC-1, nucleotide pyrophosphatase/phosphodiesterase I | Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
411 | - |
PC-1, phosphodiesterase I activity, substrate: p-nitrophenylthymidine 5'-phosphate | Rattus norvegicus |
Storage Stability | Organism |
---|---|
PC-1, -20øC, 150 mM NaCl | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O | PC-1 | Rattus norvegicus | 5'-AMP + diphosphate | PC-1 | ? | |
additional information | PC-1, plasma-membrane-associated enzyme with nucleotide pyrophosphatase/phosphodiesterase I activity is probably involved in the clearance of extracellular nucleotides such as ATP and diadenosine polyphosphates | Rattus norvegicus | ? | - |
? | |
p-nitrophenylthymidine 5'-phosphate + H2O | PC-1 | Rattus norvegicus | 5'-TMP + p-nitrophenol | - |
? | |
UDP-glucose + H2O | PC-1 | Rattus norvegicus | glucose-1-phosphate + 5'-UMP | PC-1 | ? |
Subunits | Comment | Organism |
---|---|---|
tetramer | x * 118000 + x * 128000, PC-1, SDS-PAGE | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
PC-1 | PC-1, plasma-cell differentiation antigen-1, a trifunctional enzyme, displaying a phosphodiesterase I /nucleotide pyrophosphatase activity, a protein threonine kinase activity, and a nucleotide-stimulated protein threonine phosphatase activity | Rattus norvegicus |